Category: 59907-12-9

Synthetic Route of 59907-12-9, A common heterocyclic compound, 59907-12-9, name is 1-Bromo-2-fluoro-3-methylbenzene, molecular formula is C7H6BrF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-Bromo-3-bromomethyl-2-fluorobenzene Obtained according to Example E but starting from 1-bromo -2-fluoro- 3-methylbenzene (prepared according to M. S. Newman and R. Kannan, J. Org. Chem., 1976, 41, 3356) and distilling the final product at 20 mm Hg. Yd.: 66% B.p.20 =95-105 C. 1 H N.M.R. (CDCl3): 4.4 (2H, s), 6.6 to 7.6 (3H, m).

The synthetic route of 59907-12-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lipha, Lyonnaise Industrielle Pharmaceutique; US5489592; (1996); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 59907-12-9, name is 1-Bromo-2-fluoro-3-methylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59907-12-9, Formula: C7H6BrF

General procedure: To an oven-dried 25 mL Schlenk tube containing a stirring bar was added 4.5 mg Pd(OAc)2 (0.02 mmol), 15.7mg nBuPAd2 (0.44 mmol), 2-bromofluorobenzene (0.50 mmol), salicylaldehyde (0.50 mmol), potassium carbonate (1.0 mmol). The Schlenk tube was vacuumed and then purged with argon before DMF (2.0 mL) was injected using a syringe. Afterwards the Schlenk tube in the ice bath was degassed by evacuation and back fillingwith argon three times. The reaction mixture was then stirred for 12 h at 120 C. After the reaction was complete,the reaction mixture was diluted with water (5 mL), extracted with ethyl acetate (3 x 10 mL) and dried withanhydrous Na2SO4. After filtration and addition of silica gel into the solution, the organic solvent was reduced evaporated. The crude product was purified by column chromatography using ethyl acetate/n-pentane.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2-fluoro-3-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Shen, Chaoren; Wu, Xiao-Feng; Synlett; vol. 27; 8; (2016); p. 1269 – 1273;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 59907-12-9, name is 1-Bromo-2-fluoro-3-methylbenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Bromo-2-fluoro-3-methylbenzene

General Procedure 2 – Sonogashira coupling of 2-ethynyl-6,7-dihydroindolizin- 8(5H)-one with aryl bromides[00225]A solution of 2-ethynyl-6,7-dihydroindolizin-8(5H)-one, an appropriate aryl bromide (1 .1 eq.) and TEA (4 eq.) in dry DMF (2.5 mL) is flushed with argon for 10 min. PdCl2(Ph3P)2 (0.05 eq.) and copper(l)iodide (0.01 eq.) are added, and the reaction mixture is heated at 90 C for 30 min under microwave conditions. After cooling down to room temperature the mixture is diluted with EtOAc (50 mL), washed with brine (3×50 mL), dried over Na2SO and concentrated in vacuo. Purification by preparative TLC (silica, 50% EtOAc/heptane) and co-evaporation with Et2O (2×2 mL) provides the final compound.Example 622-((2-Fluoro-3-methylphenyl)ethynyl)-6,7-dihydroindolizin-8(5H)-one[00294] According to General Procedure 2, 2-ethynyl-6,7-dihydroindolizin-8(5H)-one (150 mg, 0.942 mmol) is reacted with 1 -bromo-2-fluoro-3-methylbenzene (129 mu, 1 .04 mmol) to provide the title compound (45 mg, 18%) as a light yellow powder. 1H NMR (CDCIs), deltaEta: 2.28-2.34 (m, 5H), 2.62 (t, 2H), 4.13 (t, 2H), 6.96-7.31 (m, 5H). LC/MS (M+H)+ = 268

The synthetic route of 59907-12-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERZ PHARMA GmbH & CO. KGaA; ZEMRIBO, Ronalds; FOTINS, Juris; ABEL, Ulrich; KUBAS, Holger; MEYER, Udo; WOLTER, Falko Ernst; HECHENBERGER, Mirko; WO2012/172093; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary