Category: 69361-41-7

Dobbs, Adrian P. published the artcileIndole radical cyclizations: a rapid route to mitosenes, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Tetrahedron Letters (1995), 36(27), 4857-60, database is CAplus.

The syntheses and radical cyclization of 2-bromoindoles carrying an unsaturated N-alkyl group is described. The radical cyclization of 1-(3-butenyl)-2-bromo-1H-indole gave 2,3-dihydro-1-methyl-1H-pyrrolo[1,2-a]indole (79% yield). The cyclization of 2-bromo-1-(4-pentenyl)-1H-indole gave 6,7,8,9-tetrahydro-9-methylpyrido[1,2-a]indole (74% yield).

Tetrahedron Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dobbs, Adrian P. published the artcileIndole radical cyclizations: a rapid route to mitosenes, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Tetrahedron Letters (1995), 36(27), 4857-60, database is CAplus.

The syntheses and radical cyclization of 2-bromoindoles carrying an unsaturated N-alkyl group is described. The radical cyclization of 1-(3-butenyl)-2-bromo-1H-indole gave 2,3-dihydro-1-methyl-1H-pyrrolo[1,2-a]indole (79% yield). The cyclization of 2-bromo-1-(4-pentenyl)-1H-indole gave 6,7,8,9-tetrahydro-9-methylpyrido[1,2-a]indole (74% yield).

Tetrahedron Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Safety of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fox, Martin E. published the artcileN-Alkenyl nitrone dipolar cycloaddition routes to piperidines and indolizidines. Part 7. Hydroxylamine-alkyne cyclizations. Formation of cyclic nitrones and application to the synthesis of the proposed structure for (±)-acacialactam, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1994), 3379-95, database is CAplus.

The cyclization of alkynylhydroxylamines to give five-, six- and seven-membered cyclic nitrones is described. A concerted intramol. ene-like pathway is proposed for the addition of the N-O-H group across the triple bond. Using 3,7-dimethyl-3,4,5,6-tetrahydro-2H-azepine 1-oxide as the starting material, the seven-membered lactam structure proposed for the natural product acacialactam was prepared and was found to be incorrect. (E)-CH₂:CHCMe(OH)CH₂CH₂CH:CMeCONH₂ is proposed as the structure for acacialactam.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mukai, Chisato published the artcileRh(I)-catalyzed allenic Pauson-Khand reaction: first construction of the bicyclo[6.3.0]undecadienone ring system, Category: bromides-buliding-blocks, the publication is Tetrahedron (2005), 61(46), 10983-10994, database is CAplus.

The Rh(I)-catalyzed Pauson-Khand reaction of allenynes afforded the bicyclo[6.3.0]undecadienones as well as their benzo and furo derivatives E.g., [RhCl(CO)₂]₂ catalyzed the Pauson-Khand reaction of CH₂:C:C(SO₂Ph)CH₂C(CO₂Me)₂(CH₂)₃CCPh to give 43% bicyclo[6.3.0] compound I. In addition, a novel [RhCl(CO)₂]₂-catalyzed [2,3]-sigmatropic rearrangement of the sulfinic ester species of propargyl alcs. was developed. E.g., [RhCl(CO)₂]₂ catalyzed the [2,3]-sigmatropic rearrangement of PhCCCH₂OSOPh to give 63% PhSO₂CPh:C:CH₂.

Tetrahedron published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rutjes, Floris P. J. T. published the artcileCyclic 1,2-dinitrogen compounds through N,N’-bis(methoxycarbonyl)hydrazinium intermediates, Product Details of C7H13BrSi, the publication is Tetrahedron Letters (1988), 29(52), 6975-8, database is CAplus.

Acid-catalyzed cyclization of methoxymethyl-substituted acyclic hydrazides provides cyclic hydrazides in moderate to good yields. E.g., MeOCH₂[N(CO₂Me)]₂(CH₂)_nCH:CH₂ (n = 1-3) were treated with TiCl₄ in CH₂Cl₂ to give 32, 80, and 15% cyclic hydrazides I (same n), resp. A mechanism involving bis(methoxycarbonyl)hydrazinium intermediates is presented.

Tetrahedron Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Negishi, Ei-ichi published the artcileA Novel, Highly Selective, and General Methodology for the Synthesis of 1,5-Diene-Containing Oligoisoprenoids of All Possible Geometrical Combinations Exemplified by an Iterative and Convergent Synthesis of Coenzyme Q₁₀, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Organic Letters (2002), 4(2), 261-264, database is CAplus and MEDLINE.

A truly general, versatile, and highly regio- and stereoselective methodol. for the synthesis of terpenoids containing 1,5-diene units of E and/or Z geometry critically involves Pd-catalyzed homoallyl- and homopropargyl-alkenyl coupling and Zr-catalyzed carboalumination of alkynes. By using this methodol., coenzyme Q₁₀ (I), (E,Z,E)-geranylgeraniol (II), and other natural or unnatural compounds have been synthesized efficiently.

Organic Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yang, Tangpo published the artcileA bifunctional amino acid to study protein-protein interactions, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is RSC Advances (2020), 10(69), 42076-42083, database is CAplus and MEDLINE.

Protein-protein interactions (PPIs) play crucial roles in regulating essentially all cellular processes. Photo-crosslinking represents a powerful method to study PPIs. To fulfil the requirements for the exploration of different PPIs, there is a continuous demand on the development of novel photo-reactive amino acids with diverse structural properties and functionalities. Reported herein is the development of a bifunctional amino acid termed dzANA, which contains a diazirine, for photo-crosslinking, and a terminal alkyne group, for bioorthogonal tagging. Using known PPIs between histone posttranslational modifications (PTMs) and their binding partners as models, we demonstrate that the dzANA-harbouring peptide-based photoaffinity probes could efficiently and selectively capture the weak and transient PPIs mediated by histone modifications. Our study indicates the potential of dzANA to identify and characterize unknown PPIs.

RSC Advances published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C11H8F2, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dickner, Tim published the artcileStereoselective synthesis and binding properties of novel concave-shaped indolizino[3,4-b]quinolines, Product Details of C7H13BrSi, the publication is Journal fuer Praktische Chemie (Weinheim, Germany) (2000), 342(8), 804-811, database is CAplus.

Novel all-cis-configurated indolizino[3,4-b]quinoline receptors I [R = Me, R¹ = H, Ph(CH₂)₃O; R² = H, PhNHCO] were prepared via diastereoselective Lewis acid-catalyzed cyclization of N-arylimines II as a key step. In order to obtain the indolizino[3,4-b]quinoline I (R = R² = H; R¹ = Cl), an N-arylimine precursor II (III; R = Me₃Si; R¹ = Cl; R² = H) was prepared in 8 steps from L-prolinol. In contrast to the known β-effect of silyl groups, cyclization of III proceeded via α-carbenium ion species to give the diastereomeric products I (R = Me₃Si; R¹ = Cl; R² = H), which were desilylated to I (R = R² = H; R¹ = Cl). The association constants for receptors I decreased in the order I (R = R² = H; R¹ = Cl) > I (R = Me; R¹ = R² = H) > I (R= Me; R¹ = H; R² = PhNHCO) > I [R = Me; R¹ = Ph(CH₂)₃O; R² = H] for both acetic acid and N-Z-phenylalanine as substrates.

Journal fuer Praktische Chemie (Weinheim, Germany) published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sommer, Stefan published the artcileSolid-phase synthesis of [5.5]-spiroketals, Synthetic Route of 69361-41-7, the publication is Advanced Synthesis & Catalysis (2008), 350(11+12), 1736-1750, database is CAplus.

An efficient and reliable multi-step synthesis of 251 natural product-like [5.5]-spiroketals on solid supports has been developed. As central key step, a double intramol. hetero-Michael (DIHMA) reaction to alkynones was applied. The sequence allows for introduction of numerous substituents on the scaffold and for variation of stereochem. [5.5]-Spiroketals bearing an addnl. ketone were obtained in high overall yields. Further diversification was achieved by reduction of the ketone and reductive amination using polymer-supported borohydride, Grignard reaction and conversion to oxime derivatives in the solution phase.

Advanced Synthesis & Catalysis published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C15H12O6, Synthetic Route of 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sun, Jianwei published the artcileBronsted Acid-Promoted Cyclizations of 1-Siloxy-1,5-diynes, COA of Formula: C7H13BrSi, the publication is Journal of the American Chemical Society (2005), 127(39), 13512-13513, database is CAplus and MEDLINE.

The 1st HNTf₂-promoted 5-endo-dig cyclizations of 1-siloxy-1,5-diynes was developed, which proceed with concomitant formation of C-Hal bonds as a result of halide abstraction from a halocarbon by the intermediate alkenyl cation. E.g., reaction of RCH₂CCCH₂CH₂CCOTIPS (OTIPS = triisopropylsilanolato, R = n-C₇H₁₅) with HNTf₂/CH₂Cl₂ at -78° and allowed to warm to room temperature to give 70% yield of 2-(1-chloro-2-R-ethylidene)cyclopentanone. This process is enabled by a chemoselective activation of the more electron-rich siloxy alkyne moiety of the diyne cyclization precursor and represents an efficient and highly diastereoselective method for assembly of a range of β-halo enones.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C6H5F4NO3S, COA of Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary