Category: 61150-57-0

Development of ¹⁸F-labeled radiotracers for PET imaging of the adenosine A₂A receptor: synthesis, radiolabeling and preliminary biological evaluation was written by Lai, Thu Hang;Schroder, Susann;Toussaint, Magali;Dukic-Stefanovic, Sladjana;Kranz, Mathias;Ludwig, Friedrich-Alexander;Fischer, Steffen;Steinbach, Jorg;Deuther-Conrad, Winnie;Brust, Peter;Moldovan, Rares-Petru. And the article was included in International Journal of Molecular Sciences in 2021.Related Products of 61150-57-0 This article mentions the following:

The adenosine A2A receptor (A2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomog. (PET) radiotracer to monitor changes of receptor d. and/or occupancy during the A2AR-tailored therapy, authors designed a library of fluorinated analogs based on a recently published lead compound (PPY). Among those, the highly affine 4-fluorobenzyl derivate (K_i(hA_2AR) = 5.3 nM) and the 2-fluorobenzyl derivate (K_i(hA_2AR) = 2.1 nM) were chosen for ¹⁸F-labeling via an alc. enhanced copper-mediated procedure starting from the corresponding boronic acid pinacol ester precursors. Investigations of the metabolic stability of compound I (R = p-¹⁸F, o-¹⁸F) in CD-1 mice by radio-HPLC anal. revealed parent fractions of more than 76% of total activity in the brain. Specific binding of I (R = o-¹⁸F)on mice brain slices was demonstrated by in vitro autoradiog. In vivo PET/magnetic resonance imaging (MRI) studies in CD-1 mice revealed a reasonable high initial brain uptake for both radiotracers, followed by a fast clearance. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Related Products of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular trans-Dicarbofunctionalization of Alkynes by a Formal anti-Carbopalladation/Stille Cascade was written by Milde, Bastian;Reding, Andreas;Geffers, Finn J.;Jones, Peter G.;Werz, Daniel B.. And the article was included in Chemistry – A European Journal in 2016.Synthetic Route of C7H5Br2F This article mentions the following:

An intramol. Pd-catalyzed trans-dicarbofunctionalization of internal alkynes using aryl bromides and aryl stannanes was presented. Tetrasubstituted double bonds embedded in an oligocyclic ring system were obtained in a regio- and diastereoselective fashion. The transformation featured a broad substrate scope and functional-group tolerance. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Synthetic Route of C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular Pd-Catalyzed Formal anti-Carboalkoxylation of Alkynes: Access to Tetrasubstituted Enol Ethers was written by Schitter, Theresa;Jones, Peter G.;Werz, Daniel B.. And the article was included in Chemistry – A European Journal in 2018.Computed Properties of C7H5Br2F This article mentions the following:

An intramol. Pd-catalyzed formal anti-carboalkoxylation reaction is presented that provides access to tetrasubstituted enol ethers. The key to success is a cascade consisting of a formal anti-carbopalladation of a carbon-carbon triple bond followed by a nucleophilic attack of a hydroxy group at the emerging vinyl organopalladium species. The desired transformation proceeded smoothly with primary, secondary, and tertiary alcs., and even with phenols. Depending on the substitution pattern of the enol ethers, a further Tsuji-Trost-type step may occur resulting in oligocyclic ketals. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Computed Properties of C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon–bromine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Expeditious synthesis of 1-aminoindane derivatives achieved by [1,4]-hydride shift mediated C(sp³)-H bond functionalization was written by Mori, Keiji;Kurihara, Kazuki;Akiyama, Takahiko. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Name: 2-Bromo-4-fluorobenzylbromide This article mentions the following:

Described herein is a [1,4]-hydride shift mediated expeditious synthesis of 1-aminoindane derivatives A wide variety of substrates could be employed in this reaction to afford various indane derivatives in good to excellent chem. yields. E.g., The desired [1,4]-hydride shift process was realized when benzylidenemalonate (I) was employed as the substrate. Upon treatment of I with 5 mol% Yb(OTf)₃ in refluxing ClCH₂CH₂Cl, the desired reaction proceeded smoothly to afford indane derivative II in a quant. yield with a short reaction time (0.5 h). Examination of the amine moiety revealed that the sterically hindered amine is the key to achieving both low catalyst loading and excellent chem. yields. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Name: 2-Bromo-4-fluorobenzylbromide).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Most organobromine compounds, like most organohalide compounds, are relatively nonpolar. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Name: 2-Bromo-4-fluorobenzylbromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary