Category: 70-23-5

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, Related Products of 70-23-5

Srivastava, Nitin;Kishore, Ram research published 《 Cleaner, greener synthesis, characterization, and anticancer evaluation of 2-thioxo-1,3-thiazolanes》, the research content is summarized as follows. An easy, efficient and green method for synthesizing 2-thioxo-1,3-thiazolanes I [R = Et, Bn, CH₂(2-ClC₆H₄), etc.] via reaction of Et 3-bromo-2-oxopropanoate with amines and carbon disulfide at room temperature in the presence of tetrabutylammonium iodide in aqueous medium. The synthesized compounds showed I good in vitro anticancer activity among which compounds such as I [CH₂(2-ClC₆H₄), n-Bn, CH₂(2-ClC₆H₄), 1-naphthylmethyl] which showed exceptional anticancer activity against HeLa, HCT-15, and U-87 MG, resp., could be further assessed for in vivo anticancer activities. This method used cheaper, least toxic and easily available reagents at normal laboratory temperature

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Related Products of 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Quality Control of 70-23-5.

Sigalapalli, Dilep Kumar;Kiranmai, Gaddam;Parimala Devi, G.;Tokala, Ramya;Sana, Sravani;Tripura, Chaturvedula;Jadhav, Govinda Shivaji;Kadagathur, Manasa;Shankaraiah, Nagula;Nagesh, Narayana;Babu, Bathini Nagendra;Tangellamudi, Neelima D. research published 《 Synthesis and biological evaluation of novel imidazo[1,2-a]pyridine-oxadiazole hybrids as anti-proliferative agents: study of microtubule polymerization inhibition and DNA binding》, the research content is summarized as follows. Towards the development of potential anticancer agents, a new series of imidazo[1,2-a]pyridine-oxadiazole hybrids I [R¹ = H, Me, R² = H; R¹ = Br, R² = Me; R³ = Ph, 4-Me₂NC₆H₄, 3,4,5-(MeO)₃C₆H₂, etc.] was synthesized and evaluated for their in vitro anticancer activity against lung cancer (A549) and prostate cancer (PC-3, DU-145) cell lines. Amongst the compounds tested, the compound I [R¹ = R² = H; R³ = 3,4,5-(MeO)₂C₆H₂; (II)] showed the highest potency on A549 cells with an IC₅₀ value of 2.8 ± 0.02μM. Flow cytometric anal. of A549 cells, treated with the compound II, showed apoptosis induction by annexin-v/PI dual staining assay and the effect of II on different phases of cell cycle was also analyzed. Target based studies demonstrated the inhibition of tubulin polymerization by the compound II at an IC₅₀ value of 3.45 ± 0.51μM and its effective binding with CT-DNA. Further, the mol. modeling studies revealed that II has a prominent binding affinity towards α/β-tubulin receptor with admirable physico-chem. properties.

Quality Control of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. Formula: C5H7BrO3

Soleimani Amiri, Somayeh;Hossaini, Zinatossadat;Azizi, Zahra research published 《 Synthesis and investigation of antioxidant and antimicrobial activity of new pyrazinopyrroloazepine derivatives using Fe₃O₄/CuO/ZnO@MWCNT MNCs as organometallic nanocatalyst by new MCRs》, the research content is summarized as follows. In this study, authors synthesized pyrazinopyrroloazepine derivatives I (R = 4-CH₃OC₆H₄, 4-CH₃C₆H₄, 4-O₂NC₆H₄, etc.; R¹ = CO₂Me, CO₂Et, H; R² = CO₂Me, CO₂Et; R³ = H, Me, NO₂, Cl) in high yields using multicomponent reactions of isatoic anhydride, N-methylimidazole, alkyl bromides, activated acetylenic compounds, Et glycinate and Me aziridine in the presence of Fe3O4/CuO/ZnO@MWCNT as a high performance catalyst in water at room temperature The Fe3O4/CuO/ZnO@MWCNT synthesizes using Petasites hybridus rhizome water extract as a green media and moderate base. As well the catalyst show a good improvement in the yield of the product and displayed significant reusable activity. Investigation of antioxidant ability of synthesized compounds using radical trapping of diphenyl-picrylhydrazine (DPPH) and ferric reduction power experiment is another purpose in this research. Because of having two NH groups in the synthesized compounds, these compounds shown the good antioxidant activity relative two standards Compound I (R = 4-CH₃C₆H₄; R’ = H; R” = Me; X = H) was shown excellent antioxidant activity. Also, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on gram-pos. and gram-neg. bacteria. The pyrazinopyrroloazepines I (R = 4-CH₃OC₆H₄, R¹ = R² = CO₂Me, R³ = H; R = 4-CH₃OC₆H₄, R¹ = H, R² = CO₂Me, R³ = Me; R = 4-CH₃C₆H₄, R¹ = H,CO₂Me, R² = CO₂Me, R³ = H) have the maximum effect on E. coli compared with gram-pos. and gram-neg. bacteria because of good inhibition zone diameter

Formula: C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. Application of C5H7BrO3

Soleimani Amiri, Somayeh research published 《 Green production and antioxidant activity study of new pyrrolo[2,1-a]isoquinolines》, the research content is summarized as follows. In current research, pyrrolo[2,1-a]isoquinolines, compounds I [R¹ = CN; R² = CO₂Et, 4-BrC₆H₄, etc.; R³ = H, CO₂Me, CO₂Et; R⁴ = Me, Et; X¹ = H, Me, MeO; X² = H, Me] were synthesized via a new process of four-component reaction of phthalaldehyde or its derivatives, primary amines, alkyl bromides, activated acetylenic compounds and potassium fluoride/Clinoptilolite nanoparticles (KF/CP NPs) under solvent-free conditions at room temperature Also, Diels-Alder reactions took place in the reaction of synthesized pyrrolo[2,1-a]isoquinoline derivatives, activated acetylenic compounds and triphenylphosphine in the presence of KF/CP NPs under solvent-free conditions at room temperature As well, antioxidation property of some prepared pyrrolo[2,1-a]isoquinolines were investigated by employing trapping of diphenyl-picrylhydrazine (DPPH) radical and ability of ferric reduction experiment Among investigated compounds, compounds I [R¹ = CN, R² = 4-MeC₆H₄, R³ = CO₂Me, R⁴ = Me, X¹ = H, X² = Me] have good results relative to BHT and TBHQ as standard antioxidant. Reported method has good rate of reaction, product with high efficiency and simple removal of catalyst from mixture of reaction. In these reactions, KF/Clinoptilolite nanoparticles show a satisfactory recyclable activity.

Application of C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Electric Literature of 70-23-5.

Soleimani-Amiri, Somayeh;Hossaini, Zinatossadat;Azizi, Zahra research published 《 Synthesis and Investigation of Biological Activity of New Oxazinoazepines: Application of Fe₃O₄/CuO/ZnO@MWCNT Magnetic Nanocomposite in Reduction of 4-Nitrophenol in Water》, the research content is summarized as follows. In this study, oxazinoazepine derivatives were synthesized in high yields using multicomponent reactions of aniline, oxalylchloride, alkyl bromides, activated acetylenic compounds, Et glycinate, and Me epoxide in the presence of Fe₃O₄/CuO/ZnO@MWCNT as a high-performance catalyst in water at room temperature The Fe₃O₄/CuO/ZnO@MWCNT was synthesized using Petasites hybridus rhizome water extract as a green media and moderate base. Also, the catalytic activity of the green synthesized Fe₃O₄/CuO/ZnO@MWCNT magnetic nanocomposite (MNCs) was evaluated in the reduction of organic pollutants such as 4-nitrophenol (4-NP) in water at mild conditions. The results indicated that the biosynthesized NCs have very high and effective catalytic activity for organic pollutants within few seconds. Investigation of antioxidant ability of synthesized compounds using radical trapping of diphenyl-picrylhydrazine (DPPH) and ferric reduction power experiment is another purpose in this research. Also, the antimicrobial activity of some synthesized compounds was proved by employing the disk diffusion test on Gram-pos. and Gram-neg. bacteria. This procedure has some benefits such as short reaction time, product with excellent yields, simple catalyst, and products separation

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Electric Literature of 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Quality Control of 70-23-5.

Shirangi, Hannaneh Sadat;Varasteh Moradi, Ali;Ahmadi Golsefidi, Maziar;Hossaini, Zinatossadat;Jalilian, Hamid Reza research published 《 Fe₃O₄/CuO/ZnO@MWCNT MNCs as an efficient organometallic nanocatalyst promoted synthesis of new 1,2,4-triazolpyrimidoazepine derivatives: Investigation of antioxidant and antimicrobial activity》, the research content is summarized as follows. In this study, the new 1,2,4-triazolpyrimidoazepine derivatives I [R = methoxycarbonyl; R¹ = Me, Et; R³ = 4-methoxyphenyl, 4-chlorophenyl, 4-cyanophenyl, etc.; Ar = 4-methoxyphenyl, 4-chlorophenyl] in high yields using multicomponent reactions of isatins, alkyl bromides, activated acetylenic compounds, guanidine, aldehydes and hydrazonoyl chloride in the presence of Fe₃O₄/CuO/ZnO@MWCNT as a high performance catalyst in water at room temperature was synthesized. The Fe₃O₄/CuO/ZnO@MWCNT synthesizes using Petasites hybridus rhizome water extract as a green media and moderate base. As well Fe₃O₄/CuO/ZnO@MWCNT MNCs show a good improvement in the yield of the product and displayed significant reusable activity. Investigation of antioxidant ability of synthesized compounds I using radical trapping of diphenyl-picrylhydrazine (DPPH) and ferric reduction power experiment was another purpose in this research. Also, the antimicrobial activity of some synthesized compounds I proved by employing the disk diffusion test on Gram-pos. and Gram-neg. bacteria. This procedure was some benefits such as short reaction time, product with excellent yields, simple catalyst and products separation

Quality Control of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. HPLC of Formula: 70-23-5

Shirangi, Hannaneh Sadat;Moradi, Ali Varasteh;Golsefidi, Maziar Ahmadi;Hossaini, Zinatossadat;Jalilian, Hamid Reza research published 《 Green synthesis and investigation of antioxidant and antimicrobial activity of new schiff base of pyrimidoazepine derivatives: application of Fe₃O₄/CuO/ZnO@MWCNT MNCs as an efficient organometallic nanocatalyst》, the research content is summarized as follows. In this study, we synthesized schiff base of pyrimidoazepine derivatives in high yields using multicomponent reactions of isatins, alkyl bromides, activated acetylenic compounds, guanidine and aldehydes in the presence of Fe₃O₄/CuO/ZnO@ Multi Walled Carbon Nanotubes (MWCNT) as a high performance catalyst in water at room temperature The Fe₃O₄/CuO/ZnO@MWCNT synthesizes using Petasites hybridus rhizome water extract as a green media and moderate base. As well Fe₃O₄/CuO/ZnO@MWCNT magnetic nanocomposites show a good improvement in the yield of the product and displayed significant reusable activity. Investigation of antioxidant ability of synthesized compounds using radical trapping of diphenyl-picrylhydrazine and ferric reduction power experiment is another purpose in this research. Also, the antimicrobial activity of some synthesized compounds proved by employing the disk diffusion test on Gram-pos. and Gram-neg. bacteria. This procedure has some benefits such as short reaction time, product with excellent yields, simple catalyst and products separation

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., HPLC of Formula: 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. Formula: C5H7BrO3

Sharafian, Shirin;Hossaini, Zinatossadat;Rostami-Charati, Faramarz;Khalilzadeh, Mohammad A. research published 《 Ultrasound-promoted Green Synthesis of Pyrido[2,1-a]isoquinoline Derivatives and Studies on their Antioxidant Activity》, the research content is summarized as follows. In this work, synthesis of pyrido[2,1-a]isoquinolines I (R = EtO₂C, 4-MeOC₆H₄, 4-MeC₆H₄, 4-BrC₆H₄, 4-O₂NC₆H₄; R¹ = H, MeO₂C, EtO₂C; R² = Me, Et) via multicomponent reaction of phthalaldehyde, methylamine, α-bromo carbonyls RC(O)CH₂Br, activated acetylenic compounds R¹CCCO₂R² and triphenylphosphine in water under ultrasonic irradiation conditions at room temperature in excellent yields in short time was performed. The subsequent Diels-Alder reaction of pyrido[2,1-a]isoquinolines I (R = EtO₂C, 4-MeOC₆H₄, 4-MeC₆H₄, 4-O₂NC₆H₄; R¹ = MeO₂C, EtO₂C; R² = Me, Et) with activated acetylenic compounds R¹CCCO₂R² afforded the corresponding adducts II. Adducts II were also prepared directly from phthalaldehyde, α-bromo carbonyls and acetylenic compounds without isolation of the intermediate pyrido[2,1-a]isoquinolines. Also, the antioxidant activities of four compounds I were evaluated by DPPH radical scavenging and ferric reducing power anal. (FRAP). The compound I (R = EtO₂C; R¹ = MeO₂C; R² = Me) exhibited excellent DPPH radical scavenging activity and FRAP compared to synthetic antioxidants BHT and TBHQ. The chief benefits of the method are high atom economy, green reaction conditions, higher yield, shorter reaction times, and easy work-up, which agree with some principles of green chem.

Formula: C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Sheikholeslami-Farahani, Fatemeh;Sadeghi Marasht, Abdollah;Mirabi, Ali;Ghazvini, Maryam;Hosseinnasab Rostam, Mohammad research published 《 Ionic Liquid as Green and Recyclable Solvent for the Synthesis of Pyrazinoquinazolines: Study of Antioxidant Activity》, the research content is summarized as follows. The preparation of pyrazinoquinazoline derivatives was performed in high yields by four component reactions of isoquinolin-3-ylmethanamine, α-haloketones, activated acetylenic compounds and Et bromoacetate in ionic liquid as green media at room temperature In addition, due to having quinazoline core in the synthesized compounds, evaluation of antioxidant activity was performed by radical trapping by DPPH and reducing power of ferric ion experiments As a result, synthesized compounds showed low radical trapping by DPPH and good reducing ability of ferric ion. The current procedure has the benefits for instance excellent yield of reaction, green media and easy separation of product.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Recommanded Product: Ethyl 3-bromo-2-oxopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Name: Ethyl 3-bromo-2-oxopropanoate.

Shi, Chen;Wang, Qian;Liao, Xuemei;Ge, Hui;Huo, Guoyong;Zhang, Leduo;Chen, Na;Zhai, Xiong;Hong, Yuan;Wang, Li;Wang, Zhe;Shi, Weijun;Mao, Yu;Yu, Jianxin;Ke, Ying;Xia, Guangxin research published 《 Discovery of a novel series of imidazo[1′,2′:1,6]pyrido[2,3-d]pyrimidin derivatives as potent cyclin-dependent kinase 4/6 inhibitors》, the research content is summarized as follows. CDK4/6 has been identified as an attractive therapeutic target for treatment of cancer. For unmet clin. needs, a novel class of imidazo [1′,2′:1,6]pyrido [2,3-d]pyrimidin derivatives, which had distinctive triheteroaryl structure, had been discovered as CDK4/6 inhibitors. The compounds 10b (I) and 10c (II), displayed the low nanomolar range activities on CDK4/6, desirable antiproliferative activities, excellent metabolic properties, and acceptable pharmacokinetic characters. In Colo-205 and U87MG xenograft models, compounds 10b and 10c also showed significant tumor growth inhibitions with controllable toxicities. All data confirmed that imidazo [1′,2′:1,6]pyrido [2,3-d]pyrimidin derivatives 10b and 10c could be promising drug candidates for cancer therapy.

Name: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary