Category: 69361-41-7

Kolundzic, Filip published the artcileA Cyclization-Rearrangement Cascade for the Synthesis of Structurally Complex Chiral Gold(I)-Aminocarbene Complexes, SDS of cas: 69361-41-7, the publication is Angewandte Chemie, International Edition (2014), 53(31), 8122-8126, database is CAplus and MEDLINE.

A facile synthesis of chiral cyclic alkyl aminocarbene-Au(I) complexes from Au-free 1,7-enyne substrates was developed. The novel cyclization-rearrangement reaction sequence is triggered by the addition of (Me₂S)AuCl to different 1,7-enynes and leads to structurally unique carbene-Au(I) complexes in high yields. These novel complexes are catalytically active and inhibit the proliferation of different human cancer cell lines.

Angewandte Chemie, International Edition published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, SDS of cas: 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Prakash, Chandran published the artcileSynthesis of angularly fused carbocycles via tandem radical cyclization of α-carbonyl radicals, Category: bromides-buliding-blocks, the publication is European Journal of Organic Chemistry (2008), 1535-1543, database is CAplus.

An α-carbonyl radical cyclization approach towards the synthesis of angularly fused tricyclic systems is described. On reduction with tributyltin hydride, bromo ketones yield a α-carbonyl radical that undergoes successive 5-exo-dig/trig cyclizations, resulting in two or four contiguous stereocenters.

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hintz, Sandra published the artcileRegio- and stereoselective cyclization reactions of unsaturated silyl enol ethers by photoinduced electron transfer. Mechanistic aspects and synthetic approach, Product Details of C7H13BrSi, the publication is European Journal of Organic Chemistry (1998), 1583-1596, database is CAplus.

Oxidative photoinduced electron transfer (PET) reactions were performed with various silyl enol ethers and silyloxy-2H-chromones bearing an olefinic or silylacetylenic side-chain. The reactions result in regioselective ring-closure with the formation of bi- to tetracyclic ring systems with a well-defined ring juncture, e.g. perhydrophenanthrenones or benzo-annelated xanthenones. Our investigations have focussed on the optimization of this cyclization method with regard to irradiation time and product yield. The irradiation times could be reduced by using the cosensitized PET method. Modifying the substrate at the silyl group led to enhanced yields. In addition, it was found that solvent and pressure dependences are important tools, allowing control of the regiochem. Both the synthesis of 6-endo products by radical cationic reaction pathways as well as 5-exo ring-closure by radical intermediates was achieved. Mechanistic details, including findings from deuterium labeling experiments, are discussed.

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Negishi, Eiichi published the artcileSelective carbon-carbon bond formation via transition metal catalysis. 35. A convenient synthesis of unsymmetrical bibenzyls, homoallylarenes, and homopropargylarenes via palladium-catalyzed cross coupling, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Tetrahedron Letters (1983), 24(36), 3823-4, database is CAplus.

The Pd-catalyzed homobenzyl-aryl, homobenzyl-alkenyl, homoallyl-aryl, and homopropargyl-aryl cross coupling reactions provide the desired coupling products, 2-MeC₆H₄CH₂CH₂Ph, (E)-PhCH₂CH₂CH:CMe(CH₂)₅Me, 4-NCC₆H₄CH₂CH₂CH:CH₂, Me₃SiCCCH₂CH₂Ph, in high yields. Similar reactions involving alkynyl halides lead to low product yields.

Tetrahedron Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rinderhagen, Heiko published the artcileSynthetic applications in radical/radical cationic cascade reactions, COA of Formula: C7H13BrSi, the publication is Chemistry – A European Journal (2004), 10(4), 851-874, database is CAplus and MEDLINE.

Oxidative photoinduced electron transfer (PET) reactions have been performed with various cyclic cyclopropyl(vinyl) silyl ethers bearing an olefinic or acetylenic side chain. The reactions result in bi- to tetracyclic ring systems via a fragmentation-radical/radical cationic addition reaction pathway with well defined ring juncture. The mode of cyclization (endo/exo) can be partially controlled by addition of nucleophiles due to the suppression of radical cationic reaction pathways. Quantum chem. calculation of the cyclization transition states underline the exptl. found selectivities. Addnl. mechanistic studies concerning the saturation step reveal that the final radical is saturated mostly by the solvent and traces of water in the solvent.

Chemistry – A European Journal published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, COA of Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Krylov, Ivan M. published the artcileAccess to Functionalized α-Trifluoromethyl-α-aminophosphonates via Intermolecular Ene-Yne Metathesis, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Synlett (2014), 25(18), 2624-2628, database is CAplus.

An efficient approach to a new family of highly functionalized P analogs of α-trifluoromethyl-substituted phenylalanine and its homologues using ruthenium-catalyzed intermol. ene-yne metathesis as a key step of the reaction sequence has been developed. The method includes cross metathesis of α-alkynyl-α-trifluoromethyl-α-aminophosphonates with alkenes under catalysis by second-generation Grubbs carbene complex to afford the corresponding aminophosphonates with 1,3-diene backbone followed by one-pot Diels-Alder reaction-aromatization step.

Synlett published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Simon, Meike published the artcileDiastereoselective Intramolecular Carbolithiations of Stereodefined Secondary Alkyllithiums Bearing a Remote Alkynylsilane, Application In Synthesis of 69361-41-7, the publication is Organic Letters (2018), 20(12), 3518-3521, database is CAplus and MEDLINE.

Various secondary alkyl iodides bearing a remote alkynylsilane underwent intramol. carbolithiations triggered by an I/Li-exchange performed at -100° using t-BuLi (2.5 equiv). The resulting alkenyllithiums were stereoselectively converted to tetrasubstituted cyclopentane exo-alkylidenes. After Pd-catalyzed hydrogenation, cyclopentanes and cis-bicyclo[4.3.0]nonanes were obtained with stereocontrol of four contiguous centers.

Organic Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C4H5ClN2S, Application In Synthesis of 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

O’Brien, Christopher J. published the artcileTowards the rational design of palladium-N-heterocyclic carbene catalysts by a combined experimental and computational approach, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Tetrahedron (2005), 61(41), 9723-9735, database is CAplus.

A combined exptl. and computational approach towards the development of Pd-NHC catalysts is described. A range of benzimidazolylidinium ligands incorporating electron-rich and electron-poor substituents were prepared and evaluated in the Suzuki reaction. The most electron-rich ligand showed the highest catalytic activity. Based on this information, the first alkyl-alkyl Negishi cross-coupling reaction protocol was developed. Evaluation of N,N’-diaryl-(4,5-dihydro)imidazolylidinium ligands showed a strong dependence on the steric topog. around the metal center. A computational study of the most active ligand in the Negishi reaction, its Pd(0) and PdCl₂-complexes and related structures were modeled at the B3LYP/DZVP and HF/3-21G levels of theory. The potential energy hypersurfaces flattened with increase in ligand size. Binding energies were computed for carbene/Pd(0) adducts (in the range âˆ?1-40 kcal mol^-1), roughly double that for PH₃ (âˆ?6 kcal mol^-1). Weak intramol. interactions were found using AIM analyses.

Tetrahedron published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hadei, Niloufar published the artcileThe First Negishi Cross-Coupling Reaction of Two Alkyl Centers Utilizing a Pd-N-Heterocyclic Carbene (NHC) Catalyst, SDS of cas: 69361-41-7, the publication is Organic Letters (2005), 7(17), 3805-3807, database is CAplus and MEDLINE.

The development of an NHC-based system capable of cross-coupling sp³-sp³ centers in high yield has been a long-standing challenge. This communication describes the use of a Pd-NHC catalytic system that achieves room-temperature Negishi cross-couplings of unactivated, primary bromides and alkyl organozinc reagents with a variety of functionality. E.g., alkyl-alkyl Negishi cross-coupling of PhCH₂CH₂CH₂Br and BuZnBr in presence of Pd₂(dba)₃ and 1,3-bis(2,6-diisopropylphenyl)imidazolium chloride gave up to 75% heptylbenzene.

Organic Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, SDS of cas: 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hadei, Niloufar published the artcileRoom-Temperature Negishi Cross-Coupling of Unactivated Alkyl Bromides with Alkyl Organozinc Reagents Utilizing a Pd/N-Heterocyclic Carbene Catalyst, COA of Formula: C7H13BrSi, the publication is Journal of Organic Chemistry (2005), 70(21), 8503-8507, database is CAplus and MEDLINE.

A high-yielding cross-coupling reaction of unactivated alkyl bromides possessing β-hydrogens with alkylzinc halides utilizing a Pd/N-heterocyclic carbene (NHC) catalyst at room temperature is described. A variety of Pd sources, Pd₂(dba)₃, Pd(OAc)₂, or PdBr₂, with the com. available ligand precursor 1,3-bis(2,6-diisopropylphenyl)imidazolium chloride successfully coupled 1-bromo-3-phenylpropane with n-butylzinc bromide in THF/NMP. An investigation of different NHC precursors showed that the bulky 2,6-diisopropylphenyl moiety was necessary to achieve high coupling yields (75-85%). The corresponding Et analog was moderately active (11%). A range of unsym. NHC precursors were prepared and evaluated. The ligand precursor containing one 2,6-diisopropylphenyl and one 2,6-diethylphenyl afforded the coupling product in 47% yield, clearly suggesting a direct relationship between the steric topog. created by the flanking N-substituents and catalyst activity. Under optimal conditions, a number of alkyl bromides and alkylzinc halides possessing common functional groups (amide, nitrile, ester, acetal, and alkyne) were effectively coupled (61-92%). It is noteworthy that β-substituted alkyl bromides and alkylzinc halides successfully underwent cross-coupling. Also, under these conditions alkyl chlorides were unaffected.

Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, COA of Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary