Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 627463-18-7, name is 4-Bromo-1-ethyl-2-fluorobenzene, A new synthetic method of this compound is introduced below., COA of Formula: C8H8BrF
To a stirred solution of 4-bromo-1-ethyl-2-fluoro-benzene (1.80 g, 8.86 mmol) in N,N-dimethylformamide (20 mL), under a nitrogen atmosphere was added PdCl2(PPh3)2, CuI, and LiCl. The mixture was stirred at 60 C. for 3 hours, then poured into water and extracted with ether (3*20 mL). The extract was dried (Na2SO4) and concentrated. The residue was filtered through a pad of silica gel eluding with hexanes. Removal of solvent gave the crude, 1.67 g, which was used for the next step.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Chu, Xin-Jie; Ding, Qingjie; Jiang, Nan; Kim, Kyungjin; Lovey, Allen John; McComas, Warren William; Mullin JR., John Guilfoyle; Tilley, Jefferson Wright; US2004/6058; (2004); A1;,
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