Category: 639520-70-0

Nguyen, Julia; Chong, Andrea; Lalic, Gojko published the artcile< Nickel-catalyzed anti-Markovnikov hydroarylation of alkenes>, HPLC of Formula: 639520-70-0, the main research area is alkene aryl halide anti Markovnikov hydroarylation regioselective nickel catalyst.

We have developed a nickel-catalyzed hydroarylation of alkenes using aryl halides as coupling partners. Excellent anti-Markovnikov selectivity is achieved with aryl-substituted alkenes and enol ethers. We also show that hydroarylation occurs with alkyl substituted alkenes to yield linear products. Preliminary examination of the reaction mechanism suggests irreversible hydrometallation as the selectivity determining step of the hydroarylation.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, HPLC of Formula: 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Malysheva, Yulia B.; Combes, Sebastien; Fedorov, Alexey Yu.; Knochel, Paul; Gavryushin, Andrei E. published the artcile< New method of synthesis and biological evaluation of some combretastatin A-4 analogues>, Formula: C12H16BrNO2, the main research area is combretastatin A4 analog stereoselective preparation antitumor.

A series of novel combretastatin A-4 analogs was synthesized in 36-64% yields by Negishi cross-coupling reaction under mild conditions. The prepared compounds exhibit good cytotoxicity against HBL100 epithelial cell lines (IC50 = 0.022-10.31 μM).

Synlett published new progress about Antitumor agents. 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Formula: C12H16BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ge, Shaozhong; Arlow, Sophie I.; Mormino, Michael G.; Hartwig, John F. published the artcile< Pd-Catalyzed α-Arylation of Trimethylsilyl Enolates of α,α-Difluoroacetamides>, Product Details of C12H16BrNO2, the main research area is difluorotrimethylsilylacetamide aryl heteroaryl bromide arylation palladium catalyst; aryl difluoroketone difluoroacetaldehyde difluoroacetate difluoroethanol difluoroethylamine preparation; difluoroethanol ethylamine preparation.

We report the arylation and heteroarylation of α,α-difluoro-α-(trimethylsilyl)acetamides with aryl and heteroaryl bromides catalyzed by an air- and moisture-stable palladacyclic complex containing P(t-Bu)2Cy as ligand. A broad range of electronically varied aryl and heteroaryl bromides underwent this transformation to afford α-aryl-α,α-difluoroacetamides in high yields. Due to the electrophilicity of the fluorinated amide, this palladium-catalyzed cross-coupling reaction provides a versatile platform to generate a range of α,α-difluoro carbonyl compounds, such as α-aryl-α,α-difluoroketones, -acetaldehydes, -acetates, and acetic acids, and difluoroalkyl derivatives, such as 2-aryl-2,2-difluoroethanols and -ethylamines, under mild conditions.

Journal of the American Chemical Society published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (difluoro trimethylsilyl). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Product Details of C12H16BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Trammel, Grace L.; Kuniyil, Rositha; Crook, Phillip F.; Liu, Peng; Brown, M. Kevin published the artcile< Nickel-Catalyzed Dearomative Arylboration of Indoles: Regioselective Synthesis of C2- and C3-Borylated Indolines>, Electric Literature of 639520-70-0, the main research area is indole derivative preparation nickel catalyzed dearomative arylboration diborane; borylated arylindoline asym preparation; potential energy surface dearomative arylboration indole derivative; azamedicarpin natural product multistep enantioselective preparation.

Indole dearomatization is an important strategy to access indolines: a motif present in a variety of natural products and biol. active mols. Herein, a method for transition-metal catalyzed regioselective dearomative arylboration of indoles to generate diverse indolines is presented. The method accomplishes intermol. dearomatization of simple indoles through a migratory insertion pathway on substrates that lack activating or directing groups on the C2- or C3-positions. Synthetically useful C2- and C3-borylated indolines can be accessed through a simple change in N-protecting group in high regio- and diastereoselectivities (up to >40:1 rr and >40:1 dr) from readily available starting materials. Addnl., the origin of regioselectivity was explored exptl. and computationally to uncover the remarkable interplay between carbonyl orientation of the N-protecting group on indole, electronics of the C2-C3 π-bond, and sterics. The method enabled the 1st enantioselective synthesis of (-)-azamedicarpin.

Journal of the American Chemical Society published new progress about Borylation. 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Electric Literature of 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shi, Hang; Braun, Augustin; Wang, Lu; Liang, Steven H.; Vasdev, Neil; Ritter, Tobias published the artcile< Synthesis of 18F-Difluoromethylarenes from Aryl (Pseudo) Halides>, Recommanded Product: tert-Butyl (4-bromophenyl)(methyl)carbamate, the main research area is fluoromethyl arene 18F labeled chemoselective preparation; fluoroacetophenone chemoselective preparation bromination fluorination deacylation; coupling aryl halide pseudohalide fluoroacetophenone bromination substitution fluoride deacylation; bromination substitution 18F fluoride deacylation arylfluoromethyl phenyl ketone; aryl (pseudo) halides; difluoromethylarenes; fluorine-18; positron emission tomography; radiopharmaceuticals.

A general, operationally simple, and chemoselective method for the synthesis of [18F]difluoromethylarenes such as I (R = 18FFCH) from [18F]fluoride and aryl chlorides, bromides, iodides, and triflates or pseudohalides such as I (R = TfO) is reported. Coupling of the aryl halides or pseudohalides to α-fluoroacetophenone in the presence of a palladium biphenylamine precatalyst yields α-fluoro-α-arylmethyl Ph ketones such as I (R = PhCOCHF); α-bromination and substitution with [18F]fluoride, tetraethylammonium bromide, and N-bromophthalimide in acetonitrile and chlorobenzene followed by deacylation with aqueous KOH yielded mono-[18F]-labeled difluoromethylarenes such as I (R = 18FFCH) in 10-60% radiochem. yields. The method was used to prepared 18F-difluoromethylated analogs of pharmaceuticals such as Claritin, fluoxetine (Prozac), and DAA1106.

Angewandte Chemie, International Edition published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Recommanded Product: tert-Butyl (4-bromophenyl)(methyl)carbamate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gao, Pin; Chen, Liang-An; Brown, M. Kevin published the artcile< Nickel-Catalyzed Stereoselective Diarylation of Alkenylarenes>, Safety of tert-Butyl (4-bromophenyl)(methyl)carbamate, the main research area is aryl bromide arylboron reagent alkenylarene nickel diarylation catalyst; alkane aryl stereoselective preparation.

A three-component coupling of aryl bromides, arylboron reagents, and alkenylarenes is presented. The method tolerates a variety of substitution patterns on all of the components. In particular, 1,2-disubstituted alkenylarenes are suitable and undergo highly diastereoselective diarylation.

Journal of the American Chemical Society published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Safety of tert-Butyl (4-bromophenyl)(methyl)carbamate.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vechorkin, Oleg; Godinat, Aurelien; Scopelliti, Rosario; Hu, Xile published the artcile< Cross-Coupling of Nonactivated Alkyl Halides with Alkynyl Grignard Reagents: A Nickel Pincer Complex as the Catalyst>, Application In Synthesis of 639520-70-0, the main research area is alkyl halide alkynyl Grignard cross coupling nickel catalysis.

Alkynes containing nonactivated alkyl groups, especially those with β-hydrogen atoms, are difficult to synthesize. In this paper, we have disclosed the first general nickel-catalyzed cross-coupling of nonactivated alkyl halides with alkynyl Grignard reagents. The wide scope and high functional group tolerance makes the method attractive for the streamlined preparation of alkynes containing nonactivated alkyl groups. At this moment, only primary alkyl halides can be coupled. Methods to couple secondary alkyl halides are currently being developed in our laboratory

Angewandte Chemie, International Edition published new progress about Cross-coupling reaction. 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Application In Synthesis of 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lambright, Alison L.; Liu, Yanyao; Joyner, Isaac A.; Logan, Kaitlyn M.; Brown, M. Kevin published the artcile< Mechanism-Based Design of an Amide-Directed Ni-Catalyzed Arylboration of Cyclopentene Derivatives>, Product Details of C12H16BrNO2, the main research area is borylated cyclopentane amide derivative preparation; crystal structure borylated cyclopentane amide derivative; mol structure borylated cyclopentane amide derivative; amide directed nickel catalyzed diastereoselective arylboration cyclopentene derivative.

A method for amide-directed Ni-catalyzed diastereoselective arylboration of cyclopentenes is disclosed. The reaction allows for the synthesis of sterically congested cyclopentane scaffolds that contain an easily derivatized boronic ester and amide functional handles. The nature of the amide directing group and its influence on the reaction outcome were studied and ultimately reflect a predictably selective reaction based on the solvent and base counterion.

Organic Letters published new progress about Amides Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation) (borylated cyclopentene derivatives). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Product Details of C12H16BrNO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Linstad, Ethan J.; Vavere, Amy L.; Hu, Bao; Kempinger, Jayson J.; Snyder, Scott E.; DiMagno, Stephen G. published the artcile< Thermolysis and radiofluorination of diaryliodonium salts derived from anilines>, Synthetic Route of 639520-70-0, the main research area is aniline diaryliodonium salt preparation radiofluorination.

Aniline-derived diaryliodonium salts were synthesized and functionalized in good to excellent yields by judicious utilization of electron-withdrawing protecting groups. This simple approach opens another route to radiolabeling amino arenes in relatively complex mols., such as flutemetamol.

Organic & Biomolecular Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 639520-70-0 belongs to class bromides-buliding-blocks, and the molecular formula is C12H16BrNO2, Synthetic Route of 639520-70-0.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary