Category: 626-40-4

Related Products of 626-40-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-40-4, name is 3,5-Dibromoaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Compound II (2.25 g, 10 mmol),Compound III (2.51 g, 10 mmol)And diisopropylethylamine(DIPEA,3.88 g, 30 mmol)Dissolved in 50 mL of dry xylene,And then heat up under nitrogen protectionReflux,Until the reaction is complete (usually 5 hours).The reaction mixture was carefully poured into 200 mL of ice water, stirred, extracted with 50 mL of X3CH2C12,Combined extraction phase,Washed sequentially with 1% dilute hydrochloric acid (200 mL) and brine (100 mL)Dried over anhydrous sodium sulfate. The desiccant was removed by suction filtration,The filtrate was evaporated to dryness on a rotary evaporator,Compound IV was obtained as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromoaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Sai Bo Technology Co., Ltd.; Guo Huijun; (12 pag.)CN106831838; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 626-40-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-40-4 name is 3,5-Dibromoaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound II (2.25 g, 10 mmol), compound III (2.51 g, 10 mmol) and diisopropylethylamine (DIPEA,3.88 g, 30 mmol) was dissolved in 50 mL of dry xylene and then warmed at reflux under nitrogen until the reaction was completeOften 5 hours). The reaction mixture was carefully poured into 200 mL of ice water, stirred and extracted with 50 mL × 3 CH 2 Cl 2. The combined extracts were driedWashed sequentially with 1% dilute hydrochloric acid (200 mL) and brine (100 mL) and dried over anhydrous sodium sulfate. Remove the desiccant by suction filtrationEvaporation on a rotary evaporator gave Compound IV as a white solid

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromoaniline, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong Sai Bo Technology Co., Ltd.; Guo Huijun; (9 pag.)CN106831837; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 626-40-4,Some common heterocyclic compound, 626-40-4, name is 3,5-Dibromoaniline, molecular formula is C6H5Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 5.018 (0.02 muM) 3, 5 – dibromoaniline and 9.350 g (0.05 muM) (6 – aminonaphthalen – 2 – yl) boronic acid is added to a 500 ml three-neck bottle in, adding 400 ml tetrahydrofuran (THF), then adding 2 mol/L potassium carbonate solution of 75 ml, and add 0.5 ml of aliquat 336, magnetic stirring and open the argon gas, oil bath is heated to 75 C after, adding 0.020 g […] palladium, reflux reaction 24 h, the reaction liquid is poured into the water in the, a large amount of precipitate out. For funnel, evaporating the solvent under reduced pressure. The product in order to dichloromethane: hexane=3:1 ([…]) as the mobile phase silica gel as stationary phase makes the column chromatographic purification, collecting products and turns on lathe does, in 90 C drying in vacuum 24 h, to obtain the target product 5.632 g, yield is 75%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromoaniline, its application will become more common.

Reference:
Patent; Hunan University of Technology; Ding Qian; Tan Jinghua; Liu Yiwu; Fu Hao; (20 pag.)CN109053466; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 626-40-4,Some common heterocyclic compound, 626-40-4, name is 3,5-Dibromoaniline, molecular formula is C6H5Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Preparation of the compound 3-((3-cyano-6-cyclopropylpyridin-2-yl)thio)-N-(3,5-dibromophenyl)propanamide (19) I-3 (0.50) g, 2 mmol, 1 eq), EDCI (0.50 g, 2.6 mmol, 1.3 eq) and HOBT (0.08 g, 0.6 mmol, 0.3 eq) dissolved in DMF, not more than 10 C, The reaction was carried out for 30 min, and 3,5-dibromoaniline (0.56 g, 2.2 mmol, 1.1 eq) was added. the color of the reaction solution was darkened and reacted overnight at room temperature. The reaction was complete by TLC. Post-treatment: The reaction solution was poured into water, suction-filtered, and then filtered to give a crude product. The crude product was recrystallized from petroleum ether-ethyl acetate to afford LWTW-225 (150 mg, yield 31%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromoaniline, its application will become more common.

Reference:
Patent; Yao Da Pharmaceutical Co., Ltd.; Bian Jinlei; Zhao Lulu; Wang Jubo; Ma Yinghe; Li Zhiyu; (15 pag.)CN109574920; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-40-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 626-40-4 as follows.

Compound II (2.52 g, 10 mmol), compound III (2.51 g, 10 mmol) and diisopropylethylamine (DIPEA,3.88 g, 30 mmol) was dissolved in 50 mL of dry xylene and refluxed under nitrogen atmosphere until the reaction was completeUsually 5 hours). The reaction mixture was carefully poured into 200 mL of ice water, stirred, extracted with 50 mL of X3CH2C12, the combined phases were combined,Washed successively with 1% dilute hydrochloric acid (200 mL) and brine (100 mL), and dried over anhydrous sodium sulfate. The desiccant was removed by suction filtrationEvaporated on a rotary evaporator to give compound IV, a white solid.

According to the analysis of related databases, 626-40-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Guangdong Sai Bo Technology Co., Ltd.; Guo Huijun; (11 pag.)CN106831835; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 626-40-4,Some common heterocyclic compound, 626-40-4, name is 3,5-Dibromoaniline, molecular formula is C6H5Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Compound II-2 (2.51 g, 10 mmol), Compound III (2.06 g, 10 mmol), Pd(OAc)2 (0.22 g, Lmmol), BINAP (2,2,-bisdiphenylphosphino-1,1′-binaphthyl, 0.62g, 1mmol) and t-BuOK (2.24g, 20mmol) plus Into 50 mL of dry 1,2-dimethoxyethane (DME), the reaction mixture was stirred overnight under a nitrogen atmosphere and TLC detection was performed. The reaction is now complete. The reaction mixture was carefully poured into 200 mL of ice water, stirred, extracted with 50 mL of X 3 CH 2 Cl 2 , and the extraction phases were combined. It was washed with 1% dilute hydrochloric acid and brine and dried over anhydrous sodium sulfate. The desiccant is filtered off with suction and the filtrate is evaporated to dryness on a rotary evaporator. The residue was purified using silica gel column chromatography to give compound IV-2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromoaniline, its application will become more common.

Reference:
Patent; Guangdong Sai Bo Technology Co., Ltd.; Guo Huijun; (8 pag.)CN108003169; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 626-40-4,Some common heterocyclic compound, 626-40-4, name is 3,5-Dibromoaniline, molecular formula is C6H5Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The starting material, 3,5-dibromoaniline(125.35 g, 499.6 mmol) to a round bottom flask in CH2Cl2 (2498ml) todissolve after, acetic anhydride (56.10 g, 549.5 mmol) and K2CO3 (82.85 g,599.5 mmol) at room temperature and the mixture It was stirred. Aftercompletion of reaction, then extracted with water and CH2Cl2 and the organiclayer the product was dried with MgSO4 and concentrated to 140.50 g wasobtained (96% yield).

The synthetic route of 626-40-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DuksanNeoluxCo., Ltd.; Oh, Dae Hwan; Kim, Dae Sung; Lee, Yun Suk; Jo, Hay Min; Jung, Yeong Suk; Choe, Yeon Hee; Kim, Suk Hyun; (69 pag.)KR101535606; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 626-40-4, name is 3,5-Dibromoaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 626-40-4, Computed Properties of C6H5Br2N

This example is a method for preparing 3,5-dibromo-3-methyl-4-aminoazobenzene, comprising the following steps:(1) Preparation of diazonium salt: Into a 100 mL beaker, add 5.0132 g of 3,5-dibromoaniline and 8 mL of 20% hydrochloric acid, 0Slowly add 1.5241 g of aqueous sodium nitrite solution to the suspension at 0-5 C. The suspension is cleared and urea is added to eliminate theAmount of nitrous acid, sodium acetate solids was adjusted to pH 5, and the resulting clear solution was placed in ice water for later use.(2) Preparation of sodium o-methylanilinyl methanesulfonate: Into a 50 mL round bottom flask was added 10 mL of water and 2.3534 g of AsiaAfter dissolving sodium bisulfite and sodium bisulfite, 0.7219 g of paraformaldehyde was added. After reacting at 60C for 35 minutes, 2.1413 g of the product was added dropwise.Methylaniline, the reaction was stopped after 2 h and a mixture of sodium o-anilino methanesulfonate was obtained.(3) Preparation of azobenzene compound: After the mixture obtained in step (2) is cooled to room temperature, the mixture is stirred under vigorous stirring.Slowly dropping into the diazonium salt obtained in step (1). At this time, the clarified diazonium salt solution gradually becomes dark red viscous liquid, and the temperature is controlled at 0-5 C.The reaction was completed after 6 h. Add 50 mL of 30% aqueous sodium hydroxide, the dark red viscous liquid becomes yellow turbid liquid, nitrogen gasUnder the protection of 50 C hydrolysis 7 h, after the end of the reaction with hydrochloric acid to adjust the pH value of about 8, the crude product was separated by thin layer chromatography to obtain the dye 3,5-Dibromo-3-methyl-4-aminoazobenzene 2.1402 g (yield 30%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3,5-Dibromoaniline, and friends who are interested can also refer to it.

Reference:
Patent; Lingnan Normal University; Song Xiumei; Feng Zongcai; (9 pag.)CN105152963; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 626-40-4,Some common heterocyclic compound, 626-40-4, name is 3,5-Dibromoaniline, molecular formula is C6H5Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: All the final reactions (11a-n) were performed by 200 mg scale. To a stirred solution of acid compound 9 (1.0 equiv) and substituted aromatic amines (10a-n) (1.0 equiv) in dichloromethane was added EDCI (1.0 equiv), HOBt (1.0 equiv) and DIPEA (1.2 equiv) at room temperature. The reaction mixture was stirred for 12 h. After completion of the reaction as monitored by TLC, the reaction mixture was diluted with dichloromethane, washed with saturated solution of NaHCO3, dried over anhydrous Na2SO4, filtered and concentrated. The crude products were purified by column chromatography eluted with ethyl acetate/hexane to afford the pure compounds (11a-n).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3,5-Dibromoaniline, its application will become more common.

Reference:
Article; Venkat Swamy, Puli; Kiran Kumar, Vukoti; Radhakrishnam Raju, Ruddarraju; Venkata Reddy, Regalla; Chatterjee, Anindita; Kiran, Gangarapu; Sridhar, Gattu; Synthetic Communications; vol. 50; 1; (2020); p. 71 – 84;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-40-4, name is 3,5-Dibromoaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 3,5-Dibromoaniline

2-Trifluoromethylbenzoyl chloride (68.0mL, 0.462 mmol) and 3,5-dibromoaniline (96.0 mg, 0.383 mmol) were stirred in THF (2.0 mL) for 1 h.The reaction was then diluted with H2O (~20 mL) and sonicated, and the resulting precipitate was filtered, rinsed with H2O, collected, sonicated with sat. NaHCO3(~10 mL), filtered, rinsed with H2O, and collected.Flash chromatographic purification over silica (4:1-2:1 hexanes:EtOAc gradient elution) afforded 2-trifluoromethyl-N-(3,5-dibromophenyl)benzamide (216) as a white solid (143 mg, 88%).1H-NMR (500 MHz,d6-DMSO)d10.87 (s, 1H), 7.92 (d,J=1.7 Hz, 2H), 7.85-7.88 (m, 1H), 7.79-7.84 (m, 1H), 7.72-7.76 (m, 2H), 7.58 (t,J=1.7 Hz, 1H);13C-NMR (125 MHz,d6-DMSO)d166.00, 141.39, 135.26 (q,J=2.0 Hz), 132.73, 130.52, 128.53, 128.49, 126.45 (q,J=4.7 Hz), 125.85 (q,J=31.4 Hz), 123.63 (q,J=274 Hz), 122.44, 120.88; ESI-TOF 421.8996m/z[MH]+, C14H9Br2F3NO requires 421.8997; RP-HPLC: 95% pure.

The synthetic route of 626-40-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Connelly, Stephen; Mortenson, David E.; Choi, Sungwook; Wilson, Ian A.; Powers, Evan T.; Kelly, Jeffery W.; Johnson, Steven M.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3441 – 3449;,
Bromide – Wikipedia,
bromide – Wiktionary