Category: 61921-39-9

Related Products of 61921-39-9, These common heterocyclic compound, 61921-39-9, name is 4-Bromotetraphene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N 2 is bubbled and the 4 l flask is heat dried and 100 g (325.5 mmol) of 4-bromobenzo [a] anthracene is initially introduced into 1400 ml of anhydrous THF. The batch is cooled to -72 C. and 190 ml of 2.5 M n-butyllithium are rapidly added dropwise. In the process, it is warmed from -72 C. to -61 C. (addition time: 2 minutes). The reaction mixture is stirred for an additional 3 hours at -70 C.150 ml (637 mmol) triisopropylborate is immediately added to the solution via a dropping funnel, during which the batch is warmed to -68 C. The batch is subsequently stirred for 2 hours at -70 C. and then warmed to RT. The reaction solution is diluted with 1300 ml of ethyl acetate and 690 ml of water in a cleaned 6 l flask under N 2 flow and stirred for 60 min. The aqueous layer is subsequently separated off and the organic phase is washed twice with 750 ml of water each time. The organic phase is dried using Na 2 SO 4 and evaporated in a rotary evaporator with 70 ml of ethyl acetate solution.Yield 62.13 g(70% of the theoretical value).

The synthetic route of 61921-39-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENTGMBH; SPREITZER, HUBERT; SCHWAIGER, JOCHEN; BECKER, HEINRICH; VOGES, FRANK; HEIL, HOLGER; (117 pag.)JP5851999; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61921-39-9 as follows. Quality Control of 4-Bromotetraphene

52 ml (130 mmol) of n-butyllithium (2.5 M in n-hexane) are added dropwise with vigorous stirring to a suspension of 30.7 g (100 mmol) of 4-bromo-benz[a]anthracene (I) in 1000 ml of THF at -78 C., and the mixture is stirred for a further 2 h. 16.7 ml (150 mmol) of trimethyl borate are added in one portion to the red solution with vigorous stirring, the mixture is stirred at -78 C. for a further 30 min., then warmed to room temperature over the course of 3 h, 300 ml of water are added, and the mixture is stirred for 30 min. The organic phase is separated off and evaporated to dryness in vacuo. The solid is taken up in 100 ml of n-hexane, filtered off with suction, washed once with 100 ml of n-hexane and dried in vacuo. Yield: 23.7 g (87.0 mmol), 87.0%, purity about 90.0% (NMR) of boronic acid, with varying amounts of boronic anhydride and borinic acid. The boronic acid can be used in this form without further purification.

According to the analysis of related databases, 61921-39-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Merck Patent GmbH; Anemian, Remi Manouk; Ludemann, Aurelie; Eberle, Thomas; Hoeger, Sigurd; Reis, Eva Maria; Bobbe, Vanessa; US8906893; (2014); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 61921-39-9, name is 4-Bromotetraphene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Bromotetraphene

Example 27 Synthesis of 4-(benz[a]anthracen-4-yl)benz[a]anthracene Preparation analogous to Example 7. 9-Bromo-10-(2-naphthyl)anthracene is replaced by 15.4 g (50 mmol) of 4-bromobenz[a]anthracene. Recrystallisation four times from o-dichlorobenzene (about 15 ml/g); sublimation (p=5*10-5 mbar, T=320 C.). Yield: 16.8 g (37 mmol), 74.0%, purity 99.9% (HPLC), Tg=130.3 C.

The synthetic route of 4-Bromotetraphene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Stoessel, Philipp; Buesing, Arne; Heil, Holger; US2010/187505; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

61921-39-9, A common compound: 61921-39-9, name is 4-Bromotetraphene, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Example 54 Synthesis of 4-(diphenylamino)benz[a]anthracene 190 mul (1 mmol) of chlorodi-tert-butylphosphine and then 112 mg (0.5 mmol) of palladium(II) acetate are added to a suspension of 15.4 g (50 mmol) of 4-bromobenz[a]anthracene, 10.2 g (60 mmol) of diphenylamine and 7.7 g (80 mmol) of sodium tert-butoxide in 500 ml of toluene, and the mixture is subsequently heated under reflux for 5 h. After the mixture has been cooled to 60 C., 500 ml of water are added, the organic phase is separated off, filtered through silica gel, evaporated virtually to dryness at 80 C. in vacuo, and 300 ml of ethanol are then added. After cooling, the solid is filtered off with suction. Recrystallisation five times from dioxane (about 8 ml/g); sublimation (p=5*10-5 mbar, T=280 C.). Yield: 12.7 g (32 mmol), 64.1%, purity 99.9% (HPLC), Tg=74.7 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromotetraphene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Stoessel, Philipp; Buesing, Arne; Heil, Holger; US2010/187505; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary