Category: 69361-41-7

Li, Lin published the artcileA Small-Molecule Probe for Selective Profiling and Imaging of Monoamine Oxidase B Activities in Models of Parkinson’s Disease, Product Details of C7H13BrSi, the publication is Angewandte Chemie, International Edition (2015), 54(37), 10821-10825, database is CAplus and MEDLINE.

The design of the first dual-purpose activity-based probe of monoamine oxidase B (MAO-B) is reported. This probe is highly selective towards MAO-B, even at high MAO-A expression levels, and could sensitively report endogenous MAO-B activities by both in situ proteome profiling and live-cell bioimaging. With a built-in imaging module as part of the probe design, the probe was able to accomplish what all previously reported MAO-B imaging probes failed to do thus far: the live-cell imaging of MAO-B activities without encountering diffusion problems.

Angewandte Chemie, International Edition published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Caporusso, Anna Maria published the artcileStereoselective Synthesis of Chiral 3-Aryl-1-alkynes from Bromoallenes and Heterocuprates, Synthetic Route of 69361-41-7, the publication is Journal of Organic Chemistry (2006), 71(5), 1902-1910, database is CAplus and MEDLINE.

The synthesis of racemic and chiral 3-aryl-1-alkynes HCCCR¹R²R³ (R¹ = H, Me; R² = Me, Et, Me₃C; R³ = Ph, 2-EtC₆H₄, 4-MeOC₆H₄, 1-naphthyl, etc.) via cross-coupling of 3-alkyl- and 3,3-dialkyl-1-bromo-1,2-dienes R¹R²C:C:CHBr and arylbromocuprates (R³CuBr)MgBr·LiBr was examined With phenylcopper reagents and its para-substituted derivatives, as well as with 2-naphthyl cuprates, the reaction gave 3-aryl-1-alkynes with high regioselectivity and in good yields. On the contrary, when ortho-substituted Ph reagents and 1-naphthyl cuprates were used, the regioselectivity of the process was very dependent upon the steric requirements of the alkyl substituents on the bromoallenic substrate. When the steric bulk was increased, remarkable quantities of isomeric arylallenes R¹R²C:C:CHR³ were also observed in the reaction mixtures The high 1,3-anti stereoselectivity of the coupling process allowed us to obtain enantiomerically enriched 3-aryl-1-alkynes from optically active allenic substrates, thus indicating a simple pathway toward the synthesis of quaternary stereogenic centers characterized by an aryl group. A possible cross-coupling mechanism was also suggested to explain the regio- and stereochem. data. For the preparation of ω-functionalized 3-phenyl-1-alkynes R⁴CHPhCCH [R⁴ = H₂C:CH(CH₂)₂, Me₃SiCC(CH₂)₂, HO(CH₂)₃], the reaction of 1-bromo-3-phenylpropadiene with Knochel reagents R⁵Cu(CN)ZnCl·2LiCl [R⁵ = H₂C:CH(CH₂)₂, Me₃SiCC(CH₂)₂, ClMgO(CH₂)₃] was also studied; this reaction led to the acetylenic compounds in high yields mainly when the R⁵ group on the copper reagent was primary.

Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Synthetic Route of 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhu, Jing published the artcileSynthesis of 2,3-Dialkylated Tartaric Acid Esters via Visible Light Photoredox-Catalyzed Reductive Dimerization of α-Ketoesters, Computed Properties of 69361-41-7, the publication is ACS Omega (2017), 2(8), 4665-4677, database is CAplus and MEDLINE.

A mild transition-metal-free protocol to prepare 2,3-dialkylated tartaric acid esters has been developed by taking advantage of a visible light photoredox-catalyzed reductive dimerization of α-ketoesters with a combination of an organic dye photocatalyst and a Hantzsch-type 1,4-dihydropyridine hydrogen donor. A broad range of functional groups including cyclopropane, alkene, alkyne, 4-methoxybenzyl ether, acetal, silyl ether, carbamate, cyclic ether, cyclic thioether, bromoalkane, and N-alkoxyphthalimide are well-compatible. By employing the visible light photoredox-catalyzed reductive coupling and the subsequent optical resolution, both enantioenriched diastereomers of 2,3-dialkylated tartaric acid could be acquired conveniently.

ACS Omega published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C24H29N5O3, Computed Properties of 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Luo, Yiyang published the artcileTotal Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Journal of Antibiotics (2019), 72(6), 482-485, database is CAplus and MEDLINE.

The resorcylic macrolides are important natural products with a wide range of remarkable biol. activities. So far, most of the reported resorcylic macrolide syntheses use either macrolactonization or ring closing metathesis to build the corresponding macrocycle. In continuation of our efforts in developing novel carbonylation reactions to facilitate natural product total synthesis, we report herein a total synthesis of trans-resorcylide (I) featuring a palladium-catalyzed macrocyclic Stille carbonylation to build its 12-membered macrocycle.

Journal of Antibiotics published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Manabe, Takao published the artcileNew Examples of 1,6- and 1,7-Hydrogen Transfer Promoted by an α-Silyl Group in Rhodium(I)-Catalyzed Radical Reactions of Acyclic Enediynes, SDS of cas: 69361-41-7, the publication is Organometallics (1998), 17(14), 2942-2944, database is CAplus.

A Rh(I) catalyst triggers cycloaromatization of ω-trialkylsilylated acyclic enediynes to afford benzosilacycloalkane or vinylsilane products via 1,6- and/or 1,7-H transfer, presumably effected by radical stabilization by an α-silyl moiety and via a seven- and/or eight-membered rhodacycle intermediate. The addition of a catalytic amount of di-Me maleate is essential to obtain better yields of the products.

Organometallics published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, SDS of cas: 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Stork, Gilbert published the artcileThe Total Synthesis of a Natural Cardenolide: (+)-Digitoxigenin, Product Details of C7H13BrSi, the publication is Journal of the American Chemical Society (1996), 118(43), 10660-10661, database is CAplus.

The authors report the total synthesis of natural (+)-digitoxigenin (I), the biol. active cardenolide which, as its trisaccharide derivative digitoxin, is one of the most frequently used of the active principles isolated from Digitalis species. I was prepared from chiral decalone II via octahydrophrenanthrenone III (TBS = Me₃CSiMe₂) and steroidal aldehyde IV.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C17H37NO3, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Brase, Stefan published the artcileIntramolecular Heck couplings and cycloisomerizations of bromodienes and enynes with 1′,1′-disubstituted methylenecyclopropane terminators: Efficient syntheses of [3]dendralenes, Application In Synthesis of 69361-41-7, the publication is European Journal of Organic Chemistry (2005), 4167-4178, database is CAplus.

2-Bromoalka-1,n-dienes, e.g. I, with tetrasubstituted methylenecyclopropane end groups, under palladium catalysis, underwent cyclization with cyclopropane-ring opening to give 2-ethenyl-3-methylene-1-cycloalkenes, e.g. II, which are substituted monocyclic [3]dendralenes. The same cross-conjugated trienes were isolated in good to excellent yields (77-92 %) from the corresponding 1,6- (e.g. III) and 1,7-enynes by a more atom-economic, palladium-catalyzed cycloisomerization. The vinylpalladium halide intermediate generated by initial carbopalladation of the 1,6-enyne III with in situ generated phenylpalladium iodide also underwent the same cyclization cascade to yield the correspondingly phenyl-substituted cyclic [3]dendralene. The palladium-catalyzed cycloisomerization of an alk-1-ene-7,12-diyne gave the bicyclic cross-conjugated tetraene. Key features of the mechanism of the palladium-catalyzed cycloisomerization were proved using a specially designed model system. Like other cyclic [3]dendralenes, the ethenyl(methylene)cycloheptene IV underwent a domino-Diels-Alder reaction with N-phenyltriazoline-3,5-dione to give a single diastereomer of the pentacyclic heterocycle.

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application In Synthesis of 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hellenbrand, Tim published the artcileConjugate addition of organomagnesium cuprates to guvacine derivatives, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is European Journal of Organic Chemistry (2014), 2014(20), 4398-4409, database is CAplus.

The synthesis of 4-substituted piperidine-3-carboxylates was achieved by conjugate addition of organomagnesium cuprates to N-Me and N-tert-butoxycarbonyl guvacine derivatives Good to excellent yields were obtained with primary Grignard reagents containing alkyl, alkenyl, alkynyl, or masked aldehyde groups in a copper(I)-trimethylsilylacetylide-catalyzed and Me₃SiCl-mediated procedure.

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sokolsky, Alexander published the artcileSpirastrellolide E: synthesis of an advanced C(1)-C(24) southern hemisphere, Formula: C7H13BrSi, the publication is Tetrahedron Letters (2015), 56(23), 3160-3164, database is CAplus and MEDLINE.

The synthesis of a C(1)-C(24) advanced southern hemisphere fragment (I) towards the total synthesis of spirastrellolide E has been achieved. Highlights of the route include a highly convergent Type I Anion Relay Chem. (ARC) tactic for fragment assembly, in conjunction with a directed, regioselective gold-catalyzed alkyne functionalization to generate the central unsaturated [6,6]-spiroketal.

Tetrahedron Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C5H9IO2, Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Qu, Yongzheng published the artcileAsymmetric Total Synthesis of (+)-Waihoensene, Quality Control of 69361-41-7, the publication is Journal of the American Chemical Society (2020), 142(14), 6511-6515, database is CAplus and MEDLINE.

The asym. total synthesis of (+)-waihoensene (I), which has a cis-fused [6,5,5,5] tetracyclic core bearing an angular triquinane, a cis-fused six-membered ring, and four contiguous quaternary carbon atoms, was achieved through a sequence of chem. reactions in a stereochem. well-defined manner. The total synthesis features the following: (1) Cu-catalyzed asym. conjugated 1,4-addition; (2) diastereoselective Conia-ene type reaction; (3) diastereoselective intramol. Pauson-Khand reaction; (4) Ni-catalyzed diastereoselective conjugated 1,4-addition; and (5) radical-initiated intramol. hydrogen atom transfer (HAT). Control experiments and d. functional theory calculations support the proposed HAT process.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Quality Control of 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary