Category: 70-23-5

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Synthetic Route of 70-23-5.

Orimi, Fathali Gholami;Mirza, Behrooz;Hossaini, Zinatossadat research published 《 Production of benzazepine derivatives via four-component reaction of isatins: study of antioxidant activity》, the research content is summarized as follows. In current research, benzazepine derivatives I [R = C(O)OEt, 4-MeC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄; R¹ = H, C(O)OMe, C(O)OEt; R² = Me, Et; X = H, Cl, Me, NO₂; X¹ = H, Me; X² = X³ = H, MeO] was synthesized via a new process of four-component reaction of isatin or its derivatives, α-haloketones, activated acetylenic compounds, isoquinoline and potassium fluoride/clinoptilolite nanoparticles (KF/CP NPs) in acidic solution of H₂O₂ in water at room temperature Also, antioxidation property of some prepared benzazepines I [R = 4-MeC₆H₄, 4-MeOC₆H₄; R¹ = H, C(O)OMe; R² = Me, Et; X = H, Me; X¹ = X² = X³ = H] was investigated by employing trapping diphenyl-picrylhydrazine (DPPH) radical and ability of ferric reduction experiment Among investigated compounds I [R = 4-MeC₆H₄; R¹ = H; R² = X = Me; X¹ = X² = X³ = H], had good results relative to BHT and TBHQ as standard antioxidant. Also, the gram-pos. and gram-neg. bacteria disk diffusion research was used for the confirmation of antibacterial power of some prepared benzazepines I. The achieved outcomes of disk diffusion experiment showed that these compounds avoided the growth of bacteria. This procedure had a few benefits relative to reported method such as good rate of reaction, product with high efficiency and simple removal of catalyst from mixture of reaction. In the yield of the product, KF/clinoptilolite nanoparticles showed a satisfactory recyclable activity.

Synthetic Route of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. COA of Formula: C5H7BrO3.

Moghaddas, Seyyed Ali;Hossaini, Zinatossadat;Zareyee, Daryoush research published 《 Green synthesis and investigation of antioxidant ability new pyrazines containing pyrrolo[2,1-a]isoquinolines derivatives》, the research content is summarized as follows. In this study, a new, easy and high yield procedure was investigated for the generation of pyrazine containing pyrrolo[2,1-a]isoquinoline derivatives I [R¹ = CO₂Et, 4-MeC₆H₄, 4-BrC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄ R² = H, CO₂Me, CO₂Et; R³ = Me, Et; X = H, Me, OMe; X¹ = H, Me; X² = NH, O] II [R¹ = CO₂Et, 4-MeOC₆H₄; R² = CO₂Me; R³ = Me; X¹ = H; X² = NH, O] using multicomponent reaction of phthalaldehyde or its derivatives, primary amines, α-haloalketones, electron deficient acetylenic compounds, ammonium acetate and KF/Clinoptilolite nanoparticles (KF/CP NPs) as catalyst in water at room temperature Also, in this work, antioxidant ability was studied for a number of prepared compounds [R¹ = CO₂Et, 4-MeC₆H₄, 4-BrC₆H₄; R² = H, CO₂Me; R³ = Me; X = H, Me; X¹ = H, Me; X² = NH, O] employing the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and power of compounds for reducing of ferric ion experiments and evaluating results with synthetic antioxidants (TBHQ and BHT). Comfortable, simple, fast and fresh procedure was the advantages of this study.

COA of Formula: C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Name: Ethyl 3-bromo-2-oxopropanoate.

Mousavi, Seyyedeh Fatemeh;Hossaini, Zinatossadat;Rostami-Charati, Faramarz;Nami, Navabeh research published 《 Green synthesis of pyrrolo isoquinolines using in situ synthesis of 4-hydroxycoumarines: Study of antioxidant activity》, the research content is summarized as follows. In this research, synthesis of pyrrolo isoquinoline derivatives I (R = COOEt, Ph, 4-MeC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄; R¹ = Me, OMe, NO₂; R² = H, Me) in excellent yields was performed using the multicomponent reaction of isoquinoline, alkyl bromides, 2-hydroxyacetophenone, or its derivatives, di-Me carbonate as a green reagent and KF/clinoptinolite nanoparticles as a catalyst in the aqueous media at 80°. The Punica granatum peel water extract was used as the green media for the synthesis of PG-KF/clinoptilolite nanoparticles in high yield. The PG-KF/clinoptilolite nanoparticles show a significant basic catalytic role in these reactions in preparing the product in high yield and used for several times. In addition, for studying the antioxidant ability of some of the synthesized compounds, diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction tests are employed. The short time of the reaction, high yields of the product, easy separation of the catalyst and products are some of the advantages of this procedure.

Name: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Mashal, Neda;Azizian, Javad;Larijani, Kambiz;Nematollahi, Fereshteh;Azizian, Homa research published 《 Baker′s Yeast Promoted One-Pot Synthesis of New 1,2,4-Triazolpyrimido-1,3,4-Oxadiazoles: Investigation of Antioxidant and Antimicrobial Activity》, the research content is summarized as follows. In this study, baker′s yeast promoted one-pot synthesize of new 1,2,4-triazolpyrimidooxadiazole derivatives I (R = C(O)₂Et, Ph, 4-methylphenyl, 4-methoxyphenyl, 4-nitrophenyl; R¹ = R² = Ph, 4-methylphenyl, 4-methoxyphenyl; X = H, Me, NO₂) in high yields using multicomponent reactions of isatins II, guanidine, alkyl bromides RC(O)CH₂Br, acetaldehyde and hydrazonoyl chlorides R¹C(Cl)=NNHR² in the presence of baker′s yeast as a high performance catalyst in water at room temperature Investigation of antioxidant ability of synthesized compounds using radical trapping of diphenyl-picrylhydrazine (DPPH)and ferric reduction power experiment is another purpose in this research. Also, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on Gram-pos. and Gram-neg. bacteria. This procedure has some benefits such as short reaction time, product with excellent yields and simple, efficient, inexpensive, and environment-friendly catalyst.

Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Safety of Ethyl 3-bromo-2-oxopropanoate.

Mehrabi, Hossein;Alizadeh-Bami, Farzaneh;Meydani, Azam;Besharat, Soheila research published 《 An eco-friendly approach for the synthesis of 1,2,5-trisubstituted and 4-amino-1,2,5-tetrasubstituted imidazoles via a multi-component condensation》, the research content is summarized as follows. The synthesis of 1,2,5-trisubstituted imidazoles I (Ar = Ph, 2-chlorophenyl; Ar¹ = Ph, 4-tolyl, 4-bromophenyl, etc.) and 4-amino-1,2,5-tetrasubstituted imidazoles II (Ar² = 4-chlorophenyl, 4-bromophenyl; Ar³ = 4-tolyl, 4-methoxyphenyl, 3-nitrophenyl) was demonstrated via a two-step cyclo-condensation reaction of aryl amines Ar¹NH₂, carbonitriles ArCN, and Et bromopyruvate or aryl amines Ar³NH₂ and arylglyoxals Ar²C(O)CHO in ethanol heated under reflux in the presence of iron (III) chloride (FeCl₃), and disodium phosphate (Na₂HPO₄) as catalysts, resp. All the products I and II were obtained in good to excellent yields and their structures were established from their spectroscopic data.

Safety of Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. Reference of 70-23-5

Liu, Longbin;Johnson, Peter D.;Prime, Michael E.;Khetarpal, Vinod;Lee, Matthew R.;Brown, Christopher J.;Chen, Xuemei;Clark-Frew, Daniel;Coe, Samuel;Conlon, Mike;Davis, Randall;Ensor, Samantha;Esposito, Simone;Moren, Anton Forsberg;Gai, Xinjie;Green, Samantha;Greenaway, Catherine;Haber, James;Halldin, Christer;Hayes, Sarah;Herbst, Todd;Herrmann, Frank;Hessmann, Manuela;Hsai, Ming Min;Kotey, Adrian;Mangette, John E.;Mills, Matthew R.;Monteagudo, Edith;Nag, Sangram;Nibbio, Martina;Orsatti, Laura;Schaertl, Sabine;Scheich, Christoph;Sproston, Joanne;Stepanov, Vladimir;Varnas, Katarina;Varrone, Andrea;Wityak, John;Mrzljak, Ladislav;Munoz-Sanjuan, Ignacio;Bard, Jonathan A.;Dominguez, Celia research published 《 [¹¹C]CHDI-626, a PET Tracer Candidate for Imaging Mutant Huntingtin Aggregates with Reduced Binding to AD Pathological Proteins》, the research content is summarized as follows. The expanded polyglutamine-containing mutant huntingtin (mHTT) protein is implicated in neuronal degeneration of medium spiny neurons in Huntington′s disease (HD) for which multiple therapeutic approaches are currently being evaluated to eliminate or reduce mHTT. Development of effective and orthogonal biomarkers will ensure accurate assessment of the safety and efficacy of pharmacol. interventions. We have identified and optimized a class of ligands that bind to oligomerized/aggregated mHTT, which is a hallmark in the HD postmortem brain. These ligands are potentially useful imaging biomarkers for HD therapeutic development in both preclin. and clin. settings. We describe here the optimization of the benzo[4,5]imidazo[1,2-a]pyrimidine series that show selective binding to mHTT aggregates over Aβ- and/or tau-aggregates associated with Alzheimer′s disease pathol. Compound [¹¹C]-2 was selected as a clin. candidate based on its high free fraction in the brain, specific binding in the HD mouse model, and rapid brain uptake/washout in nonhuman primate positron emission tomog. imaging studies.

Reference of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, SDS of cas: 70-23-5

Lin, Yinuo;Ahmed, Wasim;He, Min;Xiang, Xuwen;Tang, Riyuan;Cui, Zi-Ning research published 《 Synthesis and bioactivity of phenyl substituted furan and oxazole carboxylic acid derivatives as potential PDE4 inhibitors》, the research content is summarized as follows. In this present study, a series of 5-phenyl-2-furan I [R = H, Cl, F; R¹ = H, Cl, F; R² = H, Me, Br; R³ = H, F] and II and 4-phenyl-2-oxazole derivatives III were designed and synthesized as phosphodiesterase type 4 (PDE4) inhibitors. In vitro results showed that the synthesized compounds I and II exhibited considerable inhibitory activity against PDE4B and blockade of LPS-induced TNF-α release. Among the designed compounds, Compound II [R = H, R¹ = H, R² =OMe, R³ = H] exhibited lower IC₅₀ value (1.4μM) against PDE4 than parent rolipram (2.0μM) in in vitro enzyme assay, which also displayed good in vivo activity in animal models of asthma/COPD and sepsis induced by LPS. Docking results suggested that introduction of methoxy group at para-position of Ph ring, demonstrated good interaction with metal binding pocket domain of PDE4B, which was helpful to enhance inhibitory activity.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., SDS of cas: 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Computed Properties of 70-23-5.

Le, Hai Van;Tran, Loc Van;Tran, Anh Tuan;Tran, Thao Thi Phuong;Tran, Sung Van;Tran, Chien Van research published 《 Design, synthesis, and cytotoxic activity of new tubulysin analogues》, the research content is summarized as follows. Synthesis of tubulysin analogs, containing an N-Me substituent on tubuvaline-amide together with the replacement of either the hydrophobic N-terminal N-Me pipecolic acid (Mep) or at both N- and C- terminal peptides with available heteroaromatic acids and an unsaturated tubuphenylalanine moiety, resp., were described. The in vitro cytotoxic activity by SRB assay on five cancer cell lines for sixteen tubulysins was evaluated. Among them, five analogs exhibited strong cytotoxic activities against five human cancer cell lines, including human breast carcinoma (MCF7), human colorectal adenocarcinoma (HT-29), HL-60, SW-480, human lung adenocarcinoma (A459). Interestingly, one analog showed the strongest cytotoxicity on all five tested cell lines even much higher toxicity than the reference compound ellipticine.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Computed Properties of 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Kumari, Annu;Dehaen, Wim;Chopra, Deepak;Dey, Swapan research published 《 Imidazopyridine-fluoride interaction: solvent-switched AIE effects via S···O conformational locking》, the research content is summarized as follows. Convenient and straightforward methods have been developed for the detection and quant. estimation of fluoride anions by two novel imidazopyridine-based carboxamides (C1 and C2) in organic and aqueous media. The synthesized mols. exhibit high selectivity and enhanced sensitivity towards recognizing fluoride ions through the ‘turn on’ fluorogenic mode. The fluoride ion-driven deprotonation of the N-H proton and the subsequent spectral changes have been characterized by ¹H and ¹⁹F NMR spectroscopic techniques. Single-crystal XRD elucidates the structural evidence for deprotonation upon the addition of fluoride anions, wherein C1.S (C1-.2H₂O.TBA⁺) and C2.S (C2-.2H₂O.TBA⁺) salts were generated. Accordingly, C1 unveiled broad absorption bands at λ_max 340 nm, whereas C2 displayed similar bands at λ_max 308 nm in UV-vis spectra. The peaks shift to λ_max 350 nm and λ_max 341 nm after deprotonation. C1 itself exhibits the aggregation induced emission (AIE) phenomenon in water-DMSO (1 : 1). This is the first report of an imidazopyridine moiety being involved in a solvent-switched AIE effect via S···O conformational locking. UV-vis and fluorescence spectra of the compounds were obtained to predict the stoichiometry, binding constant, and the limit of detection (LOD). The actual structures of carboxamides and the resulting deprotonated carboxamide salts have been confirmed by single-crystal X-ray diffraction data. Different intra- and intermol. H-bonds, namely O-H···N, O-H···O, N-H···O, C-H···N and C-H···O, play a significant role in the crystal packing of these compounds

Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Kung, Pei-Pei;Bingham, Patrick;Burke, Benjamin J.;Chen, Qiuxia;Cheng, Xuemin;Deng, Ya-Li;Dou, Dengfeng;Feng, Junli;Gallego, Gary M.;Gehring, Michael R.;Grant, Stephan K.;Greasley, Samantha;Harris, Anthony R.;Maegley, Karen A.;Meier, Jordan;Meng, Xiaoyun;Montano, Jose L.;Morgan, Barry A.;Naughton, Brigitte S.;Palde, Prakash B.;Paul, Thomas A.;Richardson, Paul;Sakata, Sylvie;Shaginian, Alex;Sonnenburg, William K.;Subramanyam, Chakrapani;Timofeevski, Sergei;Wan, Jinqiao;Yan, Wen;Stewart, Albert E. research published 《 Characterization of Specific N-α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library》, the research content is summarized as follows. Two novel compounds were identified as Naa50 binders/inhibitors using DNA-encoded technol. screening. Biophys. and biochem. data as well as cocrystal structures were obtained for both compounds (3a and 4a) to understand their mechanism of action. These data were also used to rationalize the binding affinity differences observed between the two compounds and a MLGP peptide-containing substrate. Cellular target engagement experiments further confirm the Naa50 binding of 4a and demonstrate its selectivity toward related enzymes (Naa10 and Naa60). Addnl. analogs of inhibitor 4a were also evaluated to study the binding mode observed in the cocrystal structures.

Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary