Category: 7051-34-5

Kuribara, Takahito; Nakajima, Masaya; Nemoto, Tetsuhiro published an article in 2022. The article was titled 《A visible-light activated secondary phosphine oxide ligand enabling Pd-catalyzed radical cross-couplings》, and you may find the article in Nature Communications.Safety of (Bromomethyl)cyclopropane The information in the text is summarized as follows:

A secondary phosphine oxide ligand bearing a visible-light sensitization moiety and apply it to Pd-catalyzed radical cross-coupling reactions was reported. The tautomeric phosphinous acid coordinates to palladium in-situ, allowing for pseudo-intramol. single-electron transfer between the ligand and palladium. Mol. design of the metal complexes aided by time-dependent d. functional theory calculations enables the involvement of allyl radicals from π-allyl palladium(II) complexes, and alkyl and aryl radicals from the corresponding halides and palladium(0) complex. This complex enables radical cross-couplings by ligand-to-Pd(II) and Pd(0)-to-ligand single-electron transfer under visible-light irradiation After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Safety of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Safety of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wang, Lucia; Lin, Shengjia; Santos, Emmanuel; Pralat, Jenna; Spotton, Kaylyn; Sharma, Abhishek published an article in Journal of Organic Chemistry. The title of the article was 《Boron-Promoted Deprotonative Conjugate Addition: Geminal Diborons as Soft Pronucleophiles and Acyl Anion Equivalents》.Recommanded Product: 7051-34-5 The author mentioned the following in the article:

The 1,4-addition of α,α-diboryl carbanions generated via deprotonation of the corresponding geminal diborons R1CH(Bpin)2 (R1 = prop-2-en-1-yl, thiophen-3-ylmethyl, cyclopropylmethyl, etc.) has been reported. The methodol. provided a general route to highly substituted and synthetically useful γ,γ-diboryl ketones R1C(Bpin)2CH(R3)C(O)R2 (R2 = C6H5, 4-ClC6H4, cyclohexyl, etc.; R3 = Me, Ph, Et, etc.). The development of geminal diborons as soft pronucleophiles also enabled their use as acyl anion equivalent via a one-pot tandem conjugate addition-oxidation sequence. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Jiao, Nianming; Yuan, Yanyan; Yao, Yuan; Liu, Long; Zhang, Yanqiang published an article in Fuel Processing Technology. The title of the article was 《Strained carbocycle based hypergolic ionic fuels with the improved energy capacity》.Product Details of 7051-34-5 The author mentioned the following in the article:

Different from the previous nitrogenous groups, we present a new strategy of improving the ionic liquids (ILs) energy capacity by introducing the strained carbocycles. The ILs with three- and/or four-member carbocycles were prepared, and their physicochem. properties as rocket fuels were studied. The ignition tests show that all of these ILs have the expected hypergolic reactivity with the oxidizer (white fuming HNO3). In virtue of the strained cyclopropane and cyclobutane substituents, the resulting hypergolic ILs possess better energy properties (heats of formation 0.784-1.968 kJ g-1; specific impulses 313.0-315.7 s) and densities (1.03-1.15 g cm-3) than the corresponding ILs with n-alkyl substituents. This strategy of introducing strained ring groups into hypergolic ILs gives a new approach to improve energy properties of hypergolic ILs. The experimental part of the paper was very detailed, including the reaction process of (Bromomethyl)cyclopropane(cas: 7051-34-5Product Details of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Product Details of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Shenghao; Luo, Chun; Zhao, Lei; Zhao, Junsong; Zhang, Lanlan; Zhu, Bolin; Wang, Chao published their research in Cell Reports Physical Science in 2021. The article was titled 《Regioselective nickel-catalyzed dicarbofunctionalization of unactivated alkenes enabled by picolinamide auxiliary》.Safety of (Bromomethyl)cyclopropane The article contains the following contents:

A removable bidentate picolinamide-assisted regioselective dicarbofunctionalization of homoallylic amines I [R = 1-(prop-2-en-1-yl)cyclohexyl, 3-methylbut-3-en-1-yl, 1-phenylbut-3-en-1-yl, etc.] with organohalides R1X (R1 = 4-methoxyphenyl, pyridin-4-yl, Bu, etc.; X = I, Br) and arylboronic acids ArB(OH)2 (Ar = Ph, 2H-1,3-benzodioxol-5-yl, 1H-indol-3-yl, etc.) was developed. The catalytic system, using cost-effective and air-stable Ni(II) precatalyst, which could be activated by arylboronic acids, provides access to the regioselective diarylation and arylalkylation of inactivated alkenes. This reaction is compatible with α- or α-substituted terminal alkenes and internal alkenes and exhibits excellent functional group and heterocycle tolerance. Preliminary mechanistic studies suggest that the reaction proceeds via a NiI/NiIII catalytic cycle rather than a Ni0/NiII cycle. Notably, the general and practical protocol developed here represents, the first example of Ni-catalyzed 3-component 2,1-diarylation and arylalkylation of alkenes with arylboronic acids and organohalides. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Safety of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Safety of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Siddiqui, Sheema; Bhawar, Ramesh; Geetharani, K. published their research in Journal of Organic Chemistry in 2021. The article was titled 《Iron-Based Catalyst for Borylation of Unactivated Alkyl Halides without Using Highly Basic Organometallic Reagents》.Recommanded Product: 7051-34-5 The article contains the following contents:

The mild borylation of alkyl bromides and chlorides with bis(neopentylglycolato)diborane (B2neop2) mediated by iron-bis amide is described. The reaction proceeds with a broad substrate scope and good functional group compatibility. Moreover, sufficient catalytic activity was obtained for primary and secondary alkyl halides. Mechanistic studies indicate that the reaction proceeds through a radical pathway. In the part of experimental materials, we found many familiar compounds, such as (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Applying Gewald reaction for the preparation of some novel aminothieno derivatives featuring noroxymorphone skeletal backbone》 was written by Bagherpour, Saeed; Mojtahedi, Mohammad M.; Abaee, M. Saeed. Application In Synthesis of (Bromomethyl)cyclopropane And the article was included in Journal of Sulfur Chemistry in 2020. The article conveys some information:

Synthesis of several novel semisynthetic aminothieno derivatives containing the noroxymorphone skeletal backbone using a one-pot Gewald reaction conditions was reported. The Gewald reaction conditions involved reaction of elemental sulfur and malononitrile under refluxing piperidine/ethanol. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Application In Synthesis of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application In Synthesis of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C4H7BrIn 2019 ,《Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic μ-Opioid Receptor (MOR) Agonist/δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability》 was published in Journal of Medicinal Chemistry. The article was written by Henry, Sean P.; Fernandez, Thomas J.; Anand, Jessica P.; Griggs, Nicholas W.; Traynor, John R.; Mosberg, Henry I.. The article contains the following contents:

We have previously reported a series of μ-opioid receptor (MOR) agonist/δ-opioid receptor (DOR) antagonist ligands to serve as potential nonaddictive opioid analgesics. These ligands have been shown to be active in vivo, do not manifest withdrawal syndromes or reward behavior in conditioned-place preference assays in mice, and do not produce dependence. Although these attributes are promising, these analogs exhibit poor metabolic stability in mouse liver microsomes, likely due to the central tetrahydroquinoline scaffold in this series. As such, a structure-activity relationship (SAR) campaign was pursued to improve their metabolic stability. This resulted in a shift from our original bicyclic tetrahydroquinoline core to a monocyclic benzylic-core system. By eliminating one of the rings in this scaffold and exploring the SAR of this new core, two promising analogs were discovered. These analogs (5l and 5m) had potency and efficacy values at MOR better or comparable to morphine, retained their DOR-antagonist properties, and showed a 10-fold improvement in metabolic stability. The experimental part of the paper was very detailed, including the reaction process of (Bromomethyl)cyclopropane(cas: 7051-34-5COA of Formula: C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.COA of Formula: C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Fusaric acid and derivatives as novel antimicrobial agents》 was written by Thanh, Tung Truong; Quoc, Thang Nguyen; Xuan, Huy Luong. Formula: C4H7Br And the article was included in Medicinal Chemistry Research in 2020. The article conveys some information:

Abstract: The synthesis and screening of several fusaric acid (FA) and analogs against five common clin. pathogens (gram-pos. and gram-neg.) and in vitro hemolytic activity assay in human red blood cells, for the first time, were reported. The biol. results reveal that FA and its analogs exhibited moderate antimicrobial activities. Compounds 2-5 and 7 showed growth inhibitory activity in gram-pos. bacteria. Compounds 6 and 9 showed growth inhibitory activity in both gram-pos. and gram-neg. bacteria. None of the compounds induce hemolysis, which is potent for future drug development on this template. In addition, the structure-activity relationship and docking studies are discussed. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Formula: C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Formula: C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Yan; Liu, Deguang; Wan, Lei; Zhang, Jun-Yang; Lu, Xi; Fu, Yao published an article in 2022. The article was titled 《Ligand-Controlled Cobalt-Catalyzed Regiodivergent Alkyne Hydroalkylation》, and you may find the article in Journal of the American Chemical Society.Electric Literature of C4H7Br The information in the text is summarized as follows:

Herein, a ligand-controlled cobalt-catalyzed regiodivergent alkyne hydroalkylation was reported. The sensible selection of bisoxazoline and pyridine-oxazoline ligands led to reliable and predictable protocols that provided (E)-1,2-disubstituted and 1,1-disubstituted alkenes with high E/Z stereoselectivity and regioisomeric ratio starting from identical terminal alkyne and alkyl halide substrates and produced trisubstituted alkenes in the case of internal alkynes. This method exhibited a broad scope for terminal and internal alkynes with a wide range of activated and unactivated alkyl halides and shows excellent functional group compatibility. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Electric Literature of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Electric Literature of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: (Bromomethyl)cyclopropaneIn 2019 ,《Introducing broadened antibacterial activity to rhodanine derivatives targeting enoyl-acyl carrier protein reductase》 appeared in Chemical & Pharmaceutical Bulletin. The author of the article were Sun, Zhi-Gang; Xu, Yun-Jie; Xu, Jian-Fei; Liu, Qi-Xing; Yang, Yu-Shun; Zhu, Hai-Liang. The article conveys some information:

Broadened antibacterial activity was introduced to rhodanine derivatives targeting Mycobacterial tuberculosis enoyl-acyl carrier protein reductase (Mtb InhA) by recruiting feature of xacins to bring DNA Gyrase B inhibitory capability. This is significant for preventing further bacterial injections in the tuberculosis treatment. The most potent compound Cy14 suggested comparable bioactivity (IC50 = 3.18 microM for Mtb InhA; IC50 = 10 nM for DNA Gyrase B) with pos. controls. Structure-activity relationship discussion and mol. docking model revealed the significance of rhodanine moiety and derived methoxyl on meta-position, pointing out orientations for future modification. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary