Category: 7051-34-5

Chen, Haifeng; Yue, Huifeng; Zhu, Chen; Rueping, Magnus published an article in 2022. The article was titled 《Reactivity in Nickel-Catalyzed Multi-component Sequential Reductive Cross-Coupling Reactions》, and you may find the article in Angewandte Chemie, International Edition.SDS of cas: 7051-34-5 The information in the text is summarized as follows:

The nickel-catalyzed three-component reductive carbonylation of alkyl halides, aryl halides, and Et chloroformate is described. Et chloroformate is utilized as a safe and readily available source of CO in this multi-component protocol, providing an efficient and practical alternative for the synthesis of aryl-alkyl ketones. The reaction exhibits a wide substrate scope and good functional group compatibility. Exptl. and DFT mechanistic studies highlight the complexity of the cross-electrophile coupling and provide insight into the sequence of the three consecutive oxidative additions of aryl halide, chloroformate, and alkyl halide.(Bromomethyl)cyclopropane(cas: 7051-34-5SDS of cas: 7051-34-5) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.SDS of cas: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Catalytic Boration of Alkyl Halides with Borane without Hydrodehalogenation Enabled by Titanium Catalyst》 was written by Wang, Xianjin; Cui, Penglei; Xia, Chungu; Wu, Lipeng. HPLC of Formula: 7051-34-5This research focused ontitanium catalyzed boration alkyl pseudohalide borane radical pathway; alkyl boronate ester preparation; alkyl halides; boration; boronate ester; pinacolborane; titanium. The article conveys some information:

An unprecedented and general Ti-catalyzed boration of alkyl (pseudo)halides (alkyl-X, X = I, Br, Cl, OMs) with borane (HBpin, HBcat) is reported. The use of Ti catalyst can successfully suppress the undesired hydrodehalogenation products that prevail using other transition-metal catalysts. Synthetically useful alkyl boronate esters are readily obtained from various (primary, secondary, and tertiary) alkyl electrophiles, including unactivated alkyl chlorides, with tolerance of other reducing functional groups such as ester, alkene, and carbamate. Preliminary studies on the mechanism revealed a possible radical reaction pathway. Further extension of the authors’ strategy to aryl bromides is also demonstrated. The experimental part of the paper was very detailed, including the reaction process of (Bromomethyl)cyclopropane(cas: 7051-34-5HPLC of Formula: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.HPLC of Formula: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: (Bromomethyl)cyclopropaneIn 2019 ,《Discovery of 1,2,3-triazole-based fibroblast growth factor receptor modulators》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Sakai, Hiroki; Inoue, Hidekazu; Toba, Tetsuya; Murata, Kenji; Narii, Nobuhiro; Shimmyo, Yoshiari; Igawa, Yoshiyuki; Matsumoto, Takahiro; Takemoto, Naohiro. The article contains the following contents:

To avoid production of a phospholipidosis-inducing metabolite, we replaced the amide structure of SUN13837 (1) with a 1,2,3-triazole. The resulting 1,2,3-triazole analog of 1 (compound 2) displayed greater neuroprotective activity than 1. Structural modification of 2 yielded compound 10, which showed improved neuroprotective activity and negligible mechanism-based inactivation against CYP3A4. In addition, installation of a Me group at the 5-position of 1,2,3-triazole of 10 significantly boosted the neuroprotective activity. These 1,2,3-triazole derivatives displayed reduced phospholipidosis risk, sufficient systemic exposure, and high central nervous system penetration, and therefore may be potentially useful agents for the treatment of neurodegenerative diseases. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Name: (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Name: (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Multicomponent Reductive Cross-Coupling of an Inorganic Sulfur Dioxide Surrogate: Straightforward Construction of Diversely Functionalized Sulfones》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Meng, Yingying; Wang, Ming; Jiang, Xuefeng. Related Products of 7051-34-5 The article mentions the following:

Conventionally, sulfones are prepared by oxidation of sulfides with strong oxidants. Now, a multicomponent reductive cross-coupling involving an inorganic salt (sodium metabisulfite) for the straightforward construction of sulfones is disclosed. Both intramol. and intermol. reductive cross-couplings were comprehensively explored, and diverse sulfones were accessible from the corresponding alkyl and aryl halides. Intramol. cyclic sulfones were systematically obtained from five- to twelve-membered rings. Naturally occurring aliphatic systems, such as steroids, saccharides, and amino acids, were highly compatible with the SO2-insertion reductive cross-coupling. Four clin. applied drug mols., which include multiple heteroatoms and functional groups with active hydrogens, were successfully prepared via a late-stage SO2 insertion. Mechanistic studies show that alkyl radicals and sulfonyl radicals were both involved as intermediates in this transformation. In addition to this study using (Bromomethyl)cyclopropane, there are many other studies that have used (Bromomethyl)cyclopropane(cas: 7051-34-5Related Products of 7051-34-5) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Related Products of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 7051-34-5In 2022 ,《Design, Synthesis, Herbicidal Activity, and Molecular Docking Study of 2-Thioether-5-(Thienyl/Pyridyl)-1,3,4-Oxadiazoles as Potent Transketolase Inhibitors》 was published in Journal of Agricultural and Food Chemistry. The article was written by Wang, Yan-En; Yang, Dongchen; Dai, Longtao; Huo, Jingqian; Chen, Lai; Kang, Zhanhai; Mao, Jianyou; Zhang, Jinlin. The article contains the following contents:

A series of 2-thioether-5-(thienyl/pyridyl)-1,3,4-oxadiazoles I [R = 3-thienyl, 2-pyridyl; R1 = cyclopropylmethyl, 2-pyridyl, 2-pyridylmethyl, (3,5-dimethylisoxazol-4-yl)methy, etc.] were designed and synthesized based on TK as the new target. The preliminary bioassay results indicated that compounds I [R = 2-pyridyl, R1 = 2-pyridylmethyl; R = R1 = 2-pyridyl] displayed the best herbicidal activities against Amaranthus retroflexus (AR) and Digitaria sanguinalis (DS), with the inhibition exceeding 90% at 100-200 mg/L in vitro. Moreover, they also displayed higher postemergence herbicidal activities (90% control) against AR and DS than all of the pos. controls at 45-90 g [active ingredient (ai)]/ha in a greenhouse. Notably, compounds I [R = 2-pyridyl, R1 = 2-pyridylmethyl; R = R1 = 2-pyridyl] showed a broad spectrum of weed control at 90 g ai/ha. More significantly, compound I [R = 2-pyridyl, R1 = 2-pyridylmethyl] exhibited good crop selectivity against maize at 90 g ai/ha. Both fluorescent binding experiments and mol. docking analyses indicated that compounds I [R = 2-pyridyl, R1 = 2-pyridylmethyl; R = R1 = 2-pyridyl] exhibited strong TK inhibitory activities with superior binding affinities than the others. Preliminary mechanism studies suggested that they might exert their TK inhibitory effects by occupying the active cavity of At TK and forming more strong interactions with amino acids in the active site. Taken together, these results suggested that compound I [R = 2-pyridyl, R1 = 2-pyridylmethyl] was a potential herbicide candidate for weed control in maize fields targeting TK. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5SDS of cas: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.SDS of cas: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Primer, David N.; Yong, Kelvin; Ramirez, Antonio; Kreilein, Matthew; Ferretti, Antonio C.; Ruda, Antonio M.; Fleary-Roberts, Nadia; Moseley, Jonathan D.; Forsyth, Sian M.; Evans, Graham R.; Traverse, John F. published an article in Organic Process Research & Development. The title of the article was 《Development of a Process to a 4-Arylated 2-Methylisoquinolin-1(2H)-one for the Treatment of Solid Tumors: Lessons in Ortho-Bromination, Selective Solubility, Pd Deactivation, and Form Control》.Quality Control of (Bromomethyl)cyclopropane The author mentioned the following in the article:

Presented an optimized, scalable synthesis of bromodomain and extra-terminal (BET) inhibitor BMS-986378 (CC-90010). The original route and process 1A was 7 steps with 33.8% yield and featured numerous problematic solvents, process safety concerns, difficult to scale unit operations and challenging to control impurities. Reaction optimization to remove or mitigate these challenges resulted in first scale-up route and process, 2A. Subsequent challenges encountered on scale-up of route and process 2A warranted the creation and implementation of an enhanced process, which eliminated dichloromethane from a phenol bromination, improved catalyst performance in the penultimate cross-coupling and finally developed a concomitant solvent charging process for form control in the final API crystallization The resulting scale-up route and process, 2B, were demonstrated on a >50 kg scale and afforded the final product in 49% yield over 7 steps in >99.9% assay and area purity, meeting all ICH requirements for quality. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Quality Control of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Quality Control of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yang, Peng-Fei; Shu, Wei published an article in 2022. The article was titled 《Orthogonal Access to α-/β-Branched/Linear Aliphatic Amines by Catalyst-Tuned Regiodivergent Hydroalkylations》, and you may find the article in Angewandte Chemie, International Edition.HPLC of Formula: 7051-34-5 The information in the text is summarized as follows:

Herein, a catalyst-controlled synthesis of α-branched e.g., N-(1-phenylpentan-3-yl)benzamide, β-branched e.g., N-(2-methyl-4-phenylbutyl)benzamide and linear aliphatic amines e.g., N-(5-phenylpentyl)benzamide from Ni/Co-catalyzed regio- and site-selective hydroalkylations of alkenyl amines e.g., N-(prop-2-en-1-yl)benzamide with alkyl halides RX (R = butan-2-yl, Bn, 2-phenylethyl, 2-(1,3-dioxolan-2-yl)ethyl, etc.; X = I, Br) is developed. This catalytic protocol features the reliable prediction and control of the coupling position of alkylation to provide orthogonal access to α-branched, β-branched and linear alkyl amines from identical starting materials. This platform unlocks orthogonal reactivity and selectivity of nickel hydride and cobalt hydride chem. to catalytically repurpose three types of alkyl amines under mild conditions. In the part of experimental materials, we found many familiar compounds, such as (Bromomethyl)cyclopropane(cas: 7051-34-5HPLC of Formula: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.HPLC of Formula: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Design, Synthesis, and Herbicidal Activity of Thioether Containing 1,2,4-Triazole Schiff Bases as Transketolase Inhibitors》 was written by Wang, Yan-En; Yang, Dongchen; Huo, Jingqian; Chen, Lai; Kang, Zhanhai; Mao, Jianyou; Zhang, Jinlin. Application of 7051-34-5This research focused ontriazole Schiff base preparation herbicidal activity transketolase inhibitor; 1,2,4-triazole Schiff bases; herbicidal activity; molecular docking; transketolase; weed resistance. The article conveys some information:

Transketolase (TK) represents a potential target for novel herbicide development. To discover novel TK inhibitors with potency against resistant weeds, 36 thioether compounds containing 1,2,4-triazole Schiff bases were designed and synthesized for herbicidal activity evaluation. The results demonstrated that compounds I and II provided excellent weed control with inhibition of over 90% against the tested weeds, even at concentrations as low as 100 mg/L in vitro. In addition, compounds I and II exhibited higher postemergence herbicidal activity than all of the pos. controls against the tested weeds at 50-90 g [active ingredient (ai)]/ha in a greenhouse, while being safe for crops of maize and wheat at 90 g (ai)/ha. Fluorescent binding experiments of At TK indicated that compounds I and II had strong TK inhibitory activity and could tightly bind with the enzyme At TK. Also, mol. docking analyses revealed that the structures of compounds I and II were suitable for TK inhibitory activity. Taken together, these results suggested that compounds I and II were promising herbicide candidates for weed control in wheat and maize fields targeting TK. In the part of experimental materials, we found many familiar compounds, such as (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 7051-34-5In 2021 ,《Iron-Catalyzed Tertiary Alkylation of Terminal Alkynes with 1,3-Diesters via a Functionalized Alkyl Radical》 was published in Angewandte Chemie, International Edition. The article was written by Tian, Ming-Qing; Shen, Zhen-Yao; Zhao, Xuefei; Walsh, Patrick J.; Hu, Xu-Hong. The article contains the following contents:

Direct oxidative C(sp)-H/C(sp3)-H cross-coupling offers an ideal and environmentally benign protocol for C(sp)-C(sp3) bond formations. As such, reactivity and site-selectivity with respect to C(sp3)-H bond cleavage have remained a persistent challenge. Herein is reported a simple method for iron-catalyzed/silver-mediated tertiary alkylation of terminal alkynes with readily available and versatile 1,3-dicarbonyl compounds The reaction is suitable for an array of substrates and proceeds in a highly selective manner even employing alkanes containing other tertiary, benzylic, and C(sp3)-H bonds alpha to heteroatoms. Elaboration of the products enables the synthesis of a series of versatile building blocks. Control experiments implicate the in situ generation of a tertiary carbon-centered radical species. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Name: (Bromomethyl)cyclopropaneIn 2019 ,《Carbonylative C-C Bond Activation of Electron-Poor Cyclopropanes: Rhodium-Catalyzed (3+1+2) Cycloadditions of Cyclopropylamides》 was published in Angewandte Chemie, International Edition. The article was written by Dalling, Andrew G.; Yamauchi, Takayuki; McCreanor, Niall G.; Cox, Lydia; Bower, John F.. The article contains the following contents:

Rh-catalyzed carbonylative C-C bond activation of cyclopropylamides generates configurationally stable rhodacyclopentanones that engage tethered alkenes in (3+1+2) cycloadditions These studies provide the first examples of multicomponent cycloadditions that proceed through C-C bond activation of “”simple”” electron poor cyclopropanes. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Name: (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Name: (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary