Category: 626-88-0

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 626-88-0 as follows. category: bromides-buliding-blocks

Example 271 N-(1H-5-Indazolyl)-N-[1-(4-methylpentyl)-4-piperidyl]amine 4-Piperidone hydrochloride monohydrate (768 mg) and potassium carbonate (1.38 g) were dissolved in anhydrous N,N-dimethylformamide (10 ml), and 1-bromo-4-methylpentane (603 mg) was added dropwise to the solution at room temperature. The reaction solution was stirred at room temperature for 18 hr. Ethyl acetate was then added thereto, and the mixture was washed with water and saturated brine and was dried over anhydrous sodium sulfate. The organic layer was concentrated under the reduced pressure to give an intermediate. This intermediate (766 mg) was dissolved in titanium tetraisopropoxide (3.8 ml). 5-Aminoindazole (445 mg) was added to the solution, and the mixture was stirred at room temperature for 18 hr. Methanol (3.8 ml) and sodium borohydride (79 mg) were added to the reaction solution, and the mixture was stirred for 18 hr. The reaction solution was diluted with ethyl acetate (40 ml), and a minor amount of water was added thereto, and the mixture was then filtered under the reduced pressure. The filtrate was concentrated under the reduced pressure, and the residue was purified by column chromatography on silica gel [chloroform/methanol] to give the title compound (200 mg, yield 13.3%). 1H-NMR (CDCl3, 400 MHz): 0.89 (d, J = 6.6 Hz, 6H), 1.15 – 1.26 (m, 2H), 1.49 – 1.59 (m, 5H), 2.07 – 2.23 (m, 1H), 2.35 – 2.39 (m, 2H), 2.90 – 3.00 (m, 2H), 3.29 – 3.38 (m, 1H), 6.80 – 6.82 (m, 2H), 7.26 (s, 1H), 7.88 (s, 1H) Mass spectrum (ESI-MS, m/z): 301 (M++1), 299 (M+-1)

According to the analysis of related databases, 626-88-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KIRIN BEER KABUSHIKI KAISHA; EP1256574; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 626-88-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 626-88-0 as follows.

General procedure: To a solution of compound 3 (0.46 g, 2 mmol), in dry DMF (5 mL), and anhydrous potassium carbonate (0.5 g, 3.4 mmol) and,an appropriate bromoalkyl halide (2 equivalent) was added. Themixturewas heated for 12 h at 80 C, and then the reaction mixturewas poured over crushed ice, filtered and washed with water toyield the desired product. The isolated crude materials were furtherpurified by silica gel chromatography, using EtOAc-hexane (3:7) toprovide the desired products. The physical characteristics andspectral data of separated products are listed below.

According to the analysis of related databases, 626-88-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yahia, Eman; Mohammad, Haroon; Abdelghany, Tamer M.; Fayed, Eman; Seleem, Mohamed N.; Mayhoub, Abdelrahman S.; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 604 – 613;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-88-0, name is 1-Bromo-4-methylpentane, A new synthetic method of this compound is introduced below., Formula: C6H13Br

To a solution of the 1H-indazol-5-ol (100 mg, 0.745 mmol) obtained in Reference Example 4 in N,N-dimethylformamide (2 ml) were added 1-bromo-4-methylpentane (0.109 ml, 0.745 mmol), tetrabutylammonium iodide (28 mg, 0.1 mmol) and potassium carbonate (103 mg, 0.745 mmol), and the resulting mixture was heated to 60C. After 9 hours, the mixture was poured into water (20 ml) and extracted with ethyl acetate (20 ml x 2). The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure, and the resulting residue was purified by a silica gel column chromatography (eluent: hexane/ethyl acetate) to obtain 5-[(4-methylpentyl)oxy]-1H-indazole (60 mg, 37%). Melting point: 124-126C

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Sumitomo Pharmaceuticals Company, Limited; EP1403255; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-88-0, name is 1-Bromo-4-methylpentane, A new synthetic method of this compound is introduced below., Quality Control of 1-Bromo-4-methylpentane

General procedure: A Grignard suspension of 1-bromo-4-methylpentane in THF (50 mL) was prepared from the bromide (1.64 g, 9.94 mmol) and Mg (0.29 g, 11.92 mmol) in the usual manner. The suspension was cooled (-50 C) and Cu(I) bromide (0.712 g, 4.97 mmol) was added to it. The mixture was stirred for 15 min. To the resultant black suspension at -50 C was added compound 8a (1.5 g, 3.31 mmol) in THF (40 mL). The mixture was stirred at the same temperature for 1 h and then overnight at room temperature. The reaction was quenched by the addition of aqueous saturated NH4Cl (10 mL) and extracted with EtOAc. The organic layer was washed with 5% aqueous HCl, water, brine, and then dried over Na2SO4. Solvent removal under reduced pressure and column chromatography of the residue (silica gel, 0-10% EtOAc in hexane) afforded pure 9a (1.24 g, yield 70%) as a colorless liquid.

The synthetic route of 626-88-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Dubey, Akhil Kumar; Chattopadhyay, Angshuman; Tetrahedron Asymmetry; vol. 22; 14-15; (2011); p. 1516 – 1521;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-88-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 626-88-0, name is 1-Bromo-4-methylpentane, This compound has unique chemical properties. The synthetic route is as follows.

Take iso vanillin (3. 04g, 20nmol) to a 100ml round bottom flask and 15ml DMF, 4-methyl-1-bromopentane (3. 465g, 21nmol), anhydrous K2C03 (llg, 80nmol), stirred at room temperature overnight, TLC the reaction was complete, add Ethyl acetate and water layers were separated and extracted once with ethyl acetate, the combined organic additive water, saturated brine, dried and concentrated to give 3-(4-methyl-pentyloxy)-4-methoxy-benzaldehyde 4.6g, yield 98%.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-4-methylpentane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shanghai Institute of Materia Medica (SIMM), Chinese Academy of Sciences (CAS); NAN, FAJUN; ZUO, JIANPING; LI, JIA; ZHANG, MEI; Blom, Anna; TANG, WEI; YANG, XIAOYING; (40 pag.)CN103172543; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 626-88-0,Some common heterocyclic compound, 626-88-0, name is 1-Bromo-4-methylpentane, molecular formula is C6H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1: 2-(4-methylpentyl)-1H-isoindole-1,3(2H)-dione To a solution of 1-bromo-4-methylpentane (5.0 g, 0.030 mol) in DMF (20 mL) was added potassium phthalimide (5.9 g, 0.032 mol) in one portion at room temperature. After stirring at room temperature of 1 hr, the mixture was heated at 55 C. for 16 hr. Chloroform (30 mL) was added to the reaction mixture and the resulting mixture was poured into water (100 mL). The aqueous phase was extracted with chloroform and the combined organic phase was washed with 0.25 M NaOH (aq) and water. The organic phase was dried (Na2SO4), filtered and concentrated in vacuo to give 2-(4-methylpentyl)-1H-isoindole-1,3(2H)-dione as a pale yellow oil. (M+H) 232, 2.80 min. (LC/MS method A).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-methylpentane, its application will become more common.

Reference:
Patent; IGNAR, DIANE MICHELE; US2010/113512; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 626-88-0, name is 1-Bromo-4-methylpentane, molecular formula is C6H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 1-Bromo-4-methylpentane

General procedure: The solution of dihydroxyacetophenone (1, 1.0equiv), anhydrous potassium carbonate (2.0equiv) and corresponding alkyl bromides (2, 1.1equiv) in acetonitrile was stirred at 70-80C for 4-5h. After evaporation of acetonitrile, the reaction mixture was diluted with dichloromethane and washed with water three times. The organic layer was dried with anhydrous sodium sulfate and evaporated under reduced pressure. The crude product was purified by column chromatography to give 3. 6.1.1.2 1-(2-Hydroxy-6-(4-methylpentyloxy)phenyl)ethanone (3b) Yield 45%; light green liquid; Rf 0.60 (1:9 EA: HX); IR (KBr) 3335, 2917, 2850, 1618 cm-1; 1H NMR (CDCl3) delta 13.26 (s, 1H), 7.31 (t, J = 8.2 Hz, 1H), 6.54 (dd, J = 0.8, 8.4 Hz, 1H), 6.36 (d, J = 8.2 Hz, 1H), 4.01 (t, J = 6.5 Hz, 2H), 2.70 (s, 3H), 1.92-1.85 (m, 2H), 1.58-1.51 (m, 1H), 1.38-1.31 (m, 2H) 0.84 (d, J = 6.5 Hz, 6H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 626-88-0, its application will become more common.

Reference:
Article; Venkateswararao, Eeda; Sharma, Vinay K.; Yun, Jieun; Kim, Youngsoo; Jung, Sang-Hun; Bioorganic and Medicinal Chemistry; vol. 22; 13; (2014); p. 3386 – 3392;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 626-88-0, name is 1-Bromo-4-methylpentane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-88-0, category: bromides-buliding-blocks

To a solution of Magnesium turning (46 mg, 1.9 mmol) with catalytic amount of iodine indiethylether (1 mL) was added 1-bromo-4-methyl pentane(0.345 mL, 2.37 mmol). The reaction mixture was stirred under argon gas until complete consumption of the Magnesium turning at ambient temperature. To a reaction mixture was added 9 (500 mg,1.58 mmol) in diethylether (1 mL) at ambient temperature. The reaction mixture was stirred until the bubbling was over at ambient temperature. The reaction mixture was quenched with 2 N HCl, and diluted with EtOAc. The organic phase was washed with H2O and brine, dried over MgSO4, and concentrated in vacuo. Purification of the residue via flash column chromatography on silica gel (EtOAc:n-Hexane 1:10 to 1:5) afforded 96 mg (15%) of the desired alcohol11: 1H NMR (CDCl3, 300 MHz) d 5.35 (d, J 5.3 Hz, 1H), 3.53 (m, 1H),2.32-2.24 (m, 2H), 2.11-0.86 (m, 42H). LR-MS (FAB) m/z 425(M Na)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Kim, Kyeojin; Maharjan, Sony; Lim, Changjin; Kim, Nam-Jung; Agrawal, Vijayendra; Han, Young Taek; Lee, Sujin; An, Hongchan; Yun, Hwayoung; Choi, Hyun-Jung; Kwon, Young-Guen; Suh, Young-Ger; European Journal of Medicinal Chemistry; vol. 75; (2014); p. 184 – 194;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 626-88-0, A common heterocyclic compound, 626-88-0, name is 1-Bromo-4-methylpentane, molecular formula is C6H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Entry 7: 3,7-dimethyloctan-2-one (0.5 mmol, 78.1 mg). The remote product was 7-hydroxy-3,7-dimethyloctan-2-one (21), and the proximal product was 3-hydroxy-3,7-dimethyloctan-2-one. Purification by flash chromatography (35% EtOAc/hexanes), run 1 (46.0 mg, 0.267 mmol, 53%), run 2 (43.1 mg, 0.250 mmol, 50%). Average: 52%. Recovered starting material (rSM): 14.2 mg, 0.183 mmol, 18%. [Remote:Proximal]>99:1. Authentic proximal oxidation product was obtained by treating 1-bromo-4-methylpentane (1 equiv.) with Mg turnings (1 equiv.), followed by 2,3-butandione (1 equiv.) at -78 C. The reaction was quenched H2O, extracted with CH2Cl2 and purified by column chromatography (15% EtOAc/hexanes) to yield 3-hydroxy-3,7-dimethyloctan-2-one.

The synthetic route of 626-88-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Board of Trustees of the University of Illinois; US2011/15397; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary