Category: 61150-57-0

Development of ¹⁸F-labeled radiotracers for PET imaging of the adenosine A₂A receptor: synthesis, radiolabeling and preliminary biological evaluation was written by Lai, Thu Hang;Schroder, Susann;Toussaint, Magali;Dukic-Stefanovic, Sladjana;Kranz, Mathias;Ludwig, Friedrich-Alexander;Fischer, Steffen;Steinbach, Jorg;Deuther-Conrad, Winnie;Brust, Peter;Moldovan, Rares-Petru. And the article was included in International Journal of Molecular Sciences in 2021.Related Products of 61150-57-0 This article mentions the following:

The adenosine A2A receptor (A2AR) represents a potential therapeutic target for neurodegenerative diseases. Aiming at the development of a positron emission tomog. (PET) radiotracer to monitor changes of receptor d. and/or occupancy during the A2AR-tailored therapy, authors designed a library of fluorinated analogs based on a recently published lead compound (PPY). Among those, the highly affine 4-fluorobenzyl derivate (K_i(hA_2AR) = 5.3 nM) and the 2-fluorobenzyl derivate (K_i(hA_2AR) = 2.1 nM) were chosen for ¹⁸F-labeling via an alc. enhanced copper-mediated procedure starting from the corresponding boronic acid pinacol ester precursors. Investigations of the metabolic stability of compound I (R = p-¹⁸F, o-¹⁸F) in CD-1 mice by radio-HPLC anal. revealed parent fractions of more than 76% of total activity in the brain. Specific binding of I (R = o-¹⁸F)on mice brain slices was demonstrated by in vitro autoradiog. In vivo PET/magnetic resonance imaging (MRI) studies in CD-1 mice revealed a reasonable high initial brain uptake for both radiotracers, followed by a fast clearance. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Related Products of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular trans-Dicarbofunctionalization of Alkynes by a Formal anti-Carbopalladation/Stille Cascade was written by Milde, Bastian;Reding, Andreas;Geffers, Finn J.;Jones, Peter G.;Werz, Daniel B.. And the article was included in Chemistry – A European Journal in 2016.Synthetic Route of C7H5Br2F This article mentions the following:

An intramol. Pd-catalyzed trans-dicarbofunctionalization of internal alkynes using aryl bromides and aryl stannanes was presented. Tetrasubstituted double bonds embedded in an oligocyclic ring system were obtained in a regio- and diastereoselective fashion. The transformation featured a broad substrate scope and functional-group tolerance. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Synthetic Route of C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Synthetic Route of C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular Pd-Catalyzed Formal anti-Carboalkoxylation of Alkynes: Access to Tetrasubstituted Enol Ethers was written by Schitter, Theresa;Jones, Peter G.;Werz, Daniel B.. And the article was included in Chemistry – A European Journal in 2018.Computed Properties of C7H5Br2F This article mentions the following:

An intramol. Pd-catalyzed formal anti-carboalkoxylation reaction is presented that provides access to tetrasubstituted enol ethers. The key to success is a cascade consisting of a formal anti-carbopalladation of a carbon-carbon triple bond followed by a nucleophilic attack of a hydroxy group at the emerging vinyl organopalladium species. The desired transformation proceeded smoothly with primary, secondary, and tertiary alcs., and even with phenols. Depending on the substitution pattern of the enol ethers, a further Tsuji-Trost-type step may occur resulting in oligocyclic ketals. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Computed Properties of C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Many of the organo bromine compounds are relatively nonpolar. Bromine is more electronegative than carbon (2.8 vs 2.5) and hence the carbon in a carbon鑱砨romine bond is electrophilic in nature. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Computed Properties of C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Diversity-Oriented Synthesis of Biaryl-Containing Medium Rings Using a One Bead/One Stock Solution Platform was written by Spring, David R.;Krishnan, Shyam;Blackwell, Helen E.;Schreiber, Stuart L.. And the article was included in Journal of the American Chemical Society in 2002.Safety of 2-Bromo-4-fluorobenzylbromide This article mentions the following:

Diversity-oriented synthesis of structurally complex and diverse small mols. can be used as the first step in a process to explore cellular and organismal pathways. The success of this process is likely going to be dependent on advances in the synthesis of small mols. having natural product-like structures in an efficient and stereoselective manner. The development, scope, and mechanism of the oxidation of organocuprates was investigated and exploited in the atropdiastereoselective synthesis of biaryl-containing medium rings (9-, 10-, and 11-membered rings), e.g., I. The methodol. was performed on high-capacity, large polystyrene beads by metalating aryl bromides with i-PrBu₂MgLi, followed by transmetalating with CuCN·2LiBr and then oxidizing with 1,3-dinitrobenzene, and was used in a diversity-oriented synthesis of biaryl-containing medium rings (library total theor. maximum 1412 members). The high capacity beads were arrayed into 384-well plates and, using a process optimized during the development of a one bead/one stock solution technol. platform, converted into arrays of stock solutions, with each stock solution containing largely one compound These stock solutions were used in numerous phenotypic and protein-binding assays. The process described outlines a pathway that we feel will contribute to a comprehensive and systematic chem. approach to exploring biol. (chem. genetics). In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Safety of 2-Bromo-4-fluorobenzylbromide).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Safety of 2-Bromo-4-fluorobenzylbromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis of Quinazolines and Tetrahydroquinazolines: Copper-Catalyzed Tandem Reactions of 2-Bromobenzyl Bromides with Aldehydes and Aqueous Ammonia or Amines was written by Fan, Xuesen;Li, Bin;Guo, Shenghai;Wang, Yuanyuan;Zhang, Xinying. And the article was included in Chemistry – An Asian Journal in 2014.Recommanded Product: 2-Bromo-4-fluorobenzylbromide This article mentions the following:

An efficient synthesis of diversely substituted quinazolines and 1,2,3,4-tetrahydroquinazolines through copper-catalyzed tandem reactions of the readily available 2-bromobenzyl bromides, aldehydes, and aqueous ammonia or amines has been developed. By using ammonia and simple aliphatic amines as the nitrogen source, the present method provides a versatile and practical protocol for the synthesis of quinazolines and 1,2,3,4-tetrahydroquinazolines. E.g., in presence of Cu(OAc)₂ and DMAP in DMSO at 80 °C, reaction of 2-BrC₆H₄CH₂Br, 4-MeC₆H₄CHO and aqueous ammonia gave 64% quinazoline derivative I. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Recommanded Product: 2-Bromo-4-fluorobenzylbromide).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). Many of the alkyl bromine derivatives are excellent alkylating agents since bromides are good leaving groups. Tribromides, like tetrabutylammonium tribromide, are used as a solid source of bromine. N-bromosuccimide (NBS) is used for the selective bromination of allylic bonds.Recommanded Product: 2-Bromo-4-fluorobenzylbromide

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rapid access to 3-indolyl-1-trifluoromethyl-isobenzofurans by hybrid use of Lewis/Bronsted acid catalysts was written by Hoshino, Daiki;Mori, Keiji. And the article was included in Organic & Biomolecular Chemistry in 2020.Recommanded Product: 61150-57-0 This article mentions the following:

A rapid access to 3-indolyl-1-trifluoromethyl-isobenzofurans I [R¹ = H, 5-Me, 6-F, etc.; R² = H, 5-Me, 5-Br; R³ = H, Me, Et, Bn] via a [1,4]-hydride shift/cyclization/intermol. nucleophilic addition reaction sequence was reported. In this process, a Lewis acid promoted internal redox reaction ([1,4]-hydride shift/cyclization) followed by a Bronsted acid promoted intermol. reaction (generation of cyclic oxonium cation/intermol. Friedel-Crafts reaction) of indoles and (dibenzylamino)methyl-phenyl-trifluoro-ethanones occurred to give various 3-indolyl-1-trifluoromethyl-isobenzofurans in good chem. yields. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Recommanded Product: 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-catalyzed intramolecular desymmetrization addition of aryl halides to 1,3-diketones was written by Zhou, Pan;Xu, Tao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Synthetic Route of C7H5Br2F This article mentions the following:

A nickel-catalyzed intramol. addition of aryl halides to 1,3-diketones was first developed. This desymmetrization reaction afforded polycyclic products I [R = Me, i-Bu, Bn, etc.; R¹ = H; R² = H, Cl, OMe, etc.; R³ = H, Me; R⁴ = H, Me; R¹R² = OCH₂O] bearing two tetrasubstituted centers with excellent diastereoselectivities and high yields. Moderate enantioselectivities were achieved in the presence of a chiral ligand. This transformation had great potential for the synthesis of polycyclic compounds including spiro[4,4,3,0] compounds In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Synthetic Route of C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Synthetic Route of C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular palladium(II)/(IV) catalysed C(sp³)-H arylation of tertiary aldehydes using a transient imine directing group was written by St John-Campbell, Sahra;Bull, James A.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Related Products of 61150-57-0 This article mentions the following:

Palladium catalyzed β-C(sp³)-H activation of tertiary aldehydes RCH₂C(R₁)(R₂)CHO [R = 2-Br-5-ClC₆H₃, 2-IC₆H₄, 2-Br-4-H₃COC₆H₃, etc.; R₁ = Me, Et, n-Pr; R₂ = Me, Et] using a transient imine directing group enables intramol. arylation to form substituted indane-aldehydes I (R₄ = H, 5-F, 4-Cl, 5-CF₃, etc.). A simple amine bearing a Me ether (2-methoxyethan-1-amine) is the optimal TDG to promote C-H activation and reaction with an unactivated proximal C-Br bond. Substituent effects are studied in the preparation of various derivatives Preliminary mechanistic studies identify a reversible C-H activation and product inhibition and suggest that oxidative addition is the turnover limiting step. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives was written by Muimhneachain, Eoin O.;Pardo, Leticia M.;Bateman, Lorraine M.;Rao Khandavilli, U. B.;Lawrence, Simon E.;McGlacken, Gerard P.. And the article was included in Advanced Synthesis & Catalysis in 2017.HPLC of Formula: 61150-57-0 This article mentions the following:

A synthesis of tricyclic oxoisochromene derivatives via an intramol. direct arylation of cycloalkyl-1,3-diketone-derived α,β-unsaturated ketone substrates is described. Interesting mechanistic insight has been gathered, based on deuterium migration studies, induced by palladium (Pd). In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0HPLC of Formula: 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.HPLC of Formula: 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Indanylidenes. 2. Design and Synthesis of (E)-2-(4-Chloro-6-fluoro-1-indanylidene)-N-methylacetamide, a Potent Antiinflammatory and Analgesic Agent without Centrally Acting Muscle Relaxant Activity was written by Musso, David L.;Orr, G. Faye;Cochran, Felicia R.;Kelley, James L.;Selph, Jeffrey L.;Rigdon, Greg C.;Cooper, Barrett R.;Jones, Michael L.. And the article was included in Journal of Medicinal Chemistry in 2003.Computed Properties of C7H5Br2F This article mentions the following:

Extension of the structure-activity relationship studies that led to the discovery of the nonsedating potent muscle relaxant, antiinflammatory, and analgesic agent (E)-2-(4,6-difluoro-1-indanylidene)acetamide has given rise to (E)-2-(4-chloro-6-fluoro-1-indanylidene)-N-methylacetamide (I). I is a potent antiinflammatory and analgesic agent without centrally acting muscle relaxant activity. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Computed Properties of C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Computed Properties of C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary