Category: 6630-33-7

Chen, Yu; Panek, James S. published their research in Tetrahedron in 2021. The article was titled 《Highly regio- and diastereoselective synthesis of bis-triazolines》.SDS of cas: 6630-33-7 The article contains the following contents:

A highly stereo- and regioselective homodimerization of chiral azido-esters was achieved by a 1,3-dipolar cycloaddition on chiral (E)-Me 4-azido-6-methoxy-5-methyl-6-phenylhex-2-enoates. Both 4,5-syn and 4,5-anti allylic azides could be used effectively to access corresponding bis-triazoline dimers such as I [X = 2-Br, 2-I, 3-Br; n = 0, 1] by this reproducible method. Structural conformation of a representative dimer was established by X-ray crystal anal. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7SDS of cas: 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.SDS of cas: 6630-33-7It is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Tandem Condensation-Hydrogenation to Produce Alkylated Nitriles Using Bifunctional Catalysts: Platinum Nanoparticles Supported on MOF-Derived Carbon》 was written by Huang, Ao; Nie, Renfeng; Zhang, Biying; Pei, Yuchen; Chen, Minda; Behera, Ranjan; Yu, Jiaqi; Luan, Xuechen; Hunter, Nicholas T.; Ke, Ming; Huang, Wenyu. Product Details of 6630-33-7 And the article was included in ChemCatChem in 2020. The article conveys some information:

Tandem catalysis, which allows multiple steps of a reaction to take place without the need for separation and purification, is highly desired for the design of efficient and environmentally-friendly chem. processes. Herein, the pyrolysis of UiO-66-NH2, an amino-functionalized metal-organic framework, produces nitrogen-rich carbon-ZrO2 composite (CN-ZrO2). This composite is rich in basic sites and effectively catalyzes the Knoevenagel condensation reaction. After loading Pt nanoparticles onto this composite support, a tandem catalyst (Pt/CN-ZrO2) is produced to be capable of the one-step Knoevenagel condensation-hydrogenation reaction to produce an alpha-alkylated nitrile. The tandem catalyst exhibits >99% aldehyde conversion and >99% selectivity toward alpha-alkylated nitrile under 1 MPa H2 at 80°C. This catalyst could be reused for five times in the presence of malononitrile without significant deactivation and is versatile for one-step condensation-hydrogenation of various aldehydes. The good performance of Pt/CN-ZrO2 could be ascribed to the synergistic interaction between Pt and CN-ZrO2 composite supports that lead to the appropriate hydrogenation activity of supported Pt nanoparticles. The results came from multiple reactions, including the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Product Details of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Product Details of 6630-33-7It is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Palladium-Catalyzed Three-Component Coupling Reaction of o-Bromobenzaldehyde, N-Tosylhydrazone, and Methanol》 was published in Organic Letters in 2020. These research results belong to Zhu, Lei; Ren, Xiaojian; Yu, Yinghua; Ou, Pengcheng; Wang, Zhi-Xiang; Huang, Xueliang. Application of 6630-33-7 The article mentions the following:

A ligand-controlled palladium-catalyzed three-component reaction of o-bromoaryl aldehydes, N-tosylhydrazones and methanol was described for the synthesis of aryl esters such as I [R = H, 3-OMe, 4-F, etc.; Ar = Ph, 3-MeC6H4, 2-thienyl, etc.]. This reaction used readily available compounds as starting materials while displaying a broad substrate scope and good functional group compatibility. This methodol. was also extended to the synthesis of [methoxy(aryl)methyl]benzaldehydes II [R1 = H, 4-Me, 5-Cl, etc.; R2 = H, Me, OMe, etc.]. After reading the article, we found that the author used o-Bromobenzaldehyde(cas: 6630-33-7Application of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application of 6630-33-7It is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Das, Siuli; Mondal, Rakesh; Chakraborty, Gargi; Guin, Amit Kumar; Das, Abhishek; Paul, Nanda D. published an article in 2021. The article was titled 《Zinc Stabilized Azo-anion Radical in Dehydrogenative Synthesis of N-Heterocycles. An Exclusively Ligand Centered Redox Controlled Approach》, and you may find the article in ACS Catalysis.Synthetic Route of C7H5BrO The information in the text is summarized as follows:

Herein an exclusively ligand-centered redox controlled approach for the dehydrogenation of a variety of N-heterocycles such as 1,2,3,4-tetrahydro-2-methylquinoline, 1,2,3,4-tetrahydro-isoquinoline, indoline, 2-phenyl-2,3-dihydro-1H-benzoimidazole, 2,3-dihydro-2-phenylquinazolin-4(1H)-ones I (R = H, 2-Br, 4-Cl, 4-Me, etc.; X = C=O) and 1,2,3,4-tetrahydro-2-phenylquinazolines I (X = CH2) using a Zn(II)-stabilized azo-anion radical complexes II (R1 = H, Cl) as the catalyst was reported. A simple, easy to prepare and bench stable Zn(II)-complex III (R1 = Cl) featuring the tridentate arylazo pincer, 2-((4-chlorophenyl)diazenyl)-1,10-phenanthroline, in the presence of zinc-dust, undergoes reduction of azo-anion radical species II (R1 = Cl) which efficiently dehydrogenates various saturated N-heterocycles such as 1,2,3,4-tetrahydro-2-methylquinoline, 1,2,3,4-tetrahydro-isoquinoline, indoline, 2-phenyl-2,3-dihydro-1H-benzoimidazole, 2,3-dihydro-2-phenylquinazolin-4(1H)-ones I (X = C=O) and 1,2,3,4-tetrahydro-2-phenylquinazolines I (X = CH2) under air. The catalyst has further been found to be compatible with the cascade synthesis of these N-heterocycles IV (R2 = n-Bu, Ph, thiophen-2-yl, etc.; R3 = H, Me; R4 = H, Br, Me), V (R5 = H, Cl) and VI (R6 = H, Cl; R7 = H, Me; R8 = Ph, 2-fluorophenyl, pyridin-2-yl, etc.) via dehydrogenative coupling of alcs. R2CH2OH and 2-NH2-4-R6-C6H3CH2OH with other suitable coupling partners under air. Mechanistic investigation reveals that the dehydrogenation reactions proceed via a one-electron hydrogen atom transfer (HAT) pathway where the zinc-stabilized azo-anion radical ligand abstracts the hydrogen atom from the organic substrate(s), and the whole catalytic cycle proceeds via the exclusive involvement of the ligand-centered redox events where the zinc acts only as the template.o-Bromobenzaldehyde(cas: 6630-33-7Synthetic Route of C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Synthetic Route of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《TBAB-catalyzed 1,6-conjugate sulfonylation of para-quinone methides: a highly efficient approach to unsymmetrical gem-diarylmethyl sulfones in water》 was written by Liu, Zhang-Qin; You, Peng-Sheng; Zhang, Liang-Dong; Liu, Da-Qing; Liu, Sheng-Shu; Guan, Xiao-Yu. Application of 6630-33-7This research focused onunsym gem diarylmethyl sulfone preparation regioselective water green chem; para quinone methide sulfonyl hydrazine conjugate sulfonylation TBAB catalyst; green and sustainable chemistry; sulfa-1,6-conjugated addition; synthesis in water; unsymmetrical diarylmethyl sulfones. The article conveys some information:

A highly efficient sulfonylation of para-quinone methides with sulfonyl hydrazines in water has been developed on the basis of the mode involving a tetra-Bu ammonium bromide (TBAB)-promoted sulfa-1,6-conjugated addition pathway. This reaction provides a green and sustainable method to synthesize various unsym. diarylmethyl sulfones, showing good functional group tolerance, scalability, and regioselectivity. Further transformation of the resulting diarylmethyl sulfones provides an efficient route to some functionalized mols. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Application of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application of 6630-33-7It is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,RSC Advances included an article by Zhao, Yi-Shu; Ruan, Hong-Li; Wang, Xiu-Yang; Chen, Chen; Song, Pei-Fang; Lu, Cheng-Wei; Zou, Li-Wei. Name: o-Bromobenzaldehyde. The article was titled 《Catalyst-free visible-light-induced condensation to synthesize bis(indolyl)methanes and biological activity evaluation of them as potent human carboxylesterase 2 inhibitors》. The information in the text is summarized as follows:

A mild strategy for visible-light-induced synthesis of bis(indolyl)methanes was developed using aromatic aldehydes and indole as substrates. This reaction was performed at room temperature under catalyst- and additive-free conditions to synthesize a series of bis(indolyl)methanes in good to excellent yields. In addition, all synthesized bis(indolyl)methanes together with β-substituted indole derivatives synthesized according to our previous work, were evaluated for their inhibitory effect against human carboxylesterase (CES1 and CES2). Primary structure-activity relationship anal. of all tested compounds showed that the modifications of β-substituted indole at the β-site with another indolyl group led to a significant enhancement of the inhibitory effect on CES2 and the bisindolyl structure was essential for CES2 inhibition. These results demonstrated that these bis(indolyl)methanes were potent and selective CES2 inhibitors, which might be helpful for medicinal chemists to design and develop more potent and selective CES2 inhibitors for biomedical applications.o-Bromobenzaldehyde(cas: 6630-33-7Name: o-Bromobenzaldehyde) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Name: o-BromobenzaldehydeIt is a key starting material in the total synthesis of an anticancer agent, (-)-taxol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2019,Chemical Science included an article by Mao, Zhu; Yang, Zhan; Xu, Chao; Xie, Zongliang; Jiang, Long; Gu, Feng Long; Zhao, Juan; Zhang, Yi; Aldred, Matthew P.; Chi, Zhenguo. Quality Control of o-Bromobenzaldehyde. The article was titled 《Two-photon-excited ultralong organic room temperature phosphorescence by dual-channel triplet harvesting》. The information in the text is summarized as follows:

Due to inefficient mol. design strategies, two-photon-excited ultralong organic room temperature phosphorescence (TPUOP) has not yet been reported in single-component materials. Herein, we present an innovative design method by dual-channel triplet harvesting to obtain the first bright TPUOP mol. with a lifetime of 0.84 s and a quantum efficiency of 16.6%. In compound o-Cz the donor and acceptor units are connected at the ortho position of benzophenone, showing intramol. space charge transfer. Therefore, the two-photon absorption ability is improved due to the enhanced charge transfer character. Moreover, the small energy gap boosts dual-channel triplet harvesting via ultralong thermally activated delayed fluorescence and H-aggregation phosphorescence, which suppresses the long-lived triplet concentration quenching. Through two-photon absorption, a near-IR laser (808 nm) is able to trigger the obvious ultralong emission under ambient conditions. This research work provides valuable guidance for designing near-IR-excited ultralong organic room temperature phosphorescence materials. The experimental part of the paper was very detailed, including the reaction process of o-Bromobenzaldehyde(cas: 6630-33-7Quality Control of o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Quality Control of o-BromobenzaldehydeSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Imidazole-induced self-assembly of polyoxovanadate cluster organic framework for efficient Knoevenagel condensation under mild conditions》 was written by Dou, Ming-Yu; Zhong, Dan-Dan; Huang, Xian-Qiang; Yang, Guo-Yu. Computed Properties of C7H5BrO And the article was included in CrystEngComm in 2020. The article conveys some information:

Three polyoxovanadate (POV)-based clusters, [Ni(1-bIm)4]2(V4O12)·H2O, [Ni(1-eIm)(H2O)4]2(V10O28)(1-eImH)2·2H2O and [Ni(H2O)5]2(V10O28)(1-pImH)2·4H2O (1-bIm = 1-butylimidazole; 1-eIm = 1-ethylimidazole and 1-pIm = 1-propylimidazole) was synthesized. The (POV)-based cluster [Ni(1-bIm)4]2(V4O12)·H2O was controllably achieved by an imidazole-induced self-assembly strategy and exhibited a 2D POVCOF in which circular [V4O12]4- clusters were bridged by four six-coordinated Ni(II) atoms (NiN4O2 model). The (POV)-based clusters [Ni(1-eIm)(H2O)4]2(V10O28)(1-eImH)2·2H2O and [Ni(H2O)5]2(V10O28)(1-pImH)2·4H2O were obtained at lower pH values. Notably, among the three POV-based clusters, POVCOF [Ni(1-bIm)4]2(V4O12)·H2O displayed highly efficient heterogeneous solvent-free catalytic activity (yields of up to 99%) and excellent recyclability in Knoevenagel condensation at room temperature In addition to this study using o-Bromobenzaldehyde, there are many other studies that have used o-Bromobenzaldehyde(cas: 6630-33-7Computed Properties of C7H5BrO) was used in this study.

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Computed Properties of C7H5BrOSynthetic applications of o-Bromobenzaldehyde include: synthesis of aza-fused polycyclic quinolines through copper-catalyzed cascade reaction, preparation of 1-substituted indazoles by CuI-catalyzed coupling with N-aryl hydrazides.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 6630-33-7In 2019 ,《1JCH Coupling in Benzaldehyde Derivatives: Ortho Substitution Effect》 was published in ACS Omega. The article was written by Nepel, Angelita; Viesser, Renan V.; Tormena, Claudio F.. The article contains the following contents:

The natural J-coupling (NJC) method is applied to analyze the Fermi contact contribution of the NMR spin-spin coupling constant decomposing this contribution in terms of natural localized MOs. We investigated the influence of the basis set on the NJC anal. for the formyl group coupling constant (1JCHf) of benzaldehyde derivatives NJC and other NBO analyses, like steric and natural Coulombic energy, were chosen to explain the influence of electron-donating and electron-withdrawing groups on 1JCHf for some substituted benzaldehydes (Me, OH, OMe, F, Cl, Br, I, and NO2). For the ortho derivatives, electroneg. substituents near the C-Hf bond increase the 1JCHf coupling. This effect could be related to an increase in formyl carbon s character and changes in the carbon and hydrogen natural charges. This indicates that the substituents in ortho have a proximity effect on 1JCHf coupling mainly of electrostatic origin instead of the expected hyperconjugative interactions. The experimental process involved the reaction of o-Bromobenzaldehyde(cas: 6630-33-7Application of 6630-33-7)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Application of 6630-33-7It is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Reductive Cross-Coupling of Aldehydes and Imines Mediated by Visible Light Photoredox Catalysis》 was written by Wang, Rui; Ma, Mengyue; Gong, Xu; Fan, Xinyuan; Walsh, Patrick J.. Name: o-BromobenzaldehydeThis research focused onvicinal amino alc preparation; benzoxazine indolone preparation; iridium photoredox catalyst reductive coupling aryl ketimine aldehyde. The article conveys some information:

In the presence of an iridium photoredox catalyst, aryl ketimines such as 2-BrC6H4N:CPh2 underwent photochem. reductive coupling with aldehydes such as benzaldehyde mediated by N,N-dimethylcyclohexylamine to give di- and triarylamino alcs. such as I. Under photoredox catalysis conditions, the conventional electrophilic reactivity of ketimines is inverted to generate nucleophilic species, allowing reductive coupling with aldehydes. I was converted to benzo-fused morpholine II with a palladium catalyst, while two amino alcs. underwent cyclization and oxidation to yield 3-indolones. In the experiment, the researchers used many compounds, for example, o-Bromobenzaldehyde(cas: 6630-33-7Name: o-Bromobenzaldehyde)

o-Bromobenzaldehyde(cas: 6630-33-7) is used in L-threonine aldolase-catalyzed enantio/diastereoselective aldol reactions.Name: o-BromobenzaldehydeIt is also used in L-threonine aldolase-catalyzed enantio and diastereoselective aldol reactions. Further, it reacts with trichloromethane to prepare 1-(2-bromo-phenyl)-2,2,2-trichloro-ethanol.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary