Category: 626-39-1

These common heterocyclic compound, 626-39-1, name is 1,3,5-Tribromobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C6H3Br3

Under a nitrogen atmosphere, 250ml three-necked flask 1,3,5-bromobenzene (15.74g, 50mmol), United pinacolato ester (41.9g, 0.165mol, TCI), potassium acetate (48.58g, 0.495mol), 1,1′- bis (diphenylphosphino) ferrocene palladium dichloride (4.08g, 5mmol) and dimethylformamide (300ml), 85 The reaction mixture was stirred under heating 24h.After completion of the reaction naturally cooled, the reaction solution was extracted with ethyl acetate, washed with saturated brine three times, the resulting organic layer was dried over anhydrous magnesium sulfate.Filtration, the resulting filtrate was removed under reduced pressure to remove the solvent.Separated by column chromatography, the mobile phase was chloroform.After the spin-dry vacuum dried to give a white powder 16.25g, yield 71.3%.

The synthetic route of 1,3,5-Tribromobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; South China University of Technology; Su, Shijian; Chen, Dongcheng; (24 pag.)CN103396355; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-39-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 626-39-1 as follows.

Synthesis of Compound 1: Anhydrous DMF (10 mL) was purged with N2 and then transferred via a cannula into a three-neck round bottomed flask charged with 1, 3, 5-tribromobenzene (1.00 g, 3.17 mmol) and bis (pinacolato) diboron (2.54 g, 9.53 mmol) . Potassium acetate (1.87 g, 19.0 mmol) and Pd(dppf)Cl2 (0.087 g, 0.12 mmol) were then quickly added into the flask. The resulting mixture was stirred vigorously and heated at 90 C for 24 hours. After cooling down to room temperature, deionized water (120 mL) was added. Black precipitate was collected by filtration, and washed with deionized water three times, which was dried under vacuum (98% yield) .

According to the analysis of related databases, 626-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; YAGHI, Omar, M.; ZHANG, Yuebiao; DENG, Hexiang; WO2015/157239; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-39-1, name is 1,3,5-Tribromobenzene, A new synthetic method of this compound is introduced below., SDS of cas: 626-39-1

The synthesis processof PHT was the same as TPAT only used 1,3,5-Tribromobenzene(0.41 g, 1.3 mmol) to replace Tris(4-bromophenyl)amine and PHT was obtained as a white powder (0.38 g, yield 91%). MALDI-TOFMS(M) (m/z):325.7 [M + H]+. 1H NMR (500 MHz, CDCl3) delta 7.76(s, 1H), 7.43 (dd, J = 3.6, 1.2 Hz, 1H), 7.36 (dd, J = 5.1, 1.1 Hz, 1H),7.15 (dd, J = 5.0, 3.6 Hz, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Li, Weijun; Chen, Lan; Pan, Yuyu; Yan, Shuanma; Dai, Yuyu; Liu, Jin; Yu, Yue; Qu, Xingxing; Song, Qingbao; Ouyang, Mi; Zhang, Cheng; Journal of the Electrochemical Society; vol. 164; 4; (2017); p. E84 – E89;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 626-39-1, These common heterocyclic compound, 626-39-1, name is 1,3,5-Tribromobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[0372] 1,3,5-Tribromo-benzene (31.4 g, 100 mmol) was dissolved under argon in a flame dried three-neck flask in 1000 mL diethylether and the solution was cooled to -72C. A solution of 62 mL r°BuLi (1.6 M in hexane, 100 mmol) was added to the resulting suspension in such a fashion that temperature did not rise above -7O0C. The mixture was stirred for 30 min at -750C and the reaction was monitored by HPLC. A solution of 10.4 g (100 mmol) 3-cyanopyridine in 100 mL diethylether was added in such a fashion that temperature did not rise above -710C. The mixture was stirred at -75C for 60 min and the reaction was monitored by HPLC. The cooling bath was removed and warmed to -250C. 2 N HCl (250 mL) was added and the mixture was stirred for 20 min at room temperature. The mixture was made alkaline by addition of 1 N NaOH. The product was extracted with ethyl acetate and the combined organic layers were dried over Na2SO4. The product was purified by chromatography (700 g silica agel, CH2Cl2, then CH2Cl2 / ethyl acetate 1:1, UV) to yield 27.7 g (81 %) of (3,5-dibromo-rhohenyl)-pyridin-3-yl-methanone.

The synthetic route of 626-39-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LOCUS PHARMACEUTICALS, INC.; WO2008/8059; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-39-1,Some common heterocyclic compound, 626-39-1, name is 1,3,5-Tribromobenzene, molecular formula is C6H3Br3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1,3,5-tribromobenzene (7.96 g, 25.3 mmol), bis(pinacolato)diboron (21.2 g, 83.5 mmol), [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium (2.78 g, 3.79 mmol), potassium acetate (22.3 g, 228 mmol) in anhydrous 1,4-dioxane (400 mL) was degassed for 80 minutes. Mixture was then heated to 80 C. overnight under argon. After cooling to room temperature, the remaining solids were filtered off. The filtrate was dried under vacuum, redissolved in methylene chloride (400 mL) then washed with water (2×300 mL) and brine (300 mL). Organic layer was dried over sodium sulfate and loaded onto silica gel. A silica plug (11% ethyl acetate in hexanes) and precipitation from methylene chloride/methanol gave 4 (9.76 g, 88% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3,5-Tribromobenzene, its application will become more common.

Reference:
Patent; Zheng, Shijun; US2011/196158; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-39-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-39-1, name is 1,3,5-Tribromobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1,3,5-tribromobenzene (3.11 g, 10 mmol), pyridine-3-boronic acid (2.71 g, 22 mmol), tetrakis(triphenylphosphine)palladium(1.56 g, 1 mmol) and potassium carbonate (5.52 g, 40 mmol) were added to the reaction flask.The nitrogen was exchanged three times (10 min/time). Injecting solvent under nitrogen protection(toluene: ethanol: water = 8:1:1), after the completion of the injection, the reaction was refluxed at 120 C for 8 h;Extract, concentrate, make powder,Purification by column chromatography gave white solid product 1 in 65% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3,5-Tribromobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; South China University of Technology; Tang Benzhong; Zhao Zujin; Hu Shimin; Qin Anjun; Hu Rongrong; Wang Zhiming; (24 pag.)CN109593079; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 626-39-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 626-39-1 name is 1,3,5-Tribromobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1,3,5-Tribromobenzene (20 g, 62 mmol), Pd(PPh3)4 (3.57 g, 3.1mmol) were added to 300 mL of dry THF solution, thenphenylbronic acid (32 g, 155 mmol) and 2 M K2CO3 solution (50 mL), which was dissolved in H2O, was added to the reaction mixture. The reaction mixture was heated to 65C for 5 h under nitrogen. After the reaction was finished,extracted with diethyl ether and water. The organic layer was dried with anhydrous MgSO4 and filterd. The solvent was evaporated. The product was isolated by silica gel column chromatography using CHCl3:hexane (1:15) eluent to afforda white solid (Yield 61%). 1H NMR (300 MHz, CDCl3) delta 7.7(s, 3H), 7.6 (d, 4H), 7.45 (t, 4H), 7.4 (t, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,3,5-Tribromobenzene, and friends who are interested can also refer to it.

Reference:
Article; Shin, Hwangyu; Kang, Hyeonmi; Kim, Beomjin; Park, Youngil; Yu, Young-Jun; Park, Jongwook; Bulletin of the Korean Chemical Society; vol. 35; 10; (2014); p. 3041 – 3046;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-39-1,Some common heterocyclic compound, 626-39-1, name is 1,3,5-Tribromobenzene, molecular formula is C6H3Br3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 2 Preparation of 1,3,5-tris-(5-hydroxypent-1-ynyl)-benzene 1,3,5-Tribromobenzene (10 g, 31.76 mmol), 4-pentyn-1-ol (10.69 g, 127.06 mmol) and bis(triphenylphosphine)palladium(II) dichloride were stirred in triethylamine under nitrogen for 5 minutes. Copper(I) iodide (92 mg, 0.48 mmol) was added and the mixture was stirred for 6 hours at 80 C. The mixture was cooled to room temperature, filtered through a celite pad and rinsed with ethyl acetate. The combined filtrate was evaporated to dryness under reduced pressure. The resulting residue was purified by column chromatography (CHCl3:MeOH 10:1) to afford 7.61 g of 1,3,5-tris-(5-hydroxy-1-pentynyl)-benzene. Yield: 74%. 1H NMR (300 MHz, CDCl3) delta 7.31 (3, 3 h), 3.81 (t, J=6.0 Hz, 6H), 2.52 (t, J=6.9 Hz, 6H), 1.85 (m, 6H); 13C NMR (75 MHz, CDCl3) delta 133.8, 124.2, 90.5, 80.0, 61.9, 31.5, 16.2 ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3,5-Tribromobenzene, its application will become more common.

Reference:
Patent; University of Kentucky Research Foundation; US2010/179186; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 626-39-1, name is 1,3,5-Tribromobenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 626-39-1

n-Butyllithium (2.5 mL of a 2.5 mol/l solution in n-hexane,6.3 mmol) was added to a solution of 1,3,5-tribromobenzene (7) (2.00 g, 6.35 mmol) in Et2O (40mL) at -78 C under inert atmosphere. After 10 min, CuCN (282 mg, 3.18 mmol) was added andthe reaction mixture was allowed to warm up to -60 C within 90 min. Nitrobenzene (0.98 mL,9.53 mmol) was then added in one portion and the dark solution stirred while warming toambient temperature (16 h). An aqueous solution of NH3 (12.5% w/w, 80 mL) was slowly addedand the resulting mixture was extracted with MTBE (3 x 50 mL). The combined organic layerswere washed with water (50 mL) and brine (50 mL), dried over MgSO4, filtered and the solventwas removed in vacuum. Further purification was accomplished by column chromatography(SiO2, n-hexane, Rf 0.69). The resulting material was washed with acetone (20 mL) to give theproduct 8 as a colorless solid (722 mg, 1.54 mmol, 48%), mp 190 C (ref.22 190-191 C). 1HNMR (500 MHz, CDCl3): delta 7.70 (t, J 1.7 Hz, 2 H), 7.59 (d, J 1.7 Hz, 4 H) ppm. 13C{1H} NMR(126 MHz, CDCl3): delta 141.8 (2 C), 133.9 (2 CH), 129.0 (4 CH), 123.6 (4 C) ppm. IR (ATR):3103 (w), 3068 (m), 1579 (m), 1541 (s), 1407 (m), 1387 (m), 1098 (m), 1068 (m), 847 (s), 752(s), 672 (m), 653 (m) cm-1. MS (EI, 70 eV), m/z (%): 466 (95) [M+], 308 (25), 150 (25), 84(100). Anal. calcd. for C12H6Br4 (469.80): C 30.68, H 1.29; found C 30.68, H 1.30.

According to the analysis of related databases, 626-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Behler, Florian; Wickleder, Mathias S.; Christoffers, Jens; ARKIVOC; vol. 2015; 2; (2014); p. 64 – 75;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-39-1, A common heterocyclic compound, 626-39-1, name is 1,3,5-Tribromobenzene, molecular formula is C6H3Br3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

500 mL reactor to tribromobenzene 25 g (79 mmol), phenyl boronic acid 23.3 g (191 mmol), potassium carbonate 32.9 g (238 mmol), tetrakistriphenylphosphinepalladium, 6.12 g (3 mmol), distilled water 50 In the mL, 125 mL toluene and 125 mL 1,4dioxaneis stirred and refluxed for 24 hours. After completion of the reaction by separating the reaction layer and the organic layer was concentrated under reduced pressure. Recrystallized with toluene and methanol to give the 8-a 21 g. (85% yield)

The synthetic route of 626-39-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SFC Co.,Ltd; Yang, Byung Son; Lee, Say Jin; Lee, Bong Hyang; Oh, Hyun Ju; Yu, Jong Ho; Hwang, Mun Chan; (67 pag.)KR2015/130797; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary