Category: 69361-41-7

Harrison, Tyler J. published the artcilePyrrole Synthesis Catalyzed by AgOTf or Cationic Au(I) Complexes, Application In Synthesis of 69361-41-7, the publication is Journal of Organic Chemistry (2006), 71(12), 4525-4529, database is CAplus and MEDLINE.

Either silver trifluoromethanesulfonate or a mixture of gold(I) chloride, silver trifluoromethanesulfonate, and triphenylphosphine catalyze the formation of pyrroles from substituted β-alkynyl ketones and amines. The reactions proceed by using 5 mol % of catalyst with yields of isolated pyrroles ranging from 13% to 92%. Sixteen examples are used to compare the effectiveness of each catalyst. Example compounds thus prepared included also cyclopenta[b]pyrrole derivatives tetrahydro(methyl)indolizine. and dihydro-1H-pyrrolizine derivatives

Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application In Synthesis of 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Liming published the artcileStereocontrolled Synthesis of Kelsoene by the Homo-Favorskii Rearrangement, Computed Properties of 69361-41-7, the publication is Organic Letters (2002), 4(21), 3755-3758, database is CAplus and MEDLINE.

(±)-Kelsoene (I) has been synthesized from 2,5-dihydroanisole in 16 steps in 12.5% overall yield. The key step involves a base-catalyzed reaction of γ-keto tosylate II, which effects a homo-Favorskii rearrangement to III (X¹ = H,H; X² = O) as well as the corresponding intramol. S_N2 product IV from the enolate of II. Ketone IV can efficiently be isomerized to cyclobutanone III (X¹ = O; X² = H,H) having the kelsoene carbon skeleton upon acid treatment.

Organic Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C3H5BN2O2, Computed Properties of 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lutter, Ferdinand H. published the artcileCobalt-Catalyzed Cross-Coupling of Functionalized Alkylzinc Reagents with (Hetero)Aryl Halides, Product Details of C7H13BrSi, the publication is Angewandte Chemie, International Edition (2020), 59(14), 5546-5550, database is CAplus and MEDLINE.

A combination of 10% CoCl₂ and 20% 2,2′-bipyridine ligands enables cross-coupling of functionalized primary and secondary alkylzinc reagents RZnY (R = 3-phenylpropyl, 3-(2,5-dimethyl-1H-pyrrol-1-yl)propyl, cyclopropyl, etc.; Y = Cl, Br) with various (hetero)aryl halides R¹X (R¹ = 5-cyanopyridin-2-yl, quinolin-2-yl, pyrimidin-2-yl, etc.; X = Cl, Br). Couplings with 1,3- and 1,4-substituted cycloalkylzinc reagents R²ZnI (R² = 3-methylcyclohexyl, 4-(1H-pyrrol-1-yl)cyclohexyl, (4R,4aS,6R,8aR)-4,4a-dimethyl-6-(propan-2-yl)-decahydronaphthalen-2-yl, etc.) proceeded diastereoselectively leading to functionalized heterocycles R¹R² with high diastereoselectivities of up to 98:2. Furthermore, alkynyl bromides R³CCBr (R³ = Ph, tris(propan-2-yl)silyl) react with primary and secondary alkylzinc reagents RZnY (R = 2-(1,3-dioxan-2-yl)ethyl, 4-phenylcyclohexyl; Y = Cl, I) providing the alkylated alkynes RCCR³.

Angewandte Chemie, International Edition published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Crimmins, Michael T. published the artcileIntramolecular photocycloaddition-cyclobutane fragmentation: total synthesis of (±)-laurenene, Formula: C7H13BrSi, the publication is Journal of the American Chemical Society (1987), 109(20), 6199-200, database is CAplus.

Nature’s only known existing fenestrane, laurenene (I) was prepared via an elevated temperature intramol. [2+2] photochem. cycloaddition of diene II. This established the highly sterically congested center of the laurenene skeleton which contains 3 contiguous quaternary C. Reductive cleavage of the cyclobutane produced during the photocycloaddition provides an intermediate which was used to form the remaining 7 membered ring via an intramol. aldol-dehydration reaction. The [5.5.5.7] fenestrane III which was prepared in 12.7% yield was transformed to I in 5 steps.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mattarella, Martin published the artcileNanomolar cholera toxin inhibitors based on symmetrical pentavalent ganglioside GM1os-sym-corannulenes, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Organic & Biomolecular Chemistry (2013), 11(26), 4333-4339, database is CAplus and MEDLINE.

Eight sym. and pentavalent corannulene derivatives were functionalized with galactose and the ganglioside GM1-oligosaccharide (GM1os) via copper-catalyzed alkyne-azide cycloaddition (CuAAC) reactions. The compounds were evaluated for their ability to inhibit the binding of the pentavalent cholera toxin to its natural ligand, ganglioside GM1. In this assay, all ganglioside GM1os-sym-corannulenes proved to be highly potent nanomolar inhibitors of cholera toxin.

Organic & Biomolecular Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Leitner, Christian published the artcileTotal synthesis of (±)-20S-hydroxy-1,2-dehydro-pseudoaspidospermidine via a C-H activation/transannular cyclization strategy, Quality Control of 69361-41-7, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(54), 7451-7453, database is CAplus and MEDLINE.

A total synthesis toward the pseudoaspidospermidine family via a C-H activation/transannular cyclization strategy has been accomplished. The applicability of this approach is showcased in the concise synthesis (ten steps) of (±)-20S-hydroxy-1,2-dehydro-pseudoaspidospermidine (I) starting from known dihydropyridone II. Via a joint synthetic sequence, we were also able to address the related iboga alkaloid (±)-isovelbanamine (III) in nine steps. Key features of this synthesis are a transannular cyclization to generate the pseudoaspidospermidine skeleton (C-H activation) and a Witkop photocyclization reaction providing a 9-membered lactam. It is also worth mentioning that the joint synthetic sequence can be carried out on a multigram scale.

Chemical Communications (Cambridge, United Kingdom) published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Quality Control of 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hartrampf, Felix W. W. published the artcileA Conia-Ene-Type Cyclization under Basic Conditions Enables an Efficient Synthesis of (-)-Lycoposerramine R, COA of Formula: C7H13BrSi, the publication is Angewandte Chemie, International Edition (2017), 56(3), 893-896, database is CAplus and MEDLINE.

An enantioselective total synthesis of the Lycopodium alkaloid lycoposerramine R (I) is presented. It relies on a base-mediated cyclization that resembles the Conia-ene reaction of ynones and gold-catalyzed variants thereof. Thus, hydrindanones and other functionalized ring systems bearing an exocyclic alkene can be rapidly accessed at room temperature without noble metal catalysis or substrate preactivation.

Angewandte Chemie, International Edition published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, COA of Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Davison, Edwin C. published the artcileN-Alkenyl nitrone dipolar cycloaddition routes to piperidines and indolizidines. Part 8. The scope of tandem reactions involving hydroxylamine-alkyne cyclizations, COA of Formula: C7H13BrSi, the publication is Tetrahedron (1996), 52(35), 11601-11624, database is CAplus.

A tandem sequence of hydroxylamine-alkyne cyclization/1,3-dipolar cycloaddition, provides useful entry into tricyclic systems of type I. The scope of such reactions is explored in this paper. A novel cascade cyclization of N-hydroxypyrrolidines of type II (n = 1, 3) involving hydroxylamine-alkyne cyclization, Cope elimination and 1,3-dipolar cycloaddition is also reported.

Tetrahedron published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, COA of Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gleiter, Rolf published the artcileRegiochemistry of the intramolecular [2+2] photocycloaddition of enones to vinyl ethers as a function of chain length, Formula: C7H13BrSi, the publication is Chemische Berichte (1992), 125(8), 1899-911, database is CAplus.

The intramol. [2+2] cycloaddition of a cyclohexenone moiety bound to a vinyl ether fragment has been explored. The regiochem. and the quantum yield of the reaction have been investigated as a function of the chain length n and the position of the methoxy group. In those cases where the chain consists of 3 and 4 members the position of the methoxy group has no influence on the regiochem. but on the quantum yield. Only head-to-head cycloaddition is observed In the case of n = 2 both the regiochem. and the quantum yield depend strongly on the position of the methoxy group. The main reason for the different behavior of n = 2 is due to a through-bond effect between the two olefinic units mediated by a C₂H₄ bridge.

Chemische Berichte published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Shi, Hang published the artcileTotal Syntheses of Drimane-Type Sesquiterpenoids Enabled by a Gold-Catalyzed Tandem Reaction, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Journal of the American Chemical Society (2011), 133(38), 14944-14947, database is CAplus and MEDLINE.

Development of a gold-catalyzed tandem reaction of 1,7-diynes with both internal and external nucleophiles was realized, which constructed five chem. bonds, two rings, and two stereogenic centers in a single step. Based on the novel cascade transformation, we achieved a unified strategy toward the stereoselective total syntheses of C-15 oxygenated drimane-type sesquiterpenoids and their analogs, which provided the natural products kuehneromycin A, antrocin, anhydromarasmone, and marasmene as a proof-of-concept study.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C5H12O2, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary