Category: 626-40-4

《CuSO4-Catalyzed Tandem C(sp3)-H Insertion Cyclization of Toluenes with Isonitriles to Form Indoles》 was published in Organic Letters in 2020. These research results belong to Shan, Xiang-Huan; Wang, Mei-Mei; Tie, Lin; Qu, Jian-Ping; Kang, Yan-Biao. Computed Properties of C6H5Br2N The article mentions the following:

A CuSO4-catalyzed tandem benzylic C-H insertion cyclization of toluene derivatives and isonitriles is described. The naturally abundant salt CuSO4 serves as a low-cost ligand-free redox catalyst. This reaction provides a practical modular synthesis of N-aryl indoles from isonitriles.3,5-Dibromoaniline(cas: 626-40-4Computed Properties of C6H5Br2N) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Computed Properties of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liao, Xudong; Zhou, Yi; Ai, Chengmei; Ye, Cuijiao; Chen, Guanghui; Yan, Zhaohua; Lin, Sen published their research in Tetrahedron Letters in 2021. The article was titled 《SO2F2-mediated oxidation of primary and tertiary amines with 30% aqueous H2O2 solution》.Recommanded Product: 626-40-4 The article contains the following contents:

A highly efficient and selective oxidation of primary and tertiary amines employing SO2F2/H2O2/base system was described. Anilines were converted to the corresponding azoxybenzenes I [R = H, 4-Me, 3-Cl-4-Me, etc.], while primary benzylamines were transformed into nitriles ArC≡N [Ar = Ph, 4-ClC6H4, 4-MeOC6H4, etc.] and secondary benzylamines were rearranged to amides ArNHC(O)R1 [Ar = Ph; R1 = Me, Et]. For tertiary amine substrates quinolines, isoquinolines and pyridines, their oxidation products were the corresponding N-oxides II [R1 = R2 = Me; R3 = Me, Ph], III [R4 = H, 7-Me, 6-NO2; R5 = 2-Me, 3-Me, 4-Me], IV [R6 = H, 8-Cl, 6-Br] and V [R7 = H, 2,6-di-Me, 4-MeO, 2-Br, 4-oxiran-2-yl]. The reaction conditions were very mild and just involve SO2F2, amines, 30% aqueous H2O2 solution, and inorganic base at room temperature One unique advantage was that this oxidation system was just composed of inexpensive inorganic compounds without the use of any metal and organic compounds The results came from multiple reactions, including the reaction of 3,5-Dibromoaniline(cas: 626-40-4Recommanded Product: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Formula: C6H5Br2NIn 2017 ,《Water-Soluble Palladium Reagents for Cysteine S-Arylation under Ambient Aqueous Conditions》 was published in Organic Letters. The article was written by Rojas, Anthony J.; Pentelute, Bradley L.; Buchwald, Stephen L.. The article contains the following contents:

Authors report the use of a sulfonated biarylphosphine ligand (sSPhos) to promote the chemoselective modification of cysteine containing proteins and peptides with palladium reagents in aqueous medium. The use of sSPhos allowed for the isolation of several air-stable and water-soluble mono- and bis-palladium reagents, which were used in an improved protocol for the rapid S-arylation of cysteines under benign and physiol. relevant conditions. The cosolvent-free aqueous conditions were applied to the conjugation of a variety of biomols. with affinity tags, heterocycles, fluorophores, and functional handles. Addnl., bis-palladium reagents were used to perform macrocyclization of peptides bearing two cysteine residues. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Formula: C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Formula: C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Product Details of 626-40-4In 2019 ,《Experimental and theoretical investigations of cyclometalated ruthenium(II) complex containing CCC-pincer and anti-inflammatory drugs as ligands: synthesis, characterization, inhibition of cyclooxygenase and in vitro cytotoxicity activities in various cancer cell lines》 was published in Dalton Transactions. The article was written by Tabrizi, Leila; Olasunkanmi, Lukman O.; Fadare, Olatomide A.. The article contains the following contents:

The new cyclometalated ruthenium(II) complex, [Ru(CCC-Nap)(Ibu)(PTA)], I (3), was designed and synthesized using ibuprofen (Ibu), 1,3,5-triaza-7-phosphaadamantane (PTA) and CCC-pincer containing naproxen moiety (CCC-Nap) as ligands. The compounds were fully characterized by elemental anal., FT-IR, multinuclear (1H, 13C, and 31P) NMR spectroscopy, and electrospray ionization mass spectrometry. The cytotoxicity of 3 was found to be low, and the complex was about twice as active as cisplatin with IC50 values in the range of 0.9-1.32 μM for both MCF-7 and MDA-MB-231 cell lines. Cyclooxygenase (COX) inhibition studies revealed that 3 displayed strong interactions with COX-2, about 16 and 5 times more than free Ibu and CCC-Nap ligands, resp. The complex 3 improved the production of reactive oxygen species (ROS) by 10.7 fold compared to the control (H2O2 as a pos. control) in MCF-7 cells. Quantum chem. calculations gave more insights into the geometry and electronic properties of the novel complex 3, while mol. docking provided theor. information on the interactions of 3 with human cyclooxygenase-2 (COX-2) and the results were compared with those of the interactions of the free ligands with COX-2. In the experiment, the researchers used many compounds, for example, 3,5-Dibromoaniline(cas: 626-40-4Product Details of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Product Details of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ni, Mengshan; Geng, Lijun; Kong, Fangfang; Du, Chengrun; Zhai, Ruiping; Lyu, Yingchen; Hu, Chaosu; Ying, Hongmei published an article in 2021. The article was titled 《Induction Chemotherapy Combined With Intensity-Modulated Radiotherapy for 129 Nasopharyngeal Carcinoma Patients With Synchronous Metastases: A Retrospective Study.》, and you may find the article in Frontiers in oncology.Recommanded Product: 626-40-4 The information in the text is summarized as follows:

OBJECTIVE: To analyze the therapeutic effect and prognostic factors of nasopharyngeal carcinoma (NPC) patients with distant metastases at initial diagnosis receiving induction chemotherapy with intensity-modulated radiotherapy (IMRT). METHODS: A total of 129 patients who underwent platinum-based induction chemotherapy followed by definitive IMRT with or without concurrent or adjuvant chemotherapy for newly diagnosed distant metastatic NPC in our center between March 2008 and November 2018 were retrospectively analyzed. 41 patients underwent local therapy for metastatic sites. Kaplan-Meier method was used to estimate survival rates, Log-rank test and Cox proportional hazards model were used to figure out independent prognostic factors of overall survival (OS). RESULTS: A total of 66 patients had been dead (median follow-up time, 51.5 months). The median overall survival (OS) time was 54.2 months (range, 7-136 months), and the 1-year, 2-year, 3-year, 5-year overall survival rates were 88.0%,71.0%,58.0%, and 47.0%. Multivariate analysis found that the factors correlated with poor overall survival were pre-treatment serum lactate dehydrogenase (SLDH) >180U/L, chemotherapy cycles<4, and M1 stage subdivision (M1b, single hepatic metastasis and/or multiple metastases excluding the liver; and M1c, multiple hepatic metastases). The 5-year OS rates for M1a, M1b and M1c were 62.6%,40.4% and 0%, respectively. CONCLUSION: Platinum-containing induction chemotherapy combined with IMRT seemed to be advantageous to prolong survival for some NPC patients with synchronous metastases at initial diagnosis. The independent factors to prognosticate OS were pre-treatment SLDH, number of chemotherapy cycles, and M1 subcategories. Prospective clinical trials are needed to confirm the result. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Recommanded Product: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Zhang, Ling; Jiang, Ke; Li, Yanping; Zhao, Dian; Yang, Yu; Cui, Yuanjing; Chen, Banglin; Qian, Guodong published 《Microporous Metal-Organic Framework with Exposed Amino Functional Group for High Acetylene Storage and Excellent C2H2/CO2 and C2H2/CH4 Separations》.Crystal Growth & Design published the findings.Application In Synthesis of 3,5-Dibromoaniline The information in the text is summarized as follows:

A microporous metal-organic framework [Cu2L(H2O)2]·(DMF)0.5·(H2O)7, (ZJU-195, H4TTCA-NH2 = 5-amino-3,3,5,5-tetracarboxylic acid, DMF = N,N-dimethylformamide) has been designed, synthesized, structurally characterized, and examined for its gas storage and separation The activated ZJU-195a has achieved high C2H2 storages of 275.6 cm3·g-1 at 273 K and 214.2 cm3·g-1 at 298 K under 1.0 bar. Furthermore, ZJU-195a selectively adsorbs C2H2 over CO2 and CH4, exhibiting moderately high C2H2/CH4 and C2H2/CO2 separations at ambient conditions with an ideal adsorbed solution theory selectivity of 43.4-64.6 and 4.7-12.4, resp. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Application In Synthesis of 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Application In Synthesis of 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Nature Communications included an article by Wang, Xu-Qing; Wang, Wei; Li, Wei-Jian; Chen, Li-Jun; Yao, Rui; Yin, Guang-Qiang; Wang, Yu-Xuan; Zhang, Ying; Huang, Junlin; Tan, Hongwei; Yu, Yihua; Li, Xiaopeng; Xu, Lin; Yang, Hai-Bo. Product Details of 626-40-4. The article was titled 《Dual stimuli-responsive rotaxane-branched dendrimers with reversible dimension modulation》. The information in the text is summarized as follows:

With the aim of mimicking biol. machines, in which the delicate arrangement of nanomech. units lead to the output of specific functions upon the external stimulus, the construction of dual stimuli-responsive rotaxane-branched dendrimers was realized in this study. Starting from a switchable organometallic [2]rotaxane precursor, the employment of a controllable divergent approach allowed for the successful synthesis of a family of rotaxane-branched dendrimers up to the third generation with 21 switchable rotaxane moieties located on each branch. More importantly, upon the addition and removal of dimethylsulfoxide (DMSO) mol. or acetate anion as the external stimulus, the amplified responsiveness of the switchable rotaxane units endowed the resultant rotaxane-branched dendrimers the solvent- or anion-controlled mol. motions, thus leading to the dimension modulation. Therefore, we successfully constructed a family of rotaxane-branched dendrimers with dual stimuli-responsiveness that will be a privileged platform for the construction of dynamic supramol. materials. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Product Details of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Organometallics included an article by Martinez, Gabriel Espinosa; Nugent, Joseph W.; Fout, Alison R.. Category: bromides-buliding-blocks. The article was titled 《Simple Nickel Salts for the Amination of (Hetero)aryl Bromides and Iodides with Lithium Bis(trimethylsilyl)amide》. The information in the text is summarized as follows:

Recent developments in the chem. of C-N bond formation and the synthesis of anilines have allowed for the use of 1st-row transition metals to catalyze these transformations. Much of the progress in this area was driven by comprehensive screening for privileged/tailored ligands, which can be costly and not readily available in a research laboratory setting. The authors report a protocol in which simple Ni salts catalyze the C-N cross-coupling reaction between (hetero)aryl bromides and iodides with Li bis(trimethylsilyl)amide without the need for any additive ligand. This method is amenable to low Ni catalyst loadings (1%) as well as gram-scale reactions. Because of the good functional group tolerance and compatibility with heterocyclic moieties, this method is useful for academic laboratory settings where access to tailored ligands and noble-metal catalysts could be challenging. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Category: bromides-buliding-blocks)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Category: bromides-buliding-blocks

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Basak, Akash; Abouelhassan, Yasmeen; Norwood, Verrill M. IV; Bai, Fang; Nguyen, Minh Thu; Jin, Shouguang; Huigens, Robert W. III published 《Synthetically Tuning the 2-Position of Halogenated Quinolines: Optimizing Antibacterial and Biofilm Eradication Activities via Alkylation and Reductive Amination Pathways》.Chemistry – A European Journal published the findings.Synthetic Route of C6H5Br2N The information in the text is summarized as follows:

Agents capable of eradicating bacterial biofilms are of great importance to human health as biofilm-associated infections are tolerant to our current antibiotic therapies. We have recently discovered that halogenated quinoline (HQ) small mols. are: (1) capable of eradicating methicillin-resistant Staphylococcus aureus (MRSA), methicillin-resistant Staphylococcus epidermidis (MRSE) and vancomycin-resistant Enterococcus faecium (VRE) biofilms, and (2) synthetic tuning of the 2-position of the HQ scaffold has a significant impact on antibacterial and antibiofilm activities. Here, we report the chem. synthesis and biol. evaluation of 39 HQ analogs that have a high degree of structural diversity at the 2-position. We identified diverse analogs that are alkylated and aminated at the 2-position of the HQ scaffold and demonstrate potent antibacterial (MIC≤0.39 μM) and biofilm eradication (MBEC 1.0-93.8 μM) activities against drug-resistant Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecium strains while demonstrating <5 % haemolysis activity against human red blood cells (RBCs) at 200 μM. In addition, these HQs demonstrated low cytotoxicity against HeLa cells. Halogenated quinolines are a promising class of antibiofilm agents against Gram-pos. pathogens that could lead to useful treatments against persistent bacterial infections. In the experiment, the researchers used many compounds, for example, 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Amide derivatives of 4-azaindole: design, synthesis, and EGFR targeting anticancer agents》 was written by Venkat Swamy, Puli; Kiran Kumar, Vukoti; Radhakrishnam Raju, Ruddarraju; Venkata Reddy, Regalla; Chatterjee, Anindita; Kiran, Gangarapu; Sridhar, Gattu. Synthetic Route of C6H5Br2N And the article was included in Synthetic Communications in 2020. The article conveys some information:

A series of amide derivatives of azaindole-oxazoles (11a-11n) were designed and synthesized and their structures were confirmed by 1HNMR, 13CNMR and mass spectral anal. Further, these derivatives were screened for their anticancer activity against human cancer cell lines viz; MCF7 (breast), A549 (lung) and A375 (melanoma). In vitro anticancer activity screening indicated that most of the hybrids exhibited potent inhibitory activities in a variety of cancer cell lines. Compounds 11m (I), 11j (II), 11d, 11e, 11f, 11k, 11l and 11n (III; R= 4-OMe; 3,5-diOMe; 3,4,5-triOMe; 4-F; 4-NO2; 4-CN; resp.) each exhibited more potent activity than standard, and compounds I and II exhibited excellent activity in MCF-7 cell line with IC50 values 0.034 and 0.036μM. Moreover, all these compounds were subjected to mol. docking studies on EGFR receptor and the results indicated that two potent compounds I and II strongly bind to protein EGFR (PDB ID: 4hjo). It was found that the energy calculations were in good agreement with the observed IC50 values. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dibromoaniline(cas: 626-40-4Synthetic Route of C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Synthetic Route of C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary