Category: 69902-83-6

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69902-83-6, name is 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., name: 1-Bromo-2-methyl-3-(trifluoromethyl)benzene

Bromo-3- (trifluoromethyl) -2-methylbenzene (5.0 g, 20.9 mmol),Bromosuccinimide (3.72 g, 20.9 mmol),Azobisisobutyronitrile (300 mg) was dissolved in dry carbon tetrachloride (100 mL)Heat under reflux for 16 hours under nitrogen.The reaction was cooled to room temperature and filtered,The filtrate was added imidazole (2.85 g, 42 mmol) and potassium carbonate (4.34 g, 31.37 mmol)Heat under reflux for 5 hours under nitrogen.LC-MS showed the reaction was complete,The reaction solution was filtered,The filtrate was concentrated,The residue was dissolved in dichloromethane (50 mL)Wash with water (2 × 40 mL).Organic phase filtration,concentrate,The residue was purified by flash silica gel column to give 1- (2-bromo-6- (trifluoromethyl) benzyl) -1H-imidazole (5.0 g).

According to the analysis of related databases, 69902-83-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Tong Chaolong; Bao Rudi; Li Yuannian; (67 pag.)CN107312005; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 69902-83-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 69902-83-6 name is 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

i). Preparation of 1-bromo-2-(bromomethyl)-3-(trifluoromethyl)benzene (i-4) To a solution of 1-bromo-2-methyl-3-(trifluoromethyl)benzene (i-4a) (2 g, 8.36 mmol) in CCl4 (20 mL) was added NBS (1.49 g, 8.36 mmol), dibenzoyl peroxide (20 mg, 0.08 mmol). The mixture was stirred under nitrogen at 100 C. for 16 h. The solvent was removed in vacuo, and the residue was partitioned between water (15 mL) and DCM (15 mL). The water layer was extracted with DCM (15 mL*3). The combined organic layers were dried over anhydrous Na2SO4 and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (PE/EtOAc=50/1) to afford the title compound (1.16 g, purity 80%, yield: 43%). LCMS (ESI) calc’d for C8H5Br2F3 [M+H]+: 317. found: 317.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, and friends who are interested can also refer to it.

Reference:
Patent; Barr, Kenneth J.; Bienstock, Corey E.; MacLean, John K.; Zhang, Hongjun; Beresis, Richard T.; Anthony, Neville J.; Lapointe, Blair T.; Sciammetta, Nunzio; US2015/210687; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 69902-83-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69902-83-6, name is 1-Bromo-2-methyl-3-(trifluoromethyl)benzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of l-bromo-2-methyl-3-(trifluoromethyl)benzene (i-4a) (2 g, 8.36 mmol) in CCI4 (20 mL) was added NBS (1.49 g, 8.36 mmol), dibenzoyl peroxide (20 mg, 0.08 mmol). The mixture was stirred under nitrogen at 100 C for 16 h. The solvent was removed in vacuo, and the residue was partitioned between water (15 mL) and DCM (15 mL). The water layer was extracted with DCM (15 mL x 3). The combined organic layers were dried over anhydrous Na2S04 and evaporated under reduced pressure. The residue was purified by column chromatography on silica gel (PE/EtOAc = 50/1) to afford the title compound (1.16 g, purity 80%, yield: 43%). LCMS (ESI) calc’d for C8H5Br2F3 [M+H]+: 317, found: 317.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BARR, Kenneth Jay; BEINSTOCK, Corey; MACLEAN, John; ZHANG, Hongjun; BERESIS, Richard Thomas; WO2014/28591; (2014); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69902-83-6, name is 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H6BrF3

Bromo-3- (trifluoromethyl) -2-methylbenzene (5.0 g, 20.9 mmol),Bromosuccinimide (3.72 g, 20.9 mmol),Azobisisobutyronitrile (300 mg) was dissolved in dry carbon tetrachloride (100 mL)Heat under reflux for 16 hours under nitrogen.The reaction was cooled to room temperature and filtered,The filtrate was added imidazole (2.85 g, 42 mmol) and potassium carbonate (4.34 g, 31.37 mmol)Heat under reflux for 5 hours under nitrogen.LC-MS showed the reaction was complete,The reaction solution was filtered,The filtrate was concentrated,The residue was dissolved in dichloromethane (50 mL)Wash with water (2 × 40 mL).Organic phase filtration,concentrate,The residue was purified by flash silica gel column to give 1- (2-bromo-6- (trifluoromethyl) benzyl) -1H-imidazole (5.0 g).

According to the analysis of related databases, 69902-83-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Tong Chaolong; Bao Rudi; Li Yuannian; (67 pag.)CN107312005; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69902-83-6, name is 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Formula: C8H6BrF3

Step 1 : A mixture of 1-bromo-2-methyl-3-(trifluoromethyl)benzene (100 mu, 0.64 mmol), 4,4,5,5-tetramethyl-2-(tetramethyl-1 ,3,2-dioxaborolan-2-yl)-1 ,3,2- dioxaborolane (327 mg, 1.29 mmol), PdCI2dppf DCM (26 mg, 0.030 mmol) and potassium acetate (158 mg, 1.61 mmol) in 1 ,4-dioxane (5 mL) was heated in a sealed tube at 80C overnight. The mixture was run through a plug of silica (EtOAc), concentrated and purified by preparative HPLC to give 4,4,5,5- tetramethyl-2-[2-methyl-3-(trifluoromethyl)phenyl]-1 ,3,2-dioxaborolane.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; HOMAN, Evert; HELLEDAY, Thomas; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; FISKESUND, Roland Julius Yu; (359 pag.)WO2015/187089; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 69902-83-6, A common heterocyclic compound, 69902-83-6, name is 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, molecular formula is C8H6BrF3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1[00293] To a solution of l-bromo-2-methyl-3-(trifluoromethyl)benzene (CXXVII) (5.7 g, 23.86 mmol) in CC14 (50 niL) was added NBS (4.24 g, 23.86 mmol) and a catalytic amount of benzoyl peroxide. The reaction mixture was gently refluxed for 1 h. The reaction mixture was cooled to room temperature and the precipitate was removed by filtration. The solution was concentrated under reduced pressure and the crude product was dissolved in hexane and additional precipitate was removed by filtration. The filtrate was concentrated to dryness to give l-bromo-2-(bromomethyl)-3-(trifluoromethyl)benzene (CXXVIII) as an orange oil (7.51 g, 23.62 mmol). 1H NMR (DMSO-d6) delta ppm 4.73 (s, 2H), 7.4 (dd, J=8 Hz, J=8 Hz, 1H), 7.80 (d, J=8 Hz, 1H), 8.02 (d, J=8 Hz, 1H); 19 F NMR (DMSO-d6) delta ppm -57.85 (s, 3F). The crude product was used without further purification for step 2.

The synthetic route of 69902-83-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; REMPEX PHARMACEUTICALS, INC.; GLINKA, Tomasz; HIGUCHI, Robert; HECKER, Scott; EASTMAN, Brian; RODNY, Olga; WO2012/109164; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69902-83-6, name is 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, A new synthetic method of this compound is introduced below., Computed Properties of C8H6BrF3

Step 1: A mixture of 1-bromo-2-methyl-3-(trifluoromethyl)benzene (100 pL, 0.64 mmol), 4,4,5, 5-tetramethyl-2-(tetramethyl-1 ,3,2-dioxaborolan-2-yl)- 1,3,2- dioxaborolane (327 mg, 1.29 mmol), PdCl2dppfDCM (26 mg, 0.030 mmol) andpotassium acetate (158 mg, 1.61 mmol) in 1,4-dioxane (5 mL) was heated in a sealed tube at 8000 overnight. The mixture was run through a plug of silica (EtOAc), concentrated and purified by preparative HPLC to give 4,4,5,5- tetramethyl-2-[2-methyl-3-(trifluoromethyl)phenyl]-1 ,3,2-dioxaborolane.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; JACQUES, Sylvain; HOMAN, Evert; HELLEDAY, Thomas; WO2015/187088; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary