Category: 70-23-5

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Name: Ethyl 3-bromo-2-oxopropanoate.

Alvarez, Natalia;Velluti, Francesca;Guidali, Florencia;Serra, Gloria;Gabriela Kramer, M.;Ellena, Javier;Facchin, Gianella;Scarone, Laura;Torre, Maria H. research published 《 New BI and TRI-Thiazole copper (II) complexes in the search of new cytotoxic drugs against breast cancer cells》, the research content is summarized as follows. New thiazolyl derivatives (BT and TT) and their copper (II) complexes [Cu₂Cl₂(BT)₂] (Cu-BT) and [Cu₄ClO₂(TT)₂]PF₆·3.5H₂O (Cu-TT) were synthesized and characterized by elemental anal., ¹H NMR and ¹³C NMR, HRMS, X-ray diffraction, IR and UV-Vis spectroscopies. The crystal structure of Cu-BT shows the formation of a dinuclear complex where each copper(II) center is bonded to two thiazol N atoms, from different BT ligands, one deprotonated amide N atom, an O atom from the ester terminal groups and a chlorine atom. The structure found for Cu-TT is a pos. charged tetranuclear moiety containing two deprotonated TT ligands, a chlorine anion, two hydroxide anions acting as bridges between the copper centers and a water mol. The cytotoxic activity of both copper complexes was evaluated on metastatic breast cancer cell lines, characterized for its rapidly dividing behavior. Both, Cu-BT and Cu-TT, show higher cytotoxic activity against these tumor cells than free BT and TT and also than cisplatin. In addition, we found that both complexes interact with DNA. Consistently, they also show cytotoxicity against a rapidly dividing non-tumor cell line, although with higher IC_50, being such interaction and selectivity an indicator of the possible coexistence of more than one mechanism of action.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Name: Ethyl 3-bromo-2-oxopropanoate

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Product Details of C5H7BrO3.

Alzain, Abdulrahim A.;Brisson, Lucie;Delaye, Pierre-Olivier;Penichon, Melanie;Chadet, Stephanie;Besson, Pierre;Chevalier, Stephan;Allouchi, Hassan;Mohamed, Magdi A.;Roger, Sebastien;Enguehard-Gueiffier, Cecile research published 《 Bioinspired imidazo[1,2-a:4,5-c’]dipyridines with dual antiproliferative and anti-migrative properties in human cancer cells: The SAR investigation》, the research content is summarized as follows. Design, synthesis and evaluation of novel bioinspired imidazo[1,2-a:4,5c’]dipyridines I [X = Br or I; R¹ = Me, Et, Ph, etc.; R² = c-Pr, t-Bu, Ph, etc.; R³ = H, Me, Br, etc.; R⁴ = H, Et, Bn]. The structural optimization identified four anti-proliferative compounds Compounds I [X = Br or I; R¹ = Me, MeO, R² = Ph, t-Bu, c-Pr, R³ = H, R⁴ = Bn] exhibited excellent anticancer activities in vitro with IC₅₀ of 0.4-5μM against three human cancer cell lines (MDA-MB-468, MDA-MB-435s and MDA-MB-231). These I [X = Br or I; R¹ = Me, MeO, R² = Ph, t-Bu, c-Pr, R³ = H, R⁴ = Bn] induced apoptosis in MDA-MB-231 cells in a dose-dependent manner, targeting different apoptotic proteins expression: I [R¹ = Me, R² = Ph, R³ = H, R⁴ = Bn] increased the expression of pro-apoptotic Bax protein while 18-20 reduced the level of anti-apoptotic Bcl-2 protein. Compounds I [X = Br; R¹ = MeO, R² = t-Bu, c-Pr, R³ = H, R⁴ = Bn] also reduced MDA-MB-231 cells proliferation as measured by Ki-67 staining. Furthermore, compounds were also tested for the ability to inhibit cell migration in the highly aggressive human MDA-MB-435s cell line. Six compounds of this series I [X = Br; R¹ = Me, Ph, MeO, HO, Et, R² = t-Bu, Ph, c-Pr, R³ = H, Br, R⁴ = Bn] inhibited cell migration by 41-50% while four compounds I [X = Br; R¹ = MeO, Ph, R² = Ph, t-Bu, R³ = H, Br, Ph, 1-benzyl pyridinium-4-yl, R⁴ = Bn, H] inhibited the migration by 53-62% in wound-healing experiments Interestingly, compound I [X = Br, R¹ = OMe, R² = Ph, R³ = H, R⁴ = Bn]. presented both antiproliferative and anti-migration activities and were promising anti-metastatic agent for cancer treatment.

Product Details of C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate, COA of Formula: C5H7BrO3

Ghazvini, Maryam;Sheikholeslami-Farahani, Fatemeh;Hamedani, Naghmeh Faal;Shahvelayati, Ashraf Sadat;Rostami, Zohreh research published 《 Bio-Fe₃O₄ Magnetic Nanoparticles Promoted Green Synthesis of thioxo-1,3-Oxazole Derivatives: Study of Antimicrobial and Antioxidant Activity》, the research content is summarized as follows. In this work, 1,3-oxazoles I (R = COOEt, 4-methoxyphenyl, 4-methylphenyl, 4-bromophenyl; R¹ = t-Bu, 4-methoxyphenyl, 4-nitrophenyl; R² = COOEt, 4-methoxyphenyl, 4-methylphenyl, 4-bromophenyl) were generated using the multicomponent reaction of α-bromo ketones R/R²C(O)CH₂Br, alkyl (aryl) isothiocyanates R¹N=C=S, sodium hydride and Fe₃O₄ MNPs in the water at room temperature in good yields. The nanoparticles generated via the biosynthesis method have potential value in different purposes, such as organic synthesis. To study the antioxidant ability of some synthesized thioxo-1,3-oxazoles I, diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction testes are employed. Among the studied thioxo-1,3-oxazoles, compound I (R = R² = COOEt; R¹ = 4-nitrophenyl) have good power for radical trapping and reduction activity than the standard antioxidants such as BHT and TBHQ. In addition, the antimicrobial activity of some thioxo-1,3-oxazoles I was studied, employing the disk diffusion test on Gram-pos. bacteria and Gram-neg. bacteria. The results of the disk diffusion test showed that compounds I (R = R² = COOEt, R¹ = 4-nitrophenyl; R = R² = COOEt, R¹ = 4-methoxyphenyl; R = R² = 4-methoxyphenyl, R¹ = t-Bu; R = R² = 4-bromophenyl R¹ = 4-nitrophenyl) prevented bacterial growth. Without employing catalyst, these reactions have low yield and busy mixture The synthesis of compound I (R = R² = COOEt; R¹ = 4-methoxyphenyl) as sample reaction has a similar yield in the presence of ZnO-NPs and Fe₃O₄ MNPs (entry 20 and entry 30), but the removal of catalyst from the mixture of reaction after the completion of the reaction is comfortable in the presence of Fe₃O₄ MNPs. Some of the advantages of performing these reactions with the present procedure are to carry out these reactions in water as a green solvent and simple removal of catalyst.

COA of Formula: C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary