Category: 626-40-4

《Solid-Phase Synthesis of Sequence-Defined Informational Oligomers》 was published in Journal of Organic Chemistry in 2020. These research results belong to Strom, Kyle R.; Szostak, Jack W.. Name: 3,5-Dibromoaniline The article mentions the following:

Genetic biopolymers utilize defined sequences and monomer-specific mol. recognition to store and transfer information. Synthetic polymers that mimic these attributes using reversible covalent chem. for base-pairing pose unique synthetic challenges. Here, we describe a solid-phase synthesis methodol. for the efficient construction of ethynyl benzene oligomers with specific sequences of aniline and benzaldehyde subunits. Handling these oligomers is complicated by the fact that they often exhibit multiple conformations because of intra- or intermol. pairing. We describe conditions that allow the dynamic behavior of these oligomers to be controlled so that they may be manipulated and characterized without needing to mask the recognition units with protecting groups. The results came from multiple reactions, including the reaction of 3,5-Dibromoaniline(cas: 626-40-4Name: 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Name: 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Cheng, Yingjie; Qu, Zhonghua; Chen, Shiru; Ji, Xiaochen; Deng, Guo-Jun; Huang, Huawen published an article in Advanced Synthesis & Catalysis. The title of the article was 《Visible-Light-Induced Photoredox 1,1-Dichloromethylation of Alkenes with Chloroform》.Reference of 3,5-Dibromoaniline The author mentioned the following in the article:

A photoredox 1,1-dichloromethylation of alkenes RC(O)C(R1)=CHR2 (R = propylamino, anilino, 2,3-dihydroindol-1-yl, etc.) with the readily available bulk chem. chloroform was described, furnishing a variety of 1,1-dichloroalkane products RC(O)C(R1)C(R2)(CHCl2) selectively. Furthermore, this transformation could proceed smoothly on gram-scale, and the obtained products could transform into diverse γ-lactam derivatives such as 3-methyl-1-phenyl-1H-pyrrol-2(5H)-one, 5-methoxy/5-hydroxy-3-methyl-1-phenylpyrrolidin-2-one with simple treatment. Mechanistically, the single electron transfer (SET) with excited photocatalyst and subsequent deprotonation of triethylamine generates the key α-aminoradical intermediate, which enables selective Cl-atom transfer of chloroform. The specific selectivity, broad substrate scope, as well as the mild reaction conditions make this strategy especially attractive. After reading the article, we found that the author used 3,5-Dibromoaniline(cas: 626-40-4Reference of 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Reference of 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Schmidt, Andrea; Molano, Viviana; Hollering, Manuela; Poethig, Alexander; Casini, Angela; Kuehn, Fritz E. published 《Evaluation of New Palladium Cages as Potential Delivery Systems for the Anticancer Drug Cisplatin》.Chemistry – A European Journal published the findings.Name: 3,5-Dibromoaniline The information in the text is summarized as follows:

Self-assembled metallocages are very promising drug-delivery systems among supramol. complexes. Thus, exo-functionalized Pd2L4 (L=ligand) cages were synthesized and characterized, and the encapsulation of the anticancer drug cisplatin in their cavity has been documented. The antiproliferative effects of the metallocages and their combination with cisplatin were examined in vitro in cancer cell lines, while fluorescence microscopy was used to monitor their uptake. Notably, the hydroxymethyl-functionalized PdII cage encapsulating cisplatin showed improved cytotoxic effect against human ovarian cancer cells compared to free cisplatin. The toxicity of Pd2L4 cages was evaluated for the first time ex vivo in healthy rat-liver tissues using the precision cut-tissue slices technol., demonstrating in some cases scarce effects on liver viability. These results further highlight the potential of self-assembled Pd2L4 cages for biol. applications. In the experimental materials used by the author, we found 3,5-Dibromoaniline(cas: 626-40-4Name: 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Name: 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Fe Single Atoms and Fe2O3 Clusters Liberated from N-Doped Polyhedral Carbon for Chemoselective Hydrogenation under Mild Conditions》 was written by Yun, Ruirui; Zhan, Feiyang; Li, Na; Zhang, Beibei; Ma, Wanjiao; Hong, Lirui; Sheng, Tian; Du, Liting; Zheng, Baishu; Liu, Shoujie. HPLC of Formula: 626-40-4 And the article was included in ACS Applied Materials & Interfaces in 2020. The article conveys some information:

Fe-based catalyst FeSAs/Fe2O3ACs/N-doped polyhedral carbon (NPC) was designed and synthesized. As we expected, compared with FeSAs and FeNPs, FeSAs/Fe2O3ACs/NPC showed excellent catalytic performance (turnover frequency up to 1923 h-1, calculated with nitrobenzene), chemoselectivity, and tolerance during the hydrogenation reaction of nitro compounds under room temperature because of the synergistic effects between FeSAs and Fe2O3ACs. The theor. calculations show that FeSAs prefers to undergo hydrazine decomposition to generate hydrogen and the Fe2O3ACs surface is more active toward the nitrobenzene reduction to aniline. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4HPLC of Formula: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.HPLC of Formula: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

SDS of cas: 626-40-4In 2018 ,《Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase》 appeared in Journal of Medicinal Chemistry. The author of the article were Volkov, Oleg A.; Brockway, Anthony J.; Wring, Stephen A.; Peel, Michael; Chen, Zhe; Phillips, Margaret A.; De Brabander, Jef K.. The article conveys some information:

New therapeutic options are needed for treatment of human African trypanosomiasis (HAT) caused by protozoan parasite Trypanosoma brucei. S-Adenosylmethionine decarboxylase (AdoMetDC) is an essential enzyme in the polyamine pathway of T. brucei. Previous attempts to target this enzyme were thwarted by the lack of brain penetration of the most advanced series. Herein, the authors describe a T. brucei AdoMetDC inhibitor series based on a pyrimidineamine pharmacophore that the authors identified by target-based high-throughput screening. The pyrimidineamines showed selectivity for T. brucei AdoMetDC over the human enzyme, inhibited parasite growth in whole-cell assay, and had good predicted blood-brain barrier penetration. The medicinal chem. program elucidated structure-activity relationships within the series. Features of the series that were required for binding were revealed by determining the x-ray crystal structure of TbAdoMetDC bound to one analog. The pyrimidineamine series provides a novel starting point for an anti-HAT lead optimization. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4SDS of cas: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.SDS of cas: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Feng, Liheng; Deng, Yang; Wang, Xiaoju; Liu, Mingguang published 《Polymer fluorescent probe for Hg(II) with thiophene, benzothiazole and quinoline groups》.Sensors and Actuators, B: Chemical published the findings.Application of 626-40-4 The information in the text is summarized as follows:

A facile polymer consisted of quinoline, thiophene and benzothiazole groups was designed and synthesized by Suzuki coupling reaction. The study of photophys. property indicated that the polymer was a red light emitter with maximum absorption (490 nm) and emission (610 nm) peaks. The assays of thermal gravimetric anal. (TGA) and cyclic voltammetry (CV) revealed that the polymer possesses good thermal (Td, 228°C) and electrochem. properties. The exptl. data based on the cyclic voltammetry were in good agreement with the results of theor. calculations The sensing processes of the polymer to metal ions were investigated by UV-vis absorption and fluorescence emission spectra. The results showed that the polymer had high selectivity and sensitivity for Hg(II) ions with an obvious “”turn-on”” fluorescence in the presence of Hg(II). Noticeably, the polymer as a fluorescence probe can be applied in the detection in practical samples. The attribution of the work lies in providing a new strategy for design and application of polymer probes in anal. and testing fields. In the experiment, the researchers used 3,5-Dibromoaniline(cas: 626-40-4Application of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Application of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2015,Park, Kwang-su; Seo, Yujin; Kim, Mi Kyoung; Kim, Kyungdo; Kim, Yun Kyung; Choo, Hyunah; Chong, Youhoon published 《A curcumin-based molecular probe for near-infrared fluorescence imaging of tau fibrils in Alzheimer’s disease》.Organic & Biomolecular Chemistry published the findings.Product Details of 626-40-4 The information in the text is summarized as follows:

In recent years, there has been growing interest in the near-IR (NIR) fluorescence imaging of tau fibrils for the early diagnosis of Alzheimer’s disease (AD). In order to develop a curcumin-based NIR fluorescent probe for tau fibrils, structural modification of the curcumin scaffold was attempted by combining the following rationales: the curcumin derivative should preserve its binding affinity to tau fibrils, and, upon binding to tau fibrils, the probe should show favorable fluorescence properties. To meet these requirements, we designed a novel curcumin scaffold with various aromatic substituents. Among the series, the curcumin derivative 1c with a (4-dimethylamino-2,6-dimethoxy)phenyl moiety showed a significant change in its fluorescence properties (22.9-fold increase in quantum yield; Kd, 0.77 μM; λem, 620 nm; Φ, 0.32) after binding to tau fibrils. In addition, fluorescence imaging of tau-green fluorescent protein-transfected SHSY-5Y cells with 1c confirmed that 1c detected tau fibrils in live cells. After reading the article, we found that the author used 3,5-Dibromoaniline(cas: 626-40-4Product Details of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Product Details of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C6H5Br2NIn 2021 ,《Design, synthesis and biological evaluation of pyrazole-aromatic containing carboxamides as potent SDH inhibitors》 appeared in European Journal of Medicinal Chemistry. The author of the article were Yu, Bin; Zhao, Bin; Hao, Zesheng; Chen, Lei; Cao, Lixin; Guo, Xiaofeng; Zhang, Nailou; Yang, Dongyan; Tang, Liangfu; Fan, Zhijin. The article conveys some information:

To continue studies on discovery of new potent antifungal leads, 43 novel pyrazole-aromatic containing carboxamides were rationally designed and synthesized. Bioassays indicated that most target compounds displayed good in vitro antifungal activities against Botrytis cinerea, Rhizoctonia cerealis and Sclerotinia sclerotiorum and in vivo antifungal activity against R. solani. Compound I exhibited the most significant in vitro activity against R. cerealis (EC50 = 0.93μg/mL) with about 2-fold more potent than a previously reported lead compound N-(3-bromophenyl)-2-[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]-4-thiazolecarboxamide (EC50 = 2.01μg/mL), and about 11-fold more potent than the pos. control/com. succinate dehydrogenase inhibitor thifluzamide (EC50 = 23.09μg/mL). Structure-activity relationship anal. and mol. docking simulations indicated that the presence of difluoromethyl pyrazole-(m-benzene)carboxamide scaffold obviously increased the antifungal activity. The further enzymic bioassay showed that both thifluzamide and compound I displayed excellent SDH inhibitory effects, and fluorescence quenching anal. suggested that they may share the same target SDH. The results came from multiple reactions, including the reaction of 3,5-Dibromoaniline(cas: 626-40-4Formula: C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Formula: C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2015,Pogrebnoi, Vsevolod published 《New N-glucosylated substituted anilines》.Chemistry Journal of Moldova published the findings.Quality Control of 3,5-Dibromoaniline The information in the text is summarized as follows:

The reaction of (+)-D-glucose 1 with 4-chloroaniline 6b or 3,5-dibromoaniline 12 leads almost exclusively to the β-configuration of N-glucosylated anilines 7b and 13. Acetylated derivatives 8b, 14 and 15 were obtained by dissolving/suspending substances 7b and 13 in Ac2O/Py mixture The acetylation of 2-(3,5-dibromophenylamino)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 13 is less selective than in the case of the 2-(4-chlorophenylamino)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 7b and leads to compounds 2-(acetoxymethyl)-6-(3,5-dibromophenylamino)tetrahydro-2H-pyran-3,4,5-triyl triacetate 14 and 2-(acetoxymethyl)-6-(3,5-dibromophenylamino)-5-hydroxytetrahydro-2H-pyran-3,4-diyl diacetate 15 in a 2:1 ratio. The product 14 is formed with greater selectivity and in a higher yield (up to 80%) when the reaction is catalyzed by DMAP and stored for one week at +4°C. The results came from multiple reactions, including the reaction of 3,5-Dibromoaniline(cas: 626-40-4Quality Control of 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Quality Control of 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Application of 626-40-4In 2022 ,《Development of Sulfamoylated 4-(1-Phenyl-1H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer》 was published in Journal of Medicinal Chemistry. The article was written by Biernacki, Karol; Ciupak, Olga; Dasko, Mateusz; Rachon, Janusz; Kozak, Witold; Rak, Janusz; Kubinski, Konrad; Maslyk, Maciej; Martyna, Aleksandra; Sliwka-Kaszynska, Magdalena; Wietrzyk, Joanna; Switalska, Marta; Nocentini, Alessio; Supuran, Claudiu T.; Demkowicz, Sebastian. The article contains the following contents:

Here development of new sulfamoylated 4-(1-phenyl-1H-1,2,3-triazol-4-yl)phenol derivatives I [R = 3-Cl, 3-Br, 3-Et, etc.; X = H, SO2NH2] via sulfamoylation reaction of 4-(1-phenyl1H-1,2,3-triazol-4-yl)phenol derivatives with sulfamoyl chloride as potent steroid sulfatase (STS) inhibitors for the treatment of breast cancer was presented. Prompted by promising biol. results and in silico anal., the initial series of similar compounds were extended, appending a variety of m-substituents at the outer Ph ring. The inhibition profiles of the newly synthesized compounds were evaluated using a radioisotope enzymic assay and, together with the preceding reported derivatives, using a radioisotope assay in MCF-7 cells. The most active compound, I [R = 3,5-di-F, X = SO2NH2], demonstrated an extraordinary STS inhibitory potency in MCF-7 cells with an IC50 value improved 5-fold compared to that of the reference Irosustat (0.21 vs 1.06 nM). The five most potent compounds were assessed in vivo in a 67NR mouse mammary gland cancer model, with I [R = 3,5-di-Cl, X = SO2NH2] measured to induce up to 51% tumor growth inhibition at 50 mg/kg with no evidence of side effects and toxicity. In addition to this study using 3,5-Dibromoaniline, there are many other studies that have used 3,5-Dibromoaniline(cas: 626-40-4Application of 626-40-4) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary