Category: 6630-33-7

《Understanding the Chemoselectivity in Palladium-Catalyzed Three-Component Reaction of o-Bromobenzaldehyde, N-Tosylhydrazone, and Methanol》 was written by Ren, Xiaojian; Zhu, Lei; Yu, Yinghua; Wang, Zhi-Xiang; Huang, Xueliang. COA of Formula: C7H5BrO And the article was included in Organic Letters in 2020. The article conveys some information:

To understand the ligand-controlled palladium-catalyzed coupling of o-bromobenzaldehyde, N-tosylhydrazone, and methanol to give Me 2-benzylbenzoic ester or Me ether, we herein investigated the mechanisms which account for how C-C and C-O bonds are formed and why bidentate dppf/dppb ligands afford ester, whereas P(o-tolyl)3 ligand gives ether. The ester chemoselectivity of the bidentate ligands is attributed to the strong electron-donating effect that disfavors the C,Br-reductive elimination of the coupling intermediate of o-bromobenzaldehyde and N-tosylhydrazone.o-Bromobenzaldehyde(cas: 6630-33-7COA of Formula: C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.COA of Formula: C7H5BrOIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Zirconium-based metal-organic framework as an efficiently heterogeneous photocatalyst for oxidation of benzyl halides to aldehydes》 was written by Xue, Ping; Huang, Jiming; Lin, Liguang; Li, Rong; Tang, Mi; Wang, Zhengbang. Name: o-BromobenzaldehydeThis research focused onzirconium base metal organic framework catalyst preparation thermal stability; benzyl bromide zirconium catalyst photocatalytic oxidation green chem; benzaldehyde preparation. The article conveys some information:

Herein, for the first time, the zirconium-based metal-organic framework (UiO-66-NH2) was applied as an efficiently heterogeneous photocatalyst for conversion of benzyl halides to corresponding benzaldehydes with high selectivity (about 80%) and conversion (up to 99%) in the presence of oxygen and DMF as solvent. Through a series of experiments and anal., the reaction mechanism was proposed to involve nucleophilic attack of the N-oxide. This study provided a general, environmental and high selective method to prepare benzaldehydes and broadened the application fields of UiO-66-NH2. In the experiment, the researchers used o-Bromobenzaldehyde(cas: 6630-33-7Name: o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Name: o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Organic Letters included an article by Rocaboy, Ronan; Baudoin, Olivier. Recommanded Product: 6630-33-7. The article was titled 《1,4-Palladium Shift/C(sp3)-H Activation Strategy for the Remote Construction of Five-Membered Rings》. The information in the text is summarized as follows:

1,N-Metal shift is an elegant alternative approach enabling the functionalization of remote C-H bonds from simple precursors. In this work, a novel and simple Pd0-catalyzed domino reaction involving 1,4-palladium shift and C(sp3)-H activation and leading to (fused) five-membered rings is reported. This method allowed access to a broad range of valuable arylidene γ-lactams and indanones and was applied to the formal synthesis of (-)-pyrrolam A. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Recommanded Product: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Recommanded Product: 6630-33-7Synthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Dong, Pei-Zhen; Qiu, Bin; An, Xiao-De; Xiao, Jian published an article in Green Chemistry. The title of the article was 《Cascade dearomative [4 + 2] cycloaddition of indoles with in situ generated ortho-quinone methides: practical access to divergent indoline-fused polycycles》.Computed Properties of C7H5BrO The author mentioned the following in the article:

A rationally designed cascade dearomative [4 + 2] cycloaddition of indoles with in-situ generated ortho-quinone methide (o-QM) provided a practical, atom and step economical access to diverse indoline-fused polycycles with high yields and excellent diastereoselectivity in one step. These polycyclic indolines featured divergent [6-6-5] and [6-5-5] tricyclic core skeletons bearing three contiguous stereogenic centers. Appealingly, most of the products precipitating in ethanol solution, the use of room temperature, easy handling, broad substrate scope and gram-scale synthesis made this transformation an environmentally benign, effective and attractive method for the synthesis of polycyclic indolines. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Computed Properties of C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Computed Properties of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Catalyst-free ambient temperature synthesis of isoquinoline-fused benzimidazoles from 2-alkynylbenzaldehydes via alkyne hydroamination》 were Mishra, Manisha; Twardy, Dylan; Ellstrom, Clifford; Wheeler, Kraig A.; Dembinski, Roman; Torok, Bela. And the article was published in Green Chemistry in 2019. Electric Literature of C7H5BrO The author mentioned the following in the article:

An efficient environmentally benign route for the synthesis of benzimidazo[2,1-a]isoquinoline has been developed by reacting 2-ethynylbenzaldehyde and related substituted alkynylbenzaldehydes with variously substituted ortho-phenylenediamines and aliphatic amines in ethanol. This method provides a convenient, room temperature, atom-economical, and catalyst-free access to diversely substituted isoquinoline fused benzimidazoles. Regioselectivity of the reaction, as referred to o-phenylenediamines, was confirmed by X-ray crystallog. The reaction was found to occur in three major steps (imine formations, cyclization, and aromatization) and a mechanism has been proposed. In addition to this study using o-Bromobenzaldehyde, there are many other studies that have used o-Bromobenzaldehyde(cas: 6630-33-7Electric Literature of C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Electric Literature of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Decorated Peptide Nanofibers with Cu Nanoparticles: An Efficient Catalyst for the Multicomponent Synthesis of Chromeno[2,3-d]pyrimidin-8-amines, Quinazolines and 2H-Indazoles》 were Taherinia, Zahra; Ghorbani-Choghamarani, Arash; Hajjami, Maryam. And the article was published in ChemistrySelect in 2019. Safety of o-Bromobenzaldehyde The author mentioned the following in the article:

An efficient, simple and green protocol was developed for the synthesis of 7,10-diaryl-7H-benzo[7,8]chromeno[2,3-d]pyrimidin-8-amines I (R1 = Ph, 2-ClC6H4, 4-HOC6H4, etc.), 2-R2-substituted indazoles (R2 = Ph, 4-MeC6H4, 2,4-Cl2C6H3, etc.) and 2-R3-substituted quinazolines (R3 = Ph, 4-MeOC6H4) in the presence of peptide nanofibers decorated with Cu nanoparticles. Peptide nanofiber was synthesized by self-assembly technique. The effect of succinic anhydride was evaluated in two conditions: (i) without adding succinic anhydride at pH 4, (ii) by adding succinic anhydride at pH 5. Synthesized peptide nanofiber was characterized by 1H, 13C, DEPT NMR spectroscopies (Distortionless enhancement by polarization transfer), CHNSO, SEM, fluorescence spectroscopy, UV/Vis, FTIR and transmission electron microscopy (TEM). The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Safety of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Safety of o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Recommanded Product: o-BromobenzaldehydeIn 2019 ,《A nanostructured organic-inorganic hybrid material: Preparation, characterization and catalytic performance for the synthesis of N,N’-alkylidene bisamides》 was published in ChemistrySelect. The article was written by Zare, Abdolkarim; Khanivar, Roghayyeh; Irannejad-Gheshlaghchaei, Navid; Beyzavi, M. Hassan. The article contains the following contents:

A novel nanostructured mesoporous organic-inorganic hybrid material, based on dicationic ionic liquid – anchored with silica, namely nano-2-[N’,N’-dimethyl-N’-(silica-n-propyl)ethanaminium chloride]-N,N-dimethylaminium bisulfate {nano-[DSPECDA][HSO4]}, was prepared and characterized by FT-IR, energy-dispersive X-ray spectroscopy, field emission SEM, X-ray diffraction, thermal gravimetry, differential thermal gravimetric, DTA and adsorption/desorption porosimetry (BET, Langmuir, adsorption/desorption isotherm, BJH and t-plot) methods. Thereafter, the nanomaterial was utilized as a highly effectual, heterogeneous and recyclable nanocatalyst for the synthesis of N,N’-alkylidene bisamides RCONHCH(Ar)NHCOR [R = Me, Ph, Ar = Ph, 4-MeC6H4, 2-BrC6H4, 4-O2NC6H4, etc.] via the condensation reaction of benzaldehydes (1 equivalent) with primary amides (2 equivalent) under solvent-free conditions. The reaction results were better compared with the literature in terms of two or more of these factors: turnover frequency (TOF), yield, temperature, time and the reaction media. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Recommanded Product: o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Recommanded Product: o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C7H5BrOIn 2019 ,《Co3O4/NiO@GQD@SO3H nanocomposite as a superior catalyst for the synthesis of chromene-pyrimidines》 was published in RSC Advances. The article was written by Safaei-Ghomi, Javad; Omidshafiei, Zahra. The article contains the following contents:

A three-component reaction involving substituted benzaldehydes, 6-amino-1,3-dimethyluracil and 4-hydroxycoumarin was achieved in the presence of the Co3O4/NiO@GQD@SO3H nanocomposite as a highly effective heterogeneous catalyst to produce chromene-pyrimidines. The catalyst was characterized via FT-IR, SEM, XRD, EDS, TGA, BET and VSM. This new catalyst was demonstrated to be highly effective in the preparation of chromene-pyrimidines. Atom economy, low catalyst loading, reusable catalyst, applicability to a wide range of substrates and high product yields are some of the important features of this protocol. In the experimental materials used by the author, we found o-Bromobenzaldehyde(cas: 6630-33-7Electric Literature of C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Electric Literature of C7H5BrOIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Easy access to medium-sized lactones through metal carbene migratory insertion enabled 1,4-palladium shift》 was written by Yu, Yinghua; Chakraborty, Pushkin; Song, Jinshuai; Zhu, Lei; Li, Chunsen; Huang, Xueliang. Synthetic Route of C7H5BrO And the article was included in Nature Communications in 2020. The article conveys some information:

Herein, a valuable strategy for medium-sized lactones e.g., dibenzo[b,e]oxepin-6(11H)-one synthesis by accomplishing site-selective C-H bond functionalization via a palladium carbene migratory insertion enabled 1,4-palladium shift was described. The overall process achieves the formal dimerization of two readily available benzaldehyde derivatives RCHO (R = 6-bromo-1,3-dihydro-2-benzofuran-5-yl, 1-bromonaphthalen-2-yl, 2-iodophenyl, etc.), providing value-added products medium-sized lactones. The method is amenable to late-stage modification of approved drugs and other complex mols. Mechanistic studies including deuterium-labeling experiments and DFT calculation shed light on the reaction pathways. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Novel biocompatible core/shell Fe3O4@NFC@Co(II) as a new catalyst in a multicomponent reaction: an efficient and sustainable methodology and novel reusable material for one-pot synthesis of 4H-pyran and pyranopyrazole in aqueous media》 was published in RSC Advances in 2020. These research results belong to Kargar, Pouya Ghamari; Bagherzade, Ghodsieh; Eshghi, Hossein. Application In Synthesis of o-Bromobenzaldehyde The article mentions the following:

In this work, by controlling the interaction between the inorganic complexes and the support material, authors designed a high activity nanostructured combination of a magnetic nanoparticle Fe3O4@NFC@Co(II) terminated complex as a multi-nuclear catalyst. This protocol involves an environment friendly approach using cobalt acetate. The magnetic nanostructure Fe3O4@NFC@Co(II) was used as a novel, green and a powerful catalyst that demonstrated a short reaction time, high yield and easy procedure for the cascade Knoevenagel-Michael-cyclocondensation reaction for the one-pot synthesis of 4H-pyrans and pyranopyrazoles. The superparamagnetic nanocomposite could be conveniently separated by using an external magnet. Moreover, the catalyst could be reused at least five times in new reaction runs without a noticeable loss of activity. The prepared catalyst was characterized by FT-IR, XRD, VSM, FESEM, EDAX, TEM, ICP and TGA techniques. The experiments were achieved with good yields and implied that the catalytic method was effective and convenient for heterocyclic synthesis. In the part of experimental materials, we found many familiar compounds, such as o-Bromobenzaldehyde(cas: 6630-33-7Application In Synthesis of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application In Synthesis of o-BromobenzaldehydeSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary