Category: 7051-34-5

In 2022,Li, Xinwei; Cheng, Zengrui; Liu, Jianzhong; Zhang, Ziyao; Song, Song; Jiao, Ning published an article in Chemical Science. The title of the article was 《Selective desaturation of amides: A direct approach to enamides》.Application of 7051-34-5 The author mentioned the following in the article:

C(sp3)-H bond desaturation has been an attractive strategy in organic synthesis. Enamides are important structural fragments in pharmaceuticals and versatile synthons in organic synthesis. However, the dehydrogenation of amides usually occurs on the acyl side benefitting from enolate chem. like the desaturation of ketones and esters. Herein, the authors demonstrate an Fe-assisted regioselective oxidative desaturation of amides, which provided an efficient approach to enamides, e.g., I [R1 = Me, Ph, 4-BrC6H4, cyclopropyl, etc., R2 = R3 = H, X = (CH2)n, n = 1, 2, 3, 9], and β-halogenated enamides I [R1 = n-Pr, Ph, 4-MeC6H4, etc., R2 = Br, I, R3 = H, Me, Ph]. The results came from multiple reactions, including the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Application of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Yang, Peng-Fei; Zhu, Lei; Liang, Jian-Xing; Zhao, Han-Tong; Zhang, Jian-Xin; Zeng, Xian-Wang; Ouyang, Qin; Shu, Wei published an article in ACS Catalysis. The title of the article was 《Regio- and Enantioselective Hydroalkylations of Unactivated Olefins Enabled by Nickel Catalysis: Reaction Development and Mechanistic Insights》.Quality Control of (Bromomethyl)cyclopropane The author mentioned the following in the article:

Direct construction of fully alkyl-substituted tertiary chiral centers remote to activating groups is highly challenging and desirable. Herein, a Ni-catalyzed enantioselective hydroalkylation of unactivated alkenes with unactivated alkyl halides at room temperature is reported, providing a general and practical access to fully alkyl-substituted tertiary stereogenic carbon centers not adjacent to activating groups. This reaction undergoes regio- and stereoselective hydrometalation of unactivated alkenes with a nontrivial Markovnikov selectivity, followed by cross-coupling with unactivated alkyl electrophiles to access trialkyl tertiary saturated stereogenic centers not adjacent to activating groups. The mild and robust conditions enable the use of terminal and internal unactivated alkenes and unactivated primary and secondary alkyl, benzyl and propargyl halides to construct diverse trialkyl tertiary stereogenic carbon centers with broad functional group tolerance. Moreover, exptl. investigations support the reaction undergoing irreversible and stereoselective hydrometalation of alkenes. D. functional theory calculations provide further insights into the reaction mechanism, suggesting a stereoselective migration insertion of alkenes with Ni(II)-H species. Finally, the origin of the regio- and enantioselectivities was also investigated. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Quality Control of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Quality Control of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Gong; Zhao, Chao-Yang; Min, Xiang-Ting; Li, Ying; Zhang, Xiang-Xin; Liu, Heng; Ji, Ding-Wei; Hu, Yan-Cheng; Chen, Qing-An published an article in Nature Catalysis. The title of the article was 《Nickel-catalysed asymmetric heteroarylative cyclotelomerization of isoprene》.Recommanded Product: 7051-34-5 The author mentioned the following in the article:

Monoterpenoids are a class of isoprenoids produced from geranyl diphosphate by various monoterpene synthases. Nature has evolved over millions of years to produce various cyclic monoterpenoids. Herein, authors present a serendipitous creation of an unnatural monoterpene skeleton through heteroarylative telomerization of isoprene with heterocycles. Under nickel catalysis, a series of cyclic monoterpene derivatives bearing quaternary carbon stereocentre are constructed with up to 98% yield and 97% enantiomeric excess. Preliminary mechanistic studies suggest this atom-economic reaction proceeds through an enantioselective dimerization of isoprene and a sequential C-H alkylation of heterocycles pathway. This work not only contributes an efficient enantioselective transformation of bulk chem. isoprene, but also provides a guide to create an unnatural monoterpene framework that may exhibit different biol. activities. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5Recommanded Product: 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Recommanded Product: 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Tan, Yu-Fang; Long, Chao-Jiu; Guan, Zhi; He, Yan-Hong published an article in Green Chemistry. The title of the article was 《Selective electrochemical oxidation of tetrahydroquinolines to 3,4-dihydroquinolones》.Related Products of 7051-34-5 The author mentioned the following in the article:

Authors report an environmentally friendly electrochem. oxidation of tetrahydroquinolines to 3,4-dihydroquinolones. The reaction uses electricity as a “”traceless”” oxidant, O2 as a “”green”” oxygen source, and 2,2,6,6-tetramethylpiperidinooxy (TEMPO) as a redox mediator. NaI not only acts as an electrolyte, but may also act as a redox mediator. The reaction shows high selectivity and good functional group tolerance. In the experiment, the researchers used many compounds, for example, (Bromomethyl)cyclopropane(cas: 7051-34-5Related Products of 7051-34-5)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Related Products of 7051-34-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C4H7BrIn 2020 ,《General sulfone construction via sulfur dioxide surrogate control》 was published in Green Chemistry. The article was written by Chen, Shihao; Li, Yaping; Wang, Ming; Jiang, Xuefeng. The article contains the following contents:

A highly efficient one-step synthesis of alkyl-alkyl and aryl-alkyl sulfones with a facile combination of halides, sulfur dioxide surrogates and phosphate esters is described. When thiourea dioxide was employed as a reductive sulfur dioxide surrogate, alkyl-alkyl sulfones were obtained under transition metal free conditions. Aryl-alkyl sulfones were obtained with an extremely low catalytic loading (0.2 mol%) via altering the mask of sulfur dioxide surrogates to sodium dithionite. A phosphate ester was employed as a stable and readily available alkyl source. Notably, this protocol has been applied to the late-stage modification of natural products and bioactive mols. Thus, e.g., treatment of (2-bromoethyl)benzene with thiourea dioxide and P(:O)(OMe)3 in presence of Cs2CO3, KI and TBAI afforded [2-(methylsulfonyl)ethyl]benzene (71%). In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Synthetic Route of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Synthetic Route of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wu, Chongyang; Ying, Tao; Yang, Xinjie; Su, Weike; Dushkin, Alexandr V.; Yu, Jingbo published their research in Organic Letters in 2021. The article was titled 《Mechanochemical Magnesium-Mediated Minisci C-H Alkylation of Pyrimidines with Alkyl Bromides and Chlorides》.Formula: C4H7Br The article contains the following contents:

A novel method to synthesize 4-alkylpyrimidines by the mechanochem. magnesium-mediated Minisci reaction of pyrimidine derivatives and alkyl halides was reported. The reaction process operated with a broad substrate scope and excellent regioselectivity under mild conditions with no requirement of transition-metal catalysts, solvents, and inert gas protection. The practicality of this protocol was demonstrated by the up-scale synthesis, mechanochem. product derivatization and preparation of the antimalarial drug pyrimethamine. In the experiment, the researchers used (Bromomethyl)cyclopropane(cas: 7051-34-5Formula: C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Formula: C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Wang, Hongyu; Liu, Chen-Fei; Martin, Robert T.; Gutierrez, Osvaldo; Koh, Ming Joo published an article in Nature Chemistry. The title of the article was 《Directing-group-free catalytic dicarbofunctionalization of unactivated alkenes》.COA of Formula: C4H7Br The author mentioned the following in the article:

A directing-group-free, nickel-catalyzed strategy that couples a broad array of unactivated and activated olefins, e.g., (3-methylbut-3-en-1-yl)benzene with aryl-substituted triflates, e.g., p-tolyl trifluoromethanesulfonate and organometallic nucleophiles, e.g., phenylmagnesium bromide to afford diarylation adducts, e.g., (2-methyl-2-(p-tolyl)butane-1,4-diyl)dibenzene in either regioisomeric form, in up to 93% yield and >98% site selectivity was described. By switching the reagents involved, the present strategy may be extended to other classes of dicarbofunctionalization reactions. Mechanistic and computational investigations offer insights into the origin of the observed regiochem. outcome and the utility of the method is highlighted through the concise syntheses of biol. active mols. The catalyst control principles reported are expected to advance efforts towards the development of general site-selective alkene functionalization, removing the requirement for neighboring activating groups. After reading the article, we found that the author used (Bromomethyl)cyclopropane(cas: 7051-34-5COA of Formula: C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.COA of Formula: C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kvasovs, Nikita; Iziumchenko, Valeriia; Palchykov, Vitalii; Gevorgyan, Vladimir published an article in 2021. The article was titled 《Visible Light-Induced Pd-Catalyzed Alkyl-Heck Reaction of Oximes》, and you may find the article in ACS Catalysis.Quality Control of (Bromomethyl)cyclopropane The information in the text is summarized as follows:

A visible light-induced palladium-catalyzed oxidative C-H alkylation of oximes was developed. This mild protocol allowed for an efficient atom economical C-C bond construction of alkyl-substituted oximes. A broad range of primary, secondary and tertiary alkyl bromides and iodides, as well as a range of different formaldoximes, can efficiently underwent this transformation. The method featured visible light-induced generation of nucleophilic hybrid alkyl Pd radical intermediates, which upon radical addition at the imine moiety and a subsequent β-hydrogen elimination deliver substituted imines. The experimental process involved the reaction of (Bromomethyl)cyclopropane(cas: 7051-34-5Quality Control of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Quality Control of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Duan, Jicheng; Wang, Yuquan; Qi, Liangliang; Guo, Peng; Pang, Xiaobo; Shu, Xing-Zhong published an article in 2021. The article was titled 《Nickel-Catalyzed Cross-Electrophile C(sp3)-Si Coupling of Unactivated Alkyl Bromides with Vinyl Chlorosilanes》, and you may find the article in Organic Letters.Application In Synthesis of (Bromomethyl)cyclopropane The information in the text is summarized as follows:

Cross-electrophile C-Si coupling has emerged as a promising tool for the construction of organosilanes, but the potential of this method remains largely unexplored. Herein, we report a C(sp3)-Si coupling of unactivated alkyl bromides with vinyl chlorosilanes. The reaction proceeds under mild conditions, and it offers a new approach to alkylsilanes. Functionalities such as Grignard-sensitive groups (e.g., acid, amide, alc., ketone, and ester), acid-sensitive groups (e.g., ketal and THP protection), alkyl fluoride and chloride, aryl bromide, alkyl tosylate and mesylate, silyl ether, and amine were tolerated. Incorporation of the -Si(vinyl)R2 moiety into complex mols. and the immobilization of a glass surface by formed organosilanes were demonstrated. In the experimental materials used by the author, we found (Bromomethyl)cyclopropane(cas: 7051-34-5Application In Synthesis of (Bromomethyl)cyclopropane)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Application In Synthesis of (Bromomethyl)cyclopropane

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C4H7BrIn 2021 ,《Copper-Catalyzed Cross-Nucleophile Coupling of β-Allenyl Silanes with Tertiary C-H Bonds: A Radical Approach to Branched 1,3-Dienes》 was published in Organic Letters. The article was written by Shan, Qi-Chao; Hu, Lu-Min; Qin, Wei; Hu, Xu-Hong. The article contains the following contents:

A distinctive approach to branched 1,3-dienes through oxidative coupling of two nucleophilic substrates, β-allenyl silanes, and hydrocarbons appending latent functionality by copper catalysis were described. Notably, C(sp3)-H dienylation proceeded in a regiospecific manner, even in the presence of competitive C-H bonds that were capable of occurring hydrogen atom transfer process, such as those located at benzylic and other tertiary sites, or adjacent to an oxygen atom. Control experiments supported the intermediacy of functionalized alkyl radicals. The experimental part of the paper was very detailed, including the reaction process of (Bromomethyl)cyclopropane(cas: 7051-34-5Computed Properties of C4H7Br)

(Bromomethyl)cyclopropane(cas: 7051-34-5) is used as a synthetic building block for the introduction of the cyclopropylmethyl group. It was also used in the synthesis of 1,4-dienes via iron-catalyzed cross-coupling with alkenyl Grignard reagents.Computed Properties of C4H7Br

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary