6911-87-1 Archives - Page 7 of 15 - Bromides-buliding-blocks

Luo, Zhenli team published research in Green Chemistry in 2021 | 6911-87-1

6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., Safety of 4-Bromo-N-methylaniline

Organic compounds having carbon bonded to bromine are called organic bromides. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Safety of 4-Bromo-N-methylaniline.

Luo, Zhenli;Pan, Yixiao;Yao, Zhen;Yang, Ji;Zhang, Xin;Liu, Xintong;Xu, Lijin;Fan, Qing-Hua research published 《 BF₃·Et₂O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant》, the research content is summarized as follows. A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF₃·Et₂O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug mols. and biol. relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atm. or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF₃ and hydride transfer from formic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ma, Ben team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | 6911-87-1

Quality Control of 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 6911-87-1, formula is C7H8BrN, The most pervasive is the naturally produced bromomethane. Quality Control of 6911-87-1

Ma, Ben;Sun, Rongxia;Yang, Jingya research published 《 Cobalt-catalyzed direct α-hydroxymethylation of amides with methanol as a C1 source》, the research content is summarized as follows. Herein, a cobalt-catalyzed α-hydroxymethylation of amides RCH₂C(O)NR¹R² [R = Ph, 3-methoxyphenyl, thiophen-2-yl, etc.; R¹ = Me, Et, Ph; R² = Me, 2-fluorophenyl, 3-methylphenyl, etc.; R¹R² = -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-] and 1-(2,3-dihydro-1H-indol-1-yl)-2-phenylethan-1-one with methanol under mild conditions was reported. Using CoCl₂.6H₂O as an inexpensive and efficient catalyst, some important bioactive β-hydroxyamides RCHCH₂(OH)C(O)NR¹R² and 3-hydroxy-1-(indolin-1-yl)-2-phenylpropan-1-one were obtained in moderate to excellent yields. The developed method features a wide substrate scope and good functional group tolerance. In addition, anticholinergic tropicamide was easily synthesized in this way.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Peng team published research in Journal of Catalysis in 2021 | 6911-87-1

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline, Synthetic Route of 6911-87-1

Liu, Peng;Yang, Jiazhi;Ai, Yao;Hao, Shushu;Chen, Xiaozhong;Li, Feng research published 《 Recyclable covalent triazine framework-supported iridium catalyst for the N-methylation of amines with methanol in the presence of carbonate》, the research content is summarized as follows. An iridium complex Cp*Ir@CTF, which is synthesized by the coordinative immobilization of [Cp*IrCl₂]₂ on a functionalized covalent triazine framework (CTF), was found to be a general and highly efficient catalyst for the N-methylation of amines RNH₂ [R = octyl, adamantan-1-yl, naphthalen-2-yl, 1,3-benzoxazol-2-yl, etc.], 1,2,3,4-tetrahydroisoquinoline and 1,3-bis(4-piperidyl)propane with methanol in the presence of carbonate. Under environmentally benign conditions, a variety of desirable products RNHCH₃, RN(CH₃)₂, 2-methyl-1,2,3,4-tetrahydroisoquinoline and 1-methyl-4-(3-(1-methylpiperidin-4-yl)propyl)piperidine/R¹S(O)₂NH(CH₃) (R¹ = t-Bu, cyclopropyl, 4-chlorophenyl, thiophen-2-yl, etc.) were obtained in high yields with complete selectivities and functional group friendliness. Furthermore, the synthesized catalyst Cp*Ir@CTF could be recycled by simple filtration without obvious loss of catalytic activity after sixth cycle. Notably, this research exhibited the potential of covalent triazine framework-supported transition metal catalyst Cp*Ir@CTF for hydrogen autotransfer process.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Peng team published research in Journal of Organic Chemistry in 2021 | 6911-87-1

Recommanded Product: 4-Bromo-N-methylaniline, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Liu, Peng;Tung, Nguyen Thanh;Xu, Xiangchao;Yang, Jiazhi;Li, Feng research published 《 N-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H₂O)]》, the research content is summarized as follows. A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H₂O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover,a series of sensitive substituents such as nitro, ester, cyano and vinyl groups were tolerated under present conditions. It was confirmed that OH units in the ligand were crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen auto-transfer process.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Zhaosheng team published research in ACS Catalysis in 2021 | 6911-87-1

Liu, Zhaosheng;Zhong, Shuai;Ji, Xiaochen;Deng, Guo-Jun;Huang, Huawen research published 《 Hydroarylation of Activated Alkenes Enabled by Proton-Coupled Electron Transfer》, the research content is summarized as follows. Hydroarylation of alkenes has been demonstrated to be an atom-economic approach to access functionalized arenes from easily accessible raw materials. Herein, we report a visible light-induced photocatalytic system that enables intramol. hydroarylation of N-arylacrylamides with high 5-exo-trig selectivity through robust proton-coupled electron transfer (PCET). This mild hydroarylation protocol provides a straightforward entry to structurally valuable oxindoles and complements previously established 6-endo-trig cyclization by photochem. triplet energy transfer (TET).

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Zhaosheng team published research in Organic Letters in 2022 | 6911-87-1

Related Products of 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Liu, Zhaosheng;Zhong, Shuai;Ji, Xiaochen;Deng, Guo-Jun;Huang, Huawen research published 《 Photoredox Cyclization of N-Arylacrylamides for Synthesis of Dihydroquinolinones》, the research content is summarized as follows. Metal- and additive-free photoredox cyclization of N-arylacrylamides was herein reported that provided a concise access to the formation of dihydroquinolinones. In this protocol, sustainable visible light was used as the energy source, and the organic light-emitting mol. 4CzIPN served as the efficient photocatalyst. This reaction system features exclusive 6-endo-trig cyclization selectivity with a generally good yield of a range of functionalized dihydroquinolinones and dihydrobenzoquinolinones. Mechanistical studies reveal the feasibility of both 1,3-H shift and intersystem crossing of the diradical intermediate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liu, Hongyao team published research in Cell Proliferation in 2021 | 6911-87-1

HPLC of Formula: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Liu, Hongyao;Wu, Xiuli;Gan, Cailing;Wang, Liqun;Wang, Guan;Yue, Lin;Liu, Zhihao;Wei, Wei;Su, Xingping;Zhang, Qianyu;Tan, Zui;Yao, Yuqin;Ouyang, Liang;Yu, Luoting;Ye, Tinghong research published 《 A novel multikinase inhibitor SKLB-YTH-60 ameliorates inflammation and fibrosis in bleomycin-induced lung fibrosis mouse models》, the research content is summarized as follows. Idiopathic pulmonary fibrosis (IPF) is marked by the excessive accumulation of extracellular matrix, which participates in a variety of chronic diseases or injuries and seriously threatens human health. Due to the side effects of clin. drugs, there is still a need to develop novel and less toxic drugs to treat pulmonary fibrosis. SKLB-YTH-60 was developed through computer-aided drug design, de novo synthesis and high-throughput screening. We employed the bleomycin (BLM)-induced lung fibrosis animal models and used TGF-β₁ to induce the epithelial-mesenchymal transition (EMT) of A549 cells in vitro. Meanwhile, the protein expression of collagen I and the α-smooth muscle actin (α-SMA), E-cadherin, p-FGFR1, p-PLCγ, p-Smad2/3 and p-Erk1/2 was detected by western blot. YTH-60 has obvious anti-proliferative activity on fibroblasts and A549 cells. Moreover, YTH-60 could impair the EMT of A549 cells and suppressed fibrosis by inhibiting FGFR and TGF-β/Smad-dependent pathways. I.p. administration of preventive YTH-60 could significantly reduce the degree of fibrosis in mice and regulate the imbalance of the immune microenvironment. In addition, we observed that therapeutic YTH-60 treatment attenuated fibrotic changes in mice during the period of fibrosis. Importantly, YTH-60 has shown an acceptable oral bioavailability (F = 17.86%) and appropriate eliminated half-life time (T_1/2 = 8.03 h). Taken together, these preclin. evaluations suggested that YTH-60 could be a promising drug candidate for treating IPF.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Yigao team published research in Organic Letters in 2022 | 6911-87-1

Li, Yigao;Ren, Xiaohuang;Chen, Yi;Zhu, Xinju;Hao, Xin-Qi;Song, Mao-Ping research published 《 Fe(III)-Catalyzed N-Amidomethylation of Secondary and Primary Anilines with TosMIC》, the research content is summarized as follows. A Fe(III)-catalyzed N-amidomethylation of secondary and primary anilines with p-toluenesulfonylmethyl isocyanide (TosMIC) in water was described. TosMIC played dual roles as the source of methylene as well as an amidating reagent to form α-amino amides R¹N(R²)CH₂C(O)NHR³ [R¹ = Ph, 2-MeC₆H₄, 4-FC₆H₄, etc.; R² = H, Me, Bn, etc.; R³ = t-Bu, 4-MeC₆H₄SO₂CH₂, 4-ClC₆H₄SO₂CH₂] in this multicomponent reaction. The combination of TosMIC and other isocyanides was also investigated to give the desired products in acceptable yields. The current protocol features used of iron catalyst and nontoxic media, broad substrate scope, mild conditions and operational simplicity.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lian, Pengcheng team published research in Organic Chemistry Frontiers in 2022 | 6911-87-1

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Electric Literature of 6911-87-1.

Lian, Pengcheng;Li, Ruyi;Wan, Xiao;Xiang, Zixin;Liu, Hang;Cao, Zhiyu;Wan, Xiaobing research published 《 Acetylation of alcohols and amines under visible light irradiation: diacetyl as an acylation reagent and photosensitizer》, the research content is summarized as follows. This work developed an unprecedented strategy for the acetylation of alcs. ROH (R = 4-(benzoyloxy)butyl, 4-[(thiophen-2-yl)carbonyloxy]butyl, 4-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)butyl, etc.) and amines R¹H (R¹ = phenylaminyl, [1H-pyrrolo[2,3-b]pyridin-5-yl]aminyl, 4-(4-fluorophenyl)piperazin-1-yl, etc.) using diacetyls R²C(O)C(O)R² (R² = Me, Et, Ph) as both an acylation reagent and a photosensitizer. This environmentally friendly process exhibits excellent functional group tolerance, a wide substrate scope, operational simplicity and no need for the use of exogenous dehydrating reagents, activating reagents or photocatalysts. The potential application of this strategy to pharmaceutical chem. was demonstrated by the late-stage modification of various drug mols., and the process was found to be readily scalable without any loss of efficiency. Preliminary mechanistic results showed that the in situ generation of peracetic acid is responsible for the facile acylation of structurally diverse alcs. and amines using this technique.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liang, Qi team published research in Chinese Journal of Chemistry in 2021 | 6911-87-1

SDS of cas: 6911-87-1, 4-Bromo-N-methylaniline is a aniline based compound known to exhibit mutagenic properties.
4-Bromo-N-methylaniline is a useful research compound. Its molecular formula is C7H8BrN and its molecular weight is 186.05 g/mol. The purity is usually 95%.
4-Bromophenylmethylamine is an organic compound that has anti-inflammatory properties and is used as a pharmaceutical. It belongs to the group of amines. The hydrolysis of 4-bromophenylmethylamine by hydrochloric acid produces phenol and bromamine (NHBr). The reaction system can be used to synthesize a number of compounds, including anilines, benzofurans, and other aromatic compounds. 4-Bromophenylmethylamine reacts with muscle tissue in a similar manner as acetaminophen does. This drug also has been shown to have significant effects on the energy metabolism in the muscles of rats that are given carbon source., 6911-87-1.

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 6911-87-1, formula is C7H8BrN, Name is 4-Bromo-N-methylaniline. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. SDS of cas: 6911-87-1.

Liang, Qi;Lin, Long;Li, Guodong;Kong, Xianqiang;Xu, Bo research published 《 Synthesis of Phenanthridine and Quinoxaline Derivatives via Copper-Catalyzed Radical Cyanoalkylation of Cyclobutanone Oxime Esters and Vinyl Azides》, the research content is summarized as follows. A copper-catalyzed radical cyclization of cyclobutanone oxime esters and vinyl azide is described. This method provides facile access to cyanoalkyl-substituted phenanthridines I (R¹ = H, 1-OMe, 3-Cl, etc; R² = H, 8-CF₃, 9-Me, etc.; R³ = H, CN, Ph, etc.) and quinoxalines II (R³ = H, COOMe, OBn, etc.; R⁴ = H, 8-Me, 7-Br, etc.) with excellent isolated yields. Moreover, these reactions proceed under mild conditions with a board substrate scope and excellent functional group tolerance.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary