Category: 61613-22-7

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61613-22-7, name is 2-Bromo-N-phenylaniline, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C12H10BrN

To a dry 2 L three-necked flask was added 17.3 g (20.9 mmol) of intermediate-25 and5.2 g (20.9 mmol) of 2-bromophenylaniline, followed by drying and degassing of 300 ml of toluene as the solvent,Pass nitrogen for 15 minutes. 5.9 g (61.8 mmol) of sodium tert-butoxide, 0.38 g (2% mol)The catalyst Pd2 (dba) 3 and 1.7 ml (4% mol) of P (t-bu) 3 in toluene (m / v, 10%).The temperature was raised to 110 C and reacted for 16 hours. Until the end of the reaction, cooling to room temperature, plus activated carbon adsorption,The solvent was removed by filtration, and the solvent was removed and recrystallized from toluene and ethanol to give 16.9 g of intermediate-26 in 81% yield.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 61613-22-7.

Reference:
Patent; Nanjing Gao Guang Semiconductor Materials Co., Ltd.; Jin Zhenyu; Qian Chao; Shen Nan; Wang Xiaowei; (56 pag.)CN106892915; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 61613-22-7, The chemical industry reduces the impact on the environment during synthesis 61613-22-7, name is 2-Bromo-N-phenylaniline, I believe this compound will play a more active role in future production and life.

Di-tert-butyl dicarbonate (BOC) at room temperature in a 500 ml single-necked flask(0.2 mol, 43.6 g) was added to 400 ml of tetrahydrofuran.Then add N-(dibromophenyl)aniline (0.1 mol, 24.8 g),Pass N2 for 20 minutes and addHeat to reflux and stir24 hours. Then pour the mixture into 1L of water.The product was extracted with dichloromethane.The organic phase was dried over anhydrous magnesium sulfate, and the solvent was removed after separation.Separation and purification by silica gel column to obtain colorless oily liquid(33.0 g, yield 95%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N-phenylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Huaxing Optoelectric Co., Ltd.; Wu Yuanjun; Jiao Shibo; Shi Ting; Su Shijian; Li Wei; Li Binbin; (20 pag.)CN109438350; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

61613-22-7, name is 2-Bromo-N-phenylaniline, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C12H10BrN

2-Bromo-N-phenylaniline (10 g) was dissolved inAfter 100 ml THF (tetrahydrofuran), the reaction temperature is lowered to -78 C,20 ml of 2.5 M BuLi (butyllithium) was slowly added dropwise and stirred for 1 hour.Dissolving 15.2 g of bis(4-chlorophenyl)methanone (bis(4-chlorophenyl)methanone)After 150 ml of THF (tetrahydrofuran) was slowly added dropwise,The temperature was raised to room temperature and stirred for 12 hours. After the reaction is over,A solid obtained by extracting with distilled water and MC (dichloromethane) and removing water by using anhydrous magnesium sulfate and then filtering under reduced pressure is directly dissolved in 150 ml of acetic acid (Acetic acid) without further purification.10 ml of sulfuric acid was added dropwise and stirred under reflux. After the reaction is over,Extraction with distilled water and MC (dichloromethane) and column purification of the resulting solid10g I3. (yield 62%)

The synthetic route of 61613-22-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dongjin Shimeiken Co., Ltd.; Xian Haowan; An Xianzhe; Jin Bingyu; Han Zhengyou; Jin Jintai; (31 pag.)CN104471022; (2018); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 61613-22-7, A common heterocyclic compound, 61613-22-7, name is 2-Bromo-N-phenylaniline, molecular formula is C12H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under an Ar atmosphere, to a 500 ml, three-neck flask, Compound C (5.00 g) was put and dissolved in dehydrated THF (100 ml), and nBuLi (1.6 M in hexane, 12.6 ml) was added dropwise thereto at about -78 C. After stirring at about -78 C. for about 1 hour, a THF solution (100 ml) of B (7.01 g) was added dropwise thereto, followed by stirring for about 16 hours while gradually increasing the temperature to ambient temperature. Water was added to the resultant product, and an organic layer was extracted with CH2Cl2, separated, and dried with MgSO4. Solvents were removed by distillation under a reduced pressure. The crude product thus obtained was dissolved in toluene (100 ml), and pTsOH (11.5 g) was added thereto, followed by heating and stirring at about 80 C. for about 6 hours. After the reaction, a precipitate thus produced was obtained by filtering and separated by recrystallization to obtain 6.24 g (yield 62%) of Intermediate D. The molecular weight of Intermediate D measured by FAB-MS was 499.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SAMSUNG DISPLAY CO., LTD.; SAKAMOTO, Naoya; AKASHI, Nobutaka; (46 pag.)US2020/20866; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 61613-22-7, name is 2-Bromo-N-phenylaniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61613-22-7, 61613-22-7

After dissolving 10 g of 2-bromo-N-phenylphenylamine in 100 ml of tetrahydrofuran,The reaction temperature was lowered to -78 C, 20 ml of 2.5 M butyllithium was slowly added dropwise and stirred for 1 h.15.2 g of bis (4-chlorophenyl) methanone was dissolved in 150 ml of tetrahydrofuranAfter slowly adding dropwise, the temperature was increased to room temperature and stirred for 12 h. After the reaction is completed, distilled water and water will be usedMethylene chloride and dried under anhydrous magnesium sulfate and then filtered under reduced pressure, without further purificationPure and directly dissolved in 150 ml of acetic acid, 10 ml of sulfuric acid was added dropwise and the mixture was stirred under reflux. After the reaction is over, useDistilled water and methylene chloride and the resulting solid was subjected to column purification to give compound 9-1 (10 g, yield62%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-N-phenylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Changchun Hai Purunsi Technology Co., Ltd.; Liu Xiqing; Cai Hui; (24 pag.)CN107400085; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

61613-22-7, A common heterocyclic compound, 61613-22-7, name is 2-Bromo-N-phenylaniline, molecular formula is C12H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2) To a solution of 150 mL of a 0.194 mol/L 2-bromo-N-phenylaniline in anhydrous tetrahydrofuran at a temperature of -78 C, 2.5 mL/L of n-BuLi hexane solution 25.6 mL was added dropwise. After stirring for 2 h, 110 mmol of fluorenone was added, and after stirring for 30 min, the reaction mixture was warmed to room temperature and stirred overnight; after quenching with a large amount of water, the mixture was extracted three times with chloroform; and the combined chloroform solution was dried over anhydrous magnesium sulfate. Concentration, filtration and evaporation gave the crude hydroxy intermediate; the obtained crude hydroxy intermediate was dissolved in 150 mL of chloroform, 64.02 mmol of methanesulfonic acid was added, then refluxed for 10 hours; after cooling to room temperature, the resulting solution was carefully poured into excess carbonic acid. The mixture was stirred with chloroform for 20 min; EtOAc (EtOAc)EtOAc. -] (See Li, B.-W.; Li, Z.-Y.; Hu, T.-P.; Zhang, Y.; Wang, Y.; Yi, Y.-P.; Guo, F .-Y.;Zhao, L.-CJ Mater. Chem. C, 2018, 6, 2351-2359).The yield of the obtained 10H-spiro[acridine-9,9′-oxime] was 51%, and the purity was >99%.

The synthetic route of 61613-22-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shihezi University; He Lin; Wang Weihua; Du Guangfen; Gu Chengzhi; (22 pag.)CN109485605; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary