Category: 6630-33-7

In 2022,Si, Min; Yan, Jiaqi; Ding, Yongzheng; Huang, Hanmin published an article in Organic & Biomolecular Chemistry. The title of the article was 《Pd-Catalyzed carbonylative lactonization of 2-halidearomatic aldehydes with H2O as a nucleophile》.Name: o-Bromobenzaldehyde The author mentioned the following in the article:

A palladium-catalyzed carbonylative cyclization reaction of 2-halidebenzaldehydes with H2O was described, which provided a strategy for the synthesis of diversely substituted 3,3′-oxyphthalides. Notably, the obtained 3,3′-oxyphthalide could be easily transformed into 3-aryl and alkyl phthalides with excellent efficiency using organozinc reagents under mild reaction conditions. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Name: o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Name: o-BromobenzaldehydeSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of C7H5BrOIn 2019 ,《Enantioselective Gold-Catalyzed Pictet-Spengler Reaction》 was published in Organic Letters. The article was written by Glinsky-Olivier, Nicolas; Yang, Shengwen; Retailleau, Pascal; Gandon, Vincent; Guinchard, Xavier. The article contains the following contents:

Cationic chiral Au(I) complexes catalyze asym. Pictet-Spengler reactions between tryptamines and arylaldehydes. The resulting tetrahydro-β-carbolines I (R1 = H, 5-Me, 5-OMe; R2 = Allyl, Bn, CH2Mes, etc.; R3 = Ph, 4-Et-C6H4, 2-CN-C6H4, 3ClC6H4, etc.)are obtained with wide functional group tolerance in high yield and with high enantioselectivities (up to 95%). Aldehydes bearing polar or protic functions are well tolerated. The reaction features a hitherto unknown C2-auration of the indole as the key step, supported by d. functional theory calculations The experimental part of the paper was very detailed, including the reaction process of o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,New Journal of Chemistry included an article by Zare, Abdolkarim; Kohzadian, Alireza; Abshirini, Zahra; Sajadikhah, Seyed Sajad; Phipps, Joshua; Benamara, Mourad; Beyzavi, M. Hassan. Product Details of 6630-33-7. The article was titled 《Nano-2-(dimethylamino)-N-(silica-n-propyl)-N,N-dimethylethanaminium chloride as a novel basic catalyst for the efficient synthesis of pyrido[2,3-d:6,5-d’]dipyrimidines》. The information in the text is summarized as follows:

This study describes the synthesis and characterization of nano-2-(dimethylamino)-N-(silica-n-propyl)-N,N-dimethylethanaminium chloride {nano-[DMSPDE][Cl]}, and its application as a highly effective, heterogeneous and recyclable basic catalyst for the promotion of a useful organic reaction. The catalyst was characterized using FTIR, SEM, TEM, TGA, XRD, Brunauer-Emmett-Teller (BET) and energy-dispersive x-ray spectroscopy (EDS) methods. The nanocatalyst was used to facilitate the solvent-free preparation of pyrido[2,3-d:6,5-d’]dipyrimidines by the multi-component reaction of 2-thiobarbituric acid, arylaldehydes and NH4OAc. Nano-[DMSPDE][Cl] furnished the products in high yields and in short reaction times, and showed no significant loss of activity after multiple runs. In the literature, pyrido[2,3-d:6,5-d’]dipyrimidines were synthesized using Lewis or acidic catalysts; however, a basic catalyst was applied for their preparation In the experiment, the researchers used many compounds, for example, o-Bromobenzaldehyde(cas: 6630-33-7Product Details of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Product Details of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Green chemistry: efficient acetalization of aldehydes with alcohols using the acid red 52 photocatalyst》 was published in Environmental Chemistry Letters in 2020. These research results belong to Yu, Linyu; Lin, Chuyuan; Liao, Chunshu; Zeng, Xianghua; Chen, Xiuwen; Zhu, Zhongzhi; Huang, Yubing; Li, Yibiao; Chen, Lu. Quality Control of o-Bromobenzaldehyde The article mentions the following:

A sodium 4-[6-(diethylamino)-3-(diethyliminio)-3H-xanthen-9-yl]benzene-1,3-disulfonate (acid red 52) is used here as photocatalyst under yellow light irradiation A wide array of acyclic and cyclic acetals R1CH(OR2)2 (R1 = 4-fluorophenyl, 2-phenylethynyl, 3-methoxyphenyl, etc.; R2 = Et, methyl) and 2-(4-chlorophenyl)-1,3-dioxolane in 75-93% yields was obtained. Results show the efficient acetalization of aldehydes R1CHO with alcs. R2OH and ethylene glycol at room temperature, the use of abundant and sustainable alcs. as both the solvents and coupling agents, low catalyst loading, short reaction time, and readily available catalyst, which might be applied to green-catalyzed systems.o-Bromobenzaldehyde(cas: 6630-33-7Quality Control of o-Bromobenzaldehyde) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Quality Control of o-BromobenzaldehydeIt is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Advanced Synthesis & Catalysis included an article by Zhang, Heng; Yu, Yinghua; Huang, Shenlin; Huang, Xueliang. Synthetic Route of C7H5BrO. The article was titled 《Palladium-Catalyzed Cascade Reaction of o-Bromobenzaldehydes with N-Sulfonylhydrazones: An Efficient Approach to the Naphthalene Skeleton》. The information in the text is summarized as follows:

A new strategy for the construction of the naphthalene backbone was described. The reaction essentially started from two simple aldehydes. The key step was enabled by a palladium-carbene migratory insertion. After that, a sequence of reversible allylic alkylation and intramol. condensation took place to give the substituted naphthalene derivatives Addnl. manipulations on the sulfonyl group in the product via palladium-catalyzed Kumada coupling were also investigated.o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Microwave assisted synthesis and antibacterial activities of some N-Benzylideneaniline halogen derivatives》 were Celik, Hulya. And the article was published in Fresenius Environmental Bulletin in 2019. SDS of cas: 6630-33-7 The author mentioned the following in the article:

In this study a series of Schiff base N-benzylideneaniline halogen derivatives were synthesized by microwave-irradiation method the 4-fluoroaniline was condensed with various aromatic aldehydes to give Schiff base. The present work involved condensation of various benzaldehyde with aromatic amine in under microwave irradiation The microwave irradiation method offered advantages such as reduction of reaction time, increase in conversion, reduced wastes and good quality. The chem. structure of the compound was characterized using Mass Spectrometry, 1H-NMR and 13C-NMR techniques. The prepared compounds were tested for their in-vitro antibacterial activity. The agar well diffusion assay method was used for the assessment of in vitro antibacterial activity compounds against Escherichia coli (ATCC 10536), Pseudomonas aeruginosa (ATCC 15442), Staphylococcus aureus (ATCC 6538) and Bacillus subtilis (ATCC 6633). In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7SDS of cas: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.SDS of cas: 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Khosravi, Hormoz; Mirzaei, Saber; Balalaie, Saeed published an article in Journal of Organic Chemistry. The title of the article was 《Decarboxylative Cyclization of Proline with o-Alkynylbenzaldehyde through an Unexploited 8π-Electrocyclization: A DFT Study》.Quality Control of o-Bromobenzaldehyde The author mentioned the following in the article:

We employed d. functional theory (DFT) methods to investigate the most plausible mechanism of cyclization/ring expansion of proline with o-alkynylbenzaldehyde. This one-pot reaction starts with the in situ formation of azomethine ylide, which can undergo three different reaction pathways to form the final product. Two mechanisms are based on nucleophilic addition and 4π-electrocyclization of the azomethine ylide, and our results indicate that the rate-determining step (RDS) of these two cyclizations are 40.1 and 40.2 kcal/mol, resp. The third novel pathway relies upon 8π-electrocyclization as the key step of this reaction; interestingly, the RDS of this cyclization is ~20.6 kcal/mol, which shows this route to be most feasible. Thus, we introduce a novel mechanism for the electrocyclization reaction of conjugated azomethine ylides that can help chemists to design and access a new series of compounds The experimental part of the paper was very detailed, including the reaction process of o-Bromobenzaldehyde(cas: 6630-33-7Quality Control of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Quality Control of o-BromobenzaldehydeSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Synthesis of new functionalized triarylmethanes via Suzuki cross-coupling and Heck-type vinylation reactions》 was written by Mohammadiannejad, Kazem; Hosseini, Raziyeh; Ranjbar-Karimi, Reza. Recommanded Product: o-BromobenzaldehydeThis research focused ontriarylmethane preparation; bromoarylmethane arylboronic acid Suzuki Miyura coupling Mizoroki Heck vinylation. The article conveys some information:

A novel class of triarylmethanes (TRAMs) containing one or two biaryl moieties was synthesized efficiently through the Pd(PPh3)4-catalyzed Suzuki-Miyaura cross-coupling reaction of brominated TRAMs with arylboronic acid derivatives Author’s also demonstrate that brominated TRAMs can be efficiently functionalized via a one-pot, two-step Pd-catalyzed Heck-type process. This protocol provides convenient access to diverse vinylated TRAMs that are generally not obtained by using the common synthetic methods for TRAMs. In the experiment, the researchers used o-Bromobenzaldehyde(cas: 6630-33-7Recommanded Product: o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Recommanded Product: o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《A green and highly effective protocol for the synthesis of N,N’-alkylidene bisamides using saccharin-N-sulfonic acid》 was published in Iranian Chemical Communication in 2020. These research results belong to Zare, Abdolkarim; Dianat, Manije; Pishahang, Nasrin; Khanivar, Roghayyeh; Kaman-Torki, Soheila; Fakhraei, Fatemeh; Kordrostami, Zahra; Sadeghi-Takallo, Masoud. COA of Formula: C7H5BrO The article mentions the following:

A green and highly effective solvent-free protocol has been reported for the synthesis of N,N’-alkylidene bisamides RC(O)NHCH(Ar)NHC(O)R (R = Me, Ph; Ar = Ph, 3-O2NC6H4, 4-BrC6H4, etc.) via the reaction of arylaldehydes (1 equivalent) with primary amides (2 equivalent) in the presence of saccharin-N-sulfonic acid (SaSA) as a solid-acid catalyst. The mentioned compounds have been obtained in high yields and short reaction times. In the part of experimental materials, we found many familiar compounds, such as o-Bromobenzaldehyde(cas: 6630-33-7COA of Formula: C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.COA of Formula: C7H5BrOIt is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Tajammal, Affifa; Siddiqa, Aysha; Irfan, Ahmad; Azam, Muhammad; Hafeez, Huma; Munawar, Munawar Ali; Basra, Muhammad Asim Raza published an article in Journal of Molecular Structure. The title of the article was 《Antioxidant, molecular docking and computational investigation of new flavonoids》.Application of 6630-33-7 The author mentioned the following in the article:

Flavonoids are a group of polyphenolic compounds diverse in structure, biol. and pharmacol. functions possessing antioxidant potential. New flavonoids I (R = 2-Br, 4-Br), II (R = 3-Br, 4-Br), 2,5-(OH)2C6H3C(O)CH=CHC6H4R (III) (R = 2-Br, 3-Br), were synthesized by acid catalyzed condensation of bromo-benzaldehydes RC6H4CHO and 2,5-dihydroxyacetophenone. In vitro antioxidant potential of synthesized compounds was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonate) cation (ABTS+) radical scavenging, iron chelating, iron reducing and phosphomolybdenum activity. The results revealed that DPPH radical scavenging and ABTS+scavenging activity of compounds III were better than reference compounds i.e., trolox and ascorbic acid. Furthermore, mol. docking was performed to check the affinity of flavonoids with Keap1 for the activation of antioxidant defense system of body and computational study was carried out by DFT approach using B3LYP functional and 6-31G** basis set. All the compounds showed better results compared to the reference compounds and mol. docking studies supported the computational results. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Application of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application of 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary