Category: 699-03-6

These common heterocyclic compound, 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: bromides-buliding-blocks

General procedure: Amine (0.25 mmol), and bromide (0.25 mmol) were taken up in acetonitrile (0.3 mL) in a conical vial equipped with a stirrer bar. Potassium carbonate (0.5 mmol) was added followed by potassium iodide (10 mol%) if required. The vial was sealed with a screwcap and the reaction was stirred at 40 C until thin layer chromatography (TLC) indicated complete consumption of the starting materials. A precipitate was formed during the reaction which was removed by filtration and the filtrate concentrated under reduced pressure. The residue was purified by flash column chromatography and sent to the Netherlands Cancer Institute (NKI) for biological testing.

The synthetic route of 1-(4-Bromophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Milne, Kirsty; Sun, Jianhui; Zaal, Esther A.; Mowat, Jenna; Celie, Patrick H.N.; Fish, Alexander; Berkers, Celia R.; Forlani, Giuseppe; Loayza-Puch, Fabricio; Jamieson, Craig; Agami, Reuven; Bioorganic and Medicinal Chemistry Letters; vol. 29; 18; (2019); p. 2626 – 2631;,
Bromide – Wikipedia,
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The chemical industry reduces the impact on the environment during synthesis 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine, I believe this compound will play a more active role in future production and life. 699-03-6

The prepared Formula-G was then dissolved in dichloromethane (1.8 L). Triethylamine (1.6 moles, 223.2 mL) was added at 5 C. A solution of methyl chloroformate (1.3 moles, 100.4 mL in dichloromethane (0.2 L) was slowly added, maintaining the temperature of the mixture between about 10 C and 14 C. The reaction solution was stirred at room temperature for 12 hours. Water was added to the reaction mass and the organic phase was separated and concentrated to afford a compound of Formula-E (wherein L=Br, P=methyl carbamate).

The chemical industry reduces the impact on the environment during synthesis 699-03-6. I believe this compound will play a more active role in future production and life.

Reference:
Patent; MYLAN LABORATORIES LTD; JAYACHANDRA, Sureshbabu; SETHI, Madhuresh; KAUSHIK, Vipin Kumar; RAVI, Vijaya, Krishna; TELAGAMSETTY, Bhaskar Kumar; (44 pag.)WO2019/130229; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 699-03-6, These common heterocyclic compound, 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Amine (0.25 mmol), and bromide (0.25 mmol) were taken up in acetonitrile (0.3 mL) in a conical vial equipped with a stirrer bar. Potassium carbonate (0.5 mmol) was added followed by potassium iodide (10 mol%) if required. The vial was sealed with a screwcap and the reaction was stirred at 40 C until thin layer chromatography (TLC) indicated complete consumption of the starting materials. A precipitate was formed during the reaction which was removed by filtration and the filtrate concentrated under reduced pressure. The residue was purified by flash column chromatography and sent to the Netherlands Cancer Institute (NKI) for biological testing.

Statistics shows that 1-(4-Bromophenyl)-N-methylmethanamine is playing an increasingly important role. we look forward to future research findings about 699-03-6.

Reference:
Article; Milne, Kirsty; Sun, Jianhui; Zaal, Esther A.; Mowat, Jenna; Celie, Patrick H.N.; Fish, Alexander; Berkers, Celia R.; Forlani, Giuseppe; Loayza-Puch, Fabricio; Jamieson, Craig; Agami, Reuven; Bioorganic and Medicinal Chemistry Letters; vol. 29; 18; (2019); p. 2626 – 2631;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 699-03-6,Some common heterocyclic compound, 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine, molecular formula is C8H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of l-(4-bromophenyl)-N-methylmethanamine (2 g, 10 mmol, 1.0 eq), TEA (3 g, 30 mmol, 3 eq) was cooled to 0 C. Then acetyl chloride (942 mg, 12 mmol, 1.2 eq) in DCM (20 mL) was added. The mixture was stirred at rt for 1 h. The mixture was washed with brine,dried over Na2SO i, filtered and concentrated. The residue was purified on silica gel column (PE/EtOAc = 5/1) to give N-(4-bromobenzyl)-N-methylacetamide as a yellow oil (1.6 g, 67%).

The synthetic route of 699-03-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; WO2015/103317; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 1-(4-Bromophenyl)-N-methylmethanamine

Compound 2 (1.486 g, 5.04 mmol), 4-bromo-N-methylbenzylamine (1.00 mL, 5.00 mmol) and triethylamine (1.40 mL, 10.0 mmol) were dissolved in anhydrous dimethylformamide (10 mL) and placed in a pressure bottle, under an N2 atmosphere. The reaction was heated to 130 C. for 3 days. The reaction was cooled to room temperature and diluted into deionized water (250 mL), yielding a fluffy white precipitate with a few brown clumps. After cooling briefly and sonicating and crushing the clumps, the precipitate was collected by vacuum filtration, washing with deionized water, and dried under vacuum. The crude product was dissolved in ethyl acetate and adhered to silica gel (20 g). The silica adhered compound was purified by flash silica gel chromatography (200 g silica, 3:2 hexanes:ethyl acetate) to yield 1.67 g (81%) of 14 as a white solid. ESI-MS m/z 414.1/416.1 [M+H]+. Analysis: Calcd for C20H17BrFN3O: C, 57.98; H, 4.14; N, 10.14. Found: C, 57.82; H, 4.20; N, 10.01. 1H NMR (500 MHz, DMSO-d6) delta 10.04 (s, 1H), 8.72 (s, 1H), 8.07 (d, J=9.3 Hz, 1H), 7.77-7.75 (m, 2H), 7.53 (d, J=7.0 Hz, 2H), 7.20-7.16 (m, 4H), 6.76 (d, J=9.7 Hz, 1H), 4.86 (s, 2H), 3.11 (s, 3H).

The synthetic route of 1-(4-Bromophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Syntrix Biosystems Inc.; US2012/46243; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-(4-Bromophenyl)-N-methylmethanamine

General procedure: Aldehyde (3 mmol) was taken up in dry DCM (10 mL) in an oven dried round bottomed flask under an atmosphere of nitrogen. Acetic acid (1 mmol) was added and the reaction stirred at room temperature for 5 minutes. Amine (1 mmol) was then added and the reaction stirred at room temperature for 1 hour. The reaction was cooled to 0 C using an ice bath, then sodium triacetoxyborohydride (3 mmol) was added and the reaction warmed to room temperature and stirred until TLC indicated complete consumption of the amine. The reaction was quenched with saturated aqueous sodium bicarbonate solution. The organic layer was washed with three portions of saturated sodium bicarbonate, then acidified with concentrated hydrochloric acid. The organic layer was then washed with three portions of 2 M aqueous hydrochloric acid. The pH of the acidic washes was then adjusted to pH 10 using 4 M aqueous sodium hydroxide and the aqueous extracted with three portions of diethyl ether. The combined ether washes were dried with magnesium sulfate, filtered and concentrated to give crude product. The residue was then purified by flash column chromatography and sent to NKI for biological testing.

The synthetic route of 1-(4-Bromophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Milne, Kirsty; Sun, Jianhui; Zaal, Esther A.; Mowat, Jenna; Celie, Patrick H.N.; Fish, Alexander; Berkers, Celia R.; Forlani, Giuseppe; Loayza-Puch, Fabricio; Jamieson, Craig; Agami, Reuven; Bioorganic and Medicinal Chemistry Letters; vol. 29; 18; (2019); p. 2626 – 2631;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-(4-Bromophenyl)-N-methylmethanamine

A mixture of l-(4-bromophenyl)-N-methylmethanamine (14.0 g, 70.0 mmol), 2-(but- 3-yn-l-yl)isoindoline-l,3-dione (16.5 g, 83.0 mmol), Cul (3.33 g, 17.5 mmol) and CS2CO3 (114 g, 351 mmol) in deoxygenated dioxane (280 mL) was further deoxygenated by bubbling nitrogen gas for 1.25 h. through the mixture. PdCl2([l,r-bis(diphenylphosphino)ferrocene]) (5.71 g, 7.00 mmol) was added and the mixture further deoxygenated with nitrogen for 1 h before heating to 80C for 18 h under an atm. of N2. The reaction was allowed to cool to room temperature and filtered through celite with EtOAc. The organic mother liquor was washed with 1 molar NaOH, water, brine, dried with Na2S04, filtered and concentrated in vacuo. The residue was chromatographed on silica gel (330 g Isco column, 1 to 10% MeOH in DCM with 1% N Eh in the eluents over 36 min.) to give 23.3 g of 2-(4-(4- ((methylamino)methyl)phenyl)but-3- yn-l-yl)isoindoline-l,3-dione as a black oil that was 86% 74 by weight. The raw product was used as is in the next reaction. 1H NMR (400MHz, chloroform-d) d = 7.87 (dd, =3.0, 5.5 Hz, 2H), 7.73 (dd, J=3. l, 5.4 Hz, 2H), 7.31 – 7.28 (m, 2H), 7.23 – 7.19 (m, 2H), 3.97 (t, J=1 A Hz, 2H), 2.83 (t, J=1 A Hz, 2H), 2.43 (s, 3H), 1.19 (t, J=12 Hz, 2H). LC/MS RT = 0.49 min., 319.0 [M+H]+

The synthetic route of 699-03-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ADVITECH ADVISORY AND TECHNOLOGIES SA; BECK, Brent Christopher; PERALES, Joe B.; SPEAKE, Jason D.; FERRANDO, Ilaria; (28 pag.)WO2019/115000; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 699-03-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To an oven dried 10 mL screw cap vial equipped with a stir-bar and charged with amine 1a (0.5 mmol) was added aldehyde 2a (84 mg, 1.5 equiv) and toluene (0.2 mL) and the mixture was stirred for 5 min at room temperature. Thereafter, heteroarene 3a (88 mg, 1.2 equiv) and CuCl (10 mg, 20 mol%) were added and the vial was sealed with a Teflon cap. The reaction mixture was irradiated for 50 min at a preselected temperature of 140 oC, with a maximum irradiation power of 200 W. After completion of the reaction, the resulting mixture was diluted with ethyl acetate (50 mL) and washed with water (50 mL) and brine (50 mL). The organic phase was dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude sample was purified by silica gel column chromatography (10-20% ethyl acetate in heptane) to obtain compound 4a (127mg, 78% yield).

The synthetic route of 1-(4-Bromophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Vachhani, Dipak D.; Sharma, Abhishek; Van Der Eycken, Erik; Angewandte Chemie – International Edition; vol. 52; 9; (2013); p. 2547 – 2550; Angew. Chem.; vol. 125; 9; (2013); p. 2607 – 2610,4;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H10BrN

General procedure: Amine (0.25 mmol), and bromide (0.25 mmol) were taken up in acetonitrile (0.3 mL) in a conical vial equipped with a stirrer bar. Potassium carbonate (0.5 mmol) was added followed by potassium iodide (10 mol%) if required. The vial was sealed with a screwcap and the reaction was stirred at 40 C until thin layer chromatography (TLC) indicated complete consumption of the starting materials. A precipitate was formed during the reaction which was removed by filtration and the filtrate concentrated under reduced pressure. The residue was purified by flash column chromatography and sent to the Netherlands Cancer Institute (NKI) for biological testing.

The synthetic route of 1-(4-Bromophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Milne, Kirsty; Sun, Jianhui; Zaal, Esther A.; Mowat, Jenna; Celie, Patrick H.N.; Fish, Alexander; Berkers, Celia R.; Forlani, Giuseppe; Loayza-Puch, Fabricio; Jamieson, Craig; Agami, Reuven; Bioorganic and Medicinal Chemistry Letters; vol. 29; 18; (2019); p. 2626 – 2631;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 699-03-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of tetrafluoropyridazine 1, DIPEA, amine and THF (10 mL) was stirred for the required time under an atmosphere of nitrogen. The mixture was evaporated to dryness in vacuo, partitioned between ethyl acetate (20 mL) and water (20 mL), the phases were separated and the aqueous phase was extracted further by ethyl acetate (3 x 20 mL). The combined organic phases were dried (MgSO4) and evaporated in vacuo. Purification by column chromatography or HPLC on silica gel using cyclohexane and ethyl acetate as eluent gave the pure product.

The synthetic route of 1-(4-Bromophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pattison, Graham; Sandford, Graham; Wilson, Ian; Yufit, Dmitrii S.; Howard, Judith A.K.; Christopher, John A.; Miller, David D.; Tetrahedron; vol. 73; 5; (2017); p. 437 – 454;,
Bromide – Wikipedia,
bromide – Wiktionary