Category: 7051-34-5

In 2019,Journal of the American Chemical Society included an article by Li, Yang; Liang, Yujie; Dong, Junchao; Deng, Yi; Zhao, Chunyang; Su, Zhongmin; Guan, Wei; Bi, Xihe; Liu, Qun; Fu, Junkai. Application of 7051-34-5. The article was titled 《Directed Copper-Catalyzed Intermolecular Aminative Difunctionalization of Unactivated Alkenes》. The information in the text is summarized as follows:

A diverse collection of copper-catalyzed intermol. aminative difunctionalizations of unactivated alkenes with N-halodialkylamines as the terminal dialkylamino source is reported. A bidentate auxiliary tethered on the alkene substrates is crucial, which can promote the migratory insertion of nonactivated alkenes into the aminyl radical-metal complex and stabilize the resultant high-valent copper intermediate to allow for further transformations. By employing this strategy, the intermol. aminohalogenation reactions and a three-component aminoazidation reaction of unactivated alkenes with dialkylamino source were successively achieved in a remarkable regio- and stereoselective manner. These reactions were performed under neutral conditions and maintained excellent functional group tolerance toward a wide range of N-halodialkylamines and unactivated alkenes. Further mechanistic studies and DFT calculations supported a concerted migratory insertion of the C-C double bond into the aminyl radical-metal complex to form a Cu(III) intermediate. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Photoinduced Radical Borylation of Alkyl Bromides Catalyzed by 4-Phenylpyridine》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Zhang, Li; Wu, Zhong-Qian; Jiao, Lei. Application In Synthesis of (Bromomethyl)cyclopropane The article mentions the following:

Utilizing 4-phenylpyridine catalysis, we developed a visible-light-induced transition-metal-free radical borylation reaction of unactivated alkyl bromides that features a broad substrate scope and mild reaction conditions. Mechanistic studies revealed a novel nucleophilic substitution/photoinduced radical formation pathway, which could be utilized to trigger a variety of radical processes. In addition to this study using (Bromomethyl)cyclopropane, there are many other studies that have used (Bromomethyl)cyclopropane(cas: 7051-34-5Application In Synthesis of (Bromomethyl)cyclopropane) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application In Synthesis of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Lei; Zhu, Yuqin; Liu, Mengyuan; Xie, Leipeng; Liang, Jimin; Shi, Haoran; Meng, Xiao; Chen, Zhengyang; Han, Jian; Wang, Chao published an article in 2022. The article was titled 《Ligand-Controlled NiH-Catalyzed Regiodivergent Chain-Walking Hydroalkylation of Alkenes》, and you may find the article in Angewandte Chemie, International Edition.Computed Properties of C4H7Br The information in the text is summarized as follows:

A NiH-catalyzed migratory hydroalkylation of alkenyl amines with predictable and switchable regioselectivity is reported. By utilizing a ligand-controlled, directing group-assisted strategy, various alkyl units are site-selectively installed at inert sp3 C-H sites far away from the original C=C bonds. A range of structurally diverse α- and β-branched protected amines are conveniently synthesized via stabilization of 5- and 6-membered nickelacycles resp. This method exhibits broad scope and high functional group tolerance, and can be applied to late-stage modification of medicinally relevant mols. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Computed Properties of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Computed Properties of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Design and synthesis of 7-O-1,2,3-triazole hesperetin derivatives to relieve inflammation of acute liver injury in mice》 was written by Zheng, Yan; Zhang, Yi-long; Li, Zeng; Shi, Wen; Ji, Ya-ru; Guo, Ya-Hui; Huang, Cheng; Sun, Guo-ping; Li, Jun. Name: (Bromomethyl)cyclopropaneThis research focused ontriazole hesperetin derivative preparation treatment inflammation acute liver injury; Anti-inflammatory activity introduction; Hesperetin; Structure-activity relationships; Synthesis; Triazole. The article conveys some information:

Based on the previous research results of our research group, to further improve the anti-inflammatory activity of hesperetin, we substituted triazole at the 7-OH branch of hesperetin. We also evaluated the anti-inflammatory activity of 39 new hesperetin derivatives All compounds showed inhibitory effects on nitric oxide (NO) and inflammatory factors in lipopolysaccharide-induced RAW264.7 cells. Compound I, 4-hydroxyimino-7-O-((1-propyl-1H-1,2,3-triazol-4-yl)methyl)hesperetin showed a strong inhibitory effect on NO (half maximal inhibitory concentration = 2.34 ± 0.7μM) and tumor necrosis factor-α, interleukin (IL)-1β, and (IL-6). Structure-activity relationships indicate that 7-O-triazole is buried in a medium-sized hydrophobic cavity that binds to the receptor. Compound 4-hydroxyimino-7-O-((1-propyl-1H-1,2,3-triazol-4-yl)methyl)hesperetin can also reduce the reactive oxygen species production and significantly inhibit the expression of inducible NO synthase and cyclooxygenase-2 through the nuclear factor-κB signaling pathway. In vivo results indicate that compound I can reduce liver inflammation in mice with acute liver injury (ALI) induced by CCI4, and may be a candidate drug for treating inflammation associated with ALI. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Name: (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Name: (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ding, Chao; Ren, Yaoyu; Sun, Caocao; Long, Jiao; Yin, Guoyin published their research in Journal of the American Chemical Society in 2021. The article was titled 《Regio- and Stereoselective Alkylboration of Endocyclic Olefins Enabled by Nickel Catalysis》.Related Products of 7051-34-5 The article contains the following contents:

Whereas there is a significant interest in the rapid construction of diversely substituted saturated heterocycles, direct and modular access is currently limited to the mono-, 2,3-, or 3,4-substitution pattern. This Communication describes the straightforward and modular construction of 2,4-substituted saturated heterocycles from readily available materials in a highly stereo- and regioselective manner, which sets the stage for numerous readily accessible drug motifs. The strategy relies on chain walking catalysis. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Related Products of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Related Products of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Mechanistic Dichotomy of Magnesium- and Zinc-Based Germanium Nucleophiles in the C(sp3)-Ge Cross-Coupling with Alkyl Electrophiles》 were Xue, Weichao; Mao, Wenbin; Zhang, Liangliang; Oestreich, Martin. And the article was published in Angewandte Chemie, International Edition in 2019. Application of 7051-34-5 The author mentioned the following in the article:

Robust procedures for two mechanistically distinct C(sp3)-Ge bond formations from alkyl electrophiles and germanium nucleophiles are reported. The germanium reagents were made available as bench-stable solutions by lithium-to-magnesium and lithium-to-zinc transmetalation, resp. The germanium Grignard reagent reacts with various primary and secondary alkyl electrophiles by an ionic nucleophilic displacement. Conversely, the coupling of the corresponding zinc reagent requires a nickel catalyst, which then engages in radical bond formations with primary, secondary, and even tertiary alkyl bromides. Both methods avoid the regioselectivity issue of alkene hydrogermylation and enable the synthesis of a wide range of functionalized alkyl-substituted germanes. In the part of experimental materials, we found many familiar compounds, such as (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Ni-Catalyzed Reductive Liebeskind-Srogl Alkylation of Heterocycles》 were Ma, Yuanhong; Cammarata, Jose; Cornella, Josep. And the article was published in Journal of the American Chemical Society in 2019. Recommanded Product: 7051-34-5 The author mentioned the following in the article:

Herein we present a Ni-catalyzed alkylation of C-SMe with alkyl bromides for the decoration of heterocyclic frameworks I (R = H, 6-CN, 5-CF3, 2-thienyl, etc.; R1 = cyclohexyl, cyclobutyl, 4-pyranyl, etc.). The protocol, reminiscent to the Liebeskind-Srogl coupling, makes use of simple C(sp2)-SMe to be engaged in a reductive coupling. The reaction is suitable for a preponderance of highly valuable heterocyclic motifs. In addition to cyclic bromides, noncyclic alkyl bromides are well accommodated with exquisite levels of retention over isomerization. The protocol is scalable and permits orthogonal couplings in the presence of other functionalization handles. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Decarboxylative Bromination of Sterically Hindered Carboxylic Acids with Hypervalent Iodine(III) Reagents》 was published in Organic Process Research & Development in 2020. These research results belong to Watanabe, Ayumi; Koyamada, Kenta; Miyamoto, Kazunori; Kanazawa, Junichiro; Uchiyama, Masanobu. Electric Literature of C4H7Br The article mentions the following:

Sterically hindered three-dimensional (3D) alkyl halides are promising precursors for various reactions; however, they are difficult to synthesize via conventional reactions. Reported is an efficient and practical method for decarboxylative bromination of sterically hindered 3D aliphatic carboxylic acids using com. available (diacetoxyiodo)benzene and potassium bromide, one of the most stable and cheapest bromine sources in nature. The method features a metal-free/Br2-free system, mild reaction conditions, one-pot operation under air at room temperature, wide functional group compatibility, and gram-scale synthetic capability. This highly efficient reaction cleanly converts a broad range of carboxylic acids, the most inexpensive and readily available sources of highly strained/naturally occurring/drug-related scaffolds, into the corresponding alkyl bromides in good to high yields. In the part of experimental materials, we found many familiar compounds, such as (Bromomethyl)cyclopropane(cas: 7051-34-5Electric Literature of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Electric Literature of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Identification of C10 nitrogen-containing aporphines with dopamine D1 versus D5 receptor selectivity》 was published in Bioorganic & Medicinal Chemistry Letters in 2020. These research results belong to Karki, Anupam; Juarez, Reecan; Namballa, Hari K.; Alberts, Ian; Harding, Wayne W.. Product Details of 7051-34-5 The article mentions the following:

New aporphines containing C10 nitrogen substituents (viz. nitro, aniline or amide moieties), were synthesized and evaluated for affinity at human serotonin 5-HT1A and 5-HT2A receptors and at human dopamine D1, D2 and D5 receptors. Two series of analogs were investigated: series A which contain a sole C10 nitrogen substituent on the tetracyclic aporphine core and series B which are 1,2,10-trisubstituted aporphines. Remarkably, compounds from both series lacked affinity for the D5 receptor, thus attaining D1 vs. D5 selectivity. Compound I was the most potent D1 ligand identified. Docking studies at D1 and D5 receptors indicate that the binding mode of I at the D1 receptor allows for stronger hydrophobic contacts, (primarily with Phe residues) as compared to the D5 receptor, accounting for its D1 vs. D5 selectivity. Considering the lack of affinity for the D5 receptor (and low affinity at other receptors tested), compound I represents an interesting starting point for further structural diversification of aporphines as sub-type selective D1 receptor tools. In addition to this study using (Bromomethyl)cyclopropane, there are many other studies that have used (Bromomethyl)cyclopropane(cas: 7051-34-5Product Details of 7051-34-5) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Product Details of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Visible-Light-Driven C4-Selective Alkylation of Pyridinium Derivatives with Alkyl Bromides》 was published in Journal of the American Chemical Society in 2020. These research results belong to Jung, Sungwoo; Shin, Sanghoon; Park, Seongjin; Hong, Sungwoo. Quality Control of (Bromomethyl)cyclopropane The article mentions the following:

Reported herein is a general strategy for the photochem. cross-coupling between N-amidopyridinium salts and various alkyl bromides under photocatalyst-free conditions, granting facile access to various C4-alkylated pyridines. This approach exploits the intriguing photochem. activity of electron donor-acceptor (EDA) complexes between N-amidopyridinium salts and bromide, which provides a photoactive handle capable of generating silyl radicals and driving the alkylation process. The robustness of this protocol was further demonstrated by the late-stage functionalization of complex compounds, e.g., dehydroepiandrosterone and oxaprozin, under mild and metal-free conditions. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Quality Control of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Quality Control of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary