611-75-6 Archives - Bromides-buliding-blocks

International Journal of Pharma and Bio Sciences | Cas: 611-75-6 was involved in experiment

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) (BHH; 250μM; 24 hours) also significantly attenuates HGF-induced invasion of LNCaP and C4-2B cells that natively express TMPRSS2. No significant toxicity is observed over a 48-hour period exposing LNCaP, DU145, PC3, or HepG2 cells to Bromhexine hydrochloride concentrations ranging from 0μM to 250μM. Bromhexine hydrochloride exposure does not induce cell death or substantially suppress the growth of DU145 cells.Bromhexine hydrochloride (20 μM; 48 h) inhibits dendritic cells infection with HIV-1.Reference of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride

Bucktowar, Kelvin published 《A review on bromhexine hydrochloride and the different analytical methods used for its determination》. The research results were published in《International Journal of Pharma and Bio Sciences》 in 2017.Reference of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride The article conveys some information:

A review. Bromhexine hydrochloride is a mucolytic agent (expectorant) used in the treatment of respiratory disorders associated with viscid or excessive mucus. The active ingredient Bromhexine hydrochloride is an expectorant which works by loosening mucus in the chest, making it easier to cough up secretions. It is also used to treat productive, chesty coughs. It is chem. named 2-amino-3,5-dibromobenzyl (cyclohexyl) methylamine hydrochloride. According to IUPAC it is 2,4-dibromo-6-[[cyclohexyl (methyl) amino] methyl] aniline; hydrochloride. Bromhexine hydrochloride is a synthetic substance obtained as a synthetic analog of vasicine, a substance found in plants called Adhtoda vasica. The mechanism of action is based on phlegm degradation, thereby easing coughs. The different anal. methods used to quantify the drug as a single active pharmaceutical ingredient includes flow injection anal. with ion selective electrodes, inductively coupled plasma mass spectrometry, electrokinetic chromatog., electrochem. oxidation at the glassy carbon electrode, liquid chromatog., liquid gas chromatog., GC with mass detection, and Voltammetry. The drug has also been quantified in its combined formulations using HPLC, direct and derivative UV spectrophotometry. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

Reference:
Bromide – Wikipedia,
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Cas: 611-75-6 | Bhyan, Bhupinderpublished an article in 2016

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Computed Properties of C14H21Br2ClN2

Computed Properties of C14H21Br2ClN2In 2016, Bhyan, Bhupinder;Bhyan, Sarita Jangra;Chopra, Vivek;Berwal, Ravi published 《Formulation and evaluation of novel orodispersible drug delivery system for the administration of Bromhexine hydrochloride》. 《World Journal of Pharmacy and Pharmaceutical Sciences》published the findings. The article contains the following contents:

The aim of the research work was to formulate and evaluate novel orodispersible delivery of Bromhexine hydrochloride in the form of oral fast disintegrating films. Formulated films offers a various advantages over the liquid formulation of Bromhexine hydrochloride like ease of handling and administration, expected increased bioavailability due to elimination of hepatic first-pass metabolism These fast disintegrating films were prepared by solvent casting methods using HPMC E-3 and PVP k-30 as film forming polymers. Cardamom extract, sucralose were used as flavoring agent and sweetening agent to impart pleasant taste. To decrease the disintegration time of formulations sodium starch glycolate was used as disintegrating agent. All the prepared novel films formulations (F1-F8) was evaluated for their, weight variations, thickness tensile strength, percentage elongation, folding endurance, surface pH, in-vitro disintegration, drug content, in-vitro drug release. In the time range 40-80 s all the film formulation was completely disintegrated. Formulations F1 and F2 showed 90% in-vitro drug release within 8 min. The film showed an excellent stability at least for 3 mo when stored at 40° C and 75% in humidity.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.

Reference:
Bromide – Wikipedia,
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Cas: 611-75-6 was involved in experiment | European Journal of Organic Chemistry 2014

Sharif, Muhammad;Pews-Davtyan, Anahit;Lukas, Jan;Schranck, Johannes;Langer, Peter;Rolfs, Arndt;Beller, Matthias published 《Palladium-Catalyzed Carbonylative Transformations of Bromhexine into Bioactive Compounds as Glucocerebrosidase Inhibitors》. The research results were published in《European Journal of Organic Chemistry》 in 2014.HPLC of Formula: 611-75-6 The article conveys some information:

A general synthesis for dicarbonylated derivatives of the parent drug bromhexine is described. By using com. available Pd(OAc)₂/BuPAd₂ [CataCXium A, Ad = adamantyl, (butyl)bis(tricyclo[3.3.1.1^3,7]dec-1-yl)phosphine] catalyst system, the carbonylative arylation, amination and alkoxylation of bromohexine proceeded with up to 79% product yield. Selected synthesized derivatives of bromhexine showed improved effects as glucocerebrosidase inhibitors. The synthesis of the target compounds was achieved using 2-amino-3,5-dibromo-N-cyclohexyl-N-methylbenzenemethanamine (bromhexine) as a starting material. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

Reference:
Bromide – Wikipedia,
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Learn more about cas: 611-75-6 | International Journal for Pharmaceutical Research Scholars 2016

Ayre, Anita Pandurang;Marathe, Deepak Subhash;Borkar, Shilpa published 《Formulation and evaluation of orodispersible films of bromhexine HCl-a patient friendly approach》 in 2016. The article was appeared in 《International Journal for Pharmaceutical Research Scholars》. They have made some progress in their research.Reference of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride The article mentions the following:

The present investigation was carried out with the objective of formulating orodispersible forms of the mucolytic drug, Bromhexine HCl to enhance convenience and compliance to the elderly and pediatric patients for better therapeutic efficacy. Orodispersible films of Bromhexine HCl were prepared by solvent evaporation technique. Formulation studies were carried out using different polymer combinations, the obtained films were evaluated for their appearance, color, elegance, continuity, texture, presence of air bubbles, stickiness to Petri dish, cracks, cuttings, and imperfections. Alginate and HPMC based films recorded the fastest disintegration when used alone and in mixtures with PVP-K25 and maltodextrin. Xanthan gum film had the longest disintegration time. Moreover, adding xanthan gum, Na CMC, and carbopol prolonged the disintegration time of HPMC and alginate films. A good correlation existed between the calculated dissolution rate of each film and its disintegration time. Formulas F1and F7 showed the highest resistance against moisture absorption and recoded tensile strength values of 15.47 and 17.16 kg/mm2, resp. after storage. Films based on HPMC alone or in combination with other polymers exhibited high resistance against moisture absorption except with Na CMC. Alginate and xanthan gum based films had a higher affinity for moisture absorption. The addition of maltodextrin significantly decreased the percentage moisture absorption after storage at 97% relative humidity. This effect was concentration-dependent. Thus disintegration time of film was 25 s, drug content 92.4 % and drug release was 96.3 %. The developed formulation was found to be stable under the conditions tested. To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Xiaotong et al. published new experimental results with the assistance of cas: 611-75-6

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Category: bromides-buliding-blocks

Wang, Xiaotong;Li, Linghui;Ran, Xiaoku;Dou, Deqiang;Li, Bin;Yang, Bingyou;Li, Wei;Koike, Kazuo;Kuang, Haixue published 《What caused the changes in the usage of Atractylodis Macrocephalae Rhizoma from ancient to current times?》. The research results were published in《Journal of Natural Medicines》 in 2016.Category: bromides-buliding-blocks The article conveys some information:

Ancient Chinese medicine treatises on Atractylodis Macrocephalae Rhizoma (AMR), the rhizome of Atractylodes macrocephala Koidz, indicated that it possessed an expectorant effect. However, in modern times, it is commonly used as a tocolytic agent. In this study, the components of AMR that are responsible for its expectorant and tocolytic effects were evaluated in order to clarify the differences in its application between ancient and modern times. A decoction of AMR was separated into five fractions, namely, volatile oil (VO), petroleum ether (PE), alc. eluate from macroporous resin (AE), water eluate from macroporous resin (WE), and polysaccharides (PS), using various separation methods. The expectorant experiment indicated that the VO fraction, which mainly contains atractylone, produced an obvious expectorant effect. The experiment that assessed the irritability of uterine smooth muscle (USM) showed that the PE, which is mainly composed of atractylenolides, and the PS, which is mainly composed of inulin-type polysaccharides, were the active fractions for tocolysis, but the VO fraction had the opposite action. These data suggested that volatile oils are the key components responsible for the usage change of AMR in both ancient and current usage. The experimental procedure involved many compounds, such as 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Explore more uses of cas: 611-75-6 | Zhongguo Yaoshi (Beijing, China)

COA of Formula: C14H21Br2ClN2In 2016, Li, Wendong;Wang, Chenggang;Wu, Kechun;Liu, Haitao;Wang, Junqiu published 《Comparative study on domestic bromhexine hydrochloride tablets and primary research preparation》. 《Zhongguo Yaoshi (Beijing, China)》published the findings. The article contains the following contents:

Objective: To evaluate the quality of domestic bromhexine hydrochloride tablets and primary research preparations Methods: The dissolution curves of the tablets and preparation in four dissolution media were compared. The quality of Bromhexine Hydrochloride Tablets was analyzed with the new related substances method. Results: The comparative study showed the dissolution curve of one domestic manufacturer was similar to that of the original manufacturer. Impurity profiles anal. showed that unknown impurity X which came from API was the main reason to influence the purity level of domestic preparations, meanwhile, impurity X was not detected in primary research preparations Conclusion: The quality of API was the main factor to influence the quality of domestic preparations There was difference in manufacturing technique between foreign API and domestic API.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.

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Bromide – Wikipedia,
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Learn more about cas: 611-75-6 | Journal of Chemical and Pharmaceutical Research 2015

Rele, Rajan V. published 《Simultaneous UV-spectrophotometric estimation of bromhexine hydrochloride and salbutamol sulphate by first order derivative method in combined dosage form》 in 2015. The article was appeared in 《Journal of Chemical and Pharmaceutical Research》. They have made some progress in their research.HPLC of Formula: 611-75-6 The article mentions the following:

The objective of the study was to develop a simple, accurate, precise and rapid UV spectrophotometric, first order derivative, method for simultaneous estimation of bromhexine hydrochloride and salbutamol sulfate from combined dosage form. The validation was carried out by using ICH guidelines for the determination of bromhexine hydrochloride and salbutamol sulfate by using 0.1N hydrochloric acid as the solvent in pharmaceutical dosage form. The proposed first order derivative method involves the measurement of absorbance of one drug at zero crossing point of other; hence wavelengths 240 nm and 233 nm were selected for the estimation of bromhexine hydrochloride and salbutamol sulfate resp. The linearity of the proposed method was found in the concentration range of 2 to 14 μg /mL (r²= 0.9995) for bromhexine hydrochloride and 2 to 16 μg /mL (r² = 0.9996) for salbutamol sulfate resp. The percentage mean recovery was found to be 100.166 % for bromhexine hydrochloride and 100.147 % for salbutamol sulfate resp. The method was also statistically validated for its linearity, accuracy and precision. Both intra and inter day variations showed less percentage (%) RSD values indicating high grade of precision of this method. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

Reference:
Bromide – Wikipedia,
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Learn more about cas: 611-75-6 | European Journal of Chemistry 2022

Abdullatif, Hind Ali;Michael, Adel Magdy;Trabik, Yossra Ahmed;Ayad, Miriam Farid published 《Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: application to combined antibiotic formulations》. The research results were published in《European Journal of Chemistry》 in 2022.Category: bromides-buliding-blocks The article conveys some information:

This work describes a comparative study of two multivariate chemometric and univariate spectrophotometric methods for the determination of a ternary drug mixture containing oxytetracycline HCl, bromhexine HCl, and lidocaine HCl. All methods show high sensitivity and similar linearity range. Meanwhile, the chemometric method has the advantage of higher accuracy, higher specificity and better regression parameters. The two spectrophotometric methods are constant multiplication coupled with spectrum subtraction and successive ratio subtraction coupled with spectrum subtraction while the chemometric method used partial least square and principal component regression models. In addition, a spiking technique was used to increase the concentration of bromhexine HCl in the dosage form, allowing its determination despite its low contribution. Methods were successfully applied in the dosage form Oxyclear veterinary injection in pure powder as well as in its pharmaceutical formulation. Statistical comparison showed no significant difference between the developed methods and the reference method. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

Reference:
Bromide – Wikipedia,
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Learn more about cas: 611-75-6 | Yakhak Hoechi 2013

Computed Properties of C14H21Br2ClN2In 2013, Lee, Tae-Woong;Jeong, Rae-Seok;Jeong, Seung-A.;Kim, Jeong-Hyun;Shim, Young-Hun;Kim, In-Kyu;Park, Chang-Won published 《Development of dissolution test method for acebrophylline capsules and bromhexine hydrochloride tablets in Korean pharmaceutical codex》. 《Yakhak Hoechi》published the findings. The article contains the following contents:

Although the dissolution test can serve as an effective tool for quality control and predictor of in vivo performance, there are a number of drugs with no established dissolution specification in Korean Pharmaceutical Codex (KPC). So, with each reference and test drugs, the dissolution test method and an anal. procedure by HPLC were developed and validated to establish dissolution specification for acebrophylline capsules and bromhexine hydrochloride tablets. The dissolution condition was determined based on the “Guidelines on Specifications of Dissolution tests for Oral dosage forms” of Ministry of Food and Drug Safety (MFDS). The anal. method of HPLC was validated in specificity, linearity, precision and accuracy. Final dissolution test was performed with com. available samples of 3 lots to establish specification. In addition, no difference was observed by the inter-laboratory evaluation. Dissolution specifications and conditions will be used for revising the monograph of acebrophylline capsules and bromhexine hydrochloride tablets in next supplement of KPC. To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

New progress of cas: 611-75-6 | BMJ [British Medical Journal] 2015

Ko, Tai-Ming;Tsai, Chang-Youh;Chen, Shih-Yang;Chen, Kuo-Shu;Yu, Kuang-Hui;Chu, Chih-Sheng;Huang, Chung-Ming;Wang, Chrong-Reen;Weng, Chia-Tse;Yu, Chia-Li;Hsieh, Song-Chou;Tsai, Jer-Chia;Lai, Wen-Ter;Tsai, Wen-Chan;Yin, Guang-Dar;Ou, Tsan-Teng;Cheng, Kai-Hung;Yen, Jeng-Hsien;Liou, Teh-Ling;Lin, Tsung-Hsien;Chen, Der-Yuan;Hsiao, Pi-Jung;Weng, Meng-Yu;Chen, Yi-Ming;Chen, Chen-Hung;Liu, Ming-Fei;Yen, Hsueh-Wei;Lee, Jia-Jung;Kuo, Mei-Chuan;Wu, Chen-Ching;Hung, Shih-Yuan;Luo, Shue-Fen;Yang, Ya-Hui;Chuang, Hui-Ping;Chou, Yi-Chun;Liao, Hung-Ting;Wang, Chia-Wen;Huang, Chun-Lin;Chang, Chia-Shuo;Lee, Ming-Ta Michael;Chen, Pei;Wong, Chih-Shung;Chen, Chien-Hsiun;Wu, Jer-Yuarn;Chen, Yuan-Tsong;Shen, Chen-Yang published 《Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study》 in 2015. The article was appeared in 《BMJ [British Medical Journal]》. They have made some progress in their research.Recommanded Product: 611-75-6 The article mentions the following:

Objective: To evaluate the use of prospective screening for the HLA-B*58:01 allele to identify Taiwanese individuals at risk of severe cutaneous adverse reactions (SCARs) induced by allopurinol treatment. Design: National prospective cohort study. Setting: 15 medical centers in different regions of Taiwan, from July 2009 to August 2014. Participants 2926 people who had an indication for allopurinol treatment but had not taken allopurinol previously. Participants: were excluded if they had undergone a bone marrow transplant, were not of Han Chinese descent, and had a history of allopurinol induced hypersensitivity. DNA purified from 2910 participants’ peripheral blood was used to assess the presence of HLA-B*58:01. Main Outcome Measures: Incidence of allopurinol induced SCARs with and without screening. Results: Participants who tested pos. for HLA-B*58:01 (19.6%, n = 571) were advised to avoid allopurinol, and were referred to an alternate drug treatment or advised to continue with their prestudy treatment. Participants who tested neg. (80.4%, n = 2339) were given allopurinol. Participants were interviewed once a week for two months to monitor symptoms. The historical incidence of allopurinol induced SCARs, estimated by the National Health Insurance research database of Taiwan, was used for comparison. Mild, transient rash without blisters developed in 97 (3%) participants during follow-up. None of the participants was admitted to hospital owing to adverse drug reactions. SCARs did not develop in any of the participants receiving allopurinol who screened neg. for HLA-B*58:01. By contrast, seven cases of SCARs were expected, based on the estimated historical incidence of allopurinol induced SCARs nationwide (0.30% per yr, 95% confidence interval 0.28% to 0.31%; P = 0.0026; two side one sample binomial test). Conclusions: Prospective screening of the HLA-B*58:01 allele, coupled with an alternative drug treatment for carriers, significantly decreased the incidence of allopurinol induced SCARs in Taiwanese medical centers. The experimental procedure involved many compounds, such as 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

Reference:
Bromide – Wikipedia,
bromide – Wiktionary