Category: 7051-34-5

《Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model》 was written by Laure, Martin; Hamza, Hazem; Koch-Heier, Julia; Quernheim, Martin; Mueller, Christin; Schreiber, Andre; Mueller, Gerhard; Pleschka, Stephan; Ludwig, Stephan; Planz, Oliver. Formula: C4H7Br And the article was included in Antiviral Research in 2020. The article conveys some information:

Antiviral therapies against influenza are required, especially for high-risk patients, severe influenza and in case of highly pathogenic influenza virus (IV) strains. This may be overcome by targeting host cell factors that are required for IV propagation. IV induces a variety of host cell signaling cascades, such as the Raf/MEK/ERK kinase pathway. MEK-inhibitors block the activation of the pathway on the bottleneck of the signaling cascade leading to impaired virus propagation. In the present study, we aimed to compare the antiviral potency and bioavailability of the MEK-inhibitor CI-1040 vs. its major active metabolite ATR-002, in vitro as well as in the mouse model. In cell culture assays, an approx. 10-fold higher concentration of ATR-002 is required to generate the same antiviral activity as for CI-1040. Interestingly, we observed that considerably lower concentrations of ATR-002 were required to achieve a reduction of the viral load in vivo. Pharmacokinetic studies with ATR-002 and CI-1040 in mice have found the Cmax and AUC to be far higher for ATR-002 than for CI-1040. Our results thereby demonstrate the in vivo superiority of the active metabolite ATR-002 over CI-1040 as an antiviral agent despite its weaker cell membrane permeability. Therefore, ATR-002 is an attractive candidate for development as an efficient antiviral agent, especially given the fact that a treatment based on cellular pathway inhibition would be far less likely to lead to viral drug resistance. The experimental part of the paper was very detailed, including the reaction process of (Bromomethyl)cyclopropane(cas: 7051-34-5Formula: C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Formula: C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Direct C(sp2)-H alkylation of unactivated arenes enabled by photoinduced Pd catalysis》 was published in Nature Communications in 2020. These research results belong to Kim, Daeun; Lee, Geun Seok; Kim, Dongwook; Hong, Soon Hyeok. Quality Control of (Bromomethyl)cyclopropane The article mentions the following:

Here, the catalytic C(sp2)-H alkylation reactions of unactivated arenes with alkyl bromides via visible-light induced Pd catalysis was reported. The reaction proceeded smoothly under mild conditions without any skeletal rearrangement of the alkyl groups. The direct syntheses of structurally diverse linear and branched alkylarenes, including the late-stage phenylation of biol. active mols. and an orthogonal one-pot sequential Pd-catalyzed C-C bond-forming reaction, were achieved with exclusive chemoselectivity and exceptional functional group tolerance. Comprehensive mechanistic investigations through a combination of exptl. and computational methods revealed a distinguishable Pd(0)/Pd(I) redox catalytic cycle and the origin of the counter-intuitive reactivity differences among alkyl halides. In addition to this study using (Bromomethyl)cyclopropane, there are many other studies that have used (Bromomethyl)cyclopropane(cas: 7051-34-5Quality Control of (Bromomethyl)cyclopropane) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Quality Control of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Formal Bromine Atom Transfer Radical Addition of Nonactivated Bromoalkanes Using Photoredox Gold Catalysis》 was published in Organic Letters in 2020. These research results belong to Zidan, Montserrat; McCallum, Terry; Swann, Rowan; Barriault, Louis. SDS of cas: 7051-34-5 The article mentions the following:

Organic transformations mediated by photoredox catalysis have been at the forefront of reaction discovery. Recently, it has been demonstrated that binuclear Au(I) bisphosphine complexes, such as [Au2(μ-dppm)2]X2, are capable of mediating electron transfer to nonactivated bromoalkanes for the generation of a variety of alkyl radicals. The transfer reactions of bromine, derived from nonactivated bromoalkanes, are largely unknown. Therefore, we propose that unique metal-based mechanistic pathways are at play, as this binuclear gold catalyst has been known to produce Au(III) Lewis acid intermediates. The scope and proposed mechanistic overview for the formal bromine atom transfer reaction of nonactivated bromoalkanes mediated by photoredox Au(I) catalysis is presented. The methodol. presented afforded good yields and a broad scope which include examples using bromoalkanes and iodoarenes. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5SDS of cas: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.SDS of cas: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Boron tribromide as a reagent for anti-Markovnikov addition of HBr to cyclopropanes》 was published in Chemical Science in 2020. These research results belong to Gieuw, Matthew H.; Chen, Shuming; Ke, Zhihai; Houk, K. N.; Yeung, Ying-Yeung. Electric Literature of C4H7Br The article mentions the following:

Although radical formation from a trialkylborane is well documented, the analogus reaction mode is unknown for trihaloboranes. The generation of bromine radicals from boron tribromide and simple proton sources, such as water or tert-butanol, under open-flask conditions was discovered. Cyclopropanes bearing a variety of substituents I (R1 = Ph, naphthalen-2-yl, CN, etc.; R2 = H, Me, Ph, methoxycarbonyl, etc.; R3 = H, Ph) were hydro- and deuterio-brominated to furnish anti-Markovnikov products (R1)(R2)C(R4)CH2CH(R3)Br (R4 = H, D) in a highly regioselective fashion. NMR mechanistic studies and DFT calculations point to a radical pathway instead of the conventional ionic mechanism expected for BBr3. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Electric Literature of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Electric Literature of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium-catalyzed C(sp3)-P(III) bond formation reaction with acylphosphines as phosphorus source》 was written by Zhang, Mengyue; Ma, Zhichao; Du, Hongguang; Wang, Zhiqian. Computed Properties of C4H7Br And the article was included in Tetrahedron Letters in 2020. The article conveys some information:

Pd-catalyzed C(sp3)-P(III) bond formation reaction for alkyl substituted phosphines preparation was developed. In this reaction, various alkyl bromides and limited alkyl chlorides reacted with acylphosphine under relative mild and easily accessible condition, and differential phosphines were afforded in good yields. This reaction made up the application of Pd catalysis in C(sp3)-P(III) bond formation, and indicated a practical application of acylphosphine as a phosphination reagent. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Computed Properties of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Computed Properties of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Nickel-catalyzed reductive coupling of homoenolates and their higher homologues with unactivated alkyl bromides》 was written by Lin, Tingzhi; Gu, Yuanyun; Qian, Pengcheng; Guan, Haixing; Walsh, Patrick J.; Mao, Jianyou. HPLC of Formula: 7051-34-5 And the article was included in Nature Communications in 2020. The article conveys some information:

A nickel-catalyzed generation of homoenolates, and their higher homologues, via decarbonylation of readily available cyclic anhydrides was developed. The utility of nickel-bound homoenolates and their higher homologues was demonstrated by cross-coupling with unactivated alkyl bromides, generated a diverse array of aliphatic acids. A broad range of functional groups was tolerated. Preliminary mechanistic studies demonstrated that the oxidative addition of anhydrides by the catalyst was faster than oxidative addition of alkyl bromides. The nickel bound metallocycles were involved in this transformation. The catalyst undergoes a single electron transfer (SET) process with the alkyl bromide. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5HPLC of Formula: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.HPLC of Formula: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhan, Yi-Zhou; Xiao, Nan; Shu, Wei published their research in Nature Communications in 2021. The article was titled 《Ni-catalyzed regio- and stereo-defined intermolecular cross-electrophile dialkylation of alkynes without directing group》.Synthetic Route of C4H7Br The article contains the following contents:

The nickel-catalyzed intermol. cross-dialkylation of alkynes devoid of directing or activating groups afforded multiple aliphatic substituted alkenes in a syn-selective fashion at room temp was reported. The combination of two-electron oxidative cyclometallation and single-electron cross-electrophile coupling of nickel enabled the syn-cross-dialkylation of alkynes at room temperature This reductive protocol enabled the sequential installation of two different alkyl substituents onto alkynes in a regio- and stereo-selective manner, circumvented the tedious preformation of sensitive organometallic reagents. The synthetic utility of this protocol was demonstrated by efficient synthesis of multi-substituted unfunctionalized alkenes and diverse transformations of the product. In addition to this study using (Bromomethyl)cyclopropane, there are many other studies that have used (Bromomethyl)cyclopropane(cas: 7051-34-5Synthetic Route of C4H7Br) was used in this study.

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Synthetic Route of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Efficient synthesis of alkylboronic esters via magnetically recoverable copper nanoparticle-catalyzed borylation of alkyl chlorides and bromides》 was written by Shegavi, Mahadev L.; Agarwal, Abhishek; Bose, Shubhankar Kumar. SDS of cas: 7051-34-5 And the article was included in Green Chemistry in 2020. The article conveys some information:

We report a magnetically separable Cu nanocatalyst (Fe-DOPA-Cu) for the borylation of alkyl halides with alkoxy diboron reagents, providing alkylboronic esters in high yields, with broad functional group tolerance under mild reaction conditions. The procedure is also applicable to the borylation of benzyl chlorides and bromides. Radical clock experiments support a radical-mediated process. Easy recycling of the catalyst resulted in no significant loss of activity up to ten runs. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5SDS of cas: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.SDS of cas: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Cobalt(I)-Catalyzed Borylation of Unactivated Alkyl Bromides and Chlorides》 was published in Organic Letters in 2020. These research results belong to Verma, Piyush Kumar; Prasad, K. Sujit; Varghese, Dominic; Geetharani, K.. Synthetic Route of C4H7Br The article mentions the following:

A Co-complex-catalyzed borylation of a wide range of alkyl halides with a diboron reagent (B2pin2 or B2neop2) was developed under mild reaction conditions, demonstrating the 1st Co-mediated cross-coupling with alkyl electrophiles. This protocol allows alkyl boronic esters to be accessed from alkyl halides, including alkyl chlorides, which were used rarely as coupling partners. Mechanistic studies reveal the possible involvement of an alkyl radical intermediate in this Co-mediated catalytic cycle. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Synthetic Route of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Synthetic Route of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhong, Qidi; Wang, Yinxin; Lan, Hanyang; Zhu, Hao; Fan, Qiangwen published an article in Journal of Organic Chemistry. The title of the article was 《Construction of 3,12-Diazatetracyclododecane-dienes through Unexpected Visible-Light-Induced Radical Cascade Cyclization》.Application In Synthesis of (Bromomethyl)cyclopropane The author mentioned the following in the article:

A novel visible-light-induced cascade radical cyclization reaction of 3-cyano-4-aryl-1,4-dihydropyridines I (R1 = cyclopropylmethyl, benzyl, 4-chlorobenzyl, naphthalen-2-ylmethyl, etc.; R2 = Ph, 4-chlorophenyl, 3-methylphenyl, 2-fluorophenyl, etc.) for the construction of 3,12-diazatetracyclododecane-diene derivatives II is reported for the first time. In the presence of 410 nm blue LED lamp as the light source and ethanol as the solvent, the reactions proceed smoothly to afford photocyclization products in good yields. The process is carried out through the breaking of original C=C double bonds and the formation of three new single bonds in one pot and proved to be able to tolerate different substituents. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application In Synthesis of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application In Synthesis of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary