Category: 70-23-5

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Shi, Da-Hua;Song, Meng-qiu;Ma, Xiao-Dong;Su, Jia-Bin;Wang, Jing;Wang, Xiu-Jun;Liu, Yu-Wei;Liu, Wei-Wei;Si, Xin-Xin research published 《 Synthesis, characterization, crystal structures, and the biological evaluation of 2-phenylthiazole derivatives as cholinesterase inhibitors》, the research content is summarized as follows. Four 2-phenylthiazole derivatives I [R = 4-methylpiperazin-1-yl, 2-morpholin-4-yl-Et, 3,5-dimethylpiperidin-1-yl, etc.] were synthesized, characterized and evaluated as cholinesterase inhibitors. The structures of the 2-phenylthiazole derivatives were confirmed by ¹H and ¹³C NMR spectroscopy, single-crystal X-ray diffraction studies, and Hirshfeld surfaces anal. Hirshfeld surface anal. of the prepared compounds showed C-H···O intermol. interactions. The cholinesterase inhibition activities of the synthesized compounds were tested by Ellman’s method. Compound I [R = 3,5-dimethylpiperidin-1-yl] showed the best acetylcholinesterase inhibition activity with an IC₅₀ value of 8.86μM and the best butyrylcholinesterase inhibition activity with an IC₅₀ value of 1.03μM. A docking study demonstrated that the same compound interacted with the catalytic anionic site and peripheral anionic site of acetylcholinesterase and the catalytic anionic site of butyrylcholinesterase.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Recommanded Product: Ethyl 3-bromo-2-oxopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Electric Literature of 70-23-5.

Shafaei, Faezeh;Najar, Asef H. research published 《 Green synthesis of 4H-pyran derivatives using Fe₃O₄-MNPs as efficient nanocatalyst: study of antioxidant activity》, the research content is summarized as follows. A series of dialkyl 4-(oxo-alkoxy/aryl)-5-oxo-4,5-dihydroindeno[1,2-b]pyran-2,3-dicarboxylates I [R = CO₂Et, 4-MeC₆H₄, 4-BrC₆H₄, etc.; R¹ = Me, Et] was synthesized via a multicomponent reaction of ninhydrin, α-haloketones, dialkyl acetylenedicarboxylates and triphenylphosphine in the presence of iron oxide magnetic nanoparticles (Fe₃O₄-MNPs) as efficient nanocatalyst in ethanol at room temperature The biosynthesis of Fe₃O₄-MNPs was achieved using Clover Leaf water extract In addition, antioxidant activity was examined for some of the compounds I [R = CO₂Et, 4-MeC₆H₄, 4-MeOC₆H₄, 4-O₂NC₆H₄; R¹ = Me, Et] employing DPPH radical scavenging and ferric reduction activity potential (FRAP) experiment and compared results with synthetic antioxidants (TBHQ and BHT). Compound I [R = CO₂Et; R¹ = Et] showed excellent radical trapping activity and good reducing activity relative to standards (BHT and TBHQ). Some advantages of this procedure were easiness of reaction workup and seperation of products by simply filtration. Fe₃O₄-MNPs displayed a good improvement in the yield of the product and showed significant reusable activity.

Electric Literature of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. SDS of cas: 70-23-5

Shafaei, Faezeh;Babaei, Seyyed Ebrahim;Shahvelayati, Ashraf Sadat;Honarmand Janatabadi, Fatemeh research published 《 Biosynthesis of Fe₃O₄-magnetic nanoparticles using clover leaf aqueous extract: Green synthesis of 1,3-benzoxazole derivatives》, the research content is summarized as follows. In this research, magnetic Fe₃O₄-NP nanoparticles were synthesized employing a green biosynthetic procedure by reduction of ferric chloride solution with clover leaf water extract The nanoparticles prepared via this biosynthesis method can potentially be valuable for different purposes such as organic synthesis. In this research, 1,3-benzoxazole derivatives were generated via a multicomponent reaction of α-bromo ketones, isothiocyanate, and propiolate in the presence of a catalytic amount of bio-Fe₃O₄ MNPs and sodium hydride in water at 50°C in good yields. The catalyst was reused five times with a minor decrease in its catalytic activity.

SDS of cas: 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Reference of 70-23-5

Shamsi, Farheen;Hasan, Phool;Queen, Aarfa;Hussain, Afzal;Khan, Parvez;Zeya, Bushra;King, Hannah M.;Rana, Sandeep;Garrison, Jered;Alajmi, Mohamed F.;Rizvi, M. Moshahid Alam;Zahid, Muhammad;Imtaiyaz Hassan, Md.;Abid, Mohammad research published 《 Synthesis and SAR studies of novel 1,2,4-oxadiazole-sulfonamide based compounds as potential anticancer agents for colorectal cancer therapy》, the research content is summarized as follows. A diverse series of 1,2,4-oxadiazoles, e.g., I was designed, synthesized and evaluated as anticancer agents targeting carbonic anhydrase IX (CAIX). Initial structure-activity anal. suggested that the thiazole/thiophene-sulfonamide conjugates of 1,2,4-oxadiazoles exhibited potent anticancer activities with low μM potencies. 4-Methyl-N-(2-(3-phenyl-1,2,4-oxadiazol-5-yl)thiophen-3yl)benzenesulfonamide exhibited antiproliferative activity (IC₅₀ = 11.1μM) along with appreciable inhibition potential for tumor-associated CAIX (IC₅₀ = 4.23μM) isoform. Therefore, it was structurally optimized and its SAR oriented derivatives II [R1 = Me, Ph, 4-FC₆H₄, etc.; R² = Me, Ph] were synthesized and evaluated. This iteration resulted in compound II [R¹ = 4-H₂NC₆H₄, R² = Ph] with an almost two-fold increase in antiproliferative effect (IC₅₀ = 6.0μM) comparable to the clin. drug doxorubicin and significantly higher potency against CAIX (IC50 = 0.74μM). Addnl., compound II [R¹ = 4-H₂NC₆H₄, R² = Ph] treatment decreased the expression of CAIX, induced apoptosis and ROS production, inhibited colony formation and migration of colon cancer cells.

Reference of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Reference of 70-23-5.

Sanghavi, Kartik N.;Dhuda, Gautam Kumar;Kapadiya, Khushal M. research published 《 Facile Microwave Synthesis of Pd-Catalyzed Suzuki Reaction for Bis-6-Aryl Imidazo[1,2-a]Pyridine-2-Carboxamide Derivatives with PEG3 Linker》, the research content is summarized as follows. An efficient and facile synthetic procedure has been developed for the synthesis of novel series of Bis-6-aryl-imidazo[1,2-a]pyridine-2-carboxamide containing 3,3′-((oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine) derivatives An application of the Palladium catalyzed Suzuki reaction on amine-(CH₂)₃-PEG3-(CH₂)₃-amine linked 6-bromo imidazo[1,2-a]pyridine-2-carboxamide was reported and their products are discussed. The reaction was optimized through numerous catalytic conditions for this strategy, and it was fixed with the best approach having advantages of less reaction time, higher degree of yield, most consumption of starting material, and selection of best catalyst for the success of the reaction. The ideal spectroscopic characterization (PMR, CMR, IR and MS) have been utilized for the finalization of the synthesized adducts.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Reference of 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Quality Control of 70-23-5.

Savari, Mehdi;Varasteh-Moradi, Ali;Sayyed-Alangi, S. Zahra;Hossaini, Zinatossadat;Zafarmehrabian, Ramin research published 《 Ag/Fe₃O₄/TiO₂@MWCNTs as a reusable organometallic nanocatalyst promoted green synthesis of new pyridobenzoazepines: Study of biological activity and reduction of organic pollutants》, the research content is summarized as follows. In this research, Ag/Fe₃O₄/TiO₂@MWCNTs magnetic nanocomposites synthesized using water extract of Spinacia oleracea leaves, and the high performance of synthesized catalyst was confirmed by employing it in the multicomponent reaction of isatoic anhydride, N-methylimidazole, α-haloketones, electron-deficient acetylenic compounds, ammonium acetate, and Me epoxide in water at ambient temperature for the preparation of new pyridobenzoazepine derivatives such as I [X = H, Me, NO₂, etc.; R¹ = Me, Et; R² = CO₂Et, 4-MeC₆H₄, 4-MeOC₆H₄, etc.] in high yields. Also, the catalytic activity of the green synthesized Ag/Fe₃O₄/TiO₂@MWCNTs was evaluated in the reduction of organic pollutants such as 4-nitrophenol in water at mild conditions. The results indicated that the biosynthesized magnetic nanocomposites (MNCs) have very high and effective catalytic activity for organic pollutants within few seconds. The synthesized compounds have OH group in their structure and for this reason might be showed good antioxidant activity. Also, employing Gram-pos. and Gram-neg. bacteria in the disk diffusion procedure confirmed antimicrobial effect of the some pyridobenzoazepine derivatives The results showed that synthesized compounds prevented the bacterial growth. This used procedure for preparation of pyridobenzoazepine derivatives have some advantages such as low reaction time, product with high yields, and simple separation of catalyst and products.

Quality Control of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Recommanded Product: Ethyl 3-bromo-2-oxopropanoate

Savari, Mehdi;Varasteh-Moradi, Ali;Sayyed-Alangi, S. Zahra;Hossaini, Zinatossadat;Mehrabian, Ramin Zafar research published 《 Green novel multicomponent synthesis and biological evaluation of new oxazolopyrazoloazepines and reduction of nitrophenols in the presence of Ag/Fe₃O₄/ZnO@MWCNT MNCs》, the research content is summarized as follows. In this research, new derivatives of oxazolopyrazoloazepines I (X = H, Me, Cl, NO₂; R = H, COOMe, COOEt; R¹ = Me, Et; R² = 4-methoxyphenyl, 4-methylphenyl, COOEt, 4-nitrophenyl) were synthesized in high yields using multicomponent reaction of anilines 4-XC₆H₄NH₂, oxalylchloride, alkyl bromides BrCH₂C(O)R², activated acetylenic compounds RCCC(O)OR¹, hydrazine and Et bromopyruvate in the presence of Ag/Fe₃O₄/ZnO@MWCNT magnetic nanocomposite (MNCs) as a high-performance magnetic catalyst in ionic liquid at room temperature The Ag/Fe₃O₄/ZnO@MWCNT magnetic nanocomposites (MNCs) were synthesized using 1-octyl-3-Me imidazolium bromide ([OMIM]Br) as a stabilizer and soft template. Also, the catalytic activity of the Ag/Fe₃O₄/ZnO@MWCNT MNCs was evaluated in reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the biosynthesized nanocomposites (NCs) have high catalytic activity for organic pollutants within few seconds. Because of having benzazepine nucleus in the synthesized compounds, antioxidant property of some synthesized oxazolopyrazoloazepines I was investigated by diphenyl-picrylhydrazine radical trapping and power of ferric reduction experiment Short time of reaction, high yields of product, easy separation of catalyst and products are some advantages of this procedure.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Recommanded Product: Ethyl 3-bromo-2-oxopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, HPLC of Formula: 70-23-5

Rostamian, Rezvaneh;Khalilzadeh, Mohammad A.;Zareyee, Daryoush research published 《 Wood ash biocatalyst as a novel green catalyst and its application for the synthesis of benzochromene derivatives》, the research content is summarized as follows. This study investigates the catalytic activity of wood ash as a heterogeneous catalyst for the synthesis of benzochromene derivatives I (R = Me, 4-methoxyphenyl, Ph, Et, 4-methylphenyl; R₁ = 4-methoxyphenyl, C(O)OC₂H₅, 4-methylphenyl). Several wood ash catalysts, comprising calcium- and potassium-rich carbonates, were prepared from different natural resources under various combustion temperatures The prepared catalysts were characterized by Fourier transform IR, SEM, energy dispersive X-ray anal., transmission electron microscopy, and X-ray diffraction techniques. Catalytic efficiency of the resultant catalysts was tested in the synthesis of benzochromene derivatives I. The exptl. studies clarified that the catalyst prepared at 850°C could efficiently expedite the formation of three-component synthesis of benzochromene derivatives I in water at 80°C with high yields. Indeed, alkali, alk. metal, and metal oxides such as Al₂O₃, SiO₂, MgO, CaO, and Fe₂O₃, are widely utilized as both catalyst and catalyst support in the heterogeneous catalytic processes. The prepared wood ash catalysts (possessing metal oxides, e.g., CuO, Al₂O₃, SiO₂, and CaO) could effectively prompt the electrophilic activity of the carbonyl groups during the nucleophilic attack intermediate, enhancing the efficiency of the reactions.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., HPLC of Formula: 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. COA of Formula: C5H7BrO3

Sadeghi Meresht, Abdollah;Ezzatzadeh, Elham;Dehbandi, Behnam;Salimifard, Masoomeh;Rostamian, Rezvaneh research published 《 Fe₃O₄/CuO Nanocomposite Promoted Green Synthesis of Functionalized Quinazolines Using Water Extract of Lettuce Leaves as Green Media: Study of Antioxidant Activity》, the research content is summarized as follows. In this work, five component reactions are utilized for the production of quinazoline derivatives by utilizing the one-pot reaction of 3-hydroxyphthalaldehyde, ethylenediamine, alkyl bromides, electron deficient acetylenic compounds and Et bromoacetate in vicinity of Fe₃O₄/CuO nanocomposites as a high performance catalyst at environment temperature in water extract of lettuce leaves as green solvent. Also, water extract of lettuce leaves was used for synthesis of Fe₃O₄/CuO nanocomposites. The existing quinazoline core in the synthesized compounds caused to ability of antioxidation of synthesized quinazoline. For confirmation of this point, we are used DPPH radical trapping and ferric ion reducing power tests. Outcomes of these tests show that synthesized quinazolines have low DPPH radical trapping and good reducing ability of ferric ion. The excellent yield of reaction, green media and easy separation of product and catalyst are some benefits of this procedure. Highlights water extract of Lettuce leaves was used as solvent for the preparation of quinazolines as cyclic heteroaromatic systems. The present procedure avoids the use of toxic solvent. The present procedure runs in water extract of Lettuce leaves as a green media. This recoverable catalyst makes this protocol attractive and useful as an industrially viable and eco-safe solvent with high yields of products.

COA of Formula: C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Application In Synthesis of 70-23-5

Rani, Chekuri Sharmila;Reddy, Alugubelli Gopi;Susithra, E.;Mak, Kit-Kay;Pichika, Mallikarjuna Rao;Reddymasu, Sreenivasulu;Rao, Mandava Venkata Basaveswara research published 《 Synthesis and anticancer evaluation of amide derivatives of imidazo-pyridines》, the research content is summarized as follows. Abstract: A novel series of amide functionalized imidazo[1,2-a]pyridine (14a-14j) derivatives were synthesized and screened for their anticancer activities against breast (MCF-7 and MDA-MB-231), lung (A549), and prostate (DU-145) cancer cell lines using MTT assay with etoposide as the standard reference drug. Among them, compound 14 showed highest potency in anticancer activities against MCF-7, MDA-MB-231, A549, and DU-145 cell lines with IC₅₀ values of 0.021 ± 0.0012μM, 0.95 ± 0.039μM, 0.091 ± 0.0053μM, and 0.24 ± 0.032μM, resp.

Application In Synthesis of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary