Category: 6942-39-8

Zhang, Xiang; Hou, Wenjuan; Zhang-Negrerie, Daisy; Zhao, Kang; Du, Yunfei published the artcile< Correction to ""Hypervalent Iodine-Mediated Intramolecular trans-Aminocarboxylation and Oxoaminocarboxylation of Alkynes: Divergent Cascade Annulations of Isocoumarins under Metal-Free Conditions"" [Erratum to document cited in CA163:585666]>, Related Products of 6942-39-8, the main research area is indoloisocoumarin spiroindolone preparation cyclization amino carboxy diarylalkyne hypervalent iodine; aminocarboxylation intramol heterocyclization aminoaryl carboxyaryl alkyne erratum; hypervalent iodine oxidation heterocyclization aminocarboxylation diarylalkyne preparation indoloisocoumarin spiroindolone; erratum.

In Scheme 4, the structure of Compound 2m was drawn incorrectly due to the position of Cl. Similarly, in the Supporting Information (Page S8), the structure of 2m was also wrong. The correct structural drawing is given.

Organic Letters published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Related Products of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Yao; Liu, Yun-Qi; Hu, Le’an; Zhang, Xumu; Yin, Qin published the artcile< Asymmetric Reductive Amination/Ring-Closing Cascade: Direct Synthesis of Enantioenriched Biaryl-Bridged NH Lactams>, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate, the main research area is keto ester enantioselective ruthenium reductive amination ring closing cascade; chiral benzazepinone preparation.

We report here a Ru-catalyzed enantioselective synthesis of biaryl-bridged NH lactams through asym. reductive amination and a spontaneous ring-closing cascade from keto esters and NH4OAc with H2 as reductant. The reaction features broad substrate generality and high enantioselectivities (up to >99% ee). To showcase the practical utility, a highly enantioselective synthesis of 5-ethylindolobenzazepinone C, a promising antimitotic agent, has been rapidly completed. Furthermore, the amide group in the products enables versatile elaborations through directed C-H functionalization.

Organic Letters published new progress about Benzazepines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shahzadi, Tayyaba; Saleem, Rahman S. Z.; Chotana, Ghayoor A. published the artcile< Facile Synthesis of Halogen Decorated para-/meta-Hydroxybenzoates by Iridium-Catalyzed Borylation and Oxidation>, Formula: C8H6BrFO2, the main research area is para meta hydroxybenzoate preparation; benzoate ester boronic ester borylation oxidation iridium catalyst.

In this report, a facile preparation of 2,6- and 2,3-disubstituted 4/5-hydroxybenzoates by iridium-catalyzed borylation of resp. disubstituted benzoate esters followed by oxidation is described. This synthetic route allows for the incorporation of halogens in the final hydroxybenzoates with substitution patterns not readily accessible by the traditional routes of aromatic functionalization.

Synthesis published new progress about Aromatic esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Formula: C8H6BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Garcia-Rodriguez, Jose; Mendiratta, Saurabh; White, Michael A.; Xie, Xiao-Song; De Brabander, Jef K. published the artcile< Synthesis and structure-activity studies of the V-ATPase inhibitor saliphenylhalamide (SaliPhe) and simplified analogs>, HPLC of Formula: 6942-39-8, the main research area is salicylihalamide synthesis anticancer antiviral structure activity relationship; VATPase inhibitor salicylihalamide analog preparation; Anticancer; Antiviral; Benzolactone; Salicylihalamide; V-ATPase.

An efficient total synthesis of the potent V-ATPase inhibitor saliphenylhalamide (SaliPhe), a synthetic variant of the natural product salicylihalamide A (SaliA), has been accomplished aimed at facilitating the development of SaliPhe as an anticancer and antiviral agent. This new approach enabled facile access to derivatives for structure-activity relationship studies, leading to simplified analogs that maintain SaliPhe’s biol. properties. These studies will provide a solid foundation for the continued evaluation of SaliPhe and analogs as potential anticancer and antiviral agents.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, HPLC of Formula: 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Hynds, Hannah M.; Lemons, Holli E.; Willis, Jasmine D.; Bell, MarKayla J.; Bottcher, Sydney E.; Dye, Mei Lin N.; Echols, Emily T.; Garner, Edward L.; Hutchinson, Lauren E.; Phillips, Caleb M.; Stephens, Claudia P.; Gilbert, Thomas M.; Wilger, Dale J. published the artcile< Ni-Catalyzed Larock Indenone Annulation with Aliphatic- and Silyl-Substituted Alkynes Supported by Mechanistic Analysis>, Synthetic Route of 6942-39-8, the main research area is nickel catalyzed Larock annulation reaction ortho bromobenzoate alkyne; indenone derivative preparation.

A Ni-catalyzed annulation reaction to synthesize indenones is reported. The reaction provides high yields and regioselectivities when aliphatic- and silyl-substituted alkynes are employed. Both were challenging and underused substrate classes. Several mechanistic observations aided in the development of this reaction, including that β-hydride elimination is turnover-limiting for ortho-halogenated aldehyde substrates and that alkyne dissociation is rate-limiting for internal aliphatic alkynes. The authors anticipate that these methods will be rapidly adopted due to their synthetic ease and inherent versatility. The authors also anticipate that the mechanistic conclusions will inform further reaction development.

Organometallics published new progress about Alkynes Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), RCT (Reactant), PROC (Process), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Synthetic Route of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Qian-Qian; Li, Yaokai; Wang, Di; Chen, Zeng; Li, Yuhao; Li, Shuixing; Zhu, Haiming; Lu, Xinhui; Chen, Hongzheng; Li, Chang-Zhi published the artcile< Intrinsically Chemo- and Thermostable Electron Acceptors for Efficient Organic Solar Cells#>, Computed Properties of 6942-39-8, the main research area is organic solar cell acceptor dnor stille coupling.

The traditional preparation of non-fullerene acceptors (NFAs) via Knoevenagel condensation reaction (KCR) of aldehyde and active methylene leaves vulnerable and reversible exocyclic vinyl bonds in structures, which undermine the intrinsic chemo- and photostability of NFAs. In this work, we demonstrate a new access to acceptor-donor-acceptor (A-D-A) NFAs via Stille coupling between new electron deficient groups and classic donor core in over 90% yield, wherein the robust carbon-carbon bonds, replacing the exocyclic double bonds from traditional KCR, result in stable A-D-A acceptors, Q1-XF (X representing 0, 2 and 4 fluorine atoms, resp.). Among the three studied examples, Q1-4F exhibits improved optoelectronic and electron transport properties, leading to the best photovoltaic performance with optimal charge kinetics for Q1-4F based OSCs. Overall, this strategy can lead to a new way for developing stable photovoltaic materials.

Bulletin of the Chemical Society of Japan published new progress about Coupling reaction. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Computed Properties of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Luo, Jiaying; Lu, Youling; Liu, Saiwen; Liu, Jing; Deng, Guo-Jun published the artcile< Efficient One-Pot Synthesis of Dibenzopyranones via a Decarboxylative Cross-Coupling and Lactonization Sequence>, Safety of Methyl 2-bromo-5-fluorobenzoate, the main research area is dibenzopyranone preparation decarboxylative coupling lactonization halobenzoate nitrobenzoic acid; copper palladium catalyst decarboxylative coupling lactonization halobenzoate nitrobenzoic acid.

A highly selective palladium bis(acetoacetonate)/copper(I) chloride [Pd(acac)2/CuCl] catalytic system for the preparation of dibenzopyranones has been developed. Tandem decarboxylative coupling and lactonization can be realized in one pot using com. available starting materials. The reaction proceeded well for a range of different substrates.

Advanced Synthesis & Catalysis published new progress about Aromatic carboxylic acids Role: RCT (Reactant), RACT (Reactant or Reagent) (nitro-). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Safety of Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gustafson, Jeffrey L.; Lim, Daniel; Miller, Scott J. published the artcile< Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination>, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate, the main research area is dynamics kinetics resolution biaryl atropisomer peptide catalyzed asym bromination.

Despite the widespread use of axially chiral, or atropisomeric, biaryl ligands in modern synthesis and the occurrence of numerous natural products exhibiting axial chirality, few catalytic methods have emerged for the direct asym. preparation of this compound class. Here, the authors present a tripeptide-derived small-mol. catalyst for the dynamic kinetic resolution of racemic biaryl substrates. The reaction proceeds via an atropisomer-selective electrophilic aromatic substitution reaction using simple bromination reagents. The result is an enantioselective synthesis that delivers chiral nonracemic biaryl compounds with excellent optical purity and good isolated chem. yields (in most cases a >95:5 enantiomer ratio and isolated yields of 65 to 87%). A mechanistic model is advanced that accounts for the basis of selectivity observed

Science (Washington, DC, United States) published new progress about Atropisomers. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Melin, Lea; Abdullayev, Shuay; Fnaiche, Ahmed; Vu, Victoria; Gonzalez Suarez, Narjara; Zeng, Hong; Szewczyk, Magdalena M.; Li, Fengling; Senisterra, Guillermo; Allali-Hassani, Abdellah; Chau, Irene; Dong, Aiping; Woo, Simon; Annabi, Borhane; Halabelian, Levon; LaPlante, Steven R.; Vedadi, Masoud; Barsyte-Lovejoy, Dalia; Santhakumar, Vijayaratnam; Gagnon, Alexandre published the artcile< Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid>, Synthetic Route of 6942-39-8, the main research area is anticancer agent cell migration TEAD LM98 flufenamic acid; Flufenamic acid; Hippo pathway; SAR; TEAD; palmitic acid.

The YAP-TEAD transcriptional complex is responsible for the expression of genes that regulate cancer cell growth and proliferation. Dysregulation of the Hippo pathway due to overexpression of TEAD has been reported in a wide range of cancers. Inhibition of TEAD represses the expression of associated genes, demonstrating the value of this transcription factor for the development of novel anti-cancer therapies. We report herein the design, synthesis and biol. evaluation of LM98, a flufenamic acid analog. LM98 shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity. Binding of LM98 to TEAD was supported by 19F-NMR studies while co-crystallization experiments confirmed that LM98 is anchored within the palmitic acid pocket of TEAD. LM98 reduces the expression of CTGF and Cyr61, inhibits MDA-MB-231 breast cancer cell migration and arrests cell cycling in the S phase during cell division.

ChemMedChem published new progress about Antitumor agents. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Synthetic Route of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Bryan; Samp, Lacey; Sagal, John; Hayward, Cheryl M.; Yang, Christine; Zhang, Zhijun published the artcile< Synthesis of Quinazolin-4(3H)-ones via Amidine N-Arylation>, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate, the main research area is trifluoromethyliodonicotinic acid amidine palladium catalyst arylation; pyridopyrimidinone preparation; amindine halobenzoate palladium catalyst arylation; quinazolinone preparation.

Pyrido[4,3-d]pyrimidin-4(3H)-one was prepared by reacting 2-trifluoromethyl-4-iodo-nicotinic acid with amidine I catalyzed by Pd2(dba)3 and Xantphos, followed by cyclization effected with HBTU and subsequent demethylation using PhBCl2. The amidine arylation method was found applicable for the syntheses of quinazolin-4(3H)-ones. Thus, reaction of 2-bromo or 2-iodo benzoate esters with amidines afforded substituted quinazolin-4(3H)-ones, e.g. II, in 44-89% yields.

Journal of Organic Chemistry published new progress about Amidines Role: RCT (Reactant), RACT (Reactant or Reagent). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary