Category: 64695-79-0

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 64695-79-0, name is 2-Bromo-4,5-difluoroaniline, A new synthetic method of this compound is introduced below., Recommanded Product: 2-Bromo-4,5-difluoroaniline

To a mixture of compound 47a (10 g, 48.08 mmol) and compound 47b (20.84 g, 57.69 mmol) in toluene (200 mL) was added Pd (PPh3) 4 (2.78 g, 2.4 mmol) in one portion under N 2. The resulting black mixture was stirred at 100C for 12 h under N 2. The reaction was cooled to 25C and then treated with 6N HCl (10 mL) with stirring at 25C for 1h. It was diluted with water (400 mL) and extracted with EtOAc (120 mL 3). The combined organic layers was washed with 20%KF solution (200 mL) and brine (100 mL) successively, dried over sodium sulfate and concentrated in vacuum to give the crude product, which was purified by column chromatography on silica gel (5%EtOAc in petroleum ether) to give compound 47c (4.2 g, 51% yield) as a yellow solid. LCMS: R t = 0.709 min in 5-95AB_220&254. lcm chromatography (MERCK RP18 2.5-2mm), MS (ESI) m/z=171.9 [M+H] +. 1H NMR: (400MHz, CDCl 3) delta 7.50 (dd, J=8.8 Hz, 11.2 Hz, 1H), 6.41 (dd, J=6.8 Hz, 12.0 Hz, 1H), 6.37-6.17 (m, 2H), 2.52 (s, 3H).

The synthetic route of 64695-79-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DIZAL (JIANGSU) PHARMACEUTICAL CO., LTD; LI, Zhengtao; ZOU, Hao; ZHU, Wei; SHEN, Changmao; WANG, Rumin; LIU, Wengeng; CHEN, Xiang; TSUI, Honchung; YANG, Zhenfan; ZHANG, Xiaolin; (307 pag.)WO2019/149164; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64695-79-0, name is 2-Bromo-4,5-difluoroaniline, This compound has unique chemical properties. The synthetic route is as follows., Formula: C6H4BrF2N

To a solution of 2-bromo-4,5- difluoroaniline (1.2 g, 4.3 mmol) in DMF (4 mL) was added tetrakis(triphenylphosphine)palladium(0) (400 mg, 0.34 mmol) and zinc cyanide (800 mg, 6.8 mmol). The solution was sparged with nitrogen and heated at 120 C for 30 minutes in a Biotage microwave reactor. The resulting suspension was filtered and concentrated in vacuo to afford the crude product. Purification by column chromatography (CI 8 reverse phase, water + 0.1% NH3 H20 -> MeCN + 0.1% NH3 H2O) afforded the desired 2-Amino-4,5-difluorobenzonitrile.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 64695-79-0.

Reference:
Patent; INCEPTION 1, INC.; JACINTHO, Jason, Duarte; CLARK, Ryan, Christopher; SHENG, Tao; OBALLA, Renata, Marcella; STOCK, Nicholas, Simon; ROPPE, Jeffrey, Roger; (161 pag.)WO2017/192304; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary