Category: 608-30-0

608-30-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 608-30-0, name is 2,6-Dibromoaniline, This compound has unique chemical properties. The synthetic route is as follows.

(1) Preparation of 2,6-Bis(4-t-butylphenyl)aniline The same procedure as in Example 1(1) was used except that reaction was conducted by using 2,6-dibromoaniline (9.00 g, 35.6 mmol), Pd(PPh3)4 (5.0 g), and 4-t-butylphenyl boronic acid (19.0 g, 107 mmol). Yield 3.0 g. 1H NMR (CD2Cl2): delta 7.50 (d, 4H, Harom), 7.43 (d, 4H, Harom), 7.08 (d, 2H, Harom), 6.83 (t, 1H, Harom), 3.93 (s, 2H, NH2), 1.38 (s, 18H, t-Bu).

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Reference:
Patent; Razavi, Abbas; Marin, Vladimir; Lopez, Margarito; US2005/90385; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 608-30-0, name is 2,6-Dibromoaniline, molecular formula is C6H5Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 608-30-0

EXAMPLE 42; N-[(2-(2,6-Dibromolphenyl)-1-{[4-(1,1-dimethylethyl)phenyl]methyl}-4-hydroxy-6-oxo-1,6-dihydro-5-pyrimidinyl)carbonyl]glycine; 42a) 2,6-Dibromobenzonitrile; 2,6-Dibromoaniline (0.251 g, 1.00 mmol) was added to a stirred solution of copper (I) cyanide (0.116 g, 1.30 mmol) in dimethylsulfoxide (10 mL) at 50 C. under nitrogen. tert-Butyl nitrite (0.357 mL, 3.00 mmol) was injected over 5 min and the mixture stirred for 1 h at 50 C., then cooled and poured into 1 M aqueous hydrochloric acid (100 mL). The mixture was extracted with ethyl acetate and the extracts washed with water, brine, then dried (MgSO4). The solvent was evaporated under reduced pressure and the residue chromatographed (silica gel, 1-9% methanol/dichloromethane) to give the title compound (0.100 g, 38%). 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 7.33 (t, J=8.08 Hz, 1 H) 7.67 (d, J=8.08 Hz, 2 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 608-30-0, its application will become more common.

Reference:
Patent; Shaw, Antony N.; Duffy, Kevin J.; Tedesco, Rosanna; Wiggall, Kenneth; US2008/171756; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 608-30-0, name is 2,6-Dibromoaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. 608-30-0

[0310] 3 -Chloroperoxy benzoic acid (77%, 11.97 mmol, 2.68 g) was added to a solution of 2,6-dibromoaniline (3.39 mmol; 1.00 g) in chloroform (24 ml). The resulting thick light green suspension was stirred at room temperature overnight. The reaction mixture was diluted with chloroform, washed with saturated aqueous sodium thiosulfate solution (2X), saturated aqueous sodium bicarbonate solution (3X) and brine, dried over anhydrous sodium sulfate and concentrated to afford the titled compound as a light tan solid. This product was taken on to the next step without further purification. NMR (400 MHz, CDCh) delta 7.74 (d, J = 7.96 Hz, 1H), 7.67 (dd, J = 33.6 Hz, J = 8.12 Hz, 1H), 7.25 (m, 1H).

The synthetic route of 608-30-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION; CHILDERS, Wayne, E.; ABOU-GHARBIA, Magid, A.; MORTON, George, C.; ISSA, Jean-Pierre, J.; ZHANG, Hanghang; (209 pag.)WO2018/136766; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

608-30-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 608-30-0, name is 2,6-Dibromoaniline, A new synthetic method of this compound is introduced below.

4-tert-Butylphenylboronic acid (4.81 g, 27.0 mmol) dissolved in ethanol (18 mL) and 2 M Na2CO3 (36 mL, 72 mmol) were added to a solution of 2,6-dibromoaniline (2.258 g, 9.0 mmol) in toluene (90 mL). To this solution, Pd(PPh3)4 (1.26 g, 1.0 mmol) was added. The mixture was heated to reflux for 72 h. After cooling to room temperature, the mixture was filtered and an excess of aqueous HCl was slowly added to the filtrate until no more white solid precipitated. The residue was suspended in diethyl ether after filtration and then an excess of 2 M Na2CO3 was slowly added until the solid was totally dissolved. The organic layer was dried over Na2SO4 and then the solvent was evaporated to give white solid (1.80 g, yield 56%). 1H NMR (500 MHz, CDCl3, delta in ppm): 7.47-7.52 (m, 8H, Ar-Hm), 7.15 (d, 2H, Ar-Ho), 6.89 (t, 1H, Ar-Hp), 3.95 (s,2H, NH2), 1.40 (s, 18H, CH3).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Pan, Huijie; Zhu, Liang; Li, Jiewei; Zang, Dandan; Fu, Zhisheng; Fan, Zhiqiang; Journal of Molecular Catalysis A: Chemical; vol. 390; (2014); p. 76 – 82;,
Bromide – Wikipedia,
bromide – Wiktionary