Category: 70399-01-8

《Rational Design and Synthesis of Selective PRMT4 Inhibitors: A New Chemotype for Development of Cancer Therapeutics》 was written by Sutherland, Mathew; Li, Alice; Kaghad, Anissa; Panagopoulos, Dimitrios; Li, Fengling; Szewczyk, Magdalena; Smil, David; Scholten, Cora; Bouche, Lea; Stellfeld, Timo; Arrowsmith, Cheryl H.; Barsyte, Dalia; Vedadi, Masoud; Hartung, Ingo V.; Steuber, Holger; Britton, Robert; Santhakumar, Vijayaratnam. Category: bromides-buliding-blocks And the article was included in ChemMedChem on April 1 ,2021. The article conveys some information:

Protein arginine N-Me transferase 4 (PRMT4) asym. dimethylates the arginine residues of histone H3 and nonhistone proteins. The overexpression of PRMT4 in several cancers had stimulated interest in the discovery of inhibitors as biol. tools and, potentially, therapeutics. Although several PRMT4 inhibitors had reported, most display poor selectivity against other members of the PRMT family of Me transferases. Herein, the structure-based design of a new class of alanine-containing 3-arylindoles such as I [R = Me, i-Pr, NMe2, etc.] as potent and selective PRMT4 inhibitors was reported, and described key structure-activity relationships for this class of compounds In the experiment, the researchers used many compounds, for example, 1-Bromo-3-(isopropylsulfonyl)benzene(cas: 70399-01-8Category: bromides-buliding-blocks)

1-Bromo-3-(isopropylsulfonyl)benzene(cas: 70399-01-8) belongs to organobromine compounds.Most of the natural organobromine compounds are produced by marine organisms , and several brominated metabolites with antibacterial , antitumor , antiviral , and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. Category: bromides-buliding-blocks In contrast, terrestrial plants account only for a few bromine-containing compounds.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Nucleophilic aromatic substitution reactions of unactivated aryl halides with thiolate ions in hexamethylphosphoramide》 were Cogolli, Pietro; Maiolo, Filippo; Testaferri, Lorenzo; Tingoli, Marco; Tiecco, Marcello. And the article was published in Journal of Organic Chemistry in 1979. Application In Synthesis of 1-Bromo-3-(isopropylsulfonyl)benzene The author mentioned the following in the article:

A simple, high-yields method for the synthesis of aryl thioethers via nucleophilic displacement of unactivated aryl halides by the sodium salts of thiols in hexamethylphosphoramide (HMPA) is reported. The reactions proceed by the bimol. displacement mechanism SNAr. Competitive experiments showed that the four halobenzenes presented comparable reactivities toward isopropanethiol anions; the relative halogen mobility was I > F > Br > Cl. The effect of some substituents on the reactivity of chlorobenzene were also measured.1-Bromo-3-(isopropylsulfonyl)benzene(cas: 70399-01-8Application In Synthesis of 1-Bromo-3-(isopropylsulfonyl)benzene) was used in this study.

1-Bromo-3-(isopropylsulfonyl)benzene(cas: 70399-01-8) belongs to organobromine compounds.Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Application In Synthesis of 1-Bromo-3-(isopropylsulfonyl)benzene Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary