Category: 626-40-4

Lu, Xu; Kawazu, Ryohei; Song, Jizhou; Yoshigoe, Yusuke; Torigoe, Takeru; Kuninobu, Yoichiro published their research in Organic Letters in 2021. The article was titled 《Regioselective C-H Trifluoromethylation of Aromatic Compounds by Inclusion in Cyclodextrins》.Related Products of 626-40-4 The article contains the following contents:

A regioselective radical C-H trifluoromethylation of aromatic compounds was developed using cyclodextrins (CDs) as additives. The C-H trifluoromethylation proceeded with high regioselectivity to afford the product in good yield, even on the gram scale. In the presence of CDs, some substrates underwent a single trifluoromethylation selectively, whereas mixtures of single- and double-trifluoromethylated products were formed in the absence of the CD. 1H NMR experiments indicated that the regioselectivity was controlled by the inclusion of a substrate inside the CD cavity. After reading the article, we found that the author used 3,5-Dibromoaniline(cas: 626-40-4Related Products of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Related Products of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《Visible-Light-Promoted Oxidative Amidation of Bromoalkynes with Anilines: An Approach to α-Ketoamides》 was written by Ni, Ke; Meng, Ling-Guo; Wang, Kuai; Wang, Lei. Safety of 3,5-DibromoanilineThis research focused onvisible light oxidative amidation bromoalkyne aniline; ketoamide preparation. The article conveys some information:

A convenient and practical synthetic route to α-ketoamides from bromoalkynes and anilines through phototriggered organic transformations via a C-N cross-coupling and an oxidation of CC was developed. The reaction could be furnished without an external photocatalyst at ambient conditions, and a wide range of α-ketoamides were obtained in good yields. The experimental process involved the reaction of 3,5-Dibromoaniline(cas: 626-40-4Safety of 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Safety of 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-40-4In 2021 ,《Micellar Suzuki Cross-Coupling between Thiophene and Aniline in Water and under Air》 was published in Organics. The article was written by Yousif, Dawod; Tombolato, Silvia; Ould Maina, Elmehdi; Po, Riccardo; Biagini, Paolo; Papagni, Antonio; Vaghi, Luca. The article contains the following contents:

The Suzuki-Miyaura cross-coupling reaction plays a fundamental role in modern synthetic organic chem., both in academia and industry. For this reason, scientists continue to search for new, more effective, cheaper and environmentally friendly procedures. Recently, micellar synthetic chem. has been demonstrated to be an excellent strategy for achieving chem. transformations in a more efficient way, thanks to the creation of nanoreactors in aqueous environments using selected surfactants. In particular, the cheap and com. available surfactant Kolliphor EL (a polyethoxylated castor oil derivative) has been used with success to achieve metal-catalyzed transformations in water with high yields and short reaction times, with the advantage of using air-sensitive catalysts without the need for inert atm. In this work, the Kolliphor EL methodol. was applied to the Suzuki cross-coupling reaction between thiophene and aniline, using the highly effective catalyst Pd(dtbpf)Cl2. The cross-coupling products were achieved at up to 98% yield, with reaction times of up to only 15 min, working at room temperature and without the need for inert atm. The results came from multiple reactions, including the reaction of 3,5-Dibromoaniline(cas: 626-40-4Related Products of 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Related Products of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The author of 《Selective recognition of Fe3+ and CrO42- ions using a Zn(II) metallacycle and a Cd(II) coordination polymer and their heterogeneous catalytic application》 were Rani, Pooja; Sharma, Anjali; Husain, Ahmad; Kumar, Gulshan; Kaur, Harpreet; Bhasin, K. K.; Kumar, Girijesh. And the article was published in CrystEngComm in 2019. HPLC of Formula: 626-40-4 The author mentioned the following in the article:

We report the syntheses and structural characterization of a Zn(II) metallacycle [Zn2{(L)2(DMF)2(NO3)2}]·(NO3)2 (1) along with a Cd(II) coordination polymer [{Cd1(L)2(DMF)2}·(NO3)2]n (2) (where L = N,N′-bis-(3-pyridyl)terephthalamide; DMF = dimethylformamide) and their utilization as fluorescent probes for highly selective recognition (turn-off) of Fe3+ and CrO42- ions. Both 1 and 2 showed high fluorescence stability in aqueous solution and selectively detected Fe3+ and CrO42- ions with high quenching constants and low detection limits of 2.34 × 106 M-1 and 0.153 μM for Fe3+, 6.72 × 105 and 0.205 μM for CrO42- (for 1); 3.25 × 106 and 0.193 μM for Fe3+, 6.94 × 105 and 0.155 μM for CrO42- (for 2). Notably, ligand L itself did not display any type of recognition for any ions in DMF as well as in aqueous media. Moreover, 1 and 2 were also employed as heterogeneous catalysts for the ring-opening reaction (ROR) of epoxides with various assorted amines and up to 95% yield (TON, 47.5 and TOF, 11.9 h-1) was observed with perfect regioselectivity in the case of styrene oxide. In the experiment, the researchers used many compounds, for example, 3,5-Dibromoaniline(cas: 626-40-4HPLC of Formula: 626-40-4)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.HPLC of Formula: 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2017,Lu, Zhiyong; Xing, Yue; Du, Liting; He, Haiyan; Zhang, Jianfeng; Hang, Cheng published 《Isostructural functionalization by -OH and -NH2: different contributions to CO2 adsorption》.RSC Advances published the findings.Formula: C6H5Br2N The information in the text is summarized as follows:

Two isostructural mfj-type metal-organic frameworks, [Cu2(ABDPB)(H2O)]n (HHU-3, HHU for Hohai University; H4ABDPB for 5-amino-1,3-bis(3,5-dicarboxylphenyl)-benzene) and [Cu2(OBDPB)(H2O)]n (HHU-4; H4OBDPB for 5-hydroxyl-1,3-bis(3,5-dicarboxylphenyl)-benzene) were successfully synthesized by V-shaped tetracarboxylic ligand with amino and hydroxyl groups, resp. Compared with the prototypical MOF, PCN-306, both MOFs exhibit obviouse decreases in BET surface area and pore volume, with the values of 2354 m2 g-1 and 0.920 cm3 g-1 for HHU-3, and 2353 m2 g-1 and 0.954 cm3 g-1 for HHU-4. Although both functional groups are believed to be effective in strengthen CO2 interactions with the framework, in this type of MOF, amino group works better due to its basic nature. Meanwhile, the decoration of amino groups grafted HHU-3 high CO2 adsorption capacity (25.6 wt% at 1 bar and 273 K) and high CO2 selectivity (SCO2/N2 = 129).3,5-Dibromoaniline(cas: 626-40-4Formula: C6H5Br2N) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Formula: C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

《An amino-coordination metal-organic framework for highly selective C2H2/CH4 and C2H2/C2H4 separations through the appropriate control of window sizes》 was written by Zhang, Ling; Cui, Xili; Xing, Huabin; Yang, Yu; Cui, Yuanjing; Chen, Banglin; Qian, Guodong. Formula: C6H5Br2NThis research focused onzinc aminophenylenediacrylate MOF preparation selective acetylene methane ethylene separation; crystal structure zinc aminophenylenediacrylate metal organic framework. The article conveys some information:

The efficient separation of C2H2vs. C2H4 and CH4 to obtain high-purity C2H2 and C2H4 is of significance for making full, economic use of these raw chems. Herein, an amino-coordination microporous metal-organic framework ZJU-198, ZnL·DMF (ZJU = Zhejiang University, L = (2E,2E’)-3,3′-(5-amino-1,3-phenylene)diacrylic acid, DMF = N,N’-DMF), was demonstrated as a valuable adsorbent for C2H2/C2H4 and C2H2/CH4 separations The activated ZJU-198a exhibits moderate C2H2 uptakes (99.4 cm3 cm-3 for 273 K and 98.4 cm3 cm-3 for 298 K under 1.0 bar) and moderately high C2H2/C2H4 selectivity (5.8 to 7.7 at 273 K and 4.8 to 7.2 at 298 K). Specifically, the C2H2/CH4 selectivity of ZJU-198a reaches up to 497.9 and 391.1 at 273 K and 298 K, resp. To the best of the authors’ knowledge, the C2H2/CH4 selectivity coefficients of ZJU-198a at both 298 K and 273 K are the highest values among the reported metal-organic frameworks, meaning that there is bright potential for ZJU-198a in hydrocarbon storage and separation After reading the article, we found that the author used 3,5-Dibromoaniline(cas: 626-40-4Formula: C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Formula: C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2018,Smith, Joel D.; Chih, Edwina; Piers, Warren E.; Spasyuk, Denis M. published 《Tuning iridium(I) PCcarbeneP frameworks for facile cooperative N2O reduction》.Polyhedron published the findings.Product Details of 626-40-4 The information in the text is summarized as follows:

Two electron-rich PCP ligands were synthesized featuring -CMe2- and -SiMe2- functional groups linking the framework backbone. PCcarbeneP-Ir-Cl complexes were prepared via double C-H activation protocols and the donor strengths of the new ligands were evaluated using CO stretching frequencies of monocarbonyl cations prepared from the corresponding carbene chlorides. The new tethered systems are superior donors with respect to PCcarbeneP pincer complexes previously reported in the authors’ group. These carbene chloride complexes reacted readily with nitrous oxide (N2O) to form iridaepoxides immune to unwanted Caryl-Canchor cleavage. Rates of O atom transfer from N2O to PCcarbeneP-Ir-Cl compounds were also measured using 31P{1H} NMR spectroscopy. Results suggested a direct pos. correlation between ligand donicity and O-atom transfer rate for all ortho-phenylene derived systems. The sterically distinct 2,3-benzo[b]thiophene scaffold is an outlier of this trend with a relatively high reactivity rate and νCO.3,5-Dibromoaniline(cas: 626-40-4Product Details of 626-40-4) was used in this study.

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Product Details of 626-40-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2022,Zhang, Hongquan; Wen, Chunxi; Li, Bingting; Yan, Xinlin; Xu, Yangrong; Guo, Jialin; Hou, Shi; Chang, Jiajia; Li, Song; Xiao, Junhai published an article in Molecules. The title of the article was 《Phenoxyaromatic Acid Analogues as Novel Radiotherapy Sensitizers: Design, Synthesis and Biological Evaluation》.Formula: C6H5Br2N The author mentioned the following in the article:

Radiotherapy is a vital approach for brain tumor treatment. The standard treatment for glioblastoma (GB) is maximal surgical resection combined with radiotherapy and chemotherapy. However, the non-sensitivity of tumor cells in the hypoxic area of solid tumors to radiotherapy may cause radioresistance. Therefore, radiotherapy sensitizers that increase the oxygen concentration within the tumor are promising for increasing the effectiveness of radiation. Inspired by Hb allosteric oxygen release regulators, a series of novel phenoxyacetic acid analogs were designed and synthesized. A numerical method was applied to determine the activity and safety of newly synthesized compounds In vitro studies on the evaluation of red blood cells revealed that compounds 19c (ΔP50 = 45.50 mmHg) and 19t (ΔP50 = 44.38 mmHg) improve the oxygen-releasing property effectively compared to pos. control efaproxiral (ΔP50 = 36.40 mmHg). Preliminary safety evaluation revealed that 19c exhibited no cytotoxicity towards HEK293 and U87MG cells, while 19t was cytotoxic toward both cells with no selectivity. An in vivo activity assay confirmed that 19c exhibited a radiosensitization effect on orthotopically transplanted GB in mouse brains. Moreover, a pharmacokinetic study in rats showed that 19c was orally available. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dibromoaniline(cas: 626-40-4Formula: C6H5Br2N)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Formula: C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

In 2016,Haruna, Kabiru; Alenaizan, Asem A.; Al-Saadi, Abdulaziz A. published 《Density functional theory study of the substituent effect on the structure, conformation and vibrational spectra in halosubstituted anilines》.RSC Advances published the findings.Name: 3,5-Dibromoaniline The information in the text is summarized as follows:

A comparative d. functional theory (DFT) study exploring the structural and spectroscopic properties of the complete set of halosubstituted anilines with the halogens being F, Cl and Br was carried out. This study aims at understanding the effect of the type, number and positions of halogen substituents on the inversion barrier, geometrical properties and vibrational frequencies. The compounds were exclusively predicted to exist in the near-planar pyramidal form. While the order of stability is noted to be independent of the type of halogen substituents, the size of the inversion barrier is predicted to be sensitive to their number and positions, in accordance with former theor. and exptl. reports. The higher number of halogens leads to a more pronounced planarity character of the amino group. The deactivating nature of halogen atoms is believed to enhance the lone-pair electron delocalization in the order of bromo- > chloro- > fluoroanilines. An unusually strong electron delocalization nature is predicted to exist in the case of tetra- and penta-substituted haloanilines. The results came from multiple reactions, including the reaction of 3,5-Dibromoaniline(cas: 626-40-4Name: 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhao, Mengfei; Qin, Zengxin; Zhang, Kaixin; Li, Jizhen published their research in RSC Advances in 2021. The article was titled 《Metal-free site-selective C-H cyanoalkylation of 8-aminoquinoline and aniline-derived amides with azobisisobutyronitrile》.Reference of 3,5-Dibromoaniline The article contains the following contents:

Using K2S2O8, an efficient and metal-free site-selective C-H cyanoalkylation of 8-aminoquinoline and aniline-derived amides with AIBN (azobisisobutyronitrile) was developed. Without any catalyst, various substrates and functional groups were compatible to afford corresponding cyanoalkylated amides I [R = H, Me, Br; R1 = Me, t-Bu, Ph, cyclohexyl, 2-pyridyl; R2 = H, Me, Br, etc.] and II [R3 = Et, Ph, Bn, etc.; R4 = H, Cl] in moderate to high yields. A mechanism study displayed that a radical-radical coupling process was involved via the N-centered radical generation and delocalization of aryl amides. In the experimental materials used by the author, we found 3,5-Dibromoaniline(cas: 626-40-4Reference of 3,5-Dibromoaniline)

3,5-Dibromoaniline(cas: 626-40-4) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Reference of 3,5-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary