Category: 703-91-3

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 703-91-3, name is 5-Bromo-2-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., Quality Control of 5-Bromo-2-(trifluoromethyl)aniline

N-(5-bromo-2-(trifluoromethyl)phenyl)acrylamide (2) : To a solution of 5-bromo- 2-(trifluoromethyl) aniline (1.4 g, 5.8 mmol) in dichloromethane (5.0 mL), diisopropylethylamine (1.2 mL, 6.5 mmol) and acryloyl chloride (0.6 g, 6.6 mmol) were added at -78 C. The resulting mixture was at 0 C for 2 h. After completion of reaction, the reaction mixture was concentrated under reduced pressure. The residue obtained was diluted with sodium bicarbonate solution and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 2 (600 mg, 35%) as an off white solid. 1H NMR (400 MHz, DMSO-d6) : delta 5.783-5.788 (dd, J = 1.8, 10.2 Hz, 1H), 6.23-6.23 (dd, J = 1.8, 17.0 Hz, 1H), 6.52-6.54 (dd, J = 6.8, 17.0 Hz, 1H), 7.69 (m, 2H), 7.82 (s, 1H), 9.88 (brs, 1H). MS m/z (M+H): 294.0

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; CELGENE AVILOMICS RESEARCH, INC.; ALEXANDER, Matthew David; MCDONALD, Joseph John; NI, Yike; NIU, Deqiang; PETTER, Russell C.; QIAO, Lixin; SINGH, Juswinder; WANG, Tao; ZHU, Zhendong; WO2014/149164; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 703-91-3, name is 5-Bromo-2-(trifluoromethyl)aniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 5-Bromo-2-(trifluoromethyl)aniline

Pd(dppf)Cl2 (613 mg, 0.84 mmol) was added to a mixture of 5-bromo-2- (trifluoromethyl)aniline (Int 25a) (2.00 g, 8.37 mmol), cyclopropylboronic acid (929 mg, 12.56 mmol) and Na2CO3(1.77 g, 16.70 mmol) in dioxane (25 mL) and the mixture was stirred at 90 C overnight. The mixture was concentrated to dryness and the residue was purified by column chromatography (0-2% EtOAc in PE) to give the title compound as yellow oil.

The synthetic route of 703-91-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; DEUSCHLE, Ulrich; ALBERS, Michael; HOFFMANN, Thomas; (64 pag.)WO2018/141855; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary