Category: 6942-39-8

Capel, Estefania; Luis-Barrera, Javier; Sorazu, Ana; Uria, Uxue; Prieto, Liher; Reyes, Efraim; Carrillo, Luisa; Vicario, Jose L. published the artcile< Transannular Approach to 2,3-Dihydropyrrolo[1,2-b]isoquinolin-5(1H)-ones through Bronsted Acid-Catalyzed Amidohalogenation>, HPLC of Formula: 6942-39-8, the main research area is pyrroloisoquinolinone preparation; benzo fused ene lactam amidohalogenation elimination Bronsted acid catalyst.

A transannular approach has been developed for the construction of pyrrolo[1,2-b]isoquinolinones I (R1 = H, F, Cl, Me, OMe, etc.; R2 = H, F, etc.; R3 = H, Me, etc.; R4 = H, F) starting from benzo-fused nine-membered enelactams II. This process takes place in the presence of a halogenating agent and under Bronsted acid catalysis and proceeds via a transannular amidohalogenation, followed by elimination. The reaction has been found to be wide in scope, enabling the formation of a variety of tricyclic products I in good overall yield, regardless of the substitution pattern in the initial lactam substrate. The reaction has also been applied to the total synthesis of a reported topoisomerase I inhibitor and to the formal synthesis of rosettacin. Further extension of this methodol. allows the preparation of 10-iodopyrrolo[1,2-b]isoquinolinones III (R1 = H, Me; R2 = H, F; R3 = H, F, Me, OMe) by using an excess of halogenating agent and these compounds can be further manipulated through standard Suzuki coupling chem. into a variety of 10-aryl-substituted pyrrolo[1,2-b]isoquinolinones IV.

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, HPLC of Formula: 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Su, Shihu; Zhou, Xia; Zhou, Yan; Liao, Guoping; Shi, Li; Yang, Xia; Zhang, Xian; Jin, Linhong published the artcile< Synthesis and biological evaluation of novel sulfone derivatives containing 1,3,4-oxadiazole moiety>, Safety of Methyl 2-bromo-5-fluorobenzoate, the main research area is sulfonyl oxadiazole preparation fungicidal SAR antibacterial toxic regression.

Series of novel sulfone derivatives containing 1,3,4-oxadiazole moiety I [R1 = 4-F-2-Me, 2,5-Cl2, 2-Br-4-F, etc.; R2 = Me, Et, CH(CH3)2, n-propyl] and II [R2 = Me, Et, CH2Ph] were synthesized. All the target compounds were characterized by 1H and 13C NMR, IR spectroscopy and elemental anal. Their antifungal activities were tested in vitro with six important phytopathogenic fungi, namely, Gibberella zeae, Fusarium oxysporum, Cytospora mandshurica, Phytophthora infestans, Paralepetopsis sasakii and Sclerotinia sclerotiorum using the mycelium growth inhibition method. Their antibacterial activities were tested in vitro with two important phytopathogenic bacteria, namely, Xanthomonas oryzae and Ralstonia solanacearum from tobacco bacterial by the turbid meter test. Compounds I [R1 = 2-Cl-4-F, 4-CF3; R2 = Me] and II [R2 = Me, Et] exhibited the most potent inhibition against R. solanacearum and X. oryzae with 50% inhibition concentration (EC50) from 1.97 to 7.75 μg/mL and 0.45 to 0.52 μg/mL, resp. Their antifungal tests indicated that among target compounds exhibited good antifungal activities against six kinds of fungi, especially against S. sclerotiorum with EC50 from 3.71 to 17.44 μg/mL. In vivo antibacterial activities tests demonstrated that the controlling effect of compound II [R2 = Me] (81.9%) against rice bacterial leaf blight were better than that of bismerthiazol (50.8%) and thiodiazole-copper (44.7%). The results also demonstrated that compounds I [R1 = 2-Cl-4-F; R2 = Me] and II [R2 = Me, Et] had a better antifungal and antibacterial activity, with good characteristics of broad spectrum. The structure-activity relationships were also discussed.

World Journal of Organic Chemistry published new progress about Agrochemical antibacterial agents. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Safety of Methyl 2-bromo-5-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Huamin; Cai, Jinhui; Huang, Huawen; Deng, Guo-Jun published the artcile< Palladium-Catalyzed Phthalazinone Synthesis Using Paraformaldehyde as Carbon Source>, Product Details of C8H6BrFO2, the main research area is methyl benzoate paraformaldehyde aryl hydrazine cyclocondensation palladium catalyst; phthalazinone preparation.

A palladium-catalyzed one-pot synthesis of phthalazinones I [ Ar = ph, 4-Me-ph, 4-Et-ph, 4-OMe-ph, etc.] from 2-halomethyl benzoates, paraformaldehyde, and aryl hydrazines is described. Various substituted phthalazinones were selectively obtained in good yields using paraformaldehyde as the cheap carbon source (CH).

Organic Letters published new progress about Addition reaction catalysts. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Product Details of C8H6BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Baker, Stephen J.; Zhang, Yong-Kang; Akama, Tsutomu; Wheeler, Conrad; Plattner, Jacob J.; Rosser, Richard M.; Reid, Ronald P.; Nixon, Neil S. published the artcile< Synthesis of isotopically labelled (3-14C)- and (3,3-2H2)-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690), a new antifungal agent for the potential treatment of onychomycosis>, HPLC of Formula: 6942-39-8, the main research area is fluoro dihydro hydroxy benzoxaborole AN2690 radiolabeled antifungal onychomycosis.

5-Fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2690) is a new antifungal agent for the potential treatment of onychomycosis. During the preclin. development phase, it was necessary to synthesize the radioisotope [3-14C]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole and the deuterium isotope [3,3-2H2]-5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole for in vitro studies. We report the synthesis of these two isotopically labeled derivatives

Journal of Labelled Compounds and Radiopharmaceuticals published new progress about Fungicides. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, HPLC of Formula: 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Yue; Dai, Gaole; Chen, Yuanyuan; Wang, Ru; Li, Huamei; Shi, Xueliang; Zhang, Xiaohong; Xu, Yang; Zhao, Yu published the artcile< Effective Design Strategy of Small Bipolar Molecules through Fused Conjugation toward 2.5 V Based Redox Flow Batteries>, COA of Formula: C8H6BrFO2, the main research area is sym redox flow battery bipolar redox active mol design.

Using bipolar redox-active mols. (BRMs) as active materials is a practical way to address electrolyte crossover and resultant unpredictable side reactions in redox-flow batteries. However, the development of BRMs is greatly hindered by difficulties in finding new mols. from limited redox-active moieties and in achieving high cell voltage to compete with existing flow battery chemistries. This study proposes a strategy for design of high-voltage BRMs using fused conjugation that regulates the redox potential of integrated redox-active moieties. As a demonstration, quaternary N and ketone redox moieties are used to construct a new BRM that shows a prominent voltage gap with good electrochem. stability. A sym. redox-flow cell based on this mol. exhibits a high voltage of 2.5 V and decent cycling stability. This study provides a general strategy for designing new BRMs that may enrich the cell chemistries of organic redox-flow batteries.

ACS Energy Letters published new progress about Atomic charge. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, COA of Formula: C8H6BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Miyamoto, Shoto; Matsuoka, Aki; Yamada, Yuji; Ishikawa, Ryuta; Hayashida, Osamu published the artcile< Benzoxaborole Catalyst for Site-Selective Modification of Polyols>, Application In Synthesis of 6942-39-8, the main research area is benzoxaborole catalyst preparation; site selective protecting group free modification polyol; benzoylation tosylation benzylation glycosylation cis diol benzoxaborole catalyst.

The site-selective modification of polyols bearing several hydroxyl groups without the use of protecting groups remains a significant challenge in synthetic chem. To address this problem, novel benzoxaborole derivatives were designed as efficient catalysts for the highly site-selective and protecting-group-free modification of polyols. To identify the effective substituent groups enhancing the catalytic activity and selectivity, a series of benzoxaborole catalysts were synthesized. In-depth anal. for the substituent effect revealed that I [R = 4-F, 4-CF3, 3,5-(CF3)2], bearing multiple electron-withdrawing fluoro- and trifluoromethyl groups, exhibited the greatest catalytic activity and selectivity. Moreover, I [R = 4-F]-catalyzed benzoylation, tosylation, benzylation, and glycosylation of various cis-1,2-diol derivatives proceeded with good yield and site-selective manner.

European Journal of Organic Chemistry published new progress about Benzoxaboroles Role: CAT (Catalyst Use), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Application In Synthesis of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Murai, Takuya; Xing, Yongning; Kurokawa, Mayu; Kuribayashi, Toshifumi; Nikaido, Masanori; Elboray, Elghareeb E.; Hamada, Shohei; Kobayashi, Yusuke; Sasamori, Takahiro; Kawabata, Takeo; Furuta, Takumi published the artcile< One-Pot Preparation of (NH)-Phenanthridinones and Amide-Functionalized [7]Helicene-like Molecules from Biaryl Dicarboxylic Acids>, Category: bromides-buliding-blocks, the main research area is phenanthridinone amide helicene preparation; biaryl dicarboxylic acid Curtius rearrangement cyclization.

A one-pot transformation of biaryl dicarboxylic acids to (NH)-phenanthridinone derivatives based on a Curtius rearrangement and subsequent basic hydrolysis was developed. This method is also applicable for the preparation of optically active amide-functionalized [7]helicene-like mols. Furthermore, aza[5]helicene derivatives with a phosphate moiety were isolated as a product of the Curtius rearrangement step in the case of substrates that bear chalcogen atoms. The stereostructures of these products, revealed by X-ray diffraction anal., suggested that chalcogen-bonding and pnictogen-bonding interactions might contribute to their stabilization. The configurational stability of the helicene-like mols. and their chiroptical properties were further investigated.

Journal of Organic Chemistry published new progress about Aromatic dicarboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Hui; Li, Weishuang; Hu, Xu-Dong; Liu, Wen-Bo published the artcile< Enantioselective Synthesis of Fused Isocoumarins via Palladium-Catalyzed Annulation of Alkyne-Tethered Malononitriles>, Category: bromides-buliding-blocks, the main research area is isocoumarin preparation; phenylalkynyl malononitrile palladium catalyst enantioselective tandem oxypalladation intramol cycloaddition.

An enantioselective palladium-catalyzed annulation of alkyne-tethered malononitriles for the synthesis of 3,4-ring-fused isocoumarins were described. This cascade strategy involved oxypalladation of ortho-alkynylbenzoates and desymmetrizing addition onto one cyano group of the pendant malononitriles, which enabled the concurrent construction of two rings and an all-carbon quaternary stereocenter in a single operation.

Journal of Organic Chemistry published new progress about Aliphatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Cui; Huang, Kanglun; Wang, Bo; Xie, Longguang; Xu, Xiaohua published the artcile< Palladium-catalyzed annulation reactions of methyl o-halobenzoates with azabicyclic alkenes: a general protocol for the construction of benzo[c]phenanthridine derivatives>, COA of Formula: C8H6BrFO2, the main research area is benzophenanthridine preparation palladium catalysis annulation methyl halobenzoate azabicyclic alkene.

The annulation reaction of Me o-halobenzoates with azabicyclic alkenes proceeds efficiently to give the corresponding benzo[c]phenanthridine derivatives in good to excellent yields using a developed base-free methodol. based on our preliminary studies. Thirty-seven application examples validate the compatibility of the present strategy with different groups, particularly with the electron-deficient ones, that are difficult to access using other traditional methods. In addition, annulation reactions with non-sym. azabicyclic alkenes are achieved in high regioselectivity.

RSC Advances published new progress about Cyclization. 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, COA of Formula: C8H6BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shen, Cong; Zhu, Yuhang; Jin, Shuqi; Xu, Kejie; Luo, Shuxin; Xu, Lixia; Zhong, Guofu; Zhong, Liangjun; Zhang, Jian published the artcile< Regio- and stereo-selective olefinic C-H functionalization of aryl alkenes in ethanol>, Electric Literature of 6942-39-8, the main research area is aryl alkene palladium catalyst regioselective diastereoselective alkenylation; preparation aryl alkadiene; phenyl alkatriene preparation.

N,N-bidentate-chelation-assisted α- and β-olefinic C-H alkenylation of aryl alkenes in ethanol to afford aryl dienes/trienes with excellent regio- and stereo-selectivities was reported. The reaction of 2-alkenyl benzylamine and benzoic acid derived substrates proceeded through six-membered exo-cyclometallation and seven-membered endo-cyclometallation. The aerobic protocols feature wide functionality tolerance, high selectivities and yields, mild conditions and scalable preparation, and the directing group can be easily removed to afford Boc-protected amine by simple reduction

Organic Chemistry Frontiers published new progress about Alkadienes Role: SPN (Synthetic Preparation), PREP (Preparation). 6942-39-8 belongs to class bromides-buliding-blocks, and the molecular formula is C8H6BrFO2, Electric Literature of 6942-39-8.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary