Category: 70-23-5

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., SDS of cas: 70-23-5.

Erigur, Esra Caner;Altug, Cevher;Angeli, Andrea;Supuran, Claudiu T. research published ã€?Design, synthesis and human carbonic anhydrase I, II, IX and XII inhibitory properties of 1,3-thiazole sulfonamidesã€? the research content is summarized as follows. A series of novel 1,3-thiazole sulfonamides I [R = i-Pr, n-Bu, HOCH₂CH₂, Ph(CH₂)₄, etc.] has been designed, synthesized and studied their carbonic anhydrase (CA) inhibitory properties. The inhibition property of four human CA isoforms was investigated: hCA I, II, IX, and XII using the standard drug acetazolamide (AAZ) for comparison. The compounds I showed a wide range of inhibition potency towards the cytosolic enzyme hCA I. Nevertheless, the compounds I (R = n-Pr, i-Pr, HOCH₂CHMe, HOCHMeCH₂, MeOCH₂CH₂) have shown higher inhibition potential as compared to acetazolamide (KI = 250 nM). The abundant human cytosolic isoform, hCA II, was strongly inhibited by the most compounds in low nanomolar range (KI < 12.1 nM). On the other hand, almost all novel synthesized compounds have shown weaker inhibition potential as compared to acetazolamide against the tumor membrane- associated isoform hCA IX. Finally, the second tumor membrane-associated isoform, hCA XII, showed a wide range of potency that spanned from 9.3 to 729.6 nM.

SDS of cas: 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. HPLC of Formula: 70-23-5.

Ertas, Merve;Biltekin, Sevde Nur;Berk, Barkin;Yurttas, Leyla;Demirayak, Seref research published ã€?Synthesis of some 5,6-diaryl-1,2,4-triazine derivatives and investigation of their cyclooxygenase (COX) inhibitory activityã€? the research content is summarized as follows. Within this study, [(diaryltriazinyl)thio]-N-(benzo/thiazolyl)acetamide derivatives (I [R = H,Me, Cl, etc.; R¹ = H, Me, COOEt; R² = H, Me; R¹R² = (CH₂)₃]) were synthesized and COX inhibitory activities of the compounds were investigated. Compounds I [R = MeO; R¹ = H, Me, COOEt;R² = H; R¹ = R² = Me; R¹R² = (CH₂)₄] , which have a 4-methoxyphenyl group within their structures, showed strong inhibitory activity on COX-2 enzyme, even compound I [R = MeO; R¹ = R² = H] namely 2-{[5,6-bis(4-methoxyphenyl)-1,2,4-triazin-3-yl]thio}-N-(thiazol-2-yl)acetamide exhibited higher selectivity on this enzyme (IC₅₀:3.06 μM). Mol. docking studies were performed for compound I [R = MeO; R¹ = R² = H] on COX-1 and COX-2 enzymes and the results were found to support the mol.′s COX-2 selectivity.

HPLC of Formula: 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. Product Details of C5H7BrO3

Ezzatzadeh, Elham;Hargalani, Fariba Zamani;Shafaei, Faezeh research published ã€?Bio-Fe₃O₄-MNPs Promoted Green Synthesis of Pyrido[2,1-a]isoquinolines and Pyrido[1,2-a]quinolines: Study of Antioxidant and Antimicrobial Activityã€? the research content is summarized as follows. In this work, synthesis of pyrido[2,1-a]isoquinolines and pyrido[1,2-a]quinolines in excellent yield using multicomponent reaction of isoquinoline, Me malonyl chloride, alkyl bromides, and triphenylphosphine in the presence of catalytic amount of Fe₃O₄-MNPs in water at 80° were investigated. The reduction of ferric chloride solution with Clover Leaf water extract resulted in the synthesis of magnetic iron oxide nanoparticles (Fe₃O₄-NPs) as a green method. The antioxidant activity was studied for some newly synthesized compounds using the DPPH radical trapping and ferric ion reduction experiments and results were compared with synthetic antioxidants (TBHQ and BHT). These compounds showed trace DPPH radical trapping and excellent reducing strength of ferric ion. The antimicrobial activity of some synthesized compounds was studied employing the disk diffusion test on Gram-pos. bacteria and Gram-neg. bacteria. The results of disk diffusion test showed that these compounds prevented the bacterial growth.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Product Details of C5H7BrO3

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 70-23-5, formula is C5H7BrO3, The most pervasive is the naturally produced bromomethane. Quality Control of 70-23-5

Fan, Tingting;Guo, Weikai;Shao, Ting;Zhou, Wenbo;Hu, Pan;Liu, Mingyao;Chen, Yihua;Yi, Zhengfang research published ã€?Design, synthesis and evaluation of phenylthiazole and phenylthiophene pyrimidindiamine derivatives targeting the bacterial membraneã€? the research content is summarized as follows. A series of phenylthiazole and phenylthiophene pyrimidindiamine derivatives l [R¹ = ethylamino, propylamino, butylamino, pyrrolidino; R² = H, OMe, F, Cl, Br, etc.] were designed and synthesized by modifying the hit compound (N²-isobutyl-N4-((4-methyl-2-phenylthiazol-5-yl)methyl) pyrimidine-2,4-diamine) and their antibacterial activities were evaluated both in-vitro and in-vivo was reported. Among the tested compounds, compound I [R¹ = isobutylamino; R² = 3-bromo] displayed the best antibacterial activities, which was not only capable of inhibiting E. coli and S. aureus growth at concentrations as low as 2 and 3μg/mL in-vitro, but also efficacious in a mice model of bacteremia in vivo. Unlike conventional antibiotics, compound I [R¹ = isobutylamino; R² = 3-bromo] was elucidated to mainly destroy the bacterial cell membrane, with the dissipation of membrane potential and leakage of contents, ultimately leading to cell death. The destruction of cell structure was challenging to induce bacterial resistance, which suggested that compound I [R¹ = isobutylamino; R² = 3-bromo] was a promising alternatives to antibiotics against bacteria.

Quality Control of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Recommanded Product: Ethyl 3-bromo-2-oxopropanoate.

Fang, Lincheng;Hu, Zhaoxue;Yang, Yifei;Chen, Pan;Zhou, Jinpei;Zhang, Huibin research published ã€?Discovery of 3,5-dimethylisoxazole derivatives as novel, potent inhibitors for bromodomain and extraterminal domain (BET) familyã€? the research content is summarized as follows. Bromodomain and extra-terminal (BET) is a promising therapeutic target for various hematol. cancers. We used the BRD4 inhibitor compound 13 (I) as a lead compound to develop a variety of compounds, and we introduced diverse groups into the position of the compound 13 orienting toward the ZA channel. A series of compounds bearing triazolopyridazine motif exhibited remarkable BRD4 protein inhibitory activities. Among them, compound 39 (II) inhibited BRD4(BD1) protein with an IC₅₀ of 0.003μM which was superior to lead compound 13. Meanwhile, compound 39 possess activity, IC₅₀ = 2.1μM, in antiproliferation activity against U266 cancer cells. On the other hand, compound 39 could arrest tumor cells into the G0/G1 phase and induce apoptosis, which was consistent with its results in inhibiting cell proliferation. Biol. and biochem. data suggest that BRD4 protein might be a therapeutic target and that compound 39 is an excellent lead compound for further development.

Recommanded Product: Ethyl 3-bromo-2-oxopropanoate, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Category: bromides-buliding-blocks.

Hu, Lijun;Ren, Qiang;Deng, Liming;Zhou, Zongtao;Cai, Zongyu;Wang, Bin;Li, Zheng research published 《 Design, synthesis, and biological studies of novel 3-benzamidobenzoic acid derivatives as farnesoid X receptor partial agonist》, the research content is summarized as follows. Farnesoid X receptor (FXR), a bile acid-activated nuclear receptor, regulates the metabolism of bile acid and lipids as well as maintains the stability of internal environment. FXR was considered as a therapeutic target of liver disorders, such as drug-induced liver injury, fatty liver and cholestasis. The previous reported FXR partial agonist I was a suitable lead compound in terms of its high potent and low mol. size, while the docking study of compound I suggested a large unoccupied hydrophobic pocket, which might be provided more possibility of structure-activity relationship (SAR) study. In this study, we have performed comprehensive SAR and mol. modeling studies based on lead compound I. All of these efforts resulted in the identification of a novel series of FXR partial agonists. In this series, compound II revealed the best activity and strong interaction with binding pocket of FXR. Moreover, compound II protected mice against acetaminophen-induced hepatotoxicity by the regulation of FXR-related gene expression and improving antioxidant capacity. In summary, these results suggest that compound II is a promising FXR partial agonist suitable for further investigation.

Category: bromides-buliding-blocks, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Electric Literature of 70-23-5.

Hezarcheshmeh, Nasrin Karami;Azizian, Javad research published 《 Solvent-free synthesis of new spiropyrroloindole compounds using Fe₃O₄/TiO₂/MWCNTs MNCs via multicomponent reactions: assessment of new spiropyrroloindole antioxidant activity》, the research content is summarized as follows. In this study, water extract of Spinacia oleracea leaves was used for the synthesis of Fe₃O₄/TiO₂/MWCNTs magnetic nanocomposites and high performance of this catalyst was confirmed by employing it in the solvent-free multicomponent reactions of anilines RC₆H₄NH₂ (R = Me, OMe, NO₂), oxalyl chloride, ethane-1,2-diamine or hydroxyethylamine, electron-deficient acetylenic esters R¹OC(O)CCC(O)OR¹ (R¹ = Me, Et), α-haloketones R²C(O)CH₂Br (R² = ethoxycarbonyl, 4-methylphenyl, 4-methoxyphenyl, 4-bromophenyl) and Et₃N at room temperature for the generation of new spiropyrroloindoles I (R³ = O, NH) in high yields. This catalyst could be utilized several times and has a significant role in the yield of products I. The synthesized spiropyrroloindoles I have NH and OH group in their structure and for this reason, they have good antioxidant activity. Also, by employing Gram-pos. and Gram-neg. bacteria, the disk diffusion procedure confirmed the antimicrobial effect of some spiropyrroloindole derivatives I. The results showed that synthesized spiropyrroloindoles I prevented the bacterial growth. This used process for preparation of new spiropyrroloindoles I has some improvements such as low reaction time, product with high yields, and simple separation of catalyst and products.

Electric Literature of 70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organic compounds having carbon bonded to bromine are called organic bromides. Quality Control of 70-23-5.

Hossaini, Zinatossadat;Tabarsaei, Navisa;Khandan, Samira;Valipour, Peyman;Ghorchibeigi, Mona research published 《 ZnO/Ag/Fe₃O₄ nanoparticles supported on carbon nanotubes employing Petasites hybridus rhizome water extract: A novel organometallic nanocatalyst for the synthesis of new naphthyridines》, the research content is summarized as follows. In this study, ZnO/Ag/Fe₃O₄/CNTs nanoparticles (NPs) immobilized on carbon nanotubes (ZnO/Ag/Fe₃O₄/CNTs) were synthesized using Petasites hybridus rhizome water extract as a renewable, mild, and safe reducing agent and effective stabilizer without adding any surfactants. The ZnO/Ag/Fe3O4/CNTs magnetic NPs as a high performance catalyst was employed for the preparation of naphthyridine derivatives I [R = H, C(O)₂Me, C(O)₂Et; R¹ = Me, Et; R² = C(O)₂C₂H₅, 4-CH₃OC₆H₄, 4-CH₃C₆H₄, 4-BrC₆H₄, 4-O₂NC₆H₄] in high yields via the multicomponent reactions of phthalaldehyde, 2-aminoacetonitrile, activated acetylenic compounds RCCC(O)₂R¹, α-haloketones R²C(O)CH₂Br, triphenyphophine, and ammonium acetate in aqueous media at ambient temperature Due to having isoquinoline core, antioxidant property of some synthesized compounds I was investigated by diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment Furthermore, the disk diffusion test on Gram-pos. and Gram-neg. bacteria is utilized for investigation of antimicrobial activity of some naphthyridines I. The achieved outcomes of this experiment demonstrate that these synthesized compounds I could prevent from growth of bacteria. Short time of reaction, high yields of product, easy separation of catalyst, and products are some benefits of this process.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., Quality Control of 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic compounds having carbon bonded to bromine are called organic bromides. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. HPLC of Formula: 70-23-5.

Hamedani, Naghmeh Faal;Azad, Leila;Shafiee, Shahin;Noushin, Annataj research published 《 Green Synthesis of Thiazole Derivatives using Multi-component Reaction of Aldehydes, Isothiocyanate and Alkyl Bromides: Investigation of Antioxidant and Antimicrobial Activity》, the research content is summarized as follows. The multicomponent reaction of aldehydes, benzoylisothiocyanate and alkyl bromides in the presence of ammonium acetate, sodium cyanide and a catalytic amount of KF/Clinoptilolite nanoparticles (KF/CP NPs) in the water at 100°C was investigated. In these reactions, thiazole I [R= H, Me, i-Pr; R¹ = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] were produced in good to excellent yields and short time. Also, the antioxidant activity was studied for some newly synthesized compounds using the DPPH radical trapping and reducing of ferric ion experiments and compared the results with synthetic antioxidants (TBHQ and BHT). As a result, the compounds I [R= i-Pr; R¹ = ethoxycarbonyl] showed excellent DPPH radical trapping and reducing the strength of ferric ion. These compounds I [R= H, Me, i-Pr; R¹ = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] have biol. potential because of the thiazole core. For this reason, the antimicrobial activity of some synthesized compounds I [R= H, Me, i-Pr; R¹ = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] was studied by employing the disk diffusion test on Gram-pos. bacteria and Gram-neg. bacteria. The results of the disk diffusion test showed that these compounds I [R= H, Me, i-Pr; R¹ = ethoxycarbonyl, 4-methoxyphenyl, 4-bromophenyl] prevented bacterial growth.

70-23-5, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., HPLC of Formula: 70-23-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 70-23-5, formula is C5H7BrO3, Name is Ethyl 3-bromo-2-oxopropanoate. Organobromine compounds have fallen under increased scrutiny for their environmental impact., COA of Formula: C5H7BrO3.

Hamedani, Naghmeh Faal;Ghazvini, Maryam;Sheikholeslami-Farahani, Fatemeh;Bagherian-Jamnani, Mohammad Taghi research published 《 ZnO nanorods as efficient catalyst for the green synthesis of thiophene derivatives: Investigation of antioxidant and antimicrobial activity》, the research content is summarized as follows. In this work, thiophene derivatives I [R = 4-H₃CC₆H₄, 4-H₃COC₆H₄, 4-O₂NC₆H₄, CH₃CH₂OC(O); R¹ = Me, Et; R² = 4-H₃CC₆H₄, 4-H₃COC₆H₄] were synthesized in good yields via multicomponent reaction of isoquinoline, alkyl bromides BrCH₂C(O)R, activated acetylenic compounds R¹OC(O)CCC(O)OR¹, isothiocyanates R²N=C=S, and catalytic amounts of ZnO nanorods (NRs) at room temperature under solvent-free conditions. This procedure for the synthesis of thiophene derivatives I is green, easy, and simple with excellent yield. In addition, DPPH radical scavenging and ferric reduction power experiment has been studied for the evaluation of the antioxidant activity of some prepared thiophenes, for example, I [R = CH₃CH₂OC(O), R¹ = Me, R² = 4-H₃COC₆H₄ (A); R = 4-O₂NC₆H₄, R¹ = Me, R² = 4-H₃CC₆H₄ (B); R = CH₃CH₂OC(O), R¹ = Me, R² = 4-H₃CC₆H₄ (C); R = CH₃CH₂OC(O), R¹ = Et, R² = 4-H₃COC₆H₄ (D)]. As outcome, the compound (B) exhibited a noteworthy radical trapping activity and excellent reducing ability than synthetic antioxidants such as butylated hydroxytoluene (BHT) and 2-tertbutylhydroquinone (TBHQ). Moreover, the antimicrobial activity of some synthesized thiophenes was confirmed by employing the disk diffusion test on Gram-pos. and Gram-neg. bacteria. The obtained results of disk diffusion test showed that compounds (A), (B), (C), and (D) prevented bacterial growth.

COA of Formula: C5H7BrO3, Ethyl bromopyruvate molecular formula is C5H7BrO3 and its molecular weight is 195.01 g/mol. The purity is usually 95%.

Ethyl bromopyruvate is used in a synthesis of thioxothiazolidines from carbon disulfide and primary amines.

Ethyl bromopyruvate is a chemical inhibitor that inhibits the enzyme pyruvate dehydrogenase, which is responsible for the conversion of pyruvic acid to acetyl-CoA. This inhibition leads to a decrease in ATP levels and can cause metabolic disorders. Ethyl bromopyruvate is used as an anthelmintic drug and in asymmetric synthesis. It is also used in the synthesis of thiostrepton, an antibiotic that has been shown to have antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Streptococcus pneumoniae., 70-23-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary