Category: 7051-34-5

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7051-34-5, name is (Bromomethyl)cyclopropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 7051-34-5

a) 3-cyclopropylmethoxy-4-difluoromethoxy-benzaldehyde 4.70 g (24.98 mmol) 4-difluoromethoxy-3-hydroxybenzaldehyde are placed in 50 ml of dimethylformamide, 4.00 g (29.63 mmol) bromomethylcyclopropane and 3.50 g (25.32 mmol) potassium carbonate are added. The reaction mixture is heated to 100 C. for 20 hours, then the dimethylformamide is concentrated by evaporation. The residue is extracted with ethyl acetate and water, the organic phase is dried and evaporated to dryness. Yield: 5.83 g (96% of theoretical)

The synthetic route of 7051-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Boehringer Ingelheim International GmbH; US2006/116373; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 7051-34-5, name is (Bromomethyl)cyclopropane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7051-34-5, Application In Synthesis of (Bromomethyl)cyclopropane

Cyclopropyl methyl bromide (1.4 ml, 14.46 mmol), sodium iodide (0.986 g, 6.6 mmol) and potassium carbonate (3.64 g, 26.3 mmol) were added sequentially to a stirred solution of 4-hydroxybenzoic acid methyl ester (2.0 g, 13.14 mmol), in 25 ml of acetone at room temperature and the mixture was refluxed for 44 h. The solvent was evaporated to obtain a residue to which 10% NaOH (80 ml) was added. The solution was extracted with DCM twice. The combined DCM layers were washed with water and brine and dried over anhydrous Na2SO^ The solvent was evaporated to obtain 2.5 g (92.25%) of 4- cyclopropylmethoxybenzoic acid methyl ester. LCMS: [M+H]+ 270.3; IH-NMR (CDCl3): 7.964-7.986 (d, 2H, J=8.8 Hz), 6.895-6.917 (d, 2H, J=8.8 Hz), 3.879 (s, 3H), 3.849-3.867 (d, 2H, J=7.2 Hz), 1.262-1.281 (m, IH), 0.639-0.671 (m, 2H), 0.360-0.372 (m, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; FOREST LABORATORIES HOLDINGS LIMITED; SARMA, Pakala, Kumara Savithru; ACHARYA, Vinod, Parameshwaran; KASIBHATLA, Srinivas, Rao; VISWANADHAN, Vellarkad, Narayana; SHEKHAR, Polisetti; BISCHOFF, Alexander; WO2010/127212; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 7051-34-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7051-34-5 name is (Bromomethyl)cyclopropane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Reference Example 1-19; 2-(cyclopropylmethyO-l,3-dithiane-2-carboxylic acid ethyl esterSodium hydride (1.03 g) was suspended in toluene (40.0 mL), followed by adding a solution of ethyl l,3-dithiane-2-carboxylate (4.13 g) and (bromomethyl)cyclopropane (2.52 mL) in dimethylformamide (10 mL) to the suspension at 00C and stirring the mixture overnight at room temperature. A saturated aqueous ammonium chloride solution was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated saline solution and then dried over anhydrous sodium sulfate. Insoluble matters were filtered out, and the filtrate was concentrated under reduced pressure to give the title compound (5.20 g) as a colorless oil. mass:247(M+l)+ .

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (Bromomethyl)cyclopropane, and friends who are interested can also refer to it.

Reference:
Patent; BANYU PHARMACEUTICAL CO.,LTD.; KAMEDA, Minoru; KOBAYASHI, Kensuke; NAKAMA, Chisato; ANDO, Makoto; SATO, Nagaaki; WO2010/126163; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7051-34-5, name is (Bromomethyl)cyclopropane, A new synthetic method of this compound is introduced below., Safety of (Bromomethyl)cyclopropane

L-Cysteine (100 g, 0.825 mol) was suspended in ethanol (850 mL). A solution of sodium hydroxide (1.65 mol) in ethanol (650 mL) was added during 40 min at 20-25 C. To the solution was added bromomethylcyclopropane (0.907 mol) at 25-30 C. The reaction mixture was stirred at ambient temperature overnight, the neutralized with 2N HCl (300 mL). The suspension was concentrated under vacuum to 400 mL, then water (750 mL) was added, and pH was adjusted to 6.5 with 2N HCl. The mixture was stirred for 2 h at 0-5 C., the precipitate was filtered, washed with water and dried under vacuum to give (R)-2-amino-3-cyclopropyl-methylsulfanylpropionic acid as a white crystalline solid (128.2 g; yield=88.6 %). C7H13NO2S; MW=175.3; Tmelt=2090 C; NMR (DMSO, ppm): 0.20 (m, 2H), 0.50 (m, 2H), 0.94 (m, 1H), 2.50 (m, 2H), 2.78 (dd, J=14.5 and 8.5 Hz, 1 H), 3.08 (dd, J=14.5 and 4 Hz, 1 H) and 7.64 (ls, 1H (mobile)); SM (EI; m/z): 130 (M+-COOH), 89, 74.

The synthetic route of 7051-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AXYS PHARMACEUTICALS, INC.; AVENTIS PHARMACEUTICALS, INC.; US2004/19218; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 7051-34-5, name is (Bromomethyl)cyclopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 7051-34-5

[>^CO2Et[1,3] Dithiane-2-carboxylic acid ethyl ester (1.29 g, 6.71 mmol) and bromomethyl-cyclopropane (0.99 g, 7.38 mmol) dissolved in dry DMF (1 mL), was added slowly to a stirred suspension of NaH (60 % in mineral oil, 268 mg, 6.71 mmol) in dry toluene (2 mL). The mixture was stirred at room temperature overnight and LC-MS showed completion of the reaction. The reaction was quenched with H2O, diluted with EtOAc. The organic layers were washed with H2O and dried with MgSO^ The solution was filtered and concentrated in vacuo to give desired product, 2-cyclopropylmethyl-[l,3]dithiane-2-carboxyIic acid ethyl ester, as yellow oil (1.49 g, 91%). LC-MS (ESI+): m/e = 247.0 [M+l]+ (exact ms: 246.07).

The synthetic route of (Bromomethyl)cyclopropane has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ANADYS PHARMACEUTICALS, INC.; WO2008/82725; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 7051-34-5,Some common heterocyclic compound, 7051-34-5, name is (Bromomethyl)cyclopropane, molecular formula is C4H7Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 4-fluoro-3-hydroxybenzonitrile (10.0 g, 78.74 mmol) in dry DMF (100 mL), K2C03 (21.73 g, 157.4 mmol) was added followed by addition ofcyclopropyl methyl bromide (12.85 g, 94.48 mmol). The reaction mixture was heated at 90C for 4 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was quenched with cold water and precipitated solid wasfiltered, washed with pentane to afford XII. Yield: 12 g, 94%; ?H NMR (400 MHz, CDC13) 7.28-7.11 (m, 3H), 3.90 (d, J= 7.1 Hz, 2H), 1.32-1.29 (m, 1H), 0.76-0.63 (m, 2H), 0.45-0.32 (m, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (Bromomethyl)cyclopropane, its application will become more common.

Reference:
Patent; CV6 THERAPEUTICS (NI) LIMITED; SPYVEE, Mark; LEWIS, Michael; (300 pag.)WO2018/98204; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

7051-34-5, name is (Bromomethyl)cyclopropane, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C4H7Br

A solution of ethyl 1,3-dithiane-2-carboxylate (10.00 g, 52.00 mmol) and (bromomethyl)cyclopropane (7.02 g, 52.00 mmol) in dry DMF (20 ml_) was added dropwise over a period of 20 min to an ice cooled suspension of NaH (60% oil 15 dispension, 4.20 g, 104.00 mmol) in toluene (60 ml_). The mixture was stirred at rt overnight. Water (50 mL) was added and the mixture was extracted with EtOAc (2 x 50 ml_). The combined organic layers were dried over anhydrous Na2S04, filtered and concentrated to dryness. The residue was purified by column chromatography on silica gel (PE: EtOAc = 5:1) to give the title compound as a yellow oil.

The synthetic route of 7051-34-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHENEX DISCOVERY VERWALTUNGS-GMBH; STEENECK, Christoph; KINZEL, Olaf; ANDERHUB, Simon; HORNBERGER, Martin; PINTO, Sheena; HERKERT, Barbara; HOFFMANN, Thomas; (129 pag.)WO2019/206800; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7051-34-5 as follows. name: (Bromomethyl)cyclopropane

Reference J; Synthesis of 2(i?)-3-cyclopropylmethylsulfanyl-2-(2,2,2-trifluoro-l(itS)-phenyl- ethylamino)propan-l-ol Atty. Docket No. CLOOl 532 PCT 61 EPO Step 1; An ice water bath cooled solution of Z-cysteine in IN sodium hydroxide (740 mL) and dioxane (740 mL) was treated with bromomethylcyclopropane (50 g, 370 mmol). The reaction mixture was allowed to warm to room temperature and stirred for 16 h. Dioxane was removed under reduced pressure and the resulting aqueous solution was adjusted to pH 6 with 6N HCl and placed in a refrigerator for 20 h. The product was collected by vacuum filtration, washed with hexanes and lyophilized to give 2(i?)-amino-3-cyclopropylmethyl-sulfanylpropionic acid (57.28 g) as a white solid.

According to the analysis of related databases, 7051-34-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AXYS PHARMACEUTICALS, INC.; WO2006/34004; (2006); A2;,
Bromide – Wikipedia,
bromide – Wiktionary