Category: 69361-41-7

Szostak, Michal published the artcileSelective Reduction of Barbituric Acids Using SmI₂/H₂O: Synthesis, Reactivity, and Structural Analysis of Tetrahedral Adducts, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Angewandte Chemie, International Edition (2013), 52(48), 12559-12563, database is CAplus and MEDLINE.

Monoredn. of barbituric acids using SmI₂ was reported. The radicals formed by one-electron reduction of the amide bond have been applied in intramol. additions to alkenes. The cyclic hemiaminal products are analogous to tetrahedral intermediates derived from amide addition reactions and are formed in a formal polarity reversal event.

Angewandte Chemie, International Edition published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C10H15ClO3S, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Trost, Barry M. published the artcileRuthenium-Catalyzed Cycloisomerizations of Diynols, Category: bromides-buliding-blocks, the publication is Journal of the American Chemical Society (2005), 127(13), 4763-4776, database is CAplus and MEDLINE.

A wide variety of diynols containing tertiary, secondary, and primary propargylic alcs. undergo a cycloisomerization reaction to form dienones and dienals in the presence of a catalytic amount of [CpRu(CH₃CN)₃]PF₆. The formation of five- and six-membered rings is possible using this methodol. E.g., [CpRu(CH₃CN)₃]PF₆ catalyzed the cycloisomerization of diynol I to give 45% dienal II. Secondary diynols react to form single geometrical isomeric dienones and dienals. Primary diynols undergo a cycloisomerization as well as a hydrative cyclization process. The utility of primary diynol cycloisomerization is demonstrated in a synthesis of (+)-α-kainic acid.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C12H12F3N5O2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lawson, Kenneth V. published the artcileSynthesis of a designed sesquiterpenoid that forms useful composites with peptides and related oligomers, Category: bromides-buliding-blocks, the publication is Tetrahedron Letters (2011), 52(6), 653-654, database is CAplus.

Efficient desymmetrization of isophthalaldehyde allows a scalable asym. synthesis of cinnamylated sesquiterpenoid I. We have shown that I forms useful, property-altered composites with peptides and related oligomers. The current synthesis promises to expand those efforts considerably.

Tetrahedron Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lee, Yujin published the artcileAn Asymmetric Pathway to Dendrobine by a Transition-Metal-Catalyzed Cascade Process, Category: bromides-buliding-blocks, the publication is Angewandte Chemie, International Edition (2017), 56(40), 12250-12254, database is CAplus and MEDLINE.

An asym. pathway to the caged tetracyclic pyrrolidine alkaloid, dendrobine (I), is reported. The successful synthetic strategy features a one-pot, sequential palladium-catalyzed enyne cycloisomerization and rhodium-catalyzed diene-assisted pyrrolidine formation by allylic CH activation. The developed transition-metal-catalyzed cascade process permits rapid access to the dendrobine core structure II and circumvents the handling of labile intermediates. An intramol. aldol condensation under carefully defined reaction conditions takes place with a concomitant detosylation, followed by reductive amine methylation, to afford a late-stage intermediate (previously identified by several prior dendrobine syntheses) in only 10 synthetic steps overall.

Angewandte Chemie, International Edition published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nicolaou, K. C. published the artcile12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Journal of the American Chemical Society (2017), 139(21), 7318-7334, database is CAplus and MEDLINE.

The synthesis and biol. evaluation of a series of 12,13-aziridinyl epothilone B analogs is described. These compounds were accessed by a practical, general process that involved a 12,13-olefinic Me ketone as a starting material obtained by ozonolytic cleavage of epothilone B followed by tungsten-induced deoxygenation of the epoxide moiety. The attachment of the aziridine structural motif was achieved by application of the Ess-Kurti-Falck aziridination, while the heterocyclic side chains were introduced via stereoselective phosphonate-based olefinations. In order to ensure high (E) selectivities for the latter reaction for electron-rich heterocycles, it became necessary to develop and apply an unprecedented modification of the venerable Horner-Wadsworth-Emmons reaction, employing 2-fluoroethoxyphosphonates that may prove to be of general value in organic synthesis. These studies resulted in the discovery of some of the most potent epothilones reported to date. Equipped with functional groups to accommodate modern drug delivery technologies, some of these compounds exhibited picomolar potencies that qualify them as payloads for antibody drug conjugates (ADCs), while a number of them revealed impressive activities against drug resistant human cancer cells, making them desirable for potential medical applications.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Earle, Martyn J. published the artcileSynthesis and evaluation of a designed inhibitor for nonactin biosynthesis in S. griseus ETH A7796, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Bioorganic & Medicinal Chemistry Letters (1997), 7(17), 2187-2192, database is CAplus.

A designed suicide inhibitor of a postulated, enzyme-catalyzed step in the biosynthesis of the macrotetrolide antibiotic nonactin was synthesized and evaluated in vivo. The inhibitor reduced the rate of nonactin biosynthesis by >75% while affecting neither biomass production nor the synthesis of other secondary metabolites. The role of the inhibitor in nonactin biosynthesis is discussed.

Bioorganic & Medicinal Chemistry Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Application of (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Harwood, Stephen J. published the artcileModular terpene synthesis enabled by mild electrochemical couplings, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Science (Washington, DC, United States) (2022), 375(6582), 745-752, database is CAplus and MEDLINE.

The synthesis of terpenes is a large field of research that is woven deeply into the history of chem. Terpene biosynthesis is a case study of how the logic of a modular design can lead to diverse structures with unparalleled efficiency. This work leverages modern nickel-catalyzed electrochem. sp²-sp³ decarboxylative coupling reactions, enabled by silver nanoparticle-modified electrodes, to intuitively assemble terpene natural products and complex polyenes by using simple modular building blocks. The step change in efficiency of this approach is exemplified through the scalable preparation of 13 complex terpenes, which minimized protecting group manipulations, functional group interconversions, and redox fluctuations. The mechanistic aspects of the essential functionalized electrodes are studied in depth through a variety of spectroscopic and anal. techniques. Safety: numerous safety warnings are provided, including hazards associated with RVC dust and pyrophoric Pd/C catalysts.

Science (Washington, DC, United States) published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Booker-Milburn, Kevin I. published the artcileTandem ring expansion-cyclization reactions: a novel method for the rapid construction of the bicyclo[5.3.0]decane ring system, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Synlett (1992), 809-10, database is CAplus.

Treatment of the cyclopropyl silyl ether I with ferric chloride in DMF gave the 5,7-bicyclic chloro ketone II via a tandem free radical ring expansion-cyclization sequence. The acetylenic derivatives III (R = SiMe₃, CO₂Me) underwent the same expansion-cyclization sequence to yield similar 5,7-carbocycles.

Synlett published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Snider, Barry B. published the artcileControl of the regioselectivity of oxidative free-radical cyclizations by addition to haloalkenes, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Journal of Organic Chemistry (1992), 57(15), 4195-205, database is CAplus.

Chlorine substituents on the alkene control the regioselectivity of the cyclization of 5-hexenyl or 6-heptenyl radicals generated by oxidation of an acetoacetate ester or 1,3-diketone with Mn(OAc)₃·2H₂O. 6-exo-Cyclization of the radicals obtained by oxidation of benzoylacetone derivatives RCOCH₂CO(CH₂)₃CH:CHCl [R = Ph, 2,4-(MeO)₂C₆H₃], containing a chlorine on the terminal double bond carbon, gives α-chloroalkyl radicals that add to the aromatic ring which by elimination of HCl leads to naphthols I (R¹ = H, OMe) indicating that this reaction may be useful for aureolic acid synthesis . exo-Cyclization is the exclusive process with acetoacetates e.g., CH₂:CHCH₂CH(CO₂Me)CO(CH₂)₂CH:CHCl, containing a chlorine on the terminal double bond carbon. 6-endo-Cyclization is the exclusive process with acetoacetates e.g., CH₂:CHCH₂CH(CO₂Me)CO(CH₂)₂CCl:CH₂, containing a chlorine on the internal double bond carbon. Intra- and intermol. competition experiments indicate that these effects are primarily steric. The chlorine substituent controls the regioselectivity of the cyclization by sterically hindering attack of the radical on the chlorine bearing double bond carbon thereby retarding formation of the β-chloroalkyl radical. The chlorine substituent does not electronically accelerate attack on the other end of the double bond to give the α-chloroalkyl radical.

Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H5Br2F, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Wentian published the artcileDesign and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC), SDS of cas: 69361-41-7, the publication is Journal of Medicinal Chemistry (2019), 62(10), 5217-5241, database is CAplus and MEDLINE.

Despite advances in targeted anticancer therapies, there are still no small-mol.-based therapies available that specifically target colorectal cancer (CRC) development and progression, the second leading cause of cancer deaths. We previously disclosed the discovery of truncating adenomatous polyposis coli (APC)-selective inhibitor 1 (TASIN-1), a small mol. that specifically targets colorectal cancer cells lines with truncating mutations in the adenomatous polyposis coli (APC) tumor suppressor gene through inhibition of cholesterol biosynthesis. Here, we report a medicinal chem. evaluation of a collection of TASIN analogs and activity against colon cancer cell lines and an isogenic cell line pair reporting on the status of APC-dependent selectivity. A number of potent and selective analogs were identified, including compounds with good metabolic stability and pharmacokinetic properties. The compounds reported herein represent a first-in-class genotype-selective series that specifically target apc mutations present in the majority of CRC patients and serve as a translational platform toward a targeted therapy for colon cancer.

Journal of Medicinal Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C14H26O2, SDS of cas: 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary