Category: 603-78-1

Kalach, A. V. published the artcile< Using artificial neural networks for prediction of organic acid partition coefficients>, Reference of 603-78-1, the main research area is artificial neural network prediction organic acid partition.

Aqueous/organic phase partition coefficients of organic acids were predicted using an artificial neural network (ANN) algorithm taking benzoic acid derivatives as examples. The partition coefficients were determined by extraction of the acids from aqueous salt solutions with hydrophilic solvents (BunOH, BuiOH, and ButOH). Using the ANN approach makes it possible to obtain quant. information on the values of the title parameters.

Russian Chemical Bulletin published new progress about Algorithm. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Reference of 603-78-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Blackhall, Alexander; Brydon, Donald L.; Javaid, Khalid; Sagar, Anthony J. G.; Smith, David M. published the artcile< Substitution reactions of phenylated aza heterocycles. Part 2. Bromination of some 2,5-diaryl-1,3,4-oxadiazoles>, Application In Synthesis of 603-78-1, the main research area is aryloxadiazole bromination; bromination diaryloxadiazole; oxadiazole diaryl bromination; nitrophenylphenyloxadiazole bromination regiochem.

2,5-Diaryl-1,3,4-oxadiazoles were brominated by either Br in oleum or Br and KBrO3 in HOAc-H2SO4. E.g., treatment of 2-(4-nitrophenyl)-5-phenyl-1,3,4-oxadiazole and Br in concentrated H2SO4-HOAc by dropwise addition of aqueous KBrO3 gave the corresponding 2-, 3-, and 4-bromophenyl and 2,3-, 2,5-, and 2,6-dibromophenyl derivatives in 16, 14, 26, 1, 6, and 2% yield, resp.

Journal of Chemical Research, Synopses published new progress about Bromination. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Application In Synthesis of 603-78-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Tashiro, Masashi; Nakayama, Kouji published the artcile< Preparation of bromobenzoic acids from the corresponding bromotoluenes via the Krohnke method>, Recommanded Product: 2,3-Dibromobenzoic acid, the main research area is benzoic acid dibromo; bromobenzoic acid; bromotoluene conversion bromobenzoic acid.

Bromotoluenes were converted to acids I (n = 2, 3) via N-benzylpyridinium salts II. Thus, 2,3-Br2C6H3Me was brominated to 2,3-Br2C6H3CH2Br, the latter and pyridine gave II (Brn = 2,3-Br2), the product was treated with 4-Me2NC6H4NO and then with HCl to yield 2,3-Br2C6H3CHO, and the aldehyde was oxidized by KMnO4 to give 2,3-Br2C6H3CO2H.

Organic Preparations and Procedures International published new progress about 603-78-1. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Recommanded Product: 2,3-Dibromobenzoic acid.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Haranahalli, Krupanandan; Lazzarini, Cristina; Sun, Yi; Zambito, Julia; Pathiranage, Senuri; McCarthy, J. Brian; Mallamo, John; Del Poeta, Maurizio; Ojima, Iwao published the artcile< SAR Studies on Aromatic Acylhydrazone-Based Inhibitors of Fungal Sphingolipid Synthesis as Next-Generation Antifungal Agents>, Application of C7H4Br2O2, the main research area is antifungal activities SAR Cryptococcus synergistic additive effect fungal strains.

Recently, the fungal sphingolipid glucosylceramide (GlcCer) synthesis has emerged as a highly promising new target for drug discovery of next-generation antifungal agents, and we found two aromatic acylhydrazones as effective inhibitors of GlcCer synthesis based on HTP screening. In the present work, we have designed libraries of new aromatic acylhydrazones, evaluated their antifungal activities (MIC80 and time-kill profile) against C. neoformans, and performed an extensive SAR study, which led to the identification of five promising lead compounds, exhibiting excellent fungicidal activities with very large selectivity index. Moreover, two compounds demonstrated broad spectrum antifungal activity against six other clin. relevant fungal strains. These five lead compounds were examined for their synergism/cooperativity with five clin. drugs against seven fungal strains, and very encouraging results were obtained; e.g., the combination of all five lead compounds with voriconazole exhibited either synergistic or additive effect to all seven fungal strains.

Journal of Medicinal Chemistry published new progress about Cryptococcus neoformans. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Application of C7H4Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Li; Chen, Peng published the artcile< Development of first-stage co-liquefaction of Chinese coal with waste plastics>, Application of C7H4Br2O2, the main research area is liquefaction Chinese coal waste plastic.

Polyethylene (PE), polypropylene (PP), and polystyrene (PS), etc. were successfully converted to oil under typical direct liquefaction conditions (410-450°, reaction time of 60 min, 10 MPa of H2 cold) with Chinese coal. A series of liquefaction experiments were run using ground coal and plastic waste, individually and in combination. Results on individual plastics showed that high d. PE (HDPE) was by far the most difficult of the model plastics to convert, higher conversions could be obtained with higher temperatures Co-liquefaction experiments were performed on coal-plastic mixtures (usually 1:1 mixtures) using a Chinese Xianfeng lignite with the fly ash of molybdenum concentrates calcined (FAMo) as catalyst. The oil yields except Xianfeng lignite-HDPE co-liquefaction were as high as 60.3-78.1%, while the total conversions reached levels of over 95%. Anyway, oil yields for Chinese coal-plastic co-liquefaction were higher, typically by 5.1-22.6%, than the average of the oil yields for the coal and plastic alone, hydrogen consumption was also reduced by 7.7-17.9%, implying synergistic effects in co-liquefaction reaction of Chinese coal and waste plastics (WP).

Chemical Engineering and Processing published new progress about Coal hydroliquefaction. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Application of C7H4Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zheng, Hong-Xing; Shan, Xiang-Huan; Qu, Jian-Ping; Kang, Yan-Biao published the artcile< Strategy for Overcoming Full Reversibility of Intermolecular Radical Addition to Aldehydes: Tandem C-H and C-O Bonds Cleaving Cyclization of (Phenoxymethyl)arenes with Carbonyls to Benzofurans>, Quality Control of 603-78-1, the main research area is haloaralkyl ether aldehyde tandem intermol radical addition cyclization; benzofuran preparation.

An intermol. addition of carbon radicals enabled by a cascade radical coupling strategy is developed. It includes an intermol. alkyl radical addition to a carbonyl group followed by an intramol. alkoxy radical addition to haloarenes and produces substituted benzofurans in high yields. The radical nature of this reaction is explored by radical trapping experiments and EPR anal. The mechanism is investigated by KIE experiments and control experiments This method could provide rapid and practical access to the key intermediate of TAM-16, a safe and potent antibacterial agent for treating tuberculosis, and, therefore, is of great importance for organic synthesis and the pharmaceutical industry.

Organic Letters published new progress about Aldehydes Role: PRP (Properties), RCT (Reactant), RACT (Reactant or Reagent). 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Quality Control of 603-78-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Li, Ya-Wei; Zheng, Hong-Xing; Yang, Bo; Shan, Xiang-Huan; Qu, Jian-Ping; Kang, Yan-Biao published the artcile< tBuOK-Promoted Cyclization of Imines with Aryl Halides>, COA of Formula: C7H4Br2O2, the main research area is imine aryl halide aminyl radical potassium tert butoxide cyclization; indole preparation.

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramol. coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

Organic Letters published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, COA of Formula: C7H4Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Liedholm, Brita published the artcile< Copper(I)-catalyzed replacement of bromine by chloride ion in bromobenzoic acids>, Related Products of 603-78-1, the main research area is copper catalyst bromine exchange; bromobenzoate chloride exchange reaction.

Kinetics of the exchange reactions of 2,3-dibromobenzoic acid and of 2-bromobenzoic acid, catalyzed by dichlorocuprate(I) ion, were determined A tetrahedral intermediate complex involving the dichlorocuprate anion and the Br atom undergoing replacement was suggested.

Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry published new progress about Exchange reaction. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Related Products of 603-78-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cohen, Julius Berend; Zortman, Israel Hyman published the artcile< The relation of position isomerism to optical activity. V. The rotation of the menthyl esters of the isomeric dibromobenzoic acids>, Application In Synthesis of 603-78-1, the main research area is .

The esters were prepared by oxidizing the six dibromotoluenes to the corresponding acids, which were then converted into the acid chlorides, and the latter into the esters by heating with menthol. The preparation of menthyl 2:3-dibromobenzoate, menthyl 2:4-dibromobenzoate, menthyl 2:5-dibromobenzoate, menthyl 2:6-dibromobenzoate, menthyl 3:4-dibromobenzoate, and menthyl 3:5-dibromobenzoate are described.

Journal of the Chemical Society, Transactions published new progress about Boiling point. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Application In Synthesis of 603-78-1.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Thun-Hohenstein, Siegfried T. D.; Suits, Timothy F.; Malla, Tika R.; Tumber, Anthony; Brewitz, Lennart; Choudhry, Hani; Salah, Eidarus; Schofield, Christopher J. published the artcile< Structure-Activity Studies Reveal Scope for Optimisation of Ebselen-Type Inhibition of SARS-CoV-2 Main Protease>, Formula: C7H4Br2O2, the main research area is ebselen derivative SARS CoV2 main protease inhibitor COVID19; COVID-19; Mpro inhibition; SARS-CoV-2; ebselen; ebsulfur; nucleophilic cysteine protease..

The reactive organoselenium compound ebselen is being investigated for treatment of coronavirus disease 2019 (COVID-19) and other diseases. We report structure-activity studies on sulfur analogs of ebselen with the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro), employing turnover and protein-observed mass spectrometry-based assays. The results reveal scope for optimization of ebselen/ebselen derivative- mediated inhibition of Mpro, particularly with respect to improved selectivity.

ChemMedChem published new progress about Anticoronaviral agents. 603-78-1 belongs to class bromides-buliding-blocks, and the molecular formula is C7H4Br2O2, Formula: C7H4Br2O2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary