Category: 6134-56-1

Adding a certain compound to certain chemical reactions, such as: 6134-56-1, name is 6-Bromo-1,2,3,4-tetrahydronaphthalene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6134-56-1, Safety of 6-Bromo-1,2,3,4-tetrahydronaphthalene

A mixture of 5-bromo-1,2, 3,4-tetrahydronaphthalene and 6-bromo-1,2, 3,4- tetrahydronaphthalene (20 g), copper [(1)] cyanide (8.6 g) and anhydrous N- methylpyrrolidinone (41.3 g) were stirred under dry nitrogen at [130 C] for 40 h. The mixture was cooled to ambient temperature, further N-methylpyrrolidinone (10 g) was added along with saturated aqueous brine (30 ml), the resulting mixture was stirred at ambient for 3 hours and filtered to remove solids. The filtrates were extracted with n- hexane (3 x 50 ml). The combined organic extracts were washed with water (100 ml), dried [(MGS04)] and evaporated in vacuo to give crude product (16.2 g). This was purified by distillation to give 5,6, 7,8-tetrahydronaphthalene-2-carbonitrile along with regioisomer (13.2 g, 95% purity, 84% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Bromo-1,2,3,4-tetrahydronaphthalene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; WO2004/792; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 6134-56-1, name is 6-Bromo-1,2,3,4-tetrahydronaphthalene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 6-Bromo-1,2,3,4-tetrahydronaphthalene

[-BUTYL] lithium (9.6 ml of 2. [5M] solution in hexane) was added [DROPWIS OVER] 30 minutes to a stirred solution of [5-BROM-1,] 2,3, 4-tetrahydronaphthalene in mixture with its regioisomer [6-BROM-1,] 2,3, 4-tetrahydronaphthalene (5 g) in dry THF (125 ml) and hexane (35 ml) [AT-70 C,] stirring was continued at-78 C for 30 minutes, carbon dioxide gas was bubbled through the mixture at-70 C until no further exotherm was evident, carbon dioxide gas addition was continued for a further 10 minutes as the reaction was allowed to warm to ambient temperature, the mixture was poured into 2M aqueous hydrochloric acid (100 ml) and the resulting mixture was extracted with diethyl ether (3 x 50 ml). The combined organic extracts were washed with water (100 ml) and were then extracted with 10% aqueous sodium carbonate solution (3 x 50 ml). The combined aqueous carbonate extracts were acidified carefully by addition of 2M hydrochloric acid to adjust the pH to pH 1. The resulting mixture was extracted with diethyl ether (3 x 50 ml), the combined organic extracts were washed with water (50 ml) and dried [(MGS04)] before solvent was removed by evaporation [IN VACUO TO] give the crude product in 64% yield comprising a mixture [OF REGIOISOMERS] of 5,6, 7,8-tetrahydronaphthalene carboxylic acid. This mixture was purified by repeated recrystallisation from ethyl acetate to give 5,6, 7,8- tetrahydronaphthalene-2-carboxylic acid as crystallised solid in 93% purity along with 5,6, 7, [8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC] acid as the major component present in the crystallisation mother liquors.

The synthetic route of 6-Bromo-1,2,3,4-tetrahydronaphthalene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; WO2004/792; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary