Category: 61150-57-0

Rapid access to 3-indolyl-1-trifluoromethyl-isobenzofurans by hybrid use of Lewis/Bronsted acid catalysts was written by Hoshino, Daiki;Mori, Keiji. And the article was included in Organic & Biomolecular Chemistry in 2020.Recommanded Product: 61150-57-0 This article mentions the following:

A rapid access to 3-indolyl-1-trifluoromethyl-isobenzofurans I [R¹ = H, 5-Me, 6-F, etc.; R² = H, 5-Me, 5-Br; R³ = H, Me, Et, Bn] via a [1,4]-hydride shift/cyclization/intermol. nucleophilic addition reaction sequence was reported. In this process, a Lewis acid promoted internal redox reaction ([1,4]-hydride shift/cyclization) followed by a Bronsted acid promoted intermol. reaction (generation of cyclic oxonium cation/intermol. Friedel-Crafts reaction) of indoles and (dibenzylamino)methyl-phenyl-trifluoro-ethanones occurred to give various 3-indolyl-1-trifluoromethyl-isobenzofurans in good chem. yields. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Recommanded Product: 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Recommanded Product: 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Nickel-catalyzed intramolecular desymmetrization addition of aryl halides to 1,3-diketones was written by Zhou, Pan;Xu, Tao. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Synthetic Route of C7H5Br2F This article mentions the following:

A nickel-catalyzed intramol. addition of aryl halides to 1,3-diketones was first developed. This desymmetrization reaction afforded polycyclic products I [R = Me, i-Bu, Bn, etc.; R¹ = H; R² = H, Cl, OMe, etc.; R³ = H, Me; R⁴ = H, Me; R¹R² = OCH₂O] bearing two tetrasubstituted centers with excellent diastereoselectivities and high yields. Moderate enantioselectivities were achieved in the presence of a chiral ligand. This transformation had great potential for the synthesis of polycyclic compounds including spiro[4,4,3,0] compounds In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Synthetic Route of C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Most of the natural organobromine compounds are produced by marine organisms, and several brominated metabolites with antibacterial, antitumor, antiviral, and antifungal activity have been isolated from seaweed, sponges, corals, molluscs, and others. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.Synthetic Route of C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular palladium(II)/(IV) catalysed C(sp³)-H arylation of tertiary aldehydes using a transient imine directing group was written by St John-Campbell, Sahra;Bull, James A.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.Related Products of 61150-57-0 This article mentions the following:

Palladium catalyzed 灏?C(sp³)-H activation of tertiary aldehydes RCH₂C(R₁)(R₂)CHO [R = 2-Br-5-ClC₆H₃, 2-IC₆H₄, 2-Br-4-H₃COC₆H₃, etc.; R₁ = Me, Et, n-Pr; R₂ = Me, Et] using a transient imine directing group enables intramol. arylation to form substituted indane-aldehydes I (R₄ = H, 5-F, 4-Cl, 5-CF₃, etc.). A simple amine bearing a Me ether (2-methoxyethan-1-amine) is the optimal TDG to promote C-H activation and reaction with an unactivated proximal C-Br bond. Substituent effects are studied in the preparation of various derivatives Preliminary mechanistic studies identify a reversible C-H activation and product inhibition and suggest that oxidative addition is the turnover limiting step. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. alpha-Bromoesters are employed in the Reformatsky reaction for the synthesis of beta-hydroxyesters. When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Related Products of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Intramolecular Direct Arylation of 1,3-Diketone-Derived Enol Ethers in a Synthesis of Tricyclic Oxoisochromene Derivatives was written by Muimhneachain, Eoin O.;Pardo, Leticia M.;Bateman, Lorraine M.;Rao Khandavilli, U. B.;Lawrence, Simon E.;McGlacken, Gerard P.. And the article was included in Advanced Synthesis & Catalysis in 2017.HPLC of Formula: 61150-57-0 This article mentions the following:

A synthesis of tricyclic oxoisochromene derivatives via an intramol. direct arylation of cycloalkyl-1,3-diketone-derived 浼?灏?unsaturated ketone substrates is described. Interesting mechanistic insight has been gathered, based on deuterium migration studies, induced by palladium (Pd). In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0HPLC of Formula: 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. The principal reactions for organobromides include dehydrobromination, Grignard reactions, reductive coupling, and nucleophilic substitution.HPLC of Formula: 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Indanylidenes. 2. Design and Synthesis of (E)-2-(4-Chloro-6-fluoro-1-indanylidene)-N-methylacetamide, a Potent Antiinflammatory and Analgesic Agent without Centrally Acting Muscle Relaxant Activity was written by Musso, David L.;Orr, G. Faye;Cochran, Felicia R.;Kelley, James L.;Selph, Jeffrey L.;Rigdon, Greg C.;Cooper, Barrett R.;Jones, Michael L.. And the article was included in Journal of Medicinal Chemistry in 2003.Computed Properties of C7H5Br2F This article mentions the following:

Extension of the structure-activity relationship studies that led to the discovery of the nonsedating potent muscle relaxant, antiinflammatory, and analgesic agent (E)-2-(4,6-difluoro-1-indanylidene)acetamide has given rise to (E)-2-(4-chloro-6-fluoro-1-indanylidene)-N-methylacetamide (I). I is a potent antiinflammatory and analgesic agent without centrally acting muscle relaxant activity. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Computed Properties of C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. Organobromine compounds have fallen under increased scrutiny for their environmental impact. Bromine-containing agents predominate because not only are they more efficient than similar chlorine-containing species, but also the high atomic weight of bromine ensures that it is present in a high mass fraction within most organobromine compounds.Computed Properties of C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Coupling reactions of halobenzenes with alkynes. The synthesis of phenylacetylenes and symmetrical or unsymmetrical 1,2-diphenylacetylenes was written by Stara, Irena G.;Stary, Ivo;Kollarovic, Adrian;Teply, Filip;Saman, David;Fiedler, Pavel. And the article was included in Collection of Czechoslovak Chemical Communications in 1999.Related Products of 61150-57-0 This article mentions the following:

The Pd- or Pd/Cu-catalyzed coupling reactions of halobenzenes bearing the Me, hydroxymethyl, acetoxymethyl, methoxycarbonyl, or both methoxy and 4,4-dimethyl-4,5-dihydro-1,3-oxazol-2-yl groups in the ortho-position with gaseous or metalated acetylene, (trialkylsilyl)acetylenes, and arylacetylenes were systematically studied. Various functionalized aryl- or diarylacetylenes were synthesized in good to excellent yields. Whereas addnl. fluoro, nitro, or methoxy group attached to the benzene ring does not interfere in the coupling reactions, the presence of a methoxycarbonyl requires a careful optimization of reaction conditions to achieve moderate yields. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Related Products of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. In the pharmaceutical industry organo bromine derivatives are used as sedatives, vasodilators, antiseptic agents, and anticancer agents.Related Products of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Imidazobenzothiazine and primidobenzothiazine derivatives synthesis via an aliphatic S_N2 substitution/Cu(I) catalyzed Ullmann coupling cascade process was written by Wang, Ruihong;Qian, Weixing;Bao, Weiliang. And the article was included in Tetrahedron Letters in 2012.Formula: C7H5Br2F This article mentions the following:

An efficient method for the preparation of various imidazobenzothiazine and primidobenzothiazine derivatives from readily available 2-mercaptoimidazoles (thiouracils) and bromobenzyl bromides via a copper(I)-catalyzed one-pot cascade process has been developed. The reaction involves a S_N2 process and an intramol. C-N cross coupling cyclization. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Formula: C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). The reactivity of organobromine compounds resembles but is intermediate between the reactivity of organochlorine and organoiodine compounds. For many applications, organobromides represent a compromise of reactivity and cost.Formula: C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Double C(sp³)-H Bond Functionalization Mediated by Sequential Hydride Shift/Cyclization Process: Diastereoselective Construction of Polyheterocycles was written by Mori, Keiji;Kurihara, Kazuki;Yabe, Shinnosuke;Yamanaka, Masahiro;Akiyama, Takahiko. And the article was included in Journal of the American Chemical Society in 2014.Reference of 61150-57-0 This article mentions the following:

Described herein are two novel types of double C(sp³)-H bond functionalizations triggered by a sequential hydride shift/cyclization process: (1) construction of a bicyclo[3.2.2]nonane skeleton, e.g., I, by a [1,6]- and [1,5]-hydride shift sequence and (2) sequential [1,4]- and [1,5]-hydride shift mediated construction of a linear tricyclic skeleton, e.g., II. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Reference of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Organo bromine compounds are versatile compounds and are widely used in diverse fields. Organo bromine derivatives are used in the dye sector, as an indicator in analytical chemistry (Bromothymol blue is a popular indicator). When the molecular ion is detected, the bromine and chlorine isotope patterns are very distinct, but caution is to be exercised for certain mixed chlorinated/brominated compounds, which can look similar to homohalogen patterns.Reference of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Synthesis and evaluation of the performance of a small molecule library based on diverse tropane-related scaffolds was written by Lowe, Robert A.;Taylor, Dale;Chibale, Kelly;Nelson, Adam;Marsden, Stephen P.. And the article was included in Bioorganic & Medicinal Chemistry in 2020.Application of 61150-57-0 This article mentions the following:

A unified synthetic approach was developed that enabled the synthesis of diverse tropane-related scaffolds. The key intermediates that were exploited were cycloadducts formed by reaction between 3-hydroxypyridinium salts and vinyl sulfones or sulfonamides. The diverse tropane-related scaffolds were formed by addition of substituents to, cyclization reactions of, and fusion of addnl. ring(s) to the key bicyclic intermediates. A set of 53 screening compounds was designed, synthesized and evaluated in order to determine the biol. relevance of the scaffolds accessible using the synthetic approach. Two inhibitors of Hedgehog signalling, and four compounds with weak activity against the parasite P. falciparum, were discovered. Three of the active compounds may be considered to be indotropane or pyrrotropane pseudo natural products in which a tropane is fused with a fragment from another natural product class. It was concluded that the unified synthetic approach had yielded diverse scaffolds suitable for the design of performance-diverse screening libraries. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Application of 61150-57-0).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon閳ユ彽romine bond is electrophilic, i.e. alkyl bromides are alkylating agents. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Application of 61150-57-0

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Direct Synthesis of Pyrazolo[5,1-a]isoindoles via Intramolecular Palladium-Catalyzed C-H Bond Activation was written by Choi, Young Lok;Lee, Hyuk;Kim, Bum Tae;Choi, Kihang;Heo, Jung-Nyoung. And the article was included in Advanced Synthesis & Catalysis in 2010.Synthetic Route of C7H5Br2F This article mentions the following:

An efficient, direct synthesis of pyrazolo[5,1-a]isoindoles, e.g., I, employing a palladium-catalyzed intramol. C-H bond activation of 1-(2-halobenzyl)pyrazoles has been developed. The use of lithium chloride (LiCl) was found to be essential in these reactions, to suppress further C-H bond activation at the C-3 position of pyrazolo[5,1-a]isoindole, when C-3 is unsubstituted. This protocol can be applied to the synthesis of a pyrazolo[5,1-a]isoquinoline possessing a six-membered central ring system and a fully substituted pyrazolo[5,1-a]isoindole using sequential intra- and intermol. C-H bond activation. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0Synthetic Route of C7H5Br2F).

2-Bromo-4-fluorobenzylbromide (cas: 61150-57-0) belongs to organobromine compounds. Bromo compounds are employed in a variety of metal-catalyzed coupling reactions. They are also ideal candidates for the synthesis of Grignard reagents that have wide-applicability in organic synthesis. Commercially available organobromine pharmaceuticals include the vasodilator nicergoline, the sedative brotizolam, the anticancer agent pipobroman, and the antiseptic merbromin. Synthetic Route of C7H5Br2F

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary