Category: 615-59-8

Synthetic Route of 615-59-8,Some common heterocyclic compound, 615-59-8, name is 1,4-Dibromo-2-methylbenzene, molecular formula is C7H6Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 250 ml three-necked round-bottom flask equipped with a reflux condenser, thermometer, dropping funnel with pressure-equalizing, and magnetic stirring bar, and containing 74.9 g (0.30 mol) of 3,6-dibromotoluene, 15.5 ml (47.9 g, 0.30 mmol) of bromine was added dropwise under exposure to 500 W lamp for 3 hours at 19O0C. The resulting mixture was cooled to room temperature. Fractional distillation gave colorless liquid, b.p. 132-135°C/3 mm Hg. Yield 84.3 g (85percent).Anal. calc. for C7H5Br3: C, 25.57; H, 1.53. Found: C, 25.81; H, 1.62.1H NMR (CDCl3): delta 7.59 (m, IH, 5-H), 7.43 (m, IH, 3-H), 7.28 (m, IH, 3- H), 4.52 (s, 2H, CH2).13C NMR (CDCl3): delta 138.9, 134.6, 134.0, 133.1 , 123.0, 121.5, 32.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2-methylbenzene, its application will become more common.

Reference:
Patent; EXXONMOBIL CHEMICAL PATENTS INC.; WO2007/70041; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 615-59-8, name is 1,4-Dibromo-2-methylbenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H6Br2

In a dry 500ml round-bottomed flask (equipped with a water-cooled condenser, a gas outlet, and a stir bar) palladium acetate (0.449g, 2.00mmol), tri(o-tolyl)phosphine (1.22g, 4.00mmol), and potassium tert-butoxide (1 1 .2g, lOOmmol) were combined. The apparatus was sealed, purged with nitrogen, and 60mL anhydrous toluene was added. To the resulting suspension 3-S-methylmorpholine (4.04g, 40.0mrnoi), and 2,5-dibromotoluene (12.5g,

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; ATHENEX, INC.; SMOLINSKI, Michael P.; NASIEF ABDEL-SAYED, Nader N.; HANGAUER, JR., David G.; (197 pag.)WO2018/31988; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 615-59-8, name is 1,4-Dibromo-2-methylbenzene, A new synthetic method of this compound is introduced below., Product Details of 615-59-8

(1) 2,5-dibromotoluene (10 mmol, 2.5 g), 4-methoxycarbonylbenzeneboronic acid (24 mmol, 4.33 g) under N2 protection.caesium fluoride (40 mmol, 6.0 g) was placed in a 250 mL three-necked flask, and 5% (1.2 to 2.0 g) of Pd (PPh3) catalyst was added.100 mL of anhydrous THF was used as a solvent, and refluxed at 67 C.After completion of the reaction, the product was isolated by silica gel column chromatography (petroleum ether, dichloromethane) to give a pink solid 2.91 g, yield 81%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Shandong Normal University; Dong Yubin; Wang Jiancheng; Liu Congxue; Hu Yuhong; (14 pag.)CN108640906; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 615-59-8,Some common heterocyclic compound, 615-59-8, name is 1,4-Dibromo-2-methylbenzene, molecular formula is C7H6Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a 250 ml three-necked round-bottom flask equipped with a reflux condenser, thermometer, dropping funnel with pressure-equalizing, and magnetic stirring bar, and containing 74.9 g (0.30 mol) of 3,6-dibromotoluene, 15.5 ml (47.9 g, 0.30 mmol) of bromine was added dropwise under exposure to 500 W lamp for 3 hours at 19O0C. The resulting mixture was cooled to room temperature. Fractional distillation gave colorless liquid, b.p. 132-135°C/3 mm Hg. Yield 84.3 g (85percent).Anal. calc. for C7H5Br3: C, 25.57; H, 1.53. Found: C, 25.81; H, 1.62.1H NMR (CDCl3): delta 7.59 (m, IH, 5-H), 7.43 (m, IH, 3-H), 7.28 (m, IH, 3- H), 4.52 (s, 2H, CH2).13C NMR (CDCl3): delta 138.9, 134.6, 134.0, 133.1 , 123.0, 121.5, 32.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2-methylbenzene, its application will become more common.

Reference:
Patent; EXXONMOBIL CHEMICAL PATENTS INC.; WO2007/70041; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

615-59-8, name is 1,4-Dibromo-2-methylbenzene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1,4-Dibromo-2-methylbenzene

(1) Under nitrogen protection, 4.33 g (24 mmol) of 4-methoxycarbonylbenzeneboronic acid, 6 g (40 mmol) of cesium fluoride were placed in a 250 ml three-necked flask, and 150 ml of 1,4-dioxane and 2.754 ml (10 mmol) were added. a mixed solution of 2,5-dibromotoluene,Then 1.6 g of tetrakis(triphenylphosphine)palladium catalyst was added and refluxed at 90 C for 48 h.After the reaction was completed, an orange solution was obtained with a black precipitate. The system was evaporated to dryness under reduced pressure.A white product of 3.0 g was obtained in a yield of 82%.

The synthetic route of 615-59-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong Normal University; Dong Yubin; Wang Jiancheng; Liu Congxue; (14 pag.)CN109988079; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 615-59-8, These common heterocyclic compound, 615-59-8, name is 1,4-Dibromo-2-methylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(b) To a solution of 75 g (0.3 mol) of 2,5-dibromotoluene in 1 L of carbon tetrachloride was added 58.73 g (0.33 mol) of NBS and 50 mg of benzyl peroxide, and the resulting mixture was refluxed with stirring for 24 h. The mixture was cooled, and concentrated in vacuo. The residue was crystallized from hot methanol and washed with hexane to afford 54.5 g (55.7percent) of 2.5-dibromobenzyl bromide as a solid.

The synthetic route of 615-59-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sterling Winthrop Inc.; US5554620; (1996); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 615-59-8, The chemical industry reduces the impact on the environment during synthesis 615-59-8, name is 1,4-Dibromo-2-methylbenzene, I believe this compound will play a more active role in future production and life.

2,5-dibromotoluene (10 g, 40 mmol)Was dissolved in anhydrous tetrahydrofuran (40 mL). N-Butyllithium (10 g, 160 mmol) was slowly dropped at -78 ¡ã C., and the mixture was stirred for 2 hours and 30 minutes.Dimethylformamide (15.5 mL, 200 mmol) was added thereto, followed by stirring for 1 hour. Then, 3N hydrochloric acid was added, and anhydrous tetrahydrofuran was removed, followed by extraction with chloroform, drying over anhydrous magnesium sulfate, and purification through silica gel (SiO2, n-hexane: ethyl acetate = 5: 1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,4-Dibromo-2-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Korea National University of Transportation Industry Academy Cooperation Foundation; Lee Ji-hun; Choi Yong-seon; Shin Seong-jun; (65 pag.)KR2019/43743; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 615-59-8,Some common heterocyclic compound, 615-59-8, name is 1,4-Dibromo-2-methylbenzene, molecular formula is C7H6Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under argon atmosphere, 0.65 g (0.80 mmol) of PdCl2(dppf),5.9 g (60.0 mmol) of potassium acetate, and 15.2 g (60.0 mmol)bis(pinacolato)diboron were weighed into a 100 mL two-neck flask. 5.0 g (20.0 mmol) of 1,4-dibromo-2-methylbenzene and 100mL dry1,4-dioxane were added to the solution. After stirring at 100 C for24 h, the solution was stirred further night at room temperature, and the solvent was removed in vacuum. The residue was purified by column chromatography using silica gel (n-hexane/ethyl acetate 50:1). The product was recrystallized with dichloromethane andethanol. The product was a white solid. Yield: 5.1 g (74%). 1H NMR d:7.76 (s, 1H), 7.61 (s, 2H), 2.55 (s, 3H), 1.36 (s, 24H). 13C NMR d:143.83, 135.87, 135.03, 130.84, 83.78, 83.50, 77.46, 77.04, 76.61,24.90, 24.87, 22.03. MS (EI) m/z: 344.3(M).

The synthetic route of 615-59-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Park, Soyun; Tan, Xiaofeng; Jang, Woongsik; Cho, Jae Sang; Kim, Yun-Hi; Kwon, Soon-Ki; Wang, Dong Hwan; Organic electronics; vol. 46; (2017); p. 183 – 191;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 615-59-8, name is 1,4-Dibromo-2-methylbenzene, molecular formula is C7H6Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 615-59-8

(1) 2,5-dibromotoluene (10 mmol, 2.5 g), 4-methoxycarbonylbenzeneboronic acid (24 mmol, 4.33 g) under N2 protection.caesium fluoride (40 mmol, 6.0 g) was placed in a 250 mL three-necked flask, and 5% (1.2 to 2.0 g) of Pd (PPh3) catalyst was added.100 mL of anhydrous THF was used as a solvent, and refluxed at 67 C.After completion of the reaction, the product was isolated by silica gel column chromatography (petroleum ether, dichloromethane) to give a pink solid 2.91 g, yield 81%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 615-59-8, its application will become more common.

Reference:
Patent; Shandong Normal University; Dong Yubin; Wang Jiancheng; Liu Congxue; Hu Yuhong; (14 pag.)CN108640906; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 615-59-8 as follows. 615-59-8

3,6-Dibromobenzylbromide In a 250 ml three-necked round-bottom flask equipped with a reflux condenser, thermometer, dropping funnel with pressure-equalizing, and magnetic stirring bar, and containing 74.9 g (0.30 mol) of 3,6-dibromotoluene, 15.5 ml (47.9 g, 0.30 mmol) of bromine was added dropwise under exposure to 500 W lamp for 3 hours at 190¡ã C. The resulting mixture was cooled to room temperature. Fractional distillation gave colorless liquid, b.p. 132-135¡ã C./3 mm Hg. Yield 84.3 g (85percent). Anal. calc. for C7H5Br3: C, 25.57; H, 1.53. Found: ¡ã C, 25.81; H, 1.62. 1H NMR (CDCl3): delta 7.59 (m, 1H, 5-H), 7.43 (m, 1H, 3-H), 7.28 (m, 1H, 3-H), 4.52 (s, 2H, CH2). 13C NMR (CDCl3): delta 138.9, 134.6, 134.0, 133.1, 123.0, 121.5, 32.2.

According to the analysis of related databases, 615-59-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Voskoboynikov, Alexander Z.; Ryabov, Alexey N.; Nikulin, Mikhail V.; Lygin, Alexander V.; Coker, Catalina L.; Canich, Jo Ann M.; US2007/135595; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary