Category: 6630-33-7

Fernandes, Debora da S. M.; Lago, Aline de F. S.; Thomasi, Sergio S.; Freitas, Matheus P. published an article in 2021. The article was titled 《Conformational analysis of halobenzaldehydes: A theoretical and spectroscopic study》, and you may find the article in Journal of Molecular Structure.HPLC of Formula: 6630-33-7 The information in the text is summarized as follows:

Rotation of the formyl group in halobenzaldehydes (halo = F, Cl, and Br) has been studied through high-level d. functional theory (DFT) calculations and natural bond orbital (NBO) anal. The isomeric and conformational energies are dictated by non-Lewis and Lewis-type interactions. The 4-substituted benzaldehydes the most stable isomer due especially to an effective electron resonance and small dipole moment, while destabilizing Lewis-type interactions slightly override the non-Lewis electron delocalization both in the syn and anti conformers of meta isomer. No significant halogen effect is observed on stabilities, excepting for the least stable ortho isomer, where the halogen interacts with the formyl group. Such interaction is more repulsive in the syn conformer (where the halogen and oxygen atoms face one another), but the nature of this interaction changes from predominantly electrostatic to steric contribution on going from F to Br. IR stretching vibrations, as well as NMR chem. shifts and spin-spin coupling constants, provided valuable insight into through-bond and through-space effects influencing the stabilities of these compounds In the part of experimental materials, we found many familiar compounds, such as o-Bromobenzaldehyde(cas: 6630-33-7HPLC of Formula: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.HPLC of Formula: 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Copper-Catalyzed Construction of Trinuclear N-Fused Hybrid Scaffolds Using Cyclic Ureas as New Building Blocks》 was written by Dao, Pham Duy Quang; Cho, Chan Sik. Synthetic Route of C7H5BrOThis research focused ontrinuclear fused hetereocycle preparation cyclization benzimidazole cyclic urea. The article conveys some information:

2-(2-Bromoaryl)- and 2-(2-bromovinyl)-benzimidazoles are coupled and cyclized with cyclic ureas as new building blocks in DMF in the presence of a catalytic amount of a copper catalyst and a base to give the corresponding trinuclear N-fused hybrid scaffolds in good yields. Trinuclear N-fused hybrid scaffolds having methoxy group on benzimidazole moiety are readily oxidized to unprecedented benzimidazolequinone-fused hybrid scaffolds in high yields by treatment of ceric ammonium nitrate in acetonitrile/H2O.o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar, Akash; Verma, Shruti; Pathak, Devendra Deo published an article in 2021. The article was titled 《Synthesis and characterization of a recyclable graphene oxide-surface- engineered copper(II) Schiff base complex: Catalytic application in synthesis of 1,2,3-triazoles and 2H-indazoles》, and you may find the article in Journal of Environmental Chemical Engineering.Related Products of 6630-33-7 The information in the text is summarized as follows:

A new graphene oxide (GO) supported Cu(II) Schiff base complex (GO-SB-Cu) was synthesized by utilizing Schiff base functionalized GO (GO-SB) and copper acetate in ethanol under reflux. The synthesized complex was characterized using several techniques such as fourier transform IR spectroscopy (FTIR), powd. X-ray diffraction (PXRD), fourier transform (FT-Raman), thermo gravimetric anal. (TGA), field emission SEM (FESEM), high resolution transition electron microscopy (HRTEM), elemental dispersive X-ray anal. (EDX), elemental mapping, X-ray photo electron spectroscopy (XPS) and at. absorption spectroscopy (AAS) anal. The complex was found to be highly efficient in the click reaction for synthesis of 1,4-disubstituted 1,2,3-triazoles at room temperature and an operationally simple and efficient one-pot synthesis of 2H-indazoles from com. accessible reactants at ambient temperature, without using any base, additive or co-catalyst. A variety of electron donating/withdrawing groups were employed to explore the scope of the reactions. Interestingly, aliphatic and heterocyclic amines were also tested and found active in the synthesis of 2H-indazoles. The results demonstrated that the reaction could be scaled up conveniently and the catalyst could be easily recycled up to successive four times without any noteworthy loss in the catalytic action. High yield of the products, easy workup, environmentally benign, high stability of the catalyst and mild reaction conditions are the key points of this catalyst. All the synthesized organic products were identified by 1H and 13C NMR spectroscopy. In addition to this study using o-Bromobenzaldehyde, there are many other studies that have used o-Bromobenzaldehyde(cas: 6630-33-7Related Products of 6630-33-7) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Related Products of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Development, synthesis and biological investigation of a novel class of potent PC-PLC inhibitors》 was written by Pilkington, Lisa I.; Sparrow, Kevin; Rees, Shaun W. P.; Paulin, Emily K.; van Rensburg, Michelle; Xu, Chris Sun; Langley, Ries J.; Leung, Ivanhoe K. H.; Reynisson, Johannes; Leung, Euphemia; Barker, David. Recommanded Product: o-Bromobenzaldehyde And the article was included in European Journal of Medicinal Chemistry in 2020. The article conveys some information:

Phospholipases are enzymes that are involved in the hydrolysis of acyl and phosphate esters of phospholipids, generating secondary messengers that have implications in various cellular processes including proliferation, differentiation and motility. As such inhibitors of phospholipases have been widely studied for their use as anti-cancer therapeutics. Phosphatidylcholine-specific phospholipase C (PC-PLC) is implicated in the progression of a number of cancer cell lines including aggressing triple-neg. breast cancers. Most current studies on PC-PLC have utilized D609 as the standard inhibitor however it is known to have multiple failings, including poor stability in aqueous media. 2-Morpholinobenzoic acids were recently identified using vHTS as a potential class of lead compounds, with improvements over D609. In this work 129 analogs in this class were prepared and their PC-PLC inhibitory activity was assessed. It was found that the majority of these novel compounds had improved activity when compared to D609 with the most potent inhibitors completely inhibiting enzyme activity. It was determined that the best compound/s contained a morpholino and 2-substituted N-benzyl moieties with these findings explained using mol. modeling. The compounds reported here will allow for improved study of PC-PLC activity. After reading the article, we found that the author used o-Bromobenzaldehyde(cas: 6630-33-7Recommanded Product: o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Recommanded Product: o-BromobenzaldehydeSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Hydrazone linkage based Schiff base: synthesis, characterization and their biological applications》 were Pradhan, Alka Prof.; Koshal, Anil Kumar; Khichi, Dharmendra Singh. And the article was published in World Journal of Pharmaceutical Research in 2019. Product Details of 6630-33-7 The author mentioned the following in the article:

Synthesis of hydrazone linkage based Schiff base derivatives I [X = H, OH, Cl, Br; Y = H, 4-NO2, 4-NH2] via condensation of 2-[1-(4-aminophenyl)ethylidene]-hydrazine-1-carbothioamide intermediate II with benzaldehydes was described. Thiosemicarbazide intermediate II was obtained from reaction of 1-(4-aminophenyl)ethan-1-one and thiosemicarbazide. All synthesized compounds were screened for their antibacterial and antifungal activity by using agar well diffusion method. The results revealed that the compound I [X = H, OH, Y = H, 4-NH2] showed excellent activity against E. coli and moderate show against P. aerugenosaand and S.aureus. compound I [X = OH, Cl, Br; Y = H] were showed excellent against S.aureus. All compounds showed moderate anti-fungal activity against A. flavus and A. fumigates and show excellent against Candida albicans. In the experiment, the researchers used o-Bromobenzaldehyde(cas: 6630-33-7Product Details of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Product Details of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jeong, Myeonggyo; Kang, Seongeun; Torikai, Kohei; Lee, Songyi; Yun, Hwayoung published an article in 2021. The article was titled 《A New Julia-Kocienski Reagent for Convenient Access to the 2-Naphthylmethyl Vinyl Ethers》, and you may find the article in Organic Preparations and Procedures International.Safety of o-Bromobenzaldehyde The information in the text is summarized as follows:

A facile method for the preparation of α-naphthylmethyloxy benzothiazol-2-yl-sulfone I as a new Julia-Kocienski reagent has been developed. This modified reagent converted to be useful to prepare several 2-naphthylmethyl vinyl ethers II (R = H, 4-OMe, 4-F, 2-Br) . In the part of experimental materials, we found many familiar compounds, such as o-Bromobenzaldehyde(cas: 6630-33-7Safety of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Safety of o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar, Sandeep; Gupta, Sujeet Kumar published their research in World Journal of Pharmacy and Pharmaceutical Sciences in 2021. The article was titled 《Synthesis, characterization & biological activity of some N9 -(arylidene acetylhydrazino)-carbazole novel carbazole derivative》.Application of 6630-33-7 The article contains the following contents:

Synthesized six new derivatives of carbazole I[ R = 4-Cl, 4-NO2, 3-Br] test them for their anti-inflammatory activity using the carrageenan induced inflammation model in rat paw edema model. In scheme synthesized N-(chloroacetyl)-carbazole then react with hydrazine hydrate to give N-(hydrazinoacetyl)-carbazole were further reacted with various substituted aldehyde in the presence of ethanol and dioxan and found to six derivative of carbazole I. The structure of final product were confirmed by FTIR and 1H NMR. Value of FTIR, 1H NMR and thin layer chromatog. were found to be significant. All biol. activity screening by carrageenan induced inflammation in rat hind paw edema model. The compound I[ R = 3-Cl, 2-Br] most potent compound with compared to Diclofenc.o-Bromobenzaldehyde(cas: 6630-33-7Application of 6630-33-7) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application of 6630-33-7It is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C7H5BrOIn 2019 ,《Tandem Knoevenagel-Michael-cyclocondensation reaction of malononitrile, various aldehydes and barbituric acid derivatives using isonicotinic acid as an efficient catalyst》 appeared in Progress in Chemical and Biochemical Research. The author of the article were Moosavi-Zare, Ahmad Reza; Goudarziafshar, Hamid; Jalilian, Zahra. The article conveys some information:

Preparation of pyrano[2,3-d]pyrimidine dione derivatives I (R = H, Me; R1 = C6H5, 4-BrC6H4, 2,3-(Cl2)C6H3, etc.) by the tandem Knoevenagel-Michaelcyclocondensation reaction of malononitrile, various aldehydes R1CHO and barbituric acid derivatives like barbituric acid and 1,3-dimethylbarbituric acid in the presence of isonicotinic acid as an efficient organocatalyst has been described. After reading the article, we found that the author used o-Bromobenzaldehyde(cas: 6630-33-7Computed Properties of C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Computed Properties of C7H5BrOIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Physica B: Condensed Matter (Amsterdam, Netherlands) included an article by Satheeshchandra, S.; Haleshappa, D.; Rohith, Sandhyashree; Jayarama, A.; Shetty, Nandakumar. Related Products of 6630-33-7. The article was titled 《Novel benzofuran based chalcone material for potential nonlinear optical application》. The information in the text is summarized as follows:

A novel nonlinear optical material, (2E)-1-(1-benzofuran-2-yl)-3-(2-bromophenyl) prop-2-en-1-one monohydrate, is synthesized and crystals are grown at ambient temperature using solution growth method. Spectroscopy techniques such as FT-IR, FT-Raman and 1H NMR are used to confirm the presence of functional groups in the grown crystals. These crystals are crystallized in non-centrosym. orthorhombic structure with a space group P212121 and the powder second harmonic generation (SHG) test shows that the SHG efficiency of these crystals are 2.03 times that of KDP. UV-Vis-NIR studies of these crystal shows maximum optical transparency in the complete visible and near IR spectral region. The TGA/DTA anal. reveals that the material manifests good thermal stability (280.8 °C) as well. The nature of mol. interactions and their quant. role towards the crystal packing is being studied using Hirshfeld surface and 2-D fingerprint anal. The advantages of these crystals lie mainly in the ease of growing crystals, low cutoff wavelength (486 nm), and large SHG efficiency with good thermal stability and this makes the material promising for competent frequency doubling of laser. In the part of experimental materials, we found many familiar compounds, such as o-Bromobenzaldehyde(cas: 6630-33-7Related Products of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Related Products of 6630-33-7It is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nozawa-Kumada, Kanako; Matsuzawa, Yuta; Ono, Kanako; Shigeno, Masanori; Kondo, Yoshinori published an article in 2021. The article was titled 《Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Synthetic Route of C7H5BrO The information in the text is summarized as follows:

An aerobic copper-catalyzed synthesis of 3-hydroxyisoindolinones I (R1 = Ph, 3-thienyl, OMe, etc., R2 = Me, Ph, cyclopropyl, etc., R3 = Me, F, Cl, H, R4 = H, MeO, CF3, R3R4 = OCH2O) was developed via the benzylic double C(sp3)-H functionalization of 2-alkylbenzamides II. In this reaction, mol. oxygen was used as both an oxidant for C(sp3)-H functionalization and an oxygen source. The method can be extended to diverse benzylic C(sp3)-H bonds and shows excellent functional group tolerance. The results came from multiple reactions, including the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary