Category: 615-55-4

Nickel-Catalyzed Electroreductive Syntheses of Triphenylenes Using ortho-Dihalobenzene-Derived Benzynes was written by Li, Zhao-Ming;Shuai, Bin;Ma, Cong;Fang, Ping;Mei, Tian-Sheng. And the article was included in Chinese Journal of Chemistry in 2022.HPLC of Formula: 615-55-4 This article mentions the following:

Electrochem. nickel-catalyzed syntheses of triphenylenes e.g., I, by a reductive trimerization of ortho-dibromobenzenes e.g.., 5,6-dibromoindane or ortho-bromoarylsulfurofluoridates e.g., 2-bromo-4-fluorophenyl sulfurofluoridate, or by reductive cross-coupling of ortho-dibromobenzenes to 2,2′-diiodobiphenyls, were described. The former provides a practical means for the construction of triphenylene derivatives e.g., ,I in up to 87% isolated yield at room temperature For 1,2-dihalo-3-methylbenzenes and related ortho-trisubstituted substrates, trimerizations proceed with high substrate-controlled regioselectivity for the non-C3h sym. triphenylene isomer. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4HPLC of Formula: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.HPLC of Formula: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

The Skraup reaction of 3,4-dihaloanilines was written by Blatchly, Richard A.;Greeley, Michael A.;Markgraf, J. Hodge. And the article was included in Heterocycles in 1989.SDS of cas: 615-55-4 This article mentions the following:

Six 3,4-dihaloanilines I (R = Br, Cl, F; R¹ = Br, Cl, F, iodo) were converted by the sulfo-mix variation of the Skraup reaction to mixtures of 5,6- and 6,7-dihaloquinolines, II and III resp. Inductive effects were the dominant influence on the course of cyclization: the more highly electron-withdrawing the substituents of I, the greater was the proportion of III. Steric effects were absent. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4SDS of cas: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.SDS of cas: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of phthalonitriles using a palladium catalyst was written by Iqbal, Zafar;Lyubimtsev, Alexey;Hanack, Michael. And the article was included in Synlett in 2008.Formula: C6H5Br2N This article mentions the following:

An easy synthetic method to obtain phthalonitriles from o-dibromobenzenes under mild conditions in high yields using Zn(CN)₂ and a catalytic amount of tris(dibenzylideneacetone)dipalladium and 1,1′-bis(diphenylphosphino)ferrocene is described. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Formula: C6H5Br2N).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Formula: C6H5Br2N

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of novel potential DNA cross-linking new antineoplastic alkylating agents was written by Maroju, Sreedhar;Kumar, P. Naveen;Maroju, Ravichander;Velupula, Ganapathy;Haq, Abdul;Prasad, T. Ravi. And the article was included in Journal of Applicable Chemistry (Lumami, India) in 2014.Application In Synthesis of 3,4-Dibromoaniline This article mentions the following:

Twenty novel potential DNA crosslinking new antineoplastic alkylating agents, oxazolidin-2-ones I [R¹ = H, Me, Br, F; R² = OMe, morpholino, pyrrolidino, 3-pyridyl, etc.; R³ = N(CH₂CH₂Cl)₂] were synthesized by the reaction I (R³ = NH₂) with 1,2-dichloroethane in the presence of triethylamine in methylene dichloride under reflux. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Application In Synthesis of 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application In Synthesis of 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bromination of 3-haloanilines with 2,4,4,6-tetrabromo-2,5-cyclohexadien-1-one was written by Markgraf, J. Hodge;Marshall, G. Thomas;Greeley, Michael A.. And the article was included in Chemistry & Industry (London, United Kingdom) in 1987.Name: 3,4-Dibromoaniline This article mentions the following:

Mixtures of dihaloanilines I, II, and III (R¹ = F, Cl, Br, iodo) were obtained from the resp. 3-R¹C₆H₄NH₂. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Name: 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bromination of 4,4′,4”-trisubstituted triphenylamines. Torsional control of electrophilic aromatic substitution was written by Kelley, William S.;Monack, Louise;Rogge, Peter T.;Schwartz, Robert N.;Varimbi, Suzanne P.;Walter, Robert I.. And the article was included in Justus Liebigs Annalen der Chemie in 1971.Recommanded Product: 615-55-4 This article mentions the following:

Bromination of (p-BrC6H4)3N, (p-MeC6H4)3N (I), and (p-MeOC6H4)3N (II) gave products with only one ortho-Br atom in each ring as determined by comparison of the NMR spectra with those of the appropriate 4-substituted 2-bromo- or 3-bromoanilines. D exchange in I and II took place in all 6 ortho positions. These reactions are interpreted as a result of a stepwise electrophilic substitution which occurs only when the aromatic ring undergoing reaction is rotated close to the fully activated conformation, in which it is coplanar with the three C-N bonds. The other two rings must be rotated far out of the plane to permit the ring undergoing substitution to attain this conformation. After bromination in one ortho position, the bulky Br atom prevents a return to the fully activated position whereas the smaller H or Cl do not. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Recommanded Product: 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Recommanded Product: 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Structure-activity relationships of N²-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases was written by Hildebrand, Catherine;Sandoli, Daniele;Focher, Federico;Gambino, Joseph;Ciarrocchi, Giovanni;Spadari, Silvio;Wright, George. And the article was included in Journal of Medicinal Chemistry in 1990.Recommanded Product: 3,4-Dibromoaniline This article mentions the following:

Guanines I [R = Ph, substituted Ph, Bu, hexyl, (CH₂)₅OH, CH₂Ph, CH₂C₆H₄Cl] were prepared and tested for inhibition of the thymidine kinases encoded by Herpes simplex viruses type 1 and type 2. Compounds with hydrophobic, electron-attracting groups in the meta position of the Ph ring such as I (R = 3-CF₃C₆H₄) were the most potent inhibitors of both enzymes. Many derivatives were significantly more potent against the type 2 thymidine kinase than against the type 1 and can effectively discriminate between the two enzymes. I [R = alkyl, (un)substituted CH₂Ph] were moderately potent inhibitors, and the type 2 enzyme was again more sensitive than the type 1 enzyme. None of the compounds inhibited the thymidine kinase isolated from the host HeLa cell line, suggesting that members of this class of compounds may be useful nonsubstrate, antiviral compounds for latent herpesvirus infections. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Recommanded Product: 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Recommanded Product: 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Bifunctional Indenyl-Derived Receptors for Fluoride Chelation and Detection was written by Tirfoin, Remi;Abdalla, Joseph A. B.;Aldridge, Simon. And the article was included in Chemistry – A European Journal in 2015.Application In Synthesis of 3,4-Dibromoaniline This article mentions the following:

Anion receptors based on a [CpFe(indenyl)] scaffold offer the possibility for the incorporation of adjacent Lewis acidic functions onto a six-membered carbocyclic framework, while at the same time retaining the colorimetric/electrochem. reporter mechanisms available to synthetically simpler ferrocene systems. Thus, [CpFe(indenyl)] systems featuring mutually ortho BMes₂ and PPh₂Me⁺ substituents (with either 4,5 or 5,6 regiochem.) are accessible which are capable of cooperative fluoride ion fixation. Simultaneous binding at the borane and phosphonium centers can be established by spectroscopic, structural and computational approaches, and is responsible for the favorable thermodn. associated with F^– uptake. Thus, in contrast to simple BMes₂ systems, the binding of fluoride is found to be more favorable than the uptake of cyanide (which interacts only with the borane Lewis acid). Moreover, in the case of a 4-(MePh₂P)-5-(Mes₂B)-7-Me-indenyl derivative, fluoride chelation is signalled not only by a large cathodic shift in the Fe^II/Fe^III potential (>500 mV in THF), but also by a distinct color change from green (for the free receptor) to maroon for the adduct. In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Application In Synthesis of 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Application In Synthesis of 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Aminobenzothiazoles. XI. Synthesis of 5,4′-disubstituted 1-anilinobenzothiazoles from nuclear substituted thiocarbenilides was written by Dyson, George M.;Hunter, Robert F.;Soyka, Charles. And the article was included in Journal of the Chemical Society in 1929.Safety of 3,4-Dibromoaniline This article mentions the following:

(P-BrC₆H₄NH)₂CS and Br in CHCl₃ yield a perbromide, which, on heating, gives a hydropentabromide(I), C₁₃H₈N₂Br₂S.HBr.Br₄, orange-red needles, m. 170鎺?(decomposition) and rapidly loses Br on exposure to moist air suspended in H₂SO₃ and treated with SO₂, there results 5,4′-dibromo-1-anilinobenzothiazole(II), m. 221鎺? Ac derivative, m. 205-6鎺? HBr salt, m. 250鎺?(decomposition); Br gives I. 1-Chloro-5-bromobenzothiazole, m. 89鎺? b₁₃ 157-9鎺? results by heating p-BrC₆H₄NCS and PCl₅ 30-40 hrs. at 170-80鎺?warming with p-BrC₆H₄NH₂ gives II. p-BrC₆H₄NHCSNHPh and Br in CHCl₃ give the hydrotribromide, m. 148鎺?(decomposition), which is reduced to 4′-bromo-1-anilinobenzothiazole (III), m. 214-5鎺? also obtained from 1-chlorobenzothiazole and p-BrC₆H₄NH₂. Bromination of III gives II. 1-Anilinobenzothiazole yields a hexabromide, m. 140鎺? which yields II on being dissolved in boiling absolute EtOH. Hugershoff’s dibromoanilinobenzothiazole (Ber. 36, 3121(1903)) appears to consist mainly of II, although the m. p. could not be raised above 200鎺? Bromination of II gives an unstable orange hexabromide, m. 254鎺? which gives with hot absolute EtOH a tetra-Br substitution derivative, m. 196-8鎺? (p-ClC₆H₄NH)₂CS and Br in CHCl₃ yield a hydrotribromide, orange, m. 165-7鎺?(decompm); reduction gives 5,4′-dichloro-1-aminobenzothiazole, m. 224鎺? Ac derivative, m. 186-7鎺? HBr salt. yellow, m. 217鎺? hexabromide, orange, m. 263鎺?(decomposition). p-ClC₆H₄NHCSNHPh yields a Br addition compound, orange, m. 130鎺?(decomposition); 4′-chloro-1-anilinobenzothiazole, m. 196鎺? this is also obtained from 1-chlorobenzothiazole and p-ClC₆H₄NH₂. (p-IC₆H₄NH)₂CS and Br in CHCl₃ yield a red bromide, m. 185鎺? and a yellow, m. 211鎺? both, on reduction, yield 5,4′-diiodo-1-anilinobenzothiazole, m. 193鎺?(decomposition); this also results by treating 1-anilinobenzothiazole in AcOH with ICl, warming the solution and diluting with H₂O. (p-FC₆H₄NH)₂CS gives a hydrotribromide, orange, m. 150-2鎺?(decomposition); 5,4′-difluoro-1-anilinobenzothiazole, m. 227-8鎺? 5,4′-Dinitro-1-anilinobenzothiazole, brilliant yellow, in. 280鎺? this also results on nitration of 1-anilinobenzothiazole. (p-NCC₆H₄NH)₂CS and Br give an addition product, golden, m. 159-60鎺?(decomposition): 5,4′-dicyano-1-anilinobenzothiazole, m. 222鎺? (p-EtO₂CC₆H₄NH)₂CS yields a hydropentabromide, orange, m. 110鎺?(decompn); reduction gives Et 1-anilinobenzothiazole-5,4′-dicarboxylate, m. 190-2鎺? hydrolysis gives the free acid, does not m. 290鎺? (p-MeOC₆H₄NH)₂CS yields a brick-red bromide, m. 137鎺?(decomposition), reduced to a dibromo-5,4′-dimethoxy-1-anilinobenzothiazole, m. 240鎺? PhNHCSNAcPh yields a hydrotribromide, orange, m. 167鎺?(decomposition); the same compound is obtained from 1-acetanilinobenzothiazole, HBr and Br (Hugershoff, Ber. 36, 3136(1903)); Br in CHCl₃ gives an orange hexa-Br addition compound, m. 163鎺?(decomposition). In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Safety of 3,4-Dibromoaniline).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Safety of 3,4-Dibromoaniline

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Substituted 6-Anilinouracils and Their Inhibition of DNA Polymerase IIIC and Gram-Positive Bacterial Growth was written by Zhi, Chengxin;Long, Zheng-Yu;Gambino, Joseph;Xu, Wei-Chu;Brown, Neal C.;Barnes, Marjorie;Butler, Michelle;LaMarr, William;Wright, George E.. And the article was included in Journal of Medicinal Chemistry in 2003.Related Products of 615-55-4 This article mentions the following:

Certain substituted 6-anilinouracils are potent and selective inhibitors of Gram+ bacterial DNA polymerase IIIC (pol IIIC). In addition, analogs with 3-substituents in the uracil ring have potent antibacterial activity against Gram+ organisms in culture. In an attempt to find optimal anilino substituents for pol IIIC binding and optimal 3-substituents for antibacterial activity, several series of 3-substituted-6-aminouracils were prepared and assayed their activity against pol IIIC from Bacillus subtilis and a panel of Gram+ and Gram- bacteria in culture. The 6-(3-ethyl-4-methylanilino) group and closely related substituent patterns maximized pol IIIC inhibition potency. Among a series of 3-(substituted-butyl)-6-(3-ethyl-4-methylanilino)uracils, basic amino substituents increased pol IIIC inhibition, but decreased antibacterial activity. The most potent antibacterials were simple hydroxybutyl and methoxybutyl derivatives, and hydrophobically substituted piperidinylbutyl derivatives In the experiment, the researchers used many compounds, for example, 3,4-Dibromoaniline (cas: 615-55-4Related Products of 615-55-4).

3,4-Dibromoaniline (cas: 615-55-4) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Related Products of 615-55-4

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary