Category: 630-17-1

Adding a certain compound to certain chemical reactions, such as: 630-17-1, name is 1-Bromo-2,2-dimethylpropane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 630-17-1, name: 1-Bromo-2,2-dimethylpropane

General procedure: In the presence of tetrabutylammoniumiodide (738 mg, 2.0 mmol), 12 (800 mg,3.71 mmol) was alkylated with neopentyl bromide (2.4 mL,19 mmol) at 50 C in DMF to give 1-O-benzyl-2-O-neopentyl-3,4-O-isopropylidene-D-erythritol (14g, 409 mg, 40%) as colorless oil,[a]D23 +15.0 (c 1.05, CHCl3). IR (neat): 1477, 1454, 1369, 1253,1215, 1084, 1061, 1030 cm1. 1H NMR (500 MHz, CDCl3) d: 0.90[9H, s, OCH2C(CH3)3], 1.35/1.41 [each 3H, s, C(CH3)2], 3.13/3.35[each 1H, d, J = 8.3, OCH2C(CH3)3], 3.46 (1H, ddd, J = 6.3, 4.9, 3.2,H-2), 3.55 (1H, dd, J = 10.6, 4.9, H-1a), 3.68 (1H, dd, J = 10.6, 3.2,H-1b), 3.95 (1H, dd, J = 8.3, 6.3, H-4a), 4.05 (1H, dd, J = 8.3, 6.3, H-4b), 4.16 (1H, ddd, J = 6.3, 6.3, 6.3, H-3), 4.56 (2H, s, OCH2Ph),7.25-7.36 (5H, m, arom.). 13C NMR (125 MHz, CDCl3) d: 25.4/26.7[C(CH3)2], 26.7 [OCH2C(CH3)3], 32.2 [OCH2C(CH3)3], 66.7 (C-4),70.0 (C-1), 73.4 (OCH2Ph), 75.6 (C-3), 79.9 (C-2), 81.5 [OCH2C(CH3)3], 108.9 [C(CH3)2], 127.5/128.3 (d, arom.), 138.4 (s, arom.).LRMS (FAB, pos.) m/z: 345 [M+Na]+. HRMS (FAB, pos.): calcd forC19H30O4Na 345.2042, found 345.2052.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2,2-dimethylpropane, and friends who are interested can also refer to it.

Reference:
Article; Tanabe, Genzoh; Xie, Weijia; Balakishan, Gorre; Amer, Mumen F.A.; Tsutsui, Nozomi; Takemura, Haruka; Nakamura, Shinya; Akaki, Junji; Ninomiya, Kiyofumi; Morikawa, Toshio; Nakanishi, Isao; Muraoka, Osamu; Bioorganic and Medicinal Chemistry; vol. 24; 16; (2016); p. 3705 – 3715;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 630-17-1, name is 1-Bromo-2,2-dimethylpropane, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-2,2-dimethylpropane

EXAMPLE 15 O-Methyl P-neopentylphosphonite Magnesium turnings, 8.38 g, were crushed in 40 ml of anhydrous ether and 3.0 ml of neopentyl bromide added. Mild heating was used to initiate the reaction. Once the reaction started, the heat was removed. Then a solution of 47 g of neopentyl bromide dissolved in 80 ml of ether was added dropwise over 90 minutes. The rate of the addition was such that the reaction mixture was kept at a gentle reflux. After the addition was complete the reaction was refluxed for an additional 30 minutes and allowed to cool to room temperature and stir overnight. The Grignard solution prepared above was added dropwise over 100 minutes to a solution of 93.4 g of phosphorous trichloride in 240 ml of anhydrous ether which was cooled to -65 C. The reaction temperature was kept at or below -55 C. during the addition. The reaction solution was allowed to warm to room temperature over 90 minutes. After one hour of stirring at room temperature the reaction solution was cooled by an ice and water bath and a solution of 76.2 g of methanol and 165.9 g of pyridine was added dropwise over 90 minutes. The reaction temperature did not exceed 20 C. during the addition. After 30 minutes of additional stirring the cooling bath was removed and the reaction was allowed to stand at room temperature over the weekend. The reaction solution was vacuum filtered through Celite, the filter cake rinsed with 800 ml of ether and the filtrate concentrated to yield 43.2 g of a pale yellow oil. A vacuum of 3 Torr was pulled on the sample for 3 hours to remove the residual trimethyl phosphite. Yield was 12.6 g of a yellow liquid.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Rohm and Haas Company; US5272128; (1993); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 630-17-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 630-17-1 as follows.

To a solution of trans-N-(4-furo [3 ,2-b]pyridin-3 -ylcyclohexyl)- 1H-pyrazole-4-sulfonamide (20 mg, 1 equiv.) in DMF (1 mL), K2C03 (23.6 mg, 3 equiv.) was added, followed by 1- bromo-2,2-dimethyl-propane (10.8 tL, 1.5 equiv.). The reaction mixture was stirred for 30 mm at 150 C by using microwave irradiation, and was then purified by preparative HPLCMS to afford the expected product (8 mg). LCMS: MW (calc?d): 416.5; MS (ES, m/z):417.7 [M+H].

According to the analysis of related databases, 630-17-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; E-THERAPEUTICS PLC; KOLUND?IC, Filip; MILEK, Mateja; POLJAK, Tanja; RO?CIC, Maja; STUBBERFIELD, Colin; VADLAMUDI, Srinivasamurthy; (139 pag.)WO2019/43373; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 630-17-1, These common heterocyclic compound, 630-17-1, name is 1-Bromo-2,2-dimethylpropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A 10 mL Schlenk tube was charged with CoBr2 (6.6 mg, 0.03mmol), 1,3-diisopropyl-1H-benzimidazol-3-ium bromide (L4; 8.5mg, 0.03 mmol), 4-methoxy-N-[(1E)-1-phenylethylidene]aniline(1a, 67.6 mg, 0.30 mmol), 1-chlorooctane (2a, 76.5 muL, 0.45 mmol), and THF (0.69 mL). A 1.92 M solution of t-BuCH2MgBr inTHF (0.31 mL, 0.60 mmol) was added dropwise at 0 C, and themixture was stirred at r.t. for 6 h. The reaction was quenched by theaddition of 3 M aq HCl (1.0 mL), and the mixture was stirred at r.t.for 1 h, then extracted with EtOAc (3 ¡Á 10 mL). The organic layerswere combined, dried (MgSO4), and concentrated under reduced pressure. The crude product was purified by chromatography [silicagel, hexane-EtOAc (40:1)].

Statistics shows that 1-Bromo-2,2-dimethylpropane is playing an increasingly important role. we look forward to future research findings about 630-17-1.

Reference:
Article; Gao, Ke; Yamakawa, Takeshi; Yoshikai, Naohiko; Synthesis; vol. 46; 15; (2014); p. 2024 – 2039;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 630-17-1, name is 1-Bromo-2,2-dimethylpropane, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Bromo-2,2-dimethylpropane

To a solution of 0,8g(33,10 mmol)of magnesium turnings and 2,0g(13,2 mmol)of 1- bromo-2,2-dimethylpropane in 10 mL diethyl ether was added a solution of 1.42 g (7.76 mmol) of 4-bromostyrene and 69 mg (0.13 [MMOL) OF NI] (dppf) [C12.] The resulting reaction mixture was heated at refluc for 8 h. The reaction was quenched with [50%] saturated NH4Cl, and was extracted with MTBE (2 x 150 mL). The combined extractions were washed with water, dried and concentrated. Flash chromatography on a Biotage 40M cartridge with hexanes as the eluant afforded 1.74 g of the title compound [: LH NMR (500 MHZ) a 0.] 93 (s, 9H), 2.49 (s, 2H), 5.20 (d, J = 10.9, 1H), 5.73 (d, [J] = 17.6, 1H), 6.72 (dd, [JL] [= 17.] 6, J2 [= 10.] 8,1H), 7.10 (d, J = 8.2, 2H), 7.33 (d, J = 8.0, 2H); ESI-MS 161 (M+H); LC-1: 4.4 min.

According to the analysis of related databases, 630-17-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK & CO., INC.; WO2004/35538; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 630-17-1, name is 1-Bromo-2,2-dimethylpropane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 630-17-1, COA of Formula: C5H11Br

Example 2: Synthesis of posphoric acid mono-[2-(2, 2-dimethyl-propane-1-sulfonyl)-ethyl] ester A. 2-(2, 2-Dimethyl-propane-1-sulfonyl)-ethanol; A suspension of 2-mercapto-ethanol (110 mg, 1.41 mmol), 1-bromo-2, 2-dimethyl-propane (210 mg, 1.41 mmol) and K2C03 (195 mg, 1.41 mmol) in DMF (3 mL) was stirred at 60 C for 5 h. The reaction mixture was then cooled to room temperature and treated with a mixture of 2KHS05-KHS04 (1.30 g, 2.11 mmol) in water (0.5 mL). After stirring for 12 h at room temperature, the solvent was removed in vacuo, and the residue partitioned between ethyl acetate and water. The organic layer was dried over Na2S04, filtered, and concentrated in vacuo. The residue was purified by flash chromatography over silica gel (elution with hexane/ethyl acetate 4: 1) to give the title compound as a colorless oil. 1H NMR (300 MHz, DMSO-d6) 6 1.23 (s, 9H), 2.55 (s br. , 1H), 3.05 (s, 2H), 3.18-3. 23 (m, 2H), 4.09-4. 19 (m, 2H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; JERINI AG; WO2005/80406; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary