Category: 647020-71-1

Heiss, Christophe published the artcilePromoting or preventing haloaryllithium isomerizations: differential basicities and solvent effects as the crucial variables, Recommanded Product: Methyl 2-bromo-3-fluorobenzoate, the main research area is haloaryllithium isomerization basicity solvent effect; aryl carboxylic acid preparation.

Deprotonation-triggered heavy halogen migrations should become a favorite tool in arene synthesis if their occurrence and outcome could be made predictable. Particularly attractive, though extremely rare, are stop-and-go situations where a first intermediate, generated by metalation, can be trapped at -100 °C, whereas at -75 °C halogen migration gives rise to an isomer. As shown now, one can conveniently produce the initial aryllithium species by halogen/metal interconversion in toluene at -100 °C, under conditions that preclude halogen migration, and unleash the isomerization process by adding THF at -75 °C.

Synthesis published new progress about Basicity. 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-3-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Guo, Cui published the artcilePalladium-catalyzed annulation reactions of methyl o-halobenzoates with azabicyclic alkenes: a general protocol for the construction of benzo[c]phenanthridine derivatives, Application In Synthesis of 647020-71-1, the main research area is benzophenanthridine preparation palladium catalysis annulation methyl halobenzoate azabicyclic alkene.

The annulation reaction of Me o-halobenzoates with azabicyclic alkenes proceeds efficiently to give the corresponding benzo[c]phenanthridine derivatives in good to excellent yields using a developed base-free methodol. based on our preliminary studies. Thirty-seven application examples validate the compatibility of the present strategy with different groups, particularly with the electron-deficient ones, that are difficult to access using other traditional methods. In addition, annulation reactions with non-sym. azabicyclic alkenes are achieved in high regioselectivity.

RSC Advances published new progress about Cyclization. 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Application In Synthesis of 647020-71-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Figueiredo, Tamiris published the artcileSelf-crosslinking smart hydrogels through direct complexation between benzoxaborole derivatives and diols from hyaluronic acid, Formula: C8H6BrFO2, the main research area is hydrogel benzoxaborole derivative diol hyaluronic acid direct complexation.

Boronate ester cross-linked hydrogels have emerged as promising injectable scaffolds for biomedical applications given their rapid self-healing ability. For a rational design of such networks, all variables influencing their dynamic rheol. properties, especially the boronic acid and the diol-containing mol. selected as mol. crosslinkers have to be carefully considered. Herein, by tailoring the structure of benzoxaborole (BOR), self-crosslinking hydrogels based on hyaluronic acid (HA) modified with BOR derivatives are obtained for the first time through the direct BOR-HA diol complexation at physiol. pH. Among the different HA-BOR conjugates investigated, those prepared from 6-amino-7-fluoro-3,3-dimethyl benzoxaborole (HA-DMF6ABOR) and 7-amino-3,3-dimethyl benzoxaborole (HA-DM7ABOR) show unprecedented self-crosslinking properties, leading to the formation of self-healing hydrogels with extremely slow dynamics. These networks also exhibit remarkable pH- and glucose-responsive behaviors. These properties are related to the peculiar structure of these two BOR moieties, having as the common feature, a gem-di-Me group in the oxaborole ring and an ortho-substituent in the Ph ring. Mol. dynamic simulations are used to provide insight in the role of these substituents in the outstanding capability of DMF6ABOR and DM7ABOR to crosslink HA. They show that BOR complexation induces changes in conformation of HA favoring formation of a highly entangled 3D network.

Polymer Chemistry published new progress about Aqueous solutions. 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Formula: C8H6BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Melin, Lea published the artcileDevelopment of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid, Quality Control of 647020-71-1, the main research area is anticancer agent cell migration TEAD LM98 flufenamic acid; Flufenamic acid; Hippo pathway; SAR; TEAD; palmitic acid.

The YAP-TEAD transcriptional complex is responsible for the expression of genes that regulate cancer cell growth and proliferation. Dysregulation of the Hippo pathway due to overexpression of TEAD has been reported in a wide range of cancers. Inhibition of TEAD represses the expression of associated genes, demonstrating the value of this transcription factor for the development of novel anti-cancer therapies. We report herein the design, synthesis and biol. evaluation of LM98, a flufenamic acid analog. LM98 shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity. Binding of LM98 to TEAD was supported by 19F-NMR studies while co-crystallization experiments confirmed that LM98 is anchored within the palmitic acid pocket of TEAD. LM98 reduces the expression of CTGF and Cyr61, inhibits MDA-MB-231 breast cancer cell migration and arrests cell cycling in the S phase during cell division.

ChemMedChem published new progress about Antitumor agents. 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Quality Control of 647020-71-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zheng, Yan-Long published the artcileNickel-Catalyzed Domino Heck-Type Reactions Using Methyl Esters as Cross-Coupling Electrophiles, Synthetic Route of 647020-71-1, the main research area is nickel catalyst Heck Suzuki Miyaura coupling methyl ester electrophile; cross-coupling; cyclizations; esters; homogeneous catalysis; nickel.

While esters are frequently used as traditional electrophiles in substitution chem., their application in cross-coupling chem. is still in its infancy. Me esters can be used as coupling electrophiles in Ni-catalyzed Heck-type reactions through the challenging cleavage of the C(acyl)-O bond under relatively mild reaction conditions at either 80 or 100°. With the σ-NiII intermediate generated from the insertion of acyl NiII species into the tethered C:C bond, carbonyl-retentive products were formed by domino Heck/Suzuki-Miyaura coupling and Heck/reduction pathways when organoboron and mild hydride nucleophiles were used.

Angewandte Chemie, International Edition published new progress about Cross-coupling reaction. 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Synthetic Route of 647020-71-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Woerly, Eric M. published the artcileEnantioselective, Catalytic Fluorolactonization Reactions with a Nucleophilic Fluoride Source, Recommanded Product: Methyl 2-bromo-3-fluorobenzoate, the main research area is fluoroisochromanone enantioselective synthesis regioselectivity; alkenyl benzoate preparation fluorolactonization; bromobenzoate alkenyl boronic acid pinacol ester.

The enantioselective synthesis of 4-fluoroisochromanones via chiral aryl iodide-catalyzed fluorolactonization is reported. This methodol. uses HF-pyridine as a nucleophilic fluoride source with a peracid stoichiometric oxidant and provides access to lactones containing fluorine-bearing stereogenic centers in high enantio- and diastereoselectivity. The regioselectivity observed in these lactonization reactions is complementary to that obtained with established asym. electrophilic fluorination protocols.

Journal of the American Chemical Society published new progress about Enantioselective synthesis. 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-3-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tanimoto, Kouichi published the artcileA convenient one-pot access to phenanthridinones via Suzuki-Miyaura cross-coupling reaction, Recommanded Product: Methyl 2-bromo-3-fluorobenzoate, the main research area is phenanthridinone preparation Suzuki Miyaura coupling aminophenylboronic acid halobenzoate.

A convenient one-step access to biol. important phenanthridinones has been realized based upon Suzuki-Miyaura cross-coupling reaction. Reactions of 2-aminophenylboronic acid with 2-halobenzoate took place smoothly to afford substituted phenanthridinones in excellent yields in the presence of palladium(II) acetate and 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (SPhos) as pre-catalysts. A natural product phenaglydon was synthesized in one-pot manner from readily available starting materials in 95% yield.

Tetrahedron Letters published new progress about Aromatic carboxylic acids, esters Role: RCT (Reactant), RACT (Reactant or Reagent). 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-3-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Yan, Qiaozhi published the artcileRh-Catalyzed Asymmetric Hydrogenation of α,β- and β,β-Disubstituted Unsaturated Boronate Esters, Product Details of C8H6BrFO2, the main research area is phenethyl boronate chiral preparation styrylboronate asym hydrogenation rhodium catalyst; chiral amine alc preparation asym hydrogenation styrylboronate oxidation amination; asymmetric catalysis; asymmetric hydrogenation; chiral boronate; enantioselectivity; unsaturated boronates.

Chiral phenethyl boronates ArCHRCH2Bpin and ArCH2CHRBpin were prepared by asym. hydrogenation of α- and β-substituted β-styrylboronates. A highly enantioselective hydrogenation of α,β-unsaturated boronate esters catalyzed by Rh-(S)-DTBM-Segphos complex has been developed. Both (Z)-α,β- and β,β-disubstituted substrates can be successfully hydrogenated to afford chiral boronates with excellent enantioselectivities, up to 98% ee. Furthermore, the obtained chiral boronate esters, as important versatile synthetic intermediates are successfully transformed to the corresponding chiral alcs., amines and other important derivatives with maintained enantioselectivities.

Chemistry – A European Journal published new progress about Alcohols, chiral Role: SPN (Synthetic Preparation), PREP (Preparation). 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Product Details of C8H6BrFO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Su, Shun published the artcileBiphenyl acid derivatives as APJ receptor agonists, Name: Methyl 2-bromo-3-fluorobenzoate, the main research area is heart failure cardioprotective APJ apelin receptor agonist biphenyl acid.

The APJ receptor and its endogenous peptidic ligand apelin have been implicated as important modulators of cardiovascular function, and APJ receptor agonists may be beneficial in the treatment of heart failure. In this article, we describe the discovery of a series of biphenyl acid derivatives as potent APJ receptor agonists. Following the identification of initial high-throughput screen lead 2(I), successive optimization led to the discovery of lead compound 15a(II). II demonstrated comparable in vitro potency to apelin-13, the endogenous peptidic ligand for the APJ receptor. In vivo, II demonstrated a dose-dependent improvement in the cardiac output in male Sprague Dawley rats with no significant changes in either mean arterial blood pressure or heart rate, consistent with the hemodynamic profile of apelin-13 in an acute pressure volume loop model.

Journal of Medicinal Chemistry published new progress about Cardioprotective agents. 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Name: Methyl 2-bromo-3-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Murai, Takuya published the artcileOne-Pot Preparation of (NH)-Phenanthridinones and Amide-Functionalized [7]Helicene-like Molecules from Biaryl Dicarboxylic Acids, Recommanded Product: Methyl 2-bromo-3-fluorobenzoate, the main research area is phenanthridinone amide helicene preparation; biaryl dicarboxylic acid Curtius rearrangement cyclization.

A one-pot transformation of biaryl dicarboxylic acids to (NH)-phenanthridinone derivatives based on a Curtius rearrangement and subsequent basic hydrolysis was developed. This method is also applicable for the preparation of optically active amide-functionalized [7]helicene-like mols. Furthermore, aza[5]helicene derivatives with a phosphate moiety were isolated as a product of the Curtius rearrangement step in the case of substrates that bear chalcogen atoms. The stereostructures of these products, revealed by X-ray diffraction anal., suggested that chalcogen-bonding and pnictogen-bonding interactions might contribute to their stabilization. The configurational stability of the helicene-like mols. and their chiroptical properties were further investigated.

Journal of Organic Chemistry published new progress about Base hydrolysis. 647020-71-1 belongs to class bromides-buliding-blocks, name is Methyl 2-bromo-3-fluorobenzoate, and the molecular formula is C8H6BrFO2, Recommanded Product: Methyl 2-bromo-3-fluorobenzoate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary